NO20070665L - Derivater av 1-fenylalkankarboksylsyrer for behandlingen av neurodegenerative sykdommer - Google Patents

Derivater av 1-fenylalkankarboksylsyrer for behandlingen av neurodegenerative sykdommer

Info

Publication number
NO20070665L
NO20070665L NO20070665A NO20070665A NO20070665L NO 20070665 L NO20070665 L NO 20070665L NO 20070665 A NO20070665 A NO 20070665A NO 20070665 A NO20070665 A NO 20070665A NO 20070665 L NO20070665 L NO 20070665L
Authority
NO
Norway
Prior art keywords
treatment
neurodegenerative diseases
derivatives
phenylalkanecarboxylic
phenylalkanecarboxylic acids
Prior art date
Application number
NO20070665A
Other languages
English (en)
Other versions
NO339921B1 (no
Inventor
Gino Villetti
Luca Raveglia
Ilaria Peretto
Stefano Radaelli
Bruno Pietro Imbimbo
Andrea Rizzi
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of NO20070665L publication Critical patent/NO20070665L/no
Publication of NO339921B1 publication Critical patent/NO339921B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Abstract

Den foreliggende oppfinnelsen vedrører nye derivater av 1-fenylalkankarboksylsyre, farmasøytiske blandinger av denne, en fremgangsmåte for deres fremstilling og deres bruk i behandlingen og/eller forebyggingen av nevrodegenerative sykdommer så som Alzheimers sykdom.
NO20070665A 2004-08-03 2007-01-31 Derivater av 1-fenylalkankarboksylsyrer for behandlingen av neurodegenerative sykdommer NO339921B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04425604 2004-08-03
PCT/IB2005/002189 WO2006016219A2 (en) 2004-08-03 2005-07-26 Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases

Publications (2)

Publication Number Publication Date
NO20070665L true NO20070665L (no) 2007-05-02
NO339921B1 NO339921B1 (no) 2017-02-13

Family

ID=35462580

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070665A NO339921B1 (no) 2004-08-03 2007-01-31 Derivater av 1-fenylalkankarboksylsyrer for behandlingen av neurodegenerative sykdommer

Country Status (22)

Country Link
US (1) US7531692B2 (no)
EP (1) EP1778623B1 (no)
JP (1) JP4866851B2 (no)
KR (1) KR101156393B1 (no)
CN (1) CN1984878B (no)
AT (1) ATE399758T1 (no)
AU (1) AU2005270949B2 (no)
BR (1) BRPI0513647A (no)
CA (1) CA2576009C (no)
CY (1) CY1110401T1 (no)
DE (1) DE602005007912D1 (no)
DK (1) DK1778623T3 (no)
ES (1) ES2309778T3 (no)
HK (1) HK1104280A1 (no)
HR (1) HRP20080494T3 (no)
NO (1) NO339921B1 (no)
PL (1) PL1778623T3 (no)
PT (1) PT1778623E (no)
RS (1) RS50601B (no)
SI (1) SI1778623T1 (no)
WO (1) WO2006016219A2 (no)
ZA (1) ZA200700945B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0407662B8 (pt) 2003-02-21 2021-05-25 Chiesi Farm Spa derivados do ácido 1-fenilalcanocarboxílico para o tratamento de doenças neurodegenerativas
EP2560942B1 (en) 2010-04-21 2014-11-26 Chiesi Farmaceutici S.p.A. 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis
EP2575797A1 (en) 2010-06-04 2013-04-10 Chiesi Farmaceutici S.p.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the therapy of prion diseases
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
WO2013150072A1 (en) 2012-04-04 2013-10-10 Chiesi Farmaceutici S.P.A. Derivatives of 1-(2-halo-biphenyl-4-yl)- alkanecarboxylic acids for the treatment of neurodegenerative diseases
US20150335596A1 (en) 2014-05-26 2015-11-26 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
WO2019099294A1 (en) 2017-11-14 2019-05-23 Merck Sharp & Dohme Corp. Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
MX2020004930A (es) 2017-11-14 2020-08-27 Merck Sharp & Dohme Compuestos de biarilo sustituido novedosos como inhibidores de indolamina 2,3-dioxigenasa (ido).

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283489B1 (it) * 1996-07-23 1998-04-21 Chiesi Farma Spa Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico
US6211235B1 (en) * 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6191166B1 (en) 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6117901A (en) * 1996-11-22 2000-09-12 Athena Neurosciences, Inc. N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use
WO1998034115A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries
US5994379A (en) * 1998-02-13 1999-11-30 Merck Frosst Canada, Inc. Bisaryl COX-2 inhibiting compounds, compositions and methods of use
FR2842523A1 (fr) * 2002-07-17 2004-01-23 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
BRPI0407662B8 (pt) 2003-02-21 2021-05-25 Chiesi Farm Spa derivados do ácido 1-fenilalcanocarboxílico para o tratamento de doenças neurodegenerativas

Also Published As

Publication number Publication date
ZA200700945B (en) 2008-09-25
ES2309778T3 (es) 2008-12-16
HRP20080494T3 (en) 2008-11-30
BRPI0513647A (pt) 2008-05-13
SI1778623T1 (sl) 2008-10-31
EP1778623A2 (en) 2007-05-02
CA2576009A1 (en) 2006-02-16
DK1778623T3 (da) 2008-10-20
CA2576009C (en) 2013-02-26
JP4866851B2 (ja) 2012-02-01
US7531692B2 (en) 2009-05-12
WO2006016219A2 (en) 2006-02-16
PL1778623T3 (pl) 2008-12-31
RS50601B (sr) 2010-05-07
KR20070038982A (ko) 2007-04-11
CY1110401T1 (el) 2015-04-29
DE602005007912D1 (de) 2008-08-14
US20080096968A1 (en) 2008-04-24
CN1984878A (zh) 2007-06-20
WO2006016219A3 (en) 2006-04-27
EP1778623B1 (en) 2008-07-02
AU2005270949A1 (en) 2006-02-16
NO339921B1 (no) 2017-02-13
AU2005270949B2 (en) 2011-02-03
KR101156393B1 (ko) 2012-06-13
ATE399758T1 (de) 2008-07-15
JP2008509124A (ja) 2008-03-27
HK1104280A1 (en) 2008-01-11
PT1778623E (pt) 2008-09-29
CN1984878B (zh) 2011-06-08

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