MA29379B1 - Derives de pyrrolidine 3,4-substitues pour le traitement de l'hypertension - Google Patents

Derives de pyrrolidine 3,4-substitues pour le traitement de l'hypertension

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Publication number
MA29379B1
MA29379B1 MA30268A MA30268A MA29379B1 MA 29379 B1 MA29379 B1 MA 29379B1 MA 30268 A MA30268 A MA 30268A MA 30268 A MA30268 A MA 30268A MA 29379 B1 MA29379 B1 MA 29379B1
Authority
MA
Morocco
Prior art keywords
treatment
compounds
pyrrolidine compounds
substituted pyrrolidine
substituted
Prior art date
Application number
MA30268A
Other languages
English (en)
Inventor
Claus Ehrhardt
Osamu Irie
Edwige Liliane Jeanne Lorthiois
Juergen Klaus Maibaum
Nils Ostermann
Holger Sellner
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA29379B1 publication Critical patent/MA29379B1/fr

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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Abstract

L'INVENTION CONCERNE L'UTILISATION DE COMPOSÉS PYRROLIDINE (3,4-DI-, 3,3,4-TRI, 3,4,4-TRI- OR 3,3,4,4-TÉTRA-)SUBSTITUÉS DANS LA PRÉPARATION D'UNE FORMULATION PHARMACEUTIQUE DESTINÉE AU TRAITEMENT D'UNE MALADIE DÉPENDANT DE L'ACTIVITÉ DE LA RÉNINE; L'UTILISATION D'UN COMPOSÉ DE CETTE CLASSE DANS LE TRAITEMENT D'UNE MALADIE DÉPENDANT DE L'ACTIVITÉ DE LA RÉNINE; DES COMPOSÉS QUI FONT PARTIE D'UNE SOUS-CLASSE DESDITS COMPOSÉS PYRROLIDINE SUBSTITUÉS ET QUI SONT DESTINÉS AU DIAGNOSTIC ET AU TRAITEMENT THÉRAPEUTIQUE D'UN ANIMAL À SANG CHAUD, EN PARTICULIER AU TRAITEMENT D'UNE MALADIE (D'UN TROUBLE) DÉPENDANT DE L'ACTIVITÉ DE LA RÉNINE; DE NOUVEAUX COMPOSÉS QUI FONT PARTIE D'UNE SOUS-CLASSE DESDITS COMPOSÉS PYRROLIDINE SUBSTITUÉS; DES FORMULATIONS PHARMACEUTIQUES COMPRENANT LESDITS COMPOSÉS PYRROLIDINE, ET/OU UN PROCÉDÉ DE TRAITEMENT QUI CONSISTE À ADMINISTRER LESDITS COMPOSÉS PYRROLIDINE SUBSTITUÉS, UN PROCÉDÉ DE FABRICATION EN PARTICULIER DESDITS NOUVEAUX COMPOSÉS PYRROLIDINE SUBSTITUÉS, AINSI QUE DE NOUVEAUX INTERMÉDIAIRES, DES MATIÈRES PREMIÈRES ET/OU DES ÉTAPES PARTIELLES DE LEUR SYNTHÈSE. LES COMPOSÉS PYRROLIDINE SUBSTITUÉS DE L'INVENTION RÉPONDENT À LA FORMULE (I) SUIVANTE, DANS LAQUELLE R1, R2, R3, R4, R5 ET T SONT TELS QUE DÉFINIS DANS LA DESCRIPTION.
MA30268A 2005-03-23 2007-10-02 Derives de pyrrolidine 3,4-substitues pour le traitement de l'hypertension MA29379B1 (fr)

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
PT2420491E (pt) 2005-12-30 2013-10-14 Novartis Ag Compostos de piperidina 3,5-substituída como inibidores de renina
GB0611696D0 (en) * 2006-06-13 2006-07-26 Novartis Ag Organic compounds
EP2119702A4 (fr) 2007-01-31 2010-12-08 Dainippon Sumitomo Pharma Co Dérivé d'amide
NZ582098A (en) 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US9408914B2 (en) 2010-04-28 2016-08-09 Kyowa Hakko Kirin Co., Ltd. Cationic lipid
MX349484B (es) 2011-03-16 2017-07-31 Mitsubishi Tanabe Pharma Corp Compuesto heterocíclico saturado que contiene nitrógeno.
JP2013095755A (ja) 2011-11-02 2013-05-20 Kyowa Hakko Kirin Co Ltd カチオン性脂質
US20140045913A1 (en) 2011-12-12 2014-02-13 Kyowa Hakko Kirin Co., Ltd. Lipid nano particles comprising combination of cationic lipid
CN103420890B (zh) * 2012-05-15 2015-06-24 天津药物研究院 3-吡咯甲酸衍生物及其制备方法和用途
AU2013291125A1 (en) 2012-07-16 2015-01-22 Dicerna Pharmaceuticals, Inc. RNAi pharmaceutical composition capable of suppressing expression of KRAS gene
BR112016014830A2 (pt) 2013-12-23 2017-09-19 Bayer Pharma AG Conjugados de fármaco de anticorpo (adcs) com inibidores de ksp
JP6743015B2 (ja) 2014-12-15 2020-08-19 バイエル ファーマ アクチエンゲゼルシャフト Ｋｓｐ阻害剤の脱グリコシル化抗ｔｗｅａｋｒ抗体との抗体薬物複合体（ａｄｃ類）
CA2990076A1 (fr) 2015-06-22 2016-12-29 Bayer Pharma Aktiengesellschaft Conjugues anticorps-medicament (adc) et conjugues lieur-promedicament (apdc) a groupes enzymatiquement clivables
US20180318438A1 (en) 2015-06-23 2018-11-08 Bayer Pharma Aktiengesellschaft Antibody drug conjugates of kinesin spindel protein (ksp) inhibitors with anti-tweakr-antibodies
US11001636B2 (en) 2016-06-15 2021-05-11 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies
WO2018114804A1 (fr) 2016-12-21 2018-06-28 Bayer Pharma Aktiengesellschaft Conjugués anticorps-principe actif (adc) spécifiques renfermant des inhibiteurs de ksp
IL310558A (en) 2016-12-21 2024-03-01 Bayer Pharma AG Drug-antibody conjugates with enzymatically cleavable groups
US20230113948A1 (en) * 2019-12-20 2023-04-13 Arbutus Biopharma Corporation Synthetic processes and intermediates
CN111423411B (zh) * 2020-04-02 2021-04-16 南京生命源医药科技有限公司 一种新型肾素抑制剂
WO2024033374A1 (fr) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Nouveaux composés arylcarboxamide ou arylthioamide

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0242789A3 (fr) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Dérivés de quinoléine et procédés pour leur préparation
AU671092B2 (en) 1991-12-18 1996-08-15 Schering Corporation Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring
IL111176A0 (en) 1993-10-07 1994-12-29 Du Pont Merck Pharma Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
JP2001526178A (ja) 1997-08-28 2001-12-18 メルク エンド カムパニー インコーポレーテッド ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤
CA2333554A1 (fr) 1998-06-17 1999-12-23 Chu-Baio Xue Acides hydroxamiques cycliques utilises en tant qu'inhibiteurs de metalloproteases
US6610692B1 (en) 1998-10-30 2003-08-26 Merck & Co., Inc. Thrombin inhibitors
AU3386500A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
US6489354B1 (en) * 1999-03-02 2002-12-03 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6303593B1 (en) 1999-03-02 2001-10-16 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
WO2000051610A1 (fr) 1999-03-02 2000-09-08 Merck & Co., Inc. Modulateurs de l'activite de recepteurs de chemokine a base de pyrrolidine
PL360678A1 (en) 2000-03-17 2004-09-20 Bristol-Myers Squibb Pharma Company Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
FR2811673B1 (fr) 2000-07-17 2002-09-13 Rhodia Chimie Sa Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes
US7125887B2 (en) 2000-10-11 2006-10-24 Merck & Co., Inc. Pyrrolidine modulators of CCR5 chemokine receptor activity
US6740649B2 (en) 2001-09-17 2004-05-25 Bristol-Myers Squibb Company Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
WO2003031443A1 (fr) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Antibiotiques a action duale renfermant une oxazolidinone et une quinolone ou une fraction de naphthyridinone
AU2003301959A1 (en) 2002-05-20 2004-06-03 Bristol-Myers Squibb Company Substituted cycloalkyl p1' hepatitis c virus inhibitors
GB0212410D0 (en) 2002-05-29 2002-07-10 Novartis Ag Organic compounds
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
AU2004293178B8 (en) 2003-11-26 2009-01-08 Novartis Ag Organic compounds
JP2007518777A (ja) 2004-01-23 2007-07-12 シュペーデル・エクスペリメンタ・アーゲー アミノアルコール誘導体およびレニン阻害剤としてのその使用
CN1910135A (zh) 2004-01-23 2007-02-07 斯皮德尔实验股份公司 氨基醇衍生物及其作为血管紧张肽原酶抑制剂的活性
PL1735270T3 (pl) 2004-01-23 2010-12-31 Novartis Ag Dwuaminoalkohole i ich zastosowanie jako inhibitorów reniny
BRPI0508969A (pt) 2004-03-19 2007-08-21 Speedel Experimenta Ag compostos orgánicos
US7851634B2 (en) 2004-03-19 2010-12-14 Novartis Ag 5-amino 4-hydroxy-7-(1H-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension
CN1273452C (zh) * 2004-06-01 2006-09-06 中国医学科学院医药生物技术研究所 7－（4，4－二甲基－3－氨甲基吡咯烷－1－基）取代的新喹啉羧酸衍生物及其制法
TW200631929A (en) 2004-12-10 2006-09-16 Speedel Experimenta Ag ω -phenyloctanamides
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
US20080176947A1 (en) 2005-03-11 2008-07-24 Peter Herold Heterocyclic-Substituted Alkanamides Useful as Renin Inhibitors

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ATE486597T1 (de) 2010-11-15
EP1863477B1 (fr) 2010-11-03
US7807709B2 (en) 2010-10-05
AU2006226554B2 (en) 2010-03-11
TNSN07361A1 (en) 2008-12-31
CA2600063A1 (fr) 2006-09-28
AU2006226554A1 (en) 2006-09-28
JP2008534457A (ja) 2008-08-28
EP1863477A1 (fr) 2007-12-12
DE602006017980D1 (de) 2010-12-16
TW200700061A (en) 2007-01-01
CN101146530B (zh) 2011-05-18
AR053832A1 (es) 2007-05-23
RU2419606C2 (ru) 2011-05-27
ES2355742T3 (es) 2011-03-30
GB0505969D0 (en) 2005-04-27
GT200600089A (es) 2006-11-08
KR20070113254A (ko) 2007-11-28
WO2006100036A1 (fr) 2006-09-28
MX2007011694A (es) 2007-11-15
RU2007138892A (ru) 2009-04-27
CN101146530A (zh) 2008-03-19
IL185242A0 (en) 2008-06-05
BRPI0609671A2 (pt) 2010-04-20
NO20075365L (no) 2007-12-27
PE20061325A1 (es) 2007-01-05
JP5171612B2 (ja) 2013-03-27
PL1863477T3 (pl) 2011-04-29
ZA200706697B (en) 2008-10-29
US20080194549A1 (en) 2008-08-14
PT1863477E (pt) 2011-02-10

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