ZA200308172B - Use of IL-18 inhibitors for treating or preventing CNS injuries. - Google Patents

Use of IL-18 inhibitors for treating or preventing CNS injuries.

Info

Publication number
ZA200308172B
ZA200308172B ZA200308172A ZA200308172A ZA200308172B ZA 200308172 B ZA200308172 B ZA 200308172B ZA 200308172 A ZA200308172 A ZA 200308172A ZA 200308172 A ZA200308172 A ZA 200308172A ZA 200308172 B ZA200308172 B ZA 200308172B
Authority
ZA
South Africa
Prior art keywords
inhibitors
treating
cns injuries
preventing cns
preventing
Prior art date
Application number
ZA200308172A
Other languages
English (en)
Inventor
Esther Shohami
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of ZA200308172B publication Critical patent/ZA200308172B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA200308172A 2001-05-25 2003-10-21 Use of IL-18 inhibitors for treating or preventing CNS injuries. ZA200308172B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01112067 2001-05-25

Publications (1)

Publication Number Publication Date
ZA200308172B true ZA200308172B (en) 2004-10-21

Family

ID=8177454

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200308172A ZA200308172B (en) 2001-05-25 2003-10-21 Use of IL-18 inhibitors for treating or preventing CNS injuries.

Country Status (30)

Country Link
US (1) US7655616B2 (hu)
EP (1) EP1390070B1 (hu)
JP (1) JP4344142B2 (hu)
KR (1) KR20040030625A (hu)
CN (1) CN1305529C (hu)
AU (1) AU2002314103B2 (hu)
BG (1) BG66395B1 (hu)
BR (1) BR0210007A (hu)
CA (1) CA2445664C (hu)
CY (1) CY1119190T1 (hu)
CZ (1) CZ307321B6 (hu)
DK (1) DK1390070T3 (hu)
EA (1) EA006744B1 (hu)
EE (1) EE05263B1 (hu)
ES (1) ES2617084T3 (hu)
HK (1) HK1069762A1 (hu)
HR (1) HRP20030842B1 (hu)
HU (1) HU230294B1 (hu)
IL (2) IL159014A0 (hu)
LT (1) LT1390070T (hu)
ME (1) ME00550B (hu)
MX (1) MXPA03010743A (hu)
NO (1) NO331882B1 (hu)
PL (1) PL216228B1 (hu)
PT (1) PT1390070T (hu)
RS (1) RS56006B1 (hu)
SK (1) SK288413B6 (hu)
UA (1) UA80396C2 (hu)
WO (1) WO2002096456A1 (hu)
ZA (1) ZA200308172B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5074030B2 (ja) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Il−18結合タンパク質の活性変異体とその医学的応用
AU2005258569B2 (en) * 2004-06-30 2012-05-03 Atsuo Sekiyama Indicator agent for noninflammatory stress response and use thereof
AU2006254106B2 (en) * 2005-06-03 2012-04-26 Merck Serono Sa Use of IL-18BP isoforms for the treatment and/or prevention of neurological inflammatory diseases
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5091127B2 (ja) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Il−18結合タンパク質の精製のための方法
US8685400B2 (en) 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
MX2016002719A (es) * 2013-09-05 2016-09-06 Ab2 Bio Sa Proteina de union a interleucina 18 (il-18bp) en enfermedades inflamatorias.
EP3265807A1 (en) 2015-03-05 2018-01-10 AB2 Bio SA Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0873453A (ja) * 1994-09-02 1996-03-19 Otsuka Pharmaceut Co Ltd サイトカイン阻害剤
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
DE69925581T2 (de) * 1998-03-09 2006-04-27 Vertex Pharmaceuticals Inc., Cambridge 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
DE60134009D1 (de) 2000-05-05 2008-06-26 Inst Nat Sante Rech Med Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose
JP2003535892A (ja) * 2000-06-23 2003-12-02 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 2−アラキドニルグリセロール(2−AG)−腫瘍壊死因子−αの阻害剤および閉鎖性頭部損傷における脳の神経保護因子
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
US6671553B1 (en) * 2001-05-23 2003-12-30 Pacesetter, Inc. Implantable cardiac lead having terminating connector strain relief and method of manufacture

Also Published As

Publication number Publication date
EE05263B1 (et) 2010-02-15
BG108451A (en) 2005-02-28
MXPA03010743A (es) 2004-03-02
HU230294B1 (hu) 2015-12-28
EA200301299A1 (ru) 2004-04-29
EE200300582A (et) 2004-02-16
PT1390070T (pt) 2017-03-01
HK1069762A1 (en) 2005-06-03
ME00550B (me) 2011-10-10
CN1535160A (zh) 2004-10-06
DK1390070T3 (en) 2017-04-24
SK16032003A3 (sk) 2004-05-04
YU89403A (sh) 2006-05-25
CA2445664C (en) 2012-03-06
NO20035160L (no) 2003-11-20
JP4344142B2 (ja) 2009-10-14
HUP0304067A2 (hu) 2004-03-29
HUP0304067A3 (en) 2006-01-30
EP1390070A1 (en) 2004-02-25
UA80396C2 (en) 2007-09-25
US20040191247A1 (en) 2004-09-30
CN1305529C (zh) 2007-03-21
EA006744B1 (ru) 2006-04-28
HRP20030842A2 (en) 2005-08-31
PL216228B1 (pl) 2014-03-31
AU2002314103B8 (en) 2002-12-09
JP2004534777A (ja) 2004-11-18
IL159014A0 (en) 2004-05-12
NO331882B1 (no) 2012-04-23
EP1390070B1 (en) 2017-02-08
KR20040030625A (ko) 2004-04-09
CZ20033268A3 (en) 2004-07-14
PL367545A1 (en) 2005-02-21
NO20035160D0 (no) 2003-11-20
CY1119190T1 (el) 2018-02-14
CZ307321B6 (cs) 2018-06-06
CA2445664A1 (en) 2002-12-05
WO2002096456A1 (en) 2002-12-05
US7655616B2 (en) 2010-02-02
BR0210007A (pt) 2004-08-10
BG66395B1 (bg) 2013-12-31
LT1390070T (lt) 2017-03-10
AU2002314103B2 (en) 2007-07-12
HRP20030842B1 (hr) 2017-06-02
IL159014A (en) 2012-05-31
RS56006B1 (sr) 2017-09-29
SK288413B6 (sk) 2016-10-03
ES2617084T3 (es) 2017-06-15

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