CY1110401T1 - Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσων - Google Patents
Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσωνInfo
- Publication number
- CY1110401T1 CY1110401T1 CY20081100961T CY081100961T CY1110401T1 CY 1110401 T1 CY1110401 T1 CY 1110401T1 CY 20081100961 T CY20081100961 T CY 20081100961T CY 081100961 T CY081100961 T CY 081100961T CY 1110401 T1 CY1110401 T1 CY 1110401T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- acids
- diseases
- phenylcocarcaroxylic
- neurocological
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέα παράγωγα των 1-φαινυλαλκανοκαρβοξυλικών οξέων, τις φαρμακευτικές συνθέσεις αυτών, μια διαδικασία για την παρασκευή τους και τη χρήση τους για την αντιμετώπιση και/ή την πρόληψη των νευροεκφυλιστικών νόσων, όπως η νόσος Αλζχάιμερ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04425604 | 2004-08-03 | ||
EP05767873A EP1778623B1 (en) | 2004-08-03 | 2005-07-26 | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110401T1 true CY1110401T1 (el) | 2015-04-29 |
Family
ID=35462580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100961T CY1110401T1 (el) | 2004-08-03 | 2008-09-04 | Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσων |
Country Status (22)
Country | Link |
---|---|
US (1) | US7531692B2 (el) |
EP (1) | EP1778623B1 (el) |
JP (1) | JP4866851B2 (el) |
KR (1) | KR101156393B1 (el) |
CN (1) | CN1984878B (el) |
AT (1) | ATE399758T1 (el) |
AU (1) | AU2005270949B2 (el) |
BR (1) | BRPI0513647A (el) |
CA (1) | CA2576009C (el) |
CY (1) | CY1110401T1 (el) |
DE (1) | DE602005007912D1 (el) |
DK (1) | DK1778623T3 (el) |
ES (1) | ES2309778T3 (el) |
HK (1) | HK1104280A1 (el) |
HR (1) | HRP20080494T3 (el) |
NO (1) | NO339921B1 (el) |
PL (1) | PL1778623T3 (el) |
PT (1) | PT1778623E (el) |
RS (1) | RS50601B (el) |
SI (1) | SI1778623T1 (el) |
WO (1) | WO2006016219A2 (el) |
ZA (1) | ZA200700945B (el) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101088272B1 (ko) * | 2003-02-21 | 2011-11-30 | 키에시 파르마슈티시 엣스. 피. 에이. | 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산추출물 |
KR20130079353A (ko) | 2010-04-21 | 2013-07-10 | 키에시 파르마슈티시 엣스. 피. 에이. | 트랜스티레틴 아밀로이드증 치료용 1-(2-플루오로비페닐-4-일)-알킬 카복실산 유도체 |
KR20130080795A (ko) | 2010-06-04 | 2013-07-15 | 키에시 파르마슈티시 엣스. 피. 에이. | 프리온 질환의 치료를 위한 1-(2-플루오로비페닐-4-일)-시클로프로판카복실산 유도체 |
US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
US8835494B2 (en) | 2012-04-04 | 2014-09-16 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-(2-halo-biphenyl-4-yl)-Alkanecarboxylic for the treatment of neurodegenerative diseases |
WO2015181094A1 (en) | 2014-05-26 | 2015-12-03 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
MA50895A (fr) | 2017-11-14 | 2021-05-12 | Merck Sharp & Dohme | Nouveaux composés biaryles substitués utilisés en tant qu'inhibiteurs de l'indoléamine 2,3-dioxygénase (ido) |
WO2019099294A1 (en) | 2017-11-14 | 2019-05-23 | Merck Sharp & Dohme Corp. | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1283489B1 (it) * | 1996-07-23 | 1998-04-21 | Chiesi Farma Spa | Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico |
US6191166B1 (en) * | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6211235B1 (en) * | 1996-11-22 | 2001-04-03 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6117901A (en) * | 1996-11-22 | 2000-09-12 | Athena Neurosciences, Inc. | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use |
CA2279977A1 (en) | 1997-02-04 | 1998-08-06 | John S. Kiely | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries |
US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
KR101088272B1 (ko) | 2003-02-21 | 2011-11-30 | 키에시 파르마슈티시 엣스. 피. 에이. | 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산추출물 |
-
2005
- 2005-07-26 PL PL05767873T patent/PL1778623T3/pl unknown
- 2005-07-26 ES ES05767873T patent/ES2309778T3/es active Active
- 2005-07-26 PT PT05767873T patent/PT1778623E/pt unknown
- 2005-07-26 RS RSP-2008/0392A patent/RS50601B/sr unknown
- 2005-07-26 DE DE602005007912T patent/DE602005007912D1/de active Active
- 2005-07-26 ZA ZA200700945A patent/ZA200700945B/xx unknown
- 2005-07-26 SI SI200530328T patent/SI1778623T1/sl unknown
- 2005-07-26 JP JP2007524411A patent/JP4866851B2/ja not_active Expired - Fee Related
- 2005-07-26 CN CN200580023905XA patent/CN1984878B/zh not_active Expired - Fee Related
- 2005-07-26 AT AT05767873T patent/ATE399758T1/de active
- 2005-07-26 AU AU2005270949A patent/AU2005270949B2/en not_active Ceased
- 2005-07-26 KR KR1020067027604A patent/KR101156393B1/ko not_active IP Right Cessation
- 2005-07-26 BR BRPI0513647-4A patent/BRPI0513647A/pt not_active IP Right Cessation
- 2005-07-26 EP EP05767873A patent/EP1778623B1/en active Active
- 2005-07-26 CA CA2576009A patent/CA2576009C/en not_active Expired - Fee Related
- 2005-07-26 US US11/572,974 patent/US7531692B2/en not_active Expired - Fee Related
- 2005-07-26 WO PCT/IB2005/002189 patent/WO2006016219A2/en active Application Filing
- 2005-07-26 DK DK05767873T patent/DK1778623T3/da active
-
2007
- 2007-01-31 NO NO20070665A patent/NO339921B1/no not_active IP Right Cessation
- 2007-08-28 HK HK07109391.9A patent/HK1104280A1/xx not_active IP Right Cessation
-
2008
- 2008-09-04 CY CY20081100961T patent/CY1110401T1/el unknown
- 2008-10-01 HR HR20080494T patent/HRP20080494T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005270949B2 (en) | 2011-02-03 |
BRPI0513647A (pt) | 2008-05-13 |
CA2576009C (en) | 2013-02-26 |
ZA200700945B (en) | 2008-09-25 |
PT1778623E (pt) | 2008-09-29 |
NO339921B1 (no) | 2017-02-13 |
NO20070665L (no) | 2007-05-02 |
ES2309778T3 (es) | 2008-12-16 |
WO2006016219A3 (en) | 2006-04-27 |
JP4866851B2 (ja) | 2012-02-01 |
SI1778623T1 (sl) | 2008-10-31 |
CN1984878A (zh) | 2007-06-20 |
CN1984878B (zh) | 2011-06-08 |
EP1778623A2 (en) | 2007-05-02 |
RS50601B (sr) | 2010-05-07 |
DE602005007912D1 (de) | 2008-08-14 |
HRP20080494T3 (en) | 2008-11-30 |
HK1104280A1 (en) | 2008-01-11 |
JP2008509124A (ja) | 2008-03-27 |
US20080096968A1 (en) | 2008-04-24 |
PL1778623T3 (pl) | 2008-12-31 |
AU2005270949A1 (en) | 2006-02-16 |
KR101156393B1 (ko) | 2012-06-13 |
WO2006016219A2 (en) | 2006-02-16 |
EP1778623B1 (en) | 2008-07-02 |
ATE399758T1 (de) | 2008-07-15 |
KR20070038982A (ko) | 2007-04-11 |
US7531692B2 (en) | 2009-05-12 |
DK1778623T3 (da) | 2008-10-20 |
CA2576009A1 (en) | 2006-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1108514T1 (el) | Παραγωγα 1-φαινυλαλκανεκαρβοξυλικου οξεος για τη θεραπεια νευρογενων ασθενειων | |
CY1110401T1 (el) | Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσων | |
CY1117326T1 (el) | Παραγωγο κατεχολαμινης χρησιμο για τη θεραπεια ασθενειας parkinson | |
CY1117576T1 (el) | Δινουκλεοτιδικα προφαρμακα | |
CY1108085T1 (el) | Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπ-2-εν-1-ονης παρασκευη και χρησης αυτων | |
EA200401114A2 (ru) | Замещённые гидроксиэтиламины | |
EA201001143A1 (ru) | Активаторы прокаспаз "исполнителей" 3, 6 и 7 | |
CY1105462T1 (el) | Χρηση παραγωγων του φουμαρικου οξεος για τη θepαπεια μιτοχονδριακων ασθενειων | |
CY1112708T1 (el) | [1η-ινδολο-5-υλο)-ετεροαρυλοξυ]-(1-αζα-δικυκλο[3.3.1]εννεανια ως χολινεργικοι συνδετες του ν-achr για την θεραπεια των ψυχωτικων και νευροεκφυλιστικων διαταραχων | |
CY1109422T1 (el) | Παραγωγα φαιναιθανολαμινης για θεραπεια ασθενειων του αναπνευστικου | |
CY1113108T1 (el) | Μεσυλικο προφαρμακου λεβοντοπα, συνθεσεις αυτου, και χρησεις αυτου | |
GT200500060A (es) | Compuestos de imidazol para el tratamiento de trastornos neurodegenerativos | |
CY1115082T1 (el) | Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπανιου, παρασκευες και χρησεις αυτων | |
TW200716152A (en) | Substituted 1,2-ethylendiamines, medicaments comprising said compound, their use and their method of manufacture | |
EA200801580A1 (ru) | Новые производные пирониндола и способ их получения | |
EA200700637A1 (ru) | Соли донепезила, подходящие для получения фармацевтических композиций | |
TW200604196A (en) | New quinuclidine derivatives and pharmaceutical compositions comprising them | |
CY1111256T1 (el) | Παραγωγα αζαδικυκλοοκταν-3-ονης και χρηση τους | |
BRPI0509477A (pt) | compostos de sulfonamida para o tratamento de distúrbios neurodegenerativos | |
WO2005003103A3 (en) | 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases | |
NO20076405L (no) | Anvendelse av 24-nor-UDCA | |
ATE371724T1 (de) | Behandlung neurodegenerativer krankheiten | |
ATE407126T1 (de) | Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on | |
BRPI0509881A (pt) | combinação terapêutica para tratamento da doença de alzheimer | |
HUP0300032A2 (en) | Use of compounds useful for the treatment or prevention of a disease mediated by the alpha-2b-adrenoreceptor for preparation of pharmaceutical composition |