SI1252151T1 - A process for the preparation of quetiapine and intermediates therefor - Google Patents

A process for the preparation of quetiapine and intermediates therefor

Info

Publication number
SI1252151T1
SI1252151T1 SI200130107T SI200130107T SI1252151T1 SI 1252151 T1 SI1252151 T1 SI 1252151T1 SI 200130107 T SI200130107 T SI 200130107T SI 200130107 T SI200130107 T SI 200130107T SI 1252151 T1 SI1252151 T1 SI 1252151T1
Authority
SI
Slovenia
Prior art keywords
quetiapine
preparation
intermediates therefor
formula
thiazepine
Prior art date
Application number
SI200130107T
Other languages
English (en)
Slovenian (sl)
Inventor
Daniel Bozsing
LAX Gy�rgyi KOVANYINE
Gyula Simig
Gy�rgyne RAKOCZY
Peter T�MPE
Gyrgy KRASZNAI
DONATH Gy�rgyi VERECZKEYNE
Kalman Nagy
Original Assignee
Egis Gyogyszergyar Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Reszvenytarsasag filed Critical Egis Gyogyszergyar Reszvenytarsasag
Publication of SI1252151T1 publication Critical patent/SI1252151T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
SI200130107T 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor SI1252151T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
EP01904235A EP1252151B1 (de) 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Publications (1)

Publication Number Publication Date
SI1252151T1 true SI1252151T1 (en) 2004-08-31

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130107T SI1252151T1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Country Status (16)

Country Link
EP (1) EP1252151B1 (de)
CN (2) CN1177839C (de)
AT (1) ATE261949T1 (de)
AU (1) AU3214601A (de)
CZ (1) CZ301236B6 (de)
DE (1) DE60102357T2 (de)
DK (1) DK1252151T3 (de)
ES (1) ES2217115T3 (de)
HR (1) HRP20020579B1 (de)
HU (1) HU227039B1 (de)
PL (1) PL211338B1 (de)
RU (1) RU2258067C2 (de)
SI (1) SI1252151T1 (de)
SK (1) SK287171B6 (de)
UA (1) UA73547C2 (de)
WO (1) WO2001055125A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145429A0 (en) 1999-03-15 2002-06-30 Axys Pharm Inc N-cyanomethyl amides, processes for the preparation thereof and pharmaceutical compositions containing the same
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
US7064123B1 (en) 2000-12-22 2006-06-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
RS19504A (en) 2001-09-14 2007-02-05 Aventis Pharmaceuticals Inc., Novel compounds and compositions as cathepsin inhibitors
HUP0401906A3 (en) 2001-11-14 2008-07-28 Aventis Pharma Inc Novel cathepsin s inhibitors, process for their preparation and pharmaceutical compositions containing them
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
US7619070B2 (en) 2003-04-23 2009-11-17 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
DE602004031129D1 (de) * 2003-09-23 2011-03-03 Fermion Oy Verfahren zur herstellung von quetiapin
ES2335589T3 (es) 2003-09-23 2010-03-30 Fermion Oy Preparacion de quetiapina.
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
JP2008502707A (ja) 2005-04-14 2008-01-31 テバ ファーマシューティカル インダストリーズ リミティド クエチアピンフマレートの調製方法
WO2007036599A1 (en) 2005-09-30 2007-04-05 Fermion Oy New crystallization process of quetiapine hemifumarate
DK2262486T3 (da) 2008-08-01 2013-03-25 Krka Tovarna Zdravil D D Novo Mesto Quetiapin sammensætning
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
JP2012519683A (ja) 2009-03-04 2012-08-30 ランバクシー ラボラトリーズ リミテッド フマル酸クエチアピンの調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476753A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von 11-basisch substituierter Dibenzo(b,f)(1,4)thiazepine
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
HUP0000283A3 (en) 2002-11-28
RU2002122723A (ru) 2004-01-10
DE60102357T2 (de) 2005-01-13
PL211338B1 (pl) 2012-05-31
CN1396916A (zh) 2003-02-12
HU227039B1 (en) 2010-05-28
CN1177839C (zh) 2004-12-01
CN1537847A (zh) 2004-10-20
HUP0000283A2 (hu) 2002-04-29
DK1252151T3 (da) 2004-07-12
HRP20020579B1 (en) 2005-08-31
CZ20022463A3 (cs) 2002-10-16
AU3214601A (en) 2001-08-07
HRP20020579A2 (en) 2004-08-31
SK10602002A3 (sk) 2002-11-06
DE60102357D1 (de) 2004-04-22
RU2258067C2 (ru) 2005-08-10
CN1239487C (zh) 2006-02-01
SK287171B6 (sk) 2010-02-08
EP1252151A1 (de) 2002-10-30
UA73547C2 (uk) 2005-08-15
CZ301236B6 (cs) 2009-12-16
PL355726A1 (en) 2004-05-17
HU0000283D0 (en) 2000-03-28
ES2217115T3 (es) 2004-11-01
EP1252151B1 (de) 2004-03-17
WO2001055125A1 (en) 2001-08-02
ATE261949T1 (de) 2004-04-15

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