ATE367383T1 - Verfahren zur herstellung von 11-(4-(2-(2- hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo(b,f) 1,4)thiazepin - Google Patents
Verfahren zur herstellung von 11-(4-(2-(2- hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo(b,f) 1,4)thiazepinInfo
- Publication number
- ATE367383T1 ATE367383T1 AT04744176T AT04744176T ATE367383T1 AT E367383 T1 ATE367383 T1 AT E367383T1 AT 04744176 T AT04744176 T AT 04744176T AT 04744176 T AT04744176 T AT 04744176T AT E367383 T1 ATE367383 T1 AT E367383T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazepine
- dibenzo
- hydroxyethoxy
- piperazinyl
- ethyl
- Prior art date
Links
- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- NYERMPLPURRVGM-UHFFFAOYSA-N thiazepine Chemical compound S1C=CC=CC=N1 NYERMPLPURRVGM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 abstract 2
- 229960004431 quetiapine Drugs 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/18—Eight-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200301922A ES2223294B2 (es) | 2003-08-08 | 2003-08-08 | Procedimiento de preparacion de un compuesto farmaceuticamente activo. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE367383T1 true ATE367383T1 (de) | 2007-08-15 |
Family
ID=34130558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04744176T ATE367383T1 (de) | 2003-08-08 | 2004-07-27 | Verfahren zur herstellung von 11-(4-(2-(2- hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo(b,f) 1,4)thiazepin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7807827B2 (de) |
| EP (1) | EP1660468B1 (de) |
| JP (1) | JP2007501837A (de) |
| KR (1) | KR100864799B1 (de) |
| AT (1) | ATE367383T1 (de) |
| DE (1) | DE602004007670T2 (de) |
| ES (2) | ES2223294B2 (de) |
| PL (1) | PL1660468T3 (de) |
| PT (1) | PT1660468E (de) |
| WO (1) | WO2005014590A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003235435A1 (en) * | 2002-03-20 | 2003-10-08 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of quetiapine hemifumarate |
| DE602004024798D1 (de) * | 2003-09-23 | 2010-02-04 | Fermion Oy | Herstellung von quetiapin |
| WO2006113425A1 (en) | 2005-04-14 | 2006-10-26 | Teva Pharmaceutical Industries Ltd. | Process for preparing quetiapine fumarate |
| WO2008052354A1 (en) * | 2006-11-03 | 2008-05-08 | University Of Saskatchewan | Method of treating demyelination diseases |
| PT1958617E (pt) | 2007-02-14 | 2010-10-28 | Lesvi Laboratorios Sl | Composições farmacêuticas contendo fumarato de quetiapina |
| WO2008121415A2 (en) * | 2007-03-29 | 2008-10-09 | Teva Pharmaceutical Industries Ltd. | Improved process for preparing quetiapine fumarate |
| CA2711395A1 (en) | 2008-01-31 | 2009-08-06 | Fermion Oy | A process for the preparation of quetiapine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH422793A (de) | 1961-07-20 | 1966-10-31 | Wander Ag Dr A | Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine |
| GB8607684D0 (en) * | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
| GB8705574D0 (en) * | 1987-03-10 | 1987-04-15 | Ici Plc | Preparation of thiazepine compound |
| GB9716161D0 (en) | 1997-08-01 | 1997-10-08 | Zeneca Ltd | Process |
| HU227039B1 (en) * | 2000-01-25 | 2010-05-28 | Egis Gyogyszergyar Nyilvanosan | New process for the production of quetiapine and intermediates therefor |
| US20050080072A1 (en) * | 2003-09-01 | 2005-04-14 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of a thiazepine derivative |
-
2003
- 2003-08-08 ES ES200301922A patent/ES2223294B2/es not_active Expired - Fee Related
-
2004
- 2004-07-27 PL PL04744176T patent/PL1660468T3/pl unknown
- 2004-07-27 PT PT04744176T patent/PT1660468E/pt unknown
- 2004-07-27 DE DE602004007670T patent/DE602004007670T2/de not_active Expired - Lifetime
- 2004-07-27 ES ES04744176T patent/ES2290734T3/es not_active Expired - Lifetime
- 2004-07-27 AT AT04744176T patent/ATE367383T1/de not_active IP Right Cessation
- 2004-07-27 EP EP04744176A patent/EP1660468B1/de not_active Expired - Lifetime
- 2004-07-27 KR KR1020067002638A patent/KR100864799B1/ko not_active IP Right Cessation
- 2004-07-27 US US10/566,413 patent/US7807827B2/en not_active Expired - Fee Related
- 2004-07-27 JP JP2006523068A patent/JP2007501837A/ja active Pending
- 2004-07-27 WO PCT/IB2004/002527 patent/WO2005014590A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT1660468E (pt) | 2007-10-12 |
| WO2005014590A2 (en) | 2005-02-17 |
| EP1660468B1 (de) | 2007-07-18 |
| EP1660468A2 (de) | 2006-05-31 |
| ES2290734T3 (es) | 2008-02-16 |
| DE602004007670D1 (de) | 2007-08-30 |
| PL1660468T3 (pl) | 2007-12-31 |
| US20060189594A1 (en) | 2006-08-24 |
| KR100864799B1 (ko) | 2008-10-23 |
| JP2007501837A (ja) | 2007-02-01 |
| DE602004007670T2 (de) | 2008-04-30 |
| ES2223294A1 (es) | 2005-02-16 |
| ES2223294B2 (es) | 2005-10-01 |
| WO2005014590A3 (en) | 2005-05-06 |
| KR20060087506A (ko) | 2006-08-02 |
| US7807827B2 (en) | 2010-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |