HUP0304067A2 - IL-18-inhibitorok alkalmazása központi idegrendszeri sérülések kezelésére vagy megelőzésére - Google Patents
IL-18-inhibitorok alkalmazása központi idegrendszeri sérülések kezelésére vagy megelőzéséreInfo
- Publication number
- HUP0304067A2 HUP0304067A2 HU0304067A HUP0304067A HUP0304067A2 HU P0304067 A2 HUP0304067 A2 HU P0304067A2 HU 0304067 A HU0304067 A HU 0304067A HU P0304067 A HUP0304067 A HU P0304067A HU P0304067 A2 HUP0304067 A2 HU P0304067A2
- Authority
- HU
- Hungary
- Prior art keywords
- inhibitors
- treating
- cns injuries
- preventing cns
- inhibitor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000006378 damage Effects 0.000 title 1
- 208000001738 Nervous System Trauma Diseases 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 208000028412 nervous system injury Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 108091026890 Coding region Proteins 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
(57) A találmány tárgyát képezi IL-18-inhibitor, valamint IL-18 kódolószekvenciáját tartalmazó nukleinsav alkalmazása központi idegrendszerisérülés, előnyösen traumás fejsérülés kezelésére és/vagy megelőzéséreszolgáló gyógyszer előállítására. A találmány tárgyát képezi továbbágenetikailag oly módon módosított sejt, amely IL-18-inhibitort állítelő, alkalmazása központi idegrendszeri sérülés kezelésére és/vagymegelőzésére szolgáló gyógyszer előállítására. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112067.2 | 2001-05-25 | ||
| EP01112067 | 2001-05-25 | ||
| PCT/EP2002/005666 WO2002096456A1 (en) | 2001-05-25 | 2002-05-23 | Use of il-18 inhibitors for treating or preventing cns injuries |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0304067A2 true HUP0304067A2 (hu) | 2004-03-29 |
| HUP0304067A3 HUP0304067A3 (en) | 2006-01-30 |
| HU230294B1 HU230294B1 (hu) | 2015-12-28 |
Family
ID=8177454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0304067A HU230294B1 (hu) | 2001-05-25 | 2002-05-23 | IL-18-inhibitorok alkalmazása központi idegrendszeri sérülések kezelésére vagy megelőzésére |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7655616B2 (hu) |
| EP (1) | EP1390070B1 (hu) |
| JP (1) | JP4344142B2 (hu) |
| KR (1) | KR20040030625A (hu) |
| CN (1) | CN1305529C (hu) |
| AU (1) | AU2002314103B2 (hu) |
| BG (1) | BG66395B1 (hu) |
| BR (1) | BR0210007A (hu) |
| CA (1) | CA2445664C (hu) |
| CY (1) | CY1119190T1 (hu) |
| CZ (1) | CZ307321B6 (hu) |
| DK (1) | DK1390070T3 (hu) |
| EA (1) | EA006744B1 (hu) |
| EE (1) | EE05263B1 (hu) |
| ES (1) | ES2617084T3 (hu) |
| HK (1) | HK1069762A1 (hu) |
| HR (1) | HRP20030842B1 (hu) |
| HU (1) | HU230294B1 (hu) |
| IL (2) | IL159014A0 (hu) |
| LT (1) | LT1390070T (hu) |
| ME (1) | ME00550B (hu) |
| MX (1) | MXPA03010743A (hu) |
| NO (1) | NO331882B1 (hu) |
| PL (1) | PL216228B1 (hu) |
| PT (1) | PT1390070T (hu) |
| RS (1) | RS56006B1 (hu) |
| SK (1) | SK288413B6 (hu) |
| UA (1) | UA80396C2 (hu) |
| WO (1) | WO2002096456A1 (hu) |
| ZA (1) | ZA200308172B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1622939T1 (sl) | 2003-05-13 | 2012-06-29 | Merck Serono Sa | Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega |
| NZ552908A (en) * | 2004-06-30 | 2009-11-27 | Atsuo Sekiyama | Indicator agent for noninflammatory stress response and use thereof |
| US8128920B2 (en) * | 2005-06-03 | 2012-03-06 | Merck Serono Sa | Use of IL-18BP isoforms for the treatment and/or prevention of neurological inflammatory diseases |
| WO2006128908A1 (en) | 2005-06-03 | 2006-12-07 | Ares Trading S.A. | Production of recombinant il-18 binding protein |
| EP1891088B1 (en) | 2005-06-10 | 2011-10-19 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| US8685400B2 (en) | 2007-07-30 | 2014-04-01 | University Of Miami | Modulating inflammasome activity and inflammation in the central nervous system |
| JP6820743B2 (ja) * | 2013-09-05 | 2021-01-27 | エイビー２ バイオ ソシエテアノニム | 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ） |
| KR102511343B1 (ko) * | 2015-03-05 | 2023-03-17 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873453A (ja) * | 1994-09-02 | 1996-03-19 | Otsuka Pharmaceut Co Ltd | サイトカイン阻害剤 |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| DE69925581T2 (de) * | 1998-03-09 | 2006-04-27 | Vertex Pharmaceuticals Inc., Cambridge | 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| ME00554B (me) * | 2000-05-05 | 2012-03-20 | Serono Lab | KORIŠĆENJE IL-18 INHIBITORA ZA LIJEČENJE l/ILI PREVENCIJU ATEROSKLEROZE |
| EP1292288B1 (en) * | 2000-06-23 | 2004-09-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 2-arachidonylglycerol (2-ag) - an inhibitor of tumor necrosis factor -alfa and neuroprotector of brain in closed head injury |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| US6671553B1 (en) * | 2001-05-23 | 2003-12-30 | Pacesetter, Inc. | Implantable cardiac lead having terminating connector strain relief and method of manufacture |
-
2002
- 2002-05-23 PT PT2740641T patent/PT1390070T/pt unknown
- 2002-05-23 EA EA200301299A patent/EA006744B1/ru not_active IP Right Cessation
- 2002-05-23 SK SK1603-2003A patent/SK288413B6/sk not_active IP Right Cessation
- 2002-05-23 US US10/478,614 patent/US7655616B2/en not_active Expired - Lifetime
- 2002-05-23 IL IL15901402A patent/IL159014A0/xx unknown
- 2002-05-23 EP EP02740641.2A patent/EP1390070B1/en not_active Expired - Lifetime
- 2002-05-23 JP JP2002592965A patent/JP4344142B2/ja not_active Expired - Lifetime
- 2002-05-23 HU HU0304067A patent/HU230294B1/hu unknown
- 2002-05-23 CN CNB028147510A patent/CN1305529C/zh not_active Expired - Lifetime
- 2002-05-23 WO PCT/EP2002/005666 patent/WO2002096456A1/en active IP Right Grant
- 2002-05-23 LT LTEP02740641.2T patent/LT1390070T/lt unknown
- 2002-05-23 PL PL367545A patent/PL216228B1/pl unknown
- 2002-05-23 RS YU89403A patent/RS56006B1/sr unknown
- 2002-05-23 CA CA2445664A patent/CA2445664C/en not_active Expired - Lifetime
- 2002-05-23 KR KR10-2003-7015310A patent/KR20040030625A/ko active Search and Examination
- 2002-05-23 MX MXPA03010743A patent/MXPA03010743A/es active IP Right Grant
- 2002-05-23 BR BR0210007-0A patent/BR0210007A/pt not_active Application Discontinuation
- 2002-05-23 DK DK02740641.2T patent/DK1390070T3/en active
- 2002-05-23 AU AU2002314103A patent/AU2002314103B2/en not_active Expired
- 2002-05-23 ME MEP-2008-618A patent/ME00550B/me unknown
- 2002-05-23 ES ES02740641.2T patent/ES2617084T3/es not_active Expired - Lifetime
- 2002-05-23 EE EEP200300582A patent/EE05263B1/xx unknown
- 2002-05-23 UA UA20031212328A patent/UA80396C2/uk unknown
- 2002-05-23 CZ CZ2003-3268A patent/CZ307321B6/cs not_active IP Right Cessation
-
2003
- 2003-10-17 HR HRP20030842AA patent/HRP20030842B1/hr not_active IP Right Cessation
- 2003-10-21 ZA ZA200308172A patent/ZA200308172B/xx unknown
- 2003-11-20 NO NO20035160A patent/NO331882B1/no not_active IP Right Cessation
- 2003-11-23 IL IL159014A patent/IL159014A/en active IP Right Grant
- 2003-12-15 BG BG108451A patent/BG66395B1/bg unknown
-
2004
- 2004-12-31 HK HK04110391A patent/HK1069762A1/xx not_active IP Right Cessation
-
2017
- 2017-05-08 CY CY20171100494T patent/CY1119190T1/el unknown
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