DE60102357D1 - Verfahren zur herstellung von quetiapin und intermediate dafür - Google Patents

Verfahren zur herstellung von quetiapin und intermediate dafür

Info

Publication number
DE60102357D1
DE60102357D1 DE60102357T DE60102357T DE60102357D1 DE 60102357 D1 DE60102357 D1 DE 60102357D1 DE 60102357 T DE60102357 T DE 60102357T DE 60102357 T DE60102357 T DE 60102357T DE 60102357 D1 DE60102357 D1 DE 60102357D1
Authority
DE
Germany
Prior art keywords
quetiapine
intermediates therefor
producing
formula
producing quetiapine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60102357T
Other languages
English (en)
Other versions
DE60102357T2 (de
Inventor
Daniel Bozsing
Lax Gyoergyi Kovanyine
Gyula Simig
Gyoergyne Rakoczy
Peter Toempe
Gyoergy Krasznai
Donath Gyoergyi Vereczkeyne
Kalman Nagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of DE60102357D1 publication Critical patent/DE60102357D1/de
Publication of DE60102357T2 publication Critical patent/DE60102357T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
DE2001602357 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür Expired - Lifetime DE60102357T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
HU0000283 2000-01-25
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Publications (2)

Publication Number Publication Date
DE60102357D1 true DE60102357D1 (de) 2004-04-22
DE60102357T2 DE60102357T2 (de) 2005-01-13

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2001602357 Expired - Lifetime DE60102357T2 (de) 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür

Country Status (16)

Country Link
EP (1) EP1252151B1 (de)
CN (2) CN1239487C (de)
AT (1) ATE261949T1 (de)
AU (1) AU3214601A (de)
CZ (1) CZ301236B6 (de)
DE (1) DE60102357T2 (de)
DK (1) DK1252151T3 (de)
ES (1) ES2217115T3 (de)
HR (1) HRP20020579B1 (de)
HU (1) HU227039B1 (de)
PL (1) PL211338B1 (de)
RU (1) RU2258067C2 (de)
SI (1) SI1252151T1 (de)
SK (1) SK287171B6 (de)
UA (1) UA73547C2 (de)
WO (1) WO2001055125A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0200503A3 (en) 1999-03-15 2005-06-28 Axys Pharmaceuticals Inc South N-cyanomethyl amides as protease inhibitors and pharmaceutical compositions containing them
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2004523506A (ja) 2000-12-22 2004-08-05 アクシス・ファーマシューティカルズ・インコーポレイテッド カテプシン阻害剤としての新規な化合物と組成物
PL369312A1 (en) 2001-09-14 2005-04-18 Aventis Pharmaceuticals Inc. Novel compounds and compositions as cathepsin inhibitors
CN1324018C (zh) 2001-11-14 2007-07-04 安万特药物公司 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
MXPA05011406A (es) 2003-04-23 2005-12-12 Medarex Inc Anticuerpos humanizados para el receptor-1 de interferon alfa (ifnar-1).
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
JP2007505864A (ja) * 2003-09-23 2007-03-15 フェルミオン オサケ ユキチュア クエチアピンの製造
CA2538866A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
US7687622B2 (en) 2005-04-14 2010-03-30 Teva Pharmaceutical Industries, Ltd Process for preparing quetiapine fumarate
WO2007036599A1 (en) 2005-09-30 2007-04-05 Fermion Oy New crystallization process of quetiapine hemifumarate
DK2262486T3 (da) 2008-08-01 2013-03-25 Krka Tovarna Zdravil D D Novo Mesto Quetiapin sammensætning
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476743A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von Amidinen der Dibenzo (b,e) (1,4)-diazepin-Reihe
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
CZ301236B6 (cs) 2009-12-16
SK10602002A3 (sk) 2002-11-06
EP1252151B1 (de) 2004-03-17
AU3214601A (en) 2001-08-07
RU2258067C2 (ru) 2005-08-10
CZ20022463A3 (cs) 2002-10-16
PL355726A1 (en) 2004-05-17
DK1252151T3 (da) 2004-07-12
HRP20020579A2 (en) 2004-08-31
WO2001055125A1 (en) 2001-08-02
HU0000283D0 (en) 2000-03-28
DE60102357T2 (de) 2005-01-13
CN1396916A (zh) 2003-02-12
HU227039B1 (en) 2010-05-28
ES2217115T3 (es) 2004-11-01
SI1252151T1 (en) 2004-08-31
EP1252151A1 (de) 2002-10-30
SK287171B6 (sk) 2010-02-08
RU2002122723A (ru) 2004-01-10
HUP0000283A3 (en) 2002-11-28
ATE261949T1 (de) 2004-04-15
UA73547C2 (uk) 2005-08-15
CN1177839C (zh) 2004-12-01
HRP20020579B1 (en) 2005-08-31
CN1239487C (zh) 2006-02-01
CN1537847A (zh) 2004-10-20
HUP0000283A2 (hu) 2002-04-29
PL211338B1 (pl) 2012-05-31

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