TW200624425A - Optically active 4,4-disubstituted oxazolidine derivatives and the preparation thereof - Google Patents

Optically active 4,4-disubstituted oxazolidine derivatives and the preparation thereof

Info

Publication number
TW200624425A
TW200624425A TW094137581A TW94137581A TW200624425A TW 200624425 A TW200624425 A TW 200624425A TW 094137581 A TW094137581 A TW 094137581A TW 94137581 A TW94137581 A TW 94137581A TW 200624425 A TW200624425 A TW 200624425A
Authority
TW
Taiwan
Prior art keywords
group
oxazolidine derivatives
preparation
optically active
disubstituted oxazolidine
Prior art date
Application number
TW094137581A
Other languages
Chinese (zh)
Other versions
TWI362384B (en
Inventor
Toshihiko Onoda
Yoshitaka Nakamura
Makoto Yamaoka
Tadahiro Takeda
Noritada Sato
Masayoshi Jin
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of TW200624425A publication Critical patent/TW200624425A/en
Application granted granted Critical
Publication of TWI362384B publication Critical patent/TWI362384B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention provides photoactive 4,4-disubstituted oxazolidine derivatives and the process for preparing thereof. Photoactive 4,4-disubstituted oxazolidine derivatives of the following formula (I), , (wherein, R1 represents formyl group, hydroxylmethyl group, COOR halogenized methyl group, phosphonium methyl group etc.; R represents a C1-6 alkyl group etc.; R2 represents a C1-6 alkyl group, a C3-C10 cycloalkyl group etc.; R3 represents a C2-C6 alkanoyl group, C1-6 alkyloxycarbonyl group etc.; R4 represents a C1-6 alkyl group or a C2-C6 alkenyl group etc.;)
TW094137581A 2004-10-28 2005-10-27 Optically active 4,4-disubstituted oxazolidine derivatives and the preparation thereof TWI362384B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004313183 2004-10-28

Publications (2)

Publication Number Publication Date
TW200624425A true TW200624425A (en) 2006-07-16
TWI362384B TWI362384B (en) 2012-04-21

Family

ID=36227836

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094137581A TWI362384B (en) 2004-10-28 2005-10-27 Optically active 4,4-disubstituted oxazolidine derivatives and the preparation thereof

Country Status (10)

Country Link
US (1) US7547790B2 (en)
EP (1) EP1806344A4 (en)
JP (2) JP5477984B2 (en)
KR (1) KR101285483B1 (en)
CN (1) CN101031552B (en)
BR (1) BRPI0516173A (en)
CA (1) CA2581415C (en)
IL (1) IL182125A (en)
TW (1) TWI362384B (en)
WO (1) WO2006046595A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2470495B (en) * 2008-01-16 2012-12-26 Biotechnology Res Corp Ltd Oxazolidine derivatives as NMDA antagonists
BR102012022547B1 (en) * 2012-09-06 2020-12-08 Universidade Federal De Minas Gerais - Ufmg chiral n-substituted aromatic oxazolidines, synthesis process, pharmaceutical composition and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE38835T1 (en) * 1983-07-05 1988-12-15 Pfizer CARBONIC ACID DERIVATIVES USEFUL IN PREVENTING DECOMPOSITION OF CARTILAGE.
ZA854828B (en) * 1984-07-27 1986-03-26 Hoffmann La Roche Phenyl nonatetraenoic acid derivatives
IL107836A (en) * 1992-12-11 1998-01-04 Merck & Co Inc Spiro piperidines and homologs, their preparation and pharmaceutical compositions containing them
US5536716A (en) 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
BR0306811A (en) 2002-01-11 2004-10-26 Sankyo Co Compound, pharmacologically acceptable ester thereof, pharmaceutical composition and methods for the prevention or treatment of autoimmune diseases, rheumatoid arthritis and rejection caused by the transplantation of various organs in a mammal
DE10317878A1 (en) * 2003-04-17 2004-11-11 Consortium für elektrochemische Industrie GmbH Process for the preparation of alpha-methylated cysteine and serine derivatives
CN1926118A (en) * 2004-03-01 2007-03-07 德克萨斯大学董事会 Dimeric small molecule potentiators of apoptosis

Also Published As

Publication number Publication date
CN101031552A (en) 2007-09-05
JP5477984B2 (en) 2014-04-23
IL182125A (en) 2012-02-29
IL182125A0 (en) 2007-07-24
EP1806344A4 (en) 2012-02-01
KR101285483B1 (en) 2013-07-12
TWI362384B (en) 2012-04-21
BRPI0516173A (en) 2008-08-26
JP2012188425A (en) 2012-10-04
CA2581415A1 (en) 2006-05-04
EP1806344A1 (en) 2007-07-11
US20080108828A1 (en) 2008-05-08
JP2012176954A (en) 2012-09-13
KR20070073836A (en) 2007-07-10
WO2006046595A1 (en) 2006-05-04
US7547790B2 (en) 2009-06-16
CA2581415C (en) 2011-10-04
CN101031552B (en) 2010-11-10
JP5477983B2 (en) 2014-04-23

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees