ATE452882T1 - Herstellung von quetiapin - Google Patents

Herstellung von quetiapin

Info

Publication number
ATE452882T1
ATE452882T1 AT04767074T AT04767074T ATE452882T1 AT E452882 T1 ATE452882 T1 AT E452882T1 AT 04767074 T AT04767074 T AT 04767074T AT 04767074 T AT04767074 T AT 04767074T AT E452882 T1 ATE452882 T1 AT E452882T1
Authority
AT
Austria
Prior art keywords
quetiapine
preparation
compound
discloses
well
Prior art date
Application number
AT04767074T
Other languages
English (en)
Inventor
Petteri Rummakko
Soini Huhta
Arne Grumann
Original Assignee
Fermion Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fermion Oy filed Critical Fermion Oy
Application granted granted Critical
Publication of ATE452882T1 publication Critical patent/ATE452882T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04767074T 2003-09-23 2004-09-23 Herstellung von quetiapin ATE452882T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50498103P 2003-09-23 2003-09-23
PCT/FI2004/000560 WO2005028458A1 (en) 2003-09-23 2004-09-23 Preparation of quetiapine

Publications (1)

Publication Number Publication Date
ATE452882T1 true ATE452882T1 (de) 2010-01-15

Family

ID=34375548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04767074T ATE452882T1 (de) 2003-09-23 2004-09-23 Herstellung von quetiapin

Country Status (9)

Country Link
US (1) US7863441B2 (de)
EP (1) EP1664007B1 (de)
JP (1) JP2007505864A (de)
AT (1) ATE452882T1 (de)
CA (1) CA2538745A1 (de)
DE (1) DE602004024798D1 (de)
ES (1) ES2335589T3 (de)
PT (1) PT1664007E (de)
WO (1) WO2005028458A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE496038T1 (de) * 2003-09-23 2011-02-15 Fermion Oy Verfahren zur herstellung von quetiapin
JP2008502707A (ja) 2005-04-14 2008-01-31 テバ ファーマシューティカル インダストリーズ リミティド クエチアピンフマレートの調製方法
WO2009004480A2 (en) 2007-05-07 2009-01-08 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
US20080287418A1 (en) * 2007-05-16 2008-11-20 Astrazeneca Ab Extended Release Compositions and Methods for Their Manufacture
CN101925587B (zh) 2008-01-31 2013-05-01 费米有限公司 喹硫平的制备方法
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
CN101891707B (zh) * 2010-07-29 2012-10-17 浙江海正药业股份有限公司 喹硫平或其可药用盐的制备方法
JP6270845B2 (ja) 2012-08-21 2018-01-31 ヤンセン ファーマシューティカ エヌ．ベー． アリピプラゾールに対する抗体及びその使用
EP2888277A4 (de) 2012-08-21 2016-05-18 Ortho Clinical Diagnostics Inc Antikörper gegen paliperidon und verwendung davon
EP3492473B1 (de) 2012-08-21 2025-07-30 Janssen Pharmaceutica NV Haptene von olanzapin
WO2014031595A1 (en) 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Haptens of paliperidone
AU2013305895B2 (en) 2012-08-21 2017-10-19 Saladax Biomedical Inc. Antibodies to olanzapine haptens and use thereof
AU2013305970B2 (en) 2012-08-21 2017-08-17 Saladax Biomedical Inc. Antibodies to aripiprazole haptens and use thereof
PL2888592T3 (pl) 2012-08-21 2018-03-30 Janssen Pharmaceutica Nv Przeciwciała względem kwetiapiny i ich zastosowania
PL2888234T3 (pl) 2012-08-21 2018-07-31 Janssen Pharmaceutica Nv Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
ES2904838T3 (es) 2012-08-21 2022-04-06 Janssen Pharmaceutica Nv Haptenos de risperidona y paliperidona
AU2013305887B2 (en) 2012-08-21 2018-02-22 Saladax Biomedical Inc. Antibodies to risperidone and use thereof
CN104736566A (zh) 2012-08-21 2015-06-24 奥索临床诊断有限公司 帕潘立酮半抗原的抗体及其用途
CN104755928B (zh) 2012-08-21 2017-05-10 詹森药业有限公司 奥氮平的抗体及其用途
ES2926662T3 (es) 2012-08-21 2022-10-27 Janssen Pharmaceutica Nv Anticuerpos contra haptenos de risperidona y uso de los mismos
US9304126B2 (en) * 2012-08-21 2016-04-05 Janssen Pharmaceutica Nv Haptens of quetiapine
WO2014031665A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to quetiapine haptens and use thereof
CN103396382B (zh) * 2013-07-29 2015-05-20 太仓市茜泾化工有限公司 一种喹硫平中间体的制备方法
CN104803947A (zh) * 2015-03-12 2015-07-29 常州康丽制药有限公司 11-(1-哌嗪基)二苯并[b,f][1,4]硫氮杂*富马酸盐的制备方法
CN108368180B (zh) 2015-12-17 2022-07-26 詹森药业有限公司 喹硫平的抗体及其用途
WO2017106501A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
CN114181172B (zh) * 2021-12-27 2023-12-22 浙江苏泊尔制药有限公司 一种富马酸喹硫平的高效制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA979441A (en) * 1967-02-27 1975-12-09 American Cyanamid Company 11-(piperazinyl) dibenz (b,f) (1,4) oxazepines and analogous thiazepines
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
HU227039B1 (en) 2000-01-25 2010-05-28 Egis Gyogyszergyar Nyilvanosan New process for the production of quetiapine and intermediates therefor
CA2444031C (en) 2001-04-16 2012-02-21 Schering Corporation 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
ATE496038T1 (de) 2003-09-23 2011-02-15 Fermion Oy Verfahren zur herstellung von quetiapin

Also Published As

Publication number Publication date
US20070111987A1 (en) 2007-05-17
EP1664007B1 (de) 2009-12-23
JP2007505864A (ja) 2007-03-15
CA2538745A1 (en) 2005-03-31
DE602004024798D1 (de) 2010-02-04
PT1664007E (pt) 2010-02-15
US7863441B2 (en) 2011-01-04
ES2335589T3 (es) 2010-03-30
WO2005028458A1 (en) 2005-03-31
EP1664007A1 (de) 2006-06-07

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