DE69413789D1 - 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung - Google Patents
2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkungInfo
- Publication number
- DE69413789D1 DE69413789D1 DE69413789T DE69413789T DE69413789D1 DE 69413789 D1 DE69413789 D1 DE 69413789D1 DE 69413789 T DE69413789 T DE 69413789T DE 69413789 T DE69413789 T DE 69413789T DE 69413789 D1 DE69413789 D1 DE 69413789D1
- Authority
- DE
- Germany
- Prior art keywords
- oxo
- phenyl
- amino
- kynureninase
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001649A IT1265101B1 (it) | 1993-07-23 | 1993-07-23 | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
PCT/EP1994/002280 WO1995003271A1 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69413789D1 true DE69413789D1 (de) | 1998-11-12 |
DE69413789T2 DE69413789T2 (de) | 1999-05-06 |
Family
ID=11366678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69413789T Expired - Fee Related DE69413789T2 (de) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung |
Country Status (21)
Country | Link |
---|---|
US (1) | US20010008947A1 (de) |
EP (1) | EP0662948B1 (de) |
JP (1) | JPH08501805A (de) |
KR (1) | KR950703517A (de) |
CN (1) | CN1112786A (de) |
AT (1) | ATE171935T1 (de) |
AU (1) | AU678273B2 (de) |
CA (1) | CA2144521A1 (de) |
DE (1) | DE69413789T2 (de) |
DK (1) | DK0662948T3 (de) |
ES (1) | ES2123801T3 (de) |
FI (1) | FI951298A (de) |
HU (1) | HUT70478A (de) |
IL (1) | IL110365A (de) |
IT (1) | IT1265101B1 (de) |
NZ (1) | NZ268896A (de) |
PL (1) | PL179857B1 (de) |
RU (1) | RU2139850C1 (de) |
TW (1) | TW268937B (de) |
WO (1) | WO1995003271A1 (de) |
ZA (1) | ZA945425B (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5519055A (en) * | 1993-08-06 | 1996-05-21 | University Of Maryland At Baltimore | Substituted kynurenines and process for their preparation |
US5786508A (en) * | 1994-07-15 | 1998-07-28 | Pharmacia & Upjohn S.P.A. | Substituted kynurenines and process for their preparation |
GB9521486D0 (en) * | 1995-10-20 | 1995-12-20 | Pharmacia Spa | Fluoro-substituted benzoylpropionic acid derivatives |
GB9615441D0 (en) * | 1996-07-23 | 1996-09-04 | Pharmacia Spa | Benzoylpropionic acid ester derivatives |
ES2231879T3 (es) * | 1996-08-16 | 2005-05-16 | Warner-Lambert Company Llc | Inhibidores de metaloproteinasas de la matriz de acido butirico. |
GB9618349D0 (en) * | 1996-09-03 | 1996-10-16 | Pharmacia Spa | N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
GB9716103D0 (en) * | 1997-07-30 | 1997-10-01 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
GB9725055D0 (en) * | 1997-11-26 | 1998-01-28 | Pharmacia & Upjohn Spa | 1,3,4-thiadiazoles compounds |
GB9725141D0 (en) * | 1997-11-27 | 1998-01-28 | Pharmacia & Upjohn Spa | Benzenesulfonamide compounds |
NZ506260A (en) * | 1998-02-23 | 2003-05-30 | Univ South Alabama | Indole-3-propionic acids, salts and esters thereof used as medicaments |
US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
PT1457478T (pt) * | 1998-11-11 | 2017-10-26 | Mitsubishi Pharma Corp | Produção de 2-amino-2-[2-(4-alquil-fenil)etil]propano-1,3-dióis |
CN1144779C (zh) * | 1999-03-11 | 2004-04-07 | 杭州中美华东制药有限公司 | 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物 |
CN100344616C (zh) * | 2001-06-12 | 2007-10-24 | 维尔斯达医疗公司 | 用于治疗代谢失调的化合物 |
FR2827045B1 (fr) * | 2001-07-05 | 2007-08-10 | Univ Pasteur | Methodes et compositions pour la selection et le developpement de nouveaux agents pharmacologiques ou de nouveaux medicaments |
FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
CN1330774C (zh) * | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | 犬尿氨酸水解酶多态性及其用途 |
ITMI20041626A1 (it) * | 2004-08-06 | 2004-11-06 | Roberto Pellicciari | Inibitori della chinurenina-ammino-trasferasi |
CN1309702C (zh) * | 2005-10-28 | 2007-04-11 | 中国科学院上海有机化学研究所 | 犬尿氨酸酶的特异性抑制剂l-邻甲氧基苯甲酰基丙氨酸的合成方法 |
RU2529474C2 (ru) * | 2008-03-19 | 2014-09-27 | Новартис Аг | Способ получения 2-амино-2-[2-(4-с3-с21-алкилфенил)этил]пропан-1, 3-диолов |
HUE054020T2 (hu) * | 2014-09-26 | 2021-08-30 | Univ British Columbia | Kinurenin és antigénprezentáló sejtek (APC) kombinációja gyógyszerként és módszerek az immunmodulációban történõ használatukra |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2069921T3 (es) * | 1991-02-28 | 1995-05-16 | Merrell Dow Pharma | Antagonistas del nmda. |
US5495044A (en) * | 1991-04-18 | 1996-02-27 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
US5516936A (en) * | 1991-04-18 | 1996-05-14 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
GB9325360D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Bristol | Organic compounds |
-
1993
- 1993-07-23 IT IT93MI001649A patent/IT1265101B1/it active IP Right Grant
-
1994
- 1994-07-12 EP EP94921642A patent/EP0662948B1/de not_active Expired - Lifetime
- 1994-07-12 CA CA002144521A patent/CA2144521A1/en not_active Abandoned
- 1994-07-12 AT AT94921642T patent/ATE171935T1/de not_active IP Right Cessation
- 1994-07-12 KR KR1019950701103A patent/KR950703517A/ko active IP Right Grant
- 1994-07-12 NZ NZ268896A patent/NZ268896A/en unknown
- 1994-07-12 CN CN94190531A patent/CN1112786A/zh active Pending
- 1994-07-12 DE DE69413789T patent/DE69413789T2/de not_active Expired - Fee Related
- 1994-07-12 AU AU72285/94A patent/AU678273B2/en not_active Ceased
- 1994-07-12 WO PCT/EP1994/002280 patent/WO1995003271A1/en active IP Right Grant
- 1994-07-12 ES ES94921642T patent/ES2123801T3/es not_active Expired - Lifetime
- 1994-07-12 DK DK94921642T patent/DK0662948T3/da active
- 1994-07-12 PL PL94308142A patent/PL179857B1/pl unknown
- 1994-07-12 JP JP7503289A patent/JPH08501805A/ja active Pending
- 1994-07-12 RU RU95111308A patent/RU2139850C1/ru active
- 1994-07-12 HU HU9501146A patent/HUT70478A/hu unknown
- 1994-07-19 IL IL110365A patent/IL110365A/en not_active IP Right Cessation
- 1994-07-21 TW TW083106674A patent/TW268937B/zh active
- 1994-07-22 ZA ZA945425A patent/ZA945425B/xx unknown
-
1995
- 1995-03-20 FI FI951298A patent/FI951298A/fi unknown
-
1997
- 1997-10-14 US US08/949,392 patent/US20010008947A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PL308142A1 (en) | 1995-07-24 |
US20010008947A1 (en) | 2001-07-19 |
ZA945425B (en) | 1995-03-01 |
HU9501146D0 (en) | 1995-06-28 |
RU95111308A (ru) | 1996-12-27 |
HUT70478A (en) | 1995-10-30 |
EP0662948A1 (de) | 1995-07-19 |
JPH08501805A (ja) | 1996-02-27 |
PL179857B1 (pl) | 2000-11-30 |
IT1265101B1 (it) | 1996-10-30 |
KR950703517A (ko) | 1995-09-20 |
CN1112786A (zh) | 1995-11-29 |
ITMI931649A1 (it) | 1995-01-23 |
EP0662948B1 (de) | 1998-10-07 |
AU678273B2 (en) | 1997-05-22 |
WO1995003271A1 (en) | 1995-02-02 |
IL110365A (en) | 1998-06-15 |
NZ268896A (en) | 1997-01-29 |
AU7228594A (en) | 1995-02-20 |
CA2144521A1 (en) | 1995-02-02 |
ITMI931649A0 (it) | 1993-07-23 |
FI951298A0 (fi) | 1995-03-20 |
FI951298A (fi) | 1995-03-20 |
ATE171935T1 (de) | 1998-10-15 |
TW268937B (de) | 1996-01-21 |
DE69413789T2 (de) | 1999-05-06 |
ES2123801T3 (es) | 1999-01-16 |
RU2139850C1 (ru) | 1999-10-20 |
IL110365A0 (en) | 1994-10-21 |
DK0662948T3 (da) | 1999-06-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |