NO20075071L - Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005 - Google Patents

Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005

Info

Publication number
NO20075071L
NO20075071L NO20075071A NO20075071A NO20075071L NO 20075071 L NO20075071 L NO 20075071L NO 20075071 A NO20075071 A NO 20075071A NO 20075071 A NO20075071 A NO 20075071A NO 20075071 L NO20075071 L NO 20075071L
Authority
NO
Norway
Prior art keywords
dibenzo
piperazinyl
thiazepine
derivate
substituted
Prior art date
Application number
NO20075071A
Other languages
English (en)
Inventor
Alexander Christian Comely
Francesc Xavier Ver Espaulella
Llorenc Rafecas Jane
Antonio Domingo Coto
Original Assignee
Union Quimico Farmaceutica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Quimico Farmaceutica Sa filed Critical Union Quimico Farmaceutica Sa
Publication of NO20075071L publication Critical patent/NO20075071L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Abstract

En fremgangsmåte for fremstilling av et ll-(4-substituert-l-piperazinyl)dibenzo[b,fJ[l,4]tiazepinderivat, av generell Formel I, hvor A er hydrogen eller en. -(CH)2-OH gruppe eller en -(CH)2-0-(CH)2-OH gruppe, eller et salt derav, omfattende et trinn i hvilket 10H-dibenzo[b,fJ[l,4]tiazepin-l 1-on blir reagert med et piperazinderivat i tilstedeværelsen av et titaniumalkoksid av generell formel Ti(OR), hvor R er en rett eller forgrenet alkylgruppe som har fra ett til åtte karbonatomer for å oppnå nevnte Formel I derivat eller et salt derav. Hvor A er -(CH)2-0-(CH)2-OH, så er piperazinderivatet 1 -(2-(2-hydroksyetoksy)etyl)piperazin og. 1 l-(4-substituert-l-piperazinyl)dibenzo[b,fJ[l,4]tiazepinet er quetiapin, (1 l-(4-(2-(2-hydroksyetoksy)etyl)-l-piperazinyl)dibenzo[b,fJ[l,4]tiazepin). Prosessen kan omfatte et tilleggstrinn av å reagere quetiapinet med fumarsyre for å oppnå quetiapinhemifumarat.
NO20075071A 2005-03-07 2007-10-08 Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005 NO20075071L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200500513A ES2234447B1 (es) 2005-03-07 2005-03-07 Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
PCT/EP2005/014055 WO2006094549A1 (en) 2005-03-07 2005-12-21 A PROCESS FOR THE PREPARATION OF AN 11-(4-SUBSTITUTED-I-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE DERIVATIVE

Publications (1)

Publication Number Publication Date
NO20075071L true NO20075071L (no) 2007-11-28

Family

ID=34707636

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075071A NO20075071L (no) 2005-03-07 2007-10-08 Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005

Country Status (9)

Country Link
US (1) US7902355B2 (no)
EP (1) EP1856073B1 (no)
AT (1) ATE467624T1 (no)
DE (1) DE602005021256D1 (no)
DK (1) DK1856073T3 (no)
ES (1) ES2234447B1 (no)
NO (1) NO20075071L (no)
PT (1) PT1856073E (no)
WO (1) WO2006094549A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687622B2 (en) 2005-04-14 2010-03-30 Teva Pharmaceutical Industries, Ltd Process for preparing quetiapine fumarate
CZ300451B6 (cs) * 2006-07-03 2009-05-20 Farmak, A. S. Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
JP2011510960A (ja) * 2008-01-31 2011-04-07 フェルミオン オサケ ユキチュア ケチアピンの製造方法
JP2012519683A (ja) 2009-03-04 2012-08-30 ランバクシー ラボラトリーズ リミテッド フマル酸クエチアピンの調製方法
CN101891707B (zh) * 2010-07-29 2012-10-17 浙江海正药业股份有限公司 喹硫平或其可药用盐的制备方法
CN103664822B (zh) * 2012-09-18 2015-07-15 四川大学华西医院 一种可用作麻醉剂的化合物
CN104803947A (zh) * 2015-03-12 2015-07-29 常州康丽制药有限公司 11-(1-哌嗪基)二苯并[b,f][1,4]硫氮杂*富马酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8705574D0 (en) * 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound
GB9716161D0 (en) * 1997-08-01 1997-10-08 Zeneca Ltd Process
HU227039B1 (en) * 2000-01-25 2010-05-28 Egis Gyogyszergyar Nyilvanosan New process for the production of quetiapine and intermediates therefor
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof

Also Published As

Publication number Publication date
US7902355B2 (en) 2011-03-08
US20080171869A1 (en) 2008-07-17
DE602005021256D1 (de) 2010-06-24
DK1856073T3 (da) 2010-08-23
WO2006094549A1 (en) 2006-09-14
ES2234447A1 (es) 2005-06-16
EP1856073B1 (en) 2010-05-12
PT1856073E (pt) 2010-07-06
ES2234447B1 (es) 2006-03-01
ATE467624T1 (de) 2010-05-15
EP1856073A1 (en) 2007-11-21

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