HUP0000283A2 - Új eljárás quetiapine előállítására - Google Patents

Új eljárás quetiapine előállítására

Info

Publication number
HUP0000283A2
HUP0000283A2 HU0000283A HUP0000283A HUP0000283A2 HU P0000283 A2 HUP0000283 A2 HU P0000283A2 HU 0000283 A HU0000283 A HU 0000283A HU P0000283 A HUP0000283 A HU P0000283A HU P0000283 A2 HUP0000283 A2 HU P0000283A2
Authority
HU
Hungary
Prior art keywords
new process
quetiapine
production
ethyl
thiazepine
Prior art date
Application number
HU0000283A
Other languages
English (en)
Inventor
Dániel Bózsing
dr. Lax Györgyi Koványiné
György Krasznai
Gyula Simig
Györgyné Rákóczy
Donáth Györgyi Vereczkeyné
Kálmán Nagy
Péter Tömpe
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU0000283A priority Critical patent/HU227039B1/hu
Publication of HU0000283D0 publication Critical patent/HU0000283D0/hu
Priority to AU32146/01A priority patent/AU3214601A/en
Priority to UA2002086977A priority patent/UA73547C2/uk
Priority to ES01904235T priority patent/ES2217115T3/es
Priority to SK1060-2002A priority patent/SK287171B6/sk
Priority to PCT/HU2001/000010 priority patent/WO2001055125A1/en
Priority to DE2001602357 priority patent/DE60102357T2/de
Priority to PL355726A priority patent/PL211338B1/pl
Priority to RU2002122723/04A priority patent/RU2258067C2/ru
Priority to CNB2004100027829A priority patent/CN1239487C/zh
Priority to CZ20022463A priority patent/CZ301236B6/cs
Priority to SI200130107T priority patent/SI1252151T1/xx
Priority to CNB018040993A priority patent/CN1177839C/zh
Priority to EP01904235A priority patent/EP1252151B1/en
Priority to DK01904235T priority patent/DK1252151T3/da
Priority to AT01904235T priority patent/ATE261949T1/de
Publication of HUP0000283A2 publication Critical patent/HUP0000283A2/hu
Priority to HR20020579A priority patent/HRP20020579B1/xx
Publication of HUP0000283A3 publication Critical patent/HUP0000283A3/hu
Publication of HU227039B1 publication Critical patent/HU227039B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A tal lm ny t rgya új elj r s az (I) képletű 11-[4-/2-(2-hidroxi-etoxi)etil/-piperazin-1-il]-dibenzo[b,f]-1,4-tiazepin és gyógyszatilag alkalmas savaddíciós sója elő llít s ra. A tal lm ny szerintúgy j rnak el, hogy egy (VIII) ltal nos képletű halogén-etil-piperazinil-tiazepin-sz rmazékot, ahol Hal jelentése halogénatom,etilén-glikollal reag ltatnak. Ó
HU0000283A 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor HU227039B1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
AT01904235T ATE261949T1 (de) 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür
RU2002122723/04A RU2258067C2 (ru) 2000-01-25 2001-01-24 Способ получения кветиапина и промежуточные соединения
CZ20022463A CZ301236B6 (cs) 2000-01-25 2001-01-24 Zpusob prípravy chetiapinu a jeho meziproduktu
ES01904235T ES2217115T3 (es) 2000-01-25 2001-01-24 Procedimiento para la preparacion de quetiapina y de sus productos intermedios.
SK1060-2002A SK287171B6 (sk) 2000-01-25 2001-01-24 Spôsob prípravy chetiapínu a jeho medziproduktov
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor
DE2001602357 DE60102357T2 (de) 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür
PL355726A PL211338B1 (pl) 2000-01-25 2001-01-24 Sposób otrzymywania quetiapiny i związki przejściowe do tego procesu
AU32146/01A AU3214601A (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor
CNB2004100027829A CN1239487C (zh) 2000-01-25 2001-01-24 制备奎替阿平的中间体及所述中间体的制备方法
UA2002086977A UA73547C2 (uk) 2000-01-25 2001-01-24 Спосіб одержання кветіапіну (варіанти) і проміжні сполуки
SI200130107T SI1252151T1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor
CNB018040993A CN1177839C (zh) 2000-01-25 2001-01-24 奎替阿平及其中间体的制备方法
EP01904235A EP1252151B1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor
DK01904235T DK1252151T3 (da) 2000-01-25 2001-01-24 Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil
HR20020579A HRP20020579B1 (en) 2000-01-25 2002-07-05 A process for the preparation of quetiapine and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor

Publications (4)

Publication Number Publication Date
HU0000283D0 HU0000283D0 (en) 2000-03-28
HUP0000283A2 true HUP0000283A2 (hu) 2002-04-29
HUP0000283A3 HUP0000283A3 (en) 2002-11-28
HU227039B1 HU227039B1 (en) 2010-05-28

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor

Country Status (16)

Country Link
EP (1) EP1252151B1 (hu)
CN (2) CN1177839C (hu)
AT (1) ATE261949T1 (hu)
AU (1) AU3214601A (hu)
CZ (1) CZ301236B6 (hu)
DE (1) DE60102357T2 (hu)
DK (1) DK1252151T3 (hu)
ES (1) ES2217115T3 (hu)
HR (1) HRP20020579B1 (hu)
HU (1) HU227039B1 (hu)
PL (1) PL211338B1 (hu)
RU (1) RU2258067C2 (hu)
SI (1) SI1252151T1 (hu)
SK (1) SK287171B6 (hu)
UA (1) UA73547C2 (hu)
WO (1) WO2001055125A1 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539192A (ja) 1999-03-15 2002-11-19 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼ阻害剤としての新規な化合物及び組成物
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
CN1324008C (zh) 2001-09-14 2007-07-04 安万特药物公司 作为组织蛋白酶抑制剂的新化合物和组合物
WO2003042197A1 (en) 2001-11-14 2003-05-22 Aventis Pharmaceuticals Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
US7071331B2 (en) 2003-02-22 2006-07-04 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
AU2004233346B2 (en) 2003-04-23 2008-03-06 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
EP1664007B1 (en) * 2003-09-23 2009-12-23 Fermion Oy Preparation of quetiapine
US7858777B2 (en) 2003-09-23 2010-12-28 Fermion Oy Preparation method for quetiapine
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
WO2006113425A1 (en) 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
WO2007036599A1 (en) 2005-09-30 2007-04-05 Fermion Oy New crystallization process of quetiapine hemifumarate
DE202009018024U1 (de) 2008-08-01 2010-12-09 Krka Tovarna Zdravil, D.D., Novo Mesto Quetiapin-Zusammensetzung
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
US20120071649A1 (en) 2009-03-04 2012-03-22 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476743A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von Amidinen der Dibenzo (b,e) (1,4)-diazepin-Reihe
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
HRP20020579B1 (en) 2005-08-31
PL355726A1 (en) 2004-05-17
HUP0000283A3 (en) 2002-11-28
SK287171B6 (sk) 2010-02-08
CN1177839C (zh) 2004-12-01
RU2258067C2 (ru) 2005-08-10
HRP20020579A2 (en) 2004-08-31
UA73547C2 (uk) 2005-08-15
EP1252151B1 (en) 2004-03-17
RU2002122723A (ru) 2004-01-10
EP1252151A1 (en) 2002-10-30
AU3214601A (en) 2001-08-07
SI1252151T1 (en) 2004-08-31
DK1252151T3 (da) 2004-07-12
DE60102357T2 (de) 2005-01-13
CZ301236B6 (cs) 2009-12-16
CZ20022463A3 (cs) 2002-10-16
ES2217115T3 (es) 2004-11-01
CN1396916A (zh) 2003-02-12
WO2001055125A1 (en) 2001-08-02
HU0000283D0 (en) 2000-03-28
HU227039B1 (en) 2010-05-28
ATE261949T1 (de) 2004-04-15
PL211338B1 (pl) 2012-05-31
CN1537847A (zh) 2004-10-20
CN1239487C (zh) 2006-02-01
DE60102357D1 (de) 2004-04-22
SK10602002A3 (sk) 2002-11-06

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees