ITMI931649A1 - Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico - Google Patents
Derivati dell'acido 2-ammino-4-fenil-4-osso butirricoInfo
- Publication number
- ITMI931649A1 ITMI931649A1 IT001649A ITMI931649A ITMI931649A1 IT MI931649 A1 ITMI931649 A1 IT MI931649A1 IT 001649 A IT001649 A IT 001649A IT MI931649 A ITMI931649 A IT MI931649A IT MI931649 A1 ITMI931649 A1 IT MI931649A1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- phenyl
- amino
- butyric
- bone acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001649A IT1265101B1 (it) | 1993-07-23 | 1993-07-23 | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
PL94308142A PL179857B1 (pl) | 1993-07-23 | 1994-07-12 | Pochodne kwasu 2-amino-4-fenylo-4-okso-maslowego, sposób ich wytwarzania oraz zawierajaca je kompozycja farmaceutyczna PL PL PL PL PL PL |
ES94921642T ES2123801T3 (es) | 1993-07-23 | 1994-07-12 | Derivados de acido 2-amino-4-fenil-4-oxo-butirico con actividad inhibidora de quinureninasa y/o quinurenina-3-hidroxilasa. |
HU9501146A HUT70478A (en) | 1993-07-23 | 1994-07-12 | Process to prepare 2-amino-4-phenyl-4-oxo-butyric acid derivatives and pharmaceutical compositions contg. them with activity against neurodegenerative diseases |
AT94921642T ATE171935T1 (de) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung |
DE69413789T DE69413789T2 (de) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung |
NZ268896A NZ268896A (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives and pharmaceutical compositions thereof |
JP7503289A JPH08501805A (ja) | 1993-07-23 | 1994-07-12 | キヌレニナーゼおよび/またはキヌレニン−3−ヒドロキシラーゼ阻害活性を有する2−アミノ−4−フェニル−4−オキソ酪酸誘導体 |
RU95111308A RU2139850C1 (ru) | 1993-07-23 | 1994-07-12 | Производные 2-амино-4-фенил-4-оксомасляной кислоты и фармацевтическая композиция |
PCT/EP1994/002280 WO1995003271A1 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
AU72285/94A AU678273B2 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
EP94921642A EP0662948B1 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
CN94190531A CN1112786A (zh) | 1993-07-23 | 1994-07-12 | 2-氨基-4-苯基-4-氧代丁酸衍生物 |
SI9430206T SI0662948T1 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
CA002144521A CA2144521A1 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
KR1019950701103A KR950703517A (ko) | 1993-07-23 | 1994-07-12 | 키누레니나제 및/또는 키누레닌-3-하이드록실라제 억제 활성을 갖는 2-아미노-4-페닐-4-옥소-부티르산 유도체(2-Amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity) |
DK94921642T DK0662948T3 (da) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxosmørsyrederivater med kynureninase- og/eller kynurenin-3-hydroxylaseinhiberende virkning |
IL110365A IL110365A (en) | 1993-07-23 | 1994-07-19 | History of 2-amino-4-oxo-butyric acid, their preparation and pharmaceutical preparations containing them |
TW083106674A TW268937B (it) | 1993-07-23 | 1994-07-21 | |
ZA945425A ZA945425B (en) | 1993-07-23 | 1994-07-22 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives |
FI951298A FI951298A (fi) | 1993-07-23 | 1995-03-20 | 2-amino-4-fenyyli-4-oksovoihappojohdannaiset, joilla on kynureninaasia ja/tai kynureniini-3-hydroksylaasia inhiboiva aktiivisuus |
NO951100A NO951100L (no) | 1993-07-23 | 1995-03-22 | 2-amino-4-fenyl-4-oksosmörsyrederivater med kynurinase- og/eller kynurenin-3-hydroksylase-inhiberende aktivitet |
US08/949,392 US20010008947A1 (en) | 1993-07-23 | 1997-10-14 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001649A IT1265101B1 (it) | 1993-07-23 | 1993-07-23 | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI931649A0 ITMI931649A0 (it) | 1993-07-23 |
ITMI931649A1 true ITMI931649A1 (it) | 1995-01-23 |
IT1265101B1 IT1265101B1 (it) | 1996-10-30 |
Family
ID=11366678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93MI001649A IT1265101B1 (it) | 1993-07-23 | 1993-07-23 | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
Country Status (21)
Country | Link |
---|---|
US (1) | US20010008947A1 (it) |
EP (1) | EP0662948B1 (it) |
JP (1) | JPH08501805A (it) |
KR (1) | KR950703517A (it) |
CN (1) | CN1112786A (it) |
AT (1) | ATE171935T1 (it) |
AU (1) | AU678273B2 (it) |
CA (1) | CA2144521A1 (it) |
DE (1) | DE69413789T2 (it) |
DK (1) | DK0662948T3 (it) |
ES (1) | ES2123801T3 (it) |
FI (1) | FI951298A (it) |
HU (1) | HUT70478A (it) |
IL (1) | IL110365A (it) |
IT (1) | IT1265101B1 (it) |
NZ (1) | NZ268896A (it) |
PL (1) | PL179857B1 (it) |
RU (1) | RU2139850C1 (it) |
TW (1) | TW268937B (it) |
WO (1) | WO1995003271A1 (it) |
ZA (1) | ZA945425B (it) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5519055A (en) * | 1993-08-06 | 1996-05-21 | University Of Maryland At Baltimore | Substituted kynurenines and process for their preparation |
US5786508A (en) * | 1994-07-15 | 1998-07-28 | Pharmacia & Upjohn S.P.A. | Substituted kynurenines and process for their preparation |
GB9521486D0 (en) * | 1995-10-20 | 1995-12-20 | Pharmacia Spa | Fluoro-substituted benzoylpropionic acid derivatives |
GB9615441D0 (en) * | 1996-07-23 | 1996-09-04 | Pharmacia Spa | Benzoylpropionic acid ester derivatives |
WO1998006711A1 (en) * | 1996-08-16 | 1998-02-19 | Warner-Lambert Company | Butyric acid matrix metalloproteinase inhibitors |
GB9618349D0 (en) * | 1996-09-03 | 1996-10-16 | Pharmacia Spa | N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
GB9716103D0 (en) * | 1997-07-30 | 1997-10-01 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
GB9725055D0 (en) * | 1997-11-26 | 1998-01-28 | Pharmacia & Upjohn Spa | 1,3,4-thiadiazoles compounds |
GB9725141D0 (en) * | 1997-11-27 | 1998-01-28 | Pharmacia & Upjohn Spa | Benzenesulfonamide compounds |
PT1056452E (pt) * | 1998-02-23 | 2006-12-29 | Univ South Alabama | Acidos indole-3-propionico, seus sais e esteres utilizados como medicamentos. |
US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
WO2000027798A1 (en) * | 1998-11-11 | 2000-05-18 | Novartis Ag | Production of 2-amino-2-[2-(4-c2-20-alkyl-phenyl)ethyl]propane-1,3-diols |
CN1144779C (zh) * | 1999-03-11 | 2004-04-07 | 杭州中美华东制药有限公司 | 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物 |
HU230352B1 (hu) * | 2001-06-12 | 2016-02-29 | Wellstat Therapeutics Corporation | Metabolikus rendellenességek kezelésére adható vegyületek és ezeket tartalmazó gyógyászati készítmények |
FR2827045B1 (fr) * | 2001-07-05 | 2007-08-10 | Univ Pasteur | Methodes et compositions pour la selection et le developpement de nouveaux agents pharmacologiques ou de nouveaux medicaments |
FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
CN1330774C (zh) * | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | 犬尿氨酸水解酶多态性及其用途 |
ITMI20041626A1 (it) * | 2004-08-06 | 2004-11-06 | Roberto Pellicciari | Inibitori della chinurenina-ammino-trasferasi |
CN1309702C (zh) * | 2005-10-28 | 2007-04-11 | 中国科学院上海有机化学研究所 | 犬尿氨酸酶的特异性抑制剂l-邻甲氧基苯甲酰基丙氨酸的合成方法 |
WO2009115534A1 (en) * | 2008-03-19 | 2009-09-24 | Novartis Ag | Process for the preparation of 2-amino-2- [2- (4-c3-c21-alkyl-phenyl)ethyl] propane-1, 3-diols |
HUE054020T2 (hu) * | 2014-09-26 | 2021-08-30 | Univ British Columbia | Kinurenin és antigénprezentáló sejtek (APC) kombinációja gyógyszerként és módszerek az immunmodulációban történõ használatukra |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU643365B2 (en) * | 1991-02-28 | 1993-11-11 | Aventisub Ii Inc. | NMDA antagonists |
CA2108670A1 (en) * | 1991-04-18 | 1992-10-19 | Robert S. Phillips | Inhibitors of kynureninase |
US5495044A (en) * | 1991-04-18 | 1996-02-27 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
GB9325360D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Bristol | Organic compounds |
-
1993
- 1993-07-23 IT IT93MI001649A patent/IT1265101B1/it active IP Right Grant
-
1994
- 1994-07-12 EP EP94921642A patent/EP0662948B1/en not_active Expired - Lifetime
- 1994-07-12 DK DK94921642T patent/DK0662948T3/da active
- 1994-07-12 CA CA002144521A patent/CA2144521A1/en not_active Abandoned
- 1994-07-12 HU HU9501146A patent/HUT70478A/hu unknown
- 1994-07-12 NZ NZ268896A patent/NZ268896A/en unknown
- 1994-07-12 KR KR1019950701103A patent/KR950703517A/ko active IP Right Grant
- 1994-07-12 AU AU72285/94A patent/AU678273B2/en not_active Ceased
- 1994-07-12 RU RU95111308A patent/RU2139850C1/ru active
- 1994-07-12 WO PCT/EP1994/002280 patent/WO1995003271A1/en active IP Right Grant
- 1994-07-12 DE DE69413789T patent/DE69413789T2/de not_active Expired - Fee Related
- 1994-07-12 JP JP7503289A patent/JPH08501805A/ja active Pending
- 1994-07-12 AT AT94921642T patent/ATE171935T1/de not_active IP Right Cessation
- 1994-07-12 PL PL94308142A patent/PL179857B1/pl unknown
- 1994-07-12 ES ES94921642T patent/ES2123801T3/es not_active Expired - Lifetime
- 1994-07-12 CN CN94190531A patent/CN1112786A/zh active Pending
- 1994-07-19 IL IL110365A patent/IL110365A/en not_active IP Right Cessation
- 1994-07-21 TW TW083106674A patent/TW268937B/zh active
- 1994-07-22 ZA ZA945425A patent/ZA945425B/xx unknown
-
1995
- 1995-03-20 FI FI951298A patent/FI951298A/fi unknown
-
1997
- 1997-10-14 US US08/949,392 patent/US20010008947A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL110365A (en) | 1998-06-15 |
ES2123801T3 (es) | 1999-01-16 |
JPH08501805A (ja) | 1996-02-27 |
CA2144521A1 (en) | 1995-02-02 |
CN1112786A (zh) | 1995-11-29 |
KR950703517A (ko) | 1995-09-20 |
ITMI931649A0 (it) | 1993-07-23 |
TW268937B (it) | 1996-01-21 |
FI951298A0 (fi) | 1995-03-20 |
IL110365A0 (en) | 1994-10-21 |
EP0662948B1 (en) | 1998-10-07 |
DE69413789T2 (de) | 1999-05-06 |
AU678273B2 (en) | 1997-05-22 |
RU2139850C1 (ru) | 1999-10-20 |
HUT70478A (en) | 1995-10-30 |
DE69413789D1 (de) | 1998-11-12 |
PL179857B1 (pl) | 2000-11-30 |
DK0662948T3 (da) | 1999-06-21 |
FI951298A (fi) | 1995-03-20 |
WO1995003271A1 (en) | 1995-02-02 |
PL308142A1 (en) | 1995-07-24 |
RU95111308A (ru) | 1996-12-27 |
NZ268896A (en) | 1997-01-29 |
EP0662948A1 (en) | 1995-07-19 |
ZA945425B (en) | 1995-03-01 |
HU9501146D0 (en) | 1995-06-28 |
ATE171935T1 (de) | 1998-10-15 |
IT1265101B1 (it) | 1996-10-30 |
US20010008947A1 (en) | 2001-07-19 |
AU7228594A (en) | 1995-02-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970626 |