CY1111256T1 - Παραγωγα αζαδικυκλοοκταν-3-ονης και χρηση τους - Google Patents

Παραγωγα αζαδικυκλοοκταν-3-ονης και χρηση τους

Info

Publication number
CY1111256T1
CY1111256T1 CY20101101187T CY101101187T CY1111256T1 CY 1111256 T1 CY1111256 T1 CY 1111256T1 CY 20101101187 T CY20101101187 T CY 20101101187T CY 101101187 T CY101101187 T CY 101101187T CY 1111256 T1 CY1111256 T1 CY 1111256T1
Authority
CY
Cyprus
Prior art keywords
azadicycloktan
products
compounds
formula
cancer
Prior art date
Application number
CY20101101187T
Other languages
English (en)
Inventor
Jacob Westman
Klas Wiman
Galina Selivanova
Vladimir Bykov
Original Assignee
Aprea Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aprea Ab filed Critical Aprea Ab
Publication of CY1111256T1 publication Critical patent/CY1111256T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Ενώσεις του τύπου (I), μέθοδος παρασκευής τους, φαρμακευτικές συνθέσεις που τις περιέχουν. Η χρήση των ενώσεων του τύπου (I) για υπερπολλαπλασιαστικές ασθένειες, π.χ. καρκίνος καθώς και αυτοάνοσες ασθένειες και καρδιοπάθειες.
CY20101101187T 2004-03-22 2010-12-23 Παραγωγα αζαδικυκλοοκταν-3-ονης και χρηση τους CY1111256T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0400708A SE0400708D0 (sv) 2004-03-22 2004-03-22 New compounds and use thereof
EP05722253A EP1727817B1 (en) 2004-03-22 2005-03-22 Azabicyclooctan-3-one derivatives and use thereof

Publications (1)

Publication Number Publication Date
CY1111256T1 true CY1111256T1 (el) 2015-08-05

Family

ID=32067464

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101101187T CY1111256T1 (el) 2004-03-22 2010-12-23 Παραγωγα αζαδικυκλοοκταν-3-ονης και χρηση τους

Country Status (15)

Country Link
US (1) US7759361B2 (el)
EP (1) EP1727817B1 (el)
JP (1) JP4904561B2 (el)
AT (1) ATE482955T1 (el)
AU (1) AU2005223728B2 (el)
CA (1) CA2552855C (el)
CY (1) CY1111256T1 (el)
DE (1) DE602005023840D1 (el)
DK (1) DK1727817T3 (el)
ES (1) ES2349471T3 (el)
PL (1) PL1727817T3 (el)
PT (1) PT1727817E (el)
SE (1) SE0400708D0 (el)
SI (1) SI1727817T1 (el)
WO (1) WO2005090341A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007062030A2 (en) * 2005-11-21 2007-05-31 Ohio University Quinuclidinone derivatives as anticancer agents
WO2011089234A2 (en) * 2010-01-21 2011-07-28 Aprea Ab Method and composition
CN104860994A (zh) * 2014-02-20 2015-08-26 中国药科大学 3-奎宁环酮类含磷化合物的制备及其医药用途
WO2017159877A1 (en) * 2016-03-18 2017-09-21 Eisai R&D Management Co., Ltd. Use of eribulin and 3-quinuclidinone derivatives in the treatment of cancer
CN109280054A (zh) * 2017-07-21 2019-01-29 上海时莱生物技术有限公司 氘代3-奎宁环酮类化合物、制备方法及用途
CN109280056A (zh) * 2017-07-21 2019-01-29 上海时莱生物技术有限公司 手性3-奎宁环酮类化合物、制备方法及用途
US20220071970A1 (en) * 2018-09-20 2022-03-10 Aprea Therapeutics Ab Quinuclidine-3-one derivatives and their use in cancer treatment
US20220339141A1 (en) 2019-09-18 2022-10-27 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein
WO2021170772A1 (en) 2020-02-26 2021-09-02 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of cd47 mediated signaling
WO2021180338A1 (en) 2020-03-09 2021-09-16 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of dna methyltransferase post stem cell transplant
WO2022175402A1 (en) 2021-02-18 2022-08-25 Aprea Therapeutics Ab Quinuclidine-3-one derivatives
WO2022204109A1 (en) * 2021-03-22 2022-09-29 Newave Pharmaceutical Inc. Quinuclidinone analogues as anticancer agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384641A (en) * 1967-09-19 1968-05-21 Aldrich Chem Co Inc 2-methylene-3-quinuclidones
US3726877A (en) * 1970-10-28 1973-04-10 Univ Temple Amine substituted methylene quinuclidone anti-bacterial agents
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
EP0532527B1 (en) * 1990-06-01 1994-11-09 Pfizer Inc. 3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them
US6432975B1 (en) * 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6953855B2 (en) * 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
WO2002017358A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
DK1319000T3 (da) 2000-09-20 2009-02-16 Aprea Ab Anvendelse af 1-azabicyclo(2,2,2)oktan-3-on-derivater til behandling af cancertumorer
DE60306896T2 (de) 2002-02-21 2007-02-15 Aprea Ab Verwendung von niedermolekularen verbindungen zur herstellung eines medikaments zur behandlung von durch mutation p53-vermittelten erkrankungen
ES2315650T3 (es) * 2003-03-24 2009-04-01 Aprea Ab Uso farmaceutico de 1-azabiciclo-2,2,2 octanos y un metodo para ensayar compuetos con respecto a la capacidad de activar wt p53 inactivo.
SE0300812D0 (sv) 2003-03-24 2003-03-24 Karolinska Innovations Ab Use of chemical compounds for preparing pharmaceutical compositions, and method of testing substances for medical effect

Also Published As

Publication number Publication date
DK1727817T3 (da) 2011-01-10
AU2005223728B2 (en) 2011-02-10
SI1727817T1 (sl) 2011-01-31
CA2552855C (en) 2012-08-14
DE602005023840D1 (de) 2010-11-11
US20070142370A1 (en) 2007-06-21
AU2005223728A1 (en) 2005-09-29
EP1727817A1 (en) 2006-12-06
ATE482955T1 (de) 2010-10-15
CA2552855A1 (en) 2005-09-29
ES2349471T3 (es) 2011-01-03
EP1727817B1 (en) 2010-09-29
PL1727817T3 (pl) 2011-03-31
JP4904561B2 (ja) 2012-03-28
SE0400708D0 (sv) 2004-03-22
WO2005090341A1 (en) 2005-09-29
PT1727817E (pt) 2010-10-26
JP2007530534A (ja) 2007-11-01
US7759361B2 (en) 2010-07-20

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