DK1252151T3 - Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil - Google Patents

Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil

Info

Publication number
DK1252151T3
DK1252151T3 DK01904235T DK01904235T DK1252151T3 DK 1252151 T3 DK1252151 T3 DK 1252151T3 DK 01904235 T DK01904235 T DK 01904235T DK 01904235 T DK01904235 T DK 01904235T DK 1252151 T3 DK1252151 T3 DK 1252151T3
Authority
DK
Denmark
Prior art keywords
quetiapine
preparation
intermediates
formula
thiazepine
Prior art date
Application number
DK01904235T
Other languages
Danish (da)
English (en)
Inventor
Peter Toempe
Daniel Bozsing
Lax Gyoergyi Kovanyine
Gyula Simig
Gyoergyne Rakoczy
Donath Gyoergyi Vereczkeyne
Kalman Nagy
Gyoergy Krasznai
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of DK1252151T3 publication Critical patent/DK1252151T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
DK01904235T 2000-01-25 2001-01-24 Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil DK1252151T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Publications (1)

Publication Number Publication Date
DK1252151T3 true DK1252151T3 (da) 2004-07-12

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01904235T DK1252151T3 (da) 2000-01-25 2001-01-24 Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil

Country Status (16)

Country Link
EP (1) EP1252151B1 (de)
CN (2) CN1177839C (de)
AT (1) ATE261949T1 (de)
AU (1) AU3214601A (de)
CZ (1) CZ301236B6 (de)
DE (1) DE60102357T2 (de)
DK (1) DK1252151T3 (de)
ES (1) ES2217115T3 (de)
HR (1) HRP20020579B1 (de)
HU (1) HU227039B1 (de)
PL (1) PL211338B1 (de)
RU (1) RU2258067C2 (de)
SI (1) SI1252151T1 (de)
SK (1) SK287171B6 (de)
UA (1) UA73547C2 (de)
WO (1) WO2001055125A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145429A0 (en) 1999-03-15 2002-06-30 Axys Pharm Inc N-cyanomethyl amides, processes for the preparation thereof and pharmaceutical compositions containing the same
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
US7064123B1 (en) 2000-12-22 2006-06-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
RS19504A (en) 2001-09-14 2007-02-05 Aventis Pharmaceuticals Inc., Novel compounds and compositions as cathepsin inhibitors
HUP0401906A3 (en) 2001-11-14 2008-07-28 Aventis Pharma Inc Novel cathepsin s inhibitors, process for their preparation and pharmaceutical compositions containing them
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
US7619070B2 (en) 2003-04-23 2009-11-17 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
DE602004031129D1 (de) * 2003-09-23 2011-03-03 Fermion Oy Verfahren zur herstellung von quetiapin
ES2335589T3 (es) 2003-09-23 2010-03-30 Fermion Oy Preparacion de quetiapina.
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
JP2008502707A (ja) 2005-04-14 2008-01-31 テバ ファーマシューティカル インダストリーズ リミティド クエチアピンフマレートの調製方法
WO2007036599A1 (en) 2005-09-30 2007-04-05 Fermion Oy New crystallization process of quetiapine hemifumarate
DK2262486T3 (da) 2008-08-01 2013-03-25 Krka Tovarna Zdravil D D Novo Mesto Quetiapin sammensætning
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
JP2012519683A (ja) 2009-03-04 2012-08-30 ランバクシー ラボラトリーズ リミテッド フマル酸クエチアピンの調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476753A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von 11-basisch substituierter Dibenzo(b,f)(1,4)thiazepine
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
HUP0000283A3 (en) 2002-11-28
RU2002122723A (ru) 2004-01-10
DE60102357T2 (de) 2005-01-13
PL211338B1 (pl) 2012-05-31
CN1396916A (zh) 2003-02-12
HU227039B1 (en) 2010-05-28
CN1177839C (zh) 2004-12-01
CN1537847A (zh) 2004-10-20
HUP0000283A2 (hu) 2002-04-29
HRP20020579B1 (en) 2005-08-31
CZ20022463A3 (cs) 2002-10-16
AU3214601A (en) 2001-08-07
SI1252151T1 (en) 2004-08-31
HRP20020579A2 (en) 2004-08-31
SK10602002A3 (sk) 2002-11-06
DE60102357D1 (de) 2004-04-22
RU2258067C2 (ru) 2005-08-10
CN1239487C (zh) 2006-02-01
SK287171B6 (sk) 2010-02-08
EP1252151A1 (de) 2002-10-30
UA73547C2 (uk) 2005-08-15
CZ301236B6 (cs) 2009-12-16
PL355726A1 (en) 2004-05-17
HU0000283D0 (en) 2000-03-28
ES2217115T3 (es) 2004-11-01
EP1252151B1 (de) 2004-03-17
WO2001055125A1 (en) 2001-08-02
ATE261949T1 (de) 2004-04-15

Similar Documents

Publication Publication Date Title
DK1252151T3 (da) Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil
ATE452882T1 (de) Herstellung von quetiapin
CY1106743T1 (el) Μεθοδος παρασκευης θειαμεθοξαμης
CY1107635T1 (el) Μεθοδος για την παρασκευη σιταλοπραμης
DK1856073T3 (da) Fremgangsmåde til fremstilling af et 11-(4-substitueret-1-piperazinyl)dibenzo[b,f][1,4]thiazepinderivat
DK0781764T3 (da) Fremgangsmåde til fremstilling af alkoxyiminoacetamid-derivater
DK1206452T3 (da) Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
ATE287889T1 (de) Cefalosporin-zwischenprodukte
ATE367383T1 (de) Verfahren zur herstellung von 11-(4-(2-(2- hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo(b,f) 1,4)thiazepin
HK1037617A1 (en) Process for the preparation of imidazodiazepine intermediates
BR9917400A (pt) Processo para a preparação de um derivado de dibenzotiazepina, e, derivado de 2-nitro - 2' - carboxi - difenilsulfeto
PT1230252E (pt) Derivados de beta-d-5-tioxilose processo de preparacao e utilizacao em terapeutica
AU1874201A (en) A process for the preparation of (2-(4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl)ethoxy) acetic acid and novel intermediates therefor
MY143831A (en) Insecticidal incense composition, and emulsion and process for producing the same
ATE252566T1 (de) Herstellung von 2-(2-arylmorpholin-2- yl)ethanolderivaten und zwischenprodukte
DK1274688T3 (da) Syntese af mellemprodukter, der er nyttige ved fremstilling af tricykliske forbindelser
YU62302A (sh) Postupak za izradu jedinjenja 2-(4-alkil-1-piperazinil)- benzaldehida i benzilidenila
DK1320527T3 (da) Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler
FR2854403A1 (fr) Nouveau procede et intermediaires de preparation de composes 19-nor-steroides 17-halogenes
WO2004089890A3 (en) Process and intermediates for preparing benzazepines
AU2639999A (en) Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives
TR200001161A2 (tr) 8-Siklopentil-6-etil-3-[ikame edilmiş]-5, 8-Dihidro-4H-1, 2, 3A, 7, 8-Pentaaza-As-Indasenlerin hazırlandığı işlem ve burada yararlı ara bağlar.
MXPA04003628A (es) Derivados de benzoxanina y benzotiazina y composiciones farmaceuticas que los contienen.
ECSP992934A (es) Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente