HUP0204182A2 - Fumársavszármazékok használata mitokondriális betegségek kezelésére - Google Patents

Fumársavszármazékok használata mitokondriális betegségek kezelésére

Info

Publication number
HUP0204182A2
HUP0204182A2 HU0204182A HUP0204182A HUP0204182A2 HU P0204182 A2 HUP0204182 A2 HU P0204182A2 HU 0204182 A HU0204182 A HU 0204182A HU P0204182 A HUP0204182 A HU P0204182A HU P0204182 A2 HUP0204182 A2 HU P0204182A2
Authority
HU
Hungary
Prior art keywords
fumaric acid
disease
acid derivatives
mitochondrial diseases
treating mitochondrial
Prior art date
Application number
HU0204182A
Other languages
English (en)
Inventor
Rajendra Kumar Joshi
Hans-Peter Strebel
Original Assignee
Fumapharm Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm Ag. filed Critical Fumapharm Ag.
Publication of HUP0204182A2 publication Critical patent/HUP0204182A2/hu
Publication of HUP0204182A3 publication Critical patent/HUP0204182A3/hu
Publication of HU229138B1 publication Critical patent/HU229138B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A jelen találmány fumársavszármazékok vagy ezek keverékeinekhasználatára vonatkozik, melyeket a mitokondriális betegségek,elsődlegesen a Parkinson-féle betegség, az Alzheimer-féle kór, aChorea Huntington-betegség, a retinopathia pigmentosa és amitokondriális encephalomiopátia kezelésében gyógyszerészetiösszetételek készítéséhez alkalmaznak. Előnyösen afumársavszármazéko(ka)t a következők közül választják ki: fumársav-dialkil-észterek, fumársav-monoalkilészterek szabad sav formában vagysó formákban. Ó
HU0204182A 2000-01-10 2000-12-11 Use of fumaric acid derivatives for treating mitochondrial diseases HU229138B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10000577A DE10000577A1 (de) 2000-01-10 2000-01-10 Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
PCT/EP2000/012504 WO2001051047A1 (de) 2000-01-10 2000-12-11 Verwendung von fumarsäurederivaten zur behandlung mitochondrialer krankheiten

Publications (3)

Publication Number Publication Date
HUP0204182A2 true HUP0204182A2 (hu) 2003-04-28
HUP0204182A3 HUP0204182A3 (en) 2003-05-28
HU229138B1 HU229138B1 (en) 2013-08-28

Family

ID=7627026

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204182A HU229138B1 (en) 2000-01-10 2000-12-11 Use of fumaric acid derivatives for treating mitochondrial diseases

Country Status (28)

Country Link
US (1) US6858750B2 (hu)
EP (1) EP1248606B1 (hu)
JP (1) JP2003529556A (hu)
CN (1) CN1433303A (hu)
AT (1) ATE329590T1 (hu)
AU (1) AU772409B2 (hu)
BG (1) BG65468B1 (hu)
BR (1) BR0016935A (hu)
CA (1) CA2390886C (hu)
CY (1) CY1105462T1 (hu)
CZ (1) CZ303680B6 (hu)
DE (2) DE10000577A1 (hu)
DK (1) DK1248606T3 (hu)
EE (1) EE05051B1 (hu)
ES (1) ES2265367T3 (hu)
HU (1) HU229138B1 (hu)
IL (2) IL150516A0 (hu)
MX (1) MXPA02006695A (hu)
NO (1) NO326875B1 (hu)
NZ (1) NZ518781A (hu)
PL (1) PL223342B1 (hu)
PT (1) PT1248606E (hu)
RS (1) RS50185B (hu)
RU (1) RU2218918C1 (hu)
SI (1) SI1248606T1 (hu)
SK (1) SK286719B6 (hu)
WO (1) WO2001051047A1 (hu)
ZA (1) ZA200205481B (hu)

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DE10217314A1 (de) * 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
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EP2801354B1 (en) * 2004-10-08 2017-02-08 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
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US20120034274A1 (en) * 2009-01-09 2012-02-09 Forward Pharma A/S Pharmaceutical composition comprising one or more fumaric acid esters
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US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
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US20140142095A1 (en) * 2011-04-28 2014-05-22 Serket Pharma, Llc Agents useful for treating friedreich's ataxia and other neurodegenerative diseases
NZ618178A (en) 2011-06-08 2016-03-31 Biogen Ma Inc Process for preparing high purity and crystalline dimethyl fumarate
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US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
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CN114146080A (zh) * 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
TWI486339B (zh) 2012-02-07 2015-06-01 Xenoport Inc □啉烷基反丁烯二酸化合物、醫藥組成物以及使用之方法
CA2882713A1 (en) 2012-08-22 2014-02-27 Xenoport, Inc. Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
CA2882730C (en) 2012-08-22 2019-12-31 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
TW201436790A (zh) 2012-12-21 2014-10-01 Biogen Idec Inc 經氘取代之反丁烯二酸酯衍生物類
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
SI2970101T1 (sl) 2013-03-14 2018-09-28 Alkermes Pharma Ireland Limited Prozdravila fumaratov in njihova uporaba pri zdravljenju različnih bolezni
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途
ES2753361T3 (es) 2014-02-24 2020-04-08 Alkermes Pharma Ireland Ltd Sulfonamida y profármacos de fumaratos de sulfinamida y su uso en el tratamiento de diversas enfermedades
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
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US10085961B2 (en) 2015-06-01 2018-10-02 Sun Pharmaceutical Industries Limited Pharmaceutical compositions of dimethyl fumarate
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IT201700087359A1 (it) 2017-07-28 2019-01-28 Professional Dietetics Spa Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale
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Also Published As

Publication number Publication date
NO20022175D0 (no) 2002-05-07
PL223342B1 (pl) 2016-10-31
EP1248606A1 (de) 2002-10-16
NZ518781A (en) 2004-04-30
IL150516A (en) 2009-02-11
EE05051B1 (et) 2008-08-15
BG65468B1 (bg) 2008-09-30
US20030013761A1 (en) 2003-01-16
JP2003529556A (ja) 2003-10-07
CZ303680B6 (cs) 2013-02-27
SK286719B6 (sk) 2009-04-06
AU3156601A (en) 2001-07-24
RU2218918C1 (ru) 2003-12-20
HU229138B1 (en) 2013-08-28
BR0016935A (pt) 2003-04-01
ATE329590T1 (de) 2006-07-15
ES2265367T3 (es) 2007-02-16
CY1105462T1 (el) 2010-04-28
BG106685A (en) 2003-01-31
HUP0204182A3 (en) 2003-05-28
EE200200333A (et) 2003-08-15
ZA200205481B (en) 2004-01-28
SI1248606T1 (sl) 2006-10-31
WO2001051047A8 (de) 2001-08-16
IL150516A0 (en) 2003-02-12
WO2001051047A1 (de) 2001-07-19
NO20022175L (no) 2002-05-07
DE50013000D1 (de) 2006-07-27
CZ20021522A3 (cs) 2002-10-16
CA2390886A1 (en) 2001-07-19
RS50185B (sr) 2009-05-06
YU51402A (sh) 2006-01-16
MXPA02006695A (es) 2002-10-23
AU772409B2 (en) 2004-04-29
PL356714A1 (en) 2004-06-28
EP1248606B1 (de) 2006-06-14
PT1248606E (pt) 2006-08-31
US6858750B2 (en) 2005-02-22
DE10000577A1 (de) 2001-07-26
CN1433303A (zh) 2003-07-30
CA2390886C (en) 2008-08-19
DK1248606T3 (da) 2006-08-21
SK6522002A3 (en) 2002-11-06
NO326875B1 (no) 2009-03-09

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MM4A Lapse of definitive patent protection due to non-payment of fees