SI1252151T1 - A process for the preparation of quetiapine and intermediates therefor - Google Patents
A process for the preparation of quetiapine and intermediates thereforInfo
- Publication number
- SI1252151T1 SI1252151T1 SI200130107T SI200130107T SI1252151T1 SI 1252151 T1 SI1252151 T1 SI 1252151T1 SI 200130107 T SI200130107 T SI 200130107T SI 200130107 T SI200130107 T SI 200130107T SI 1252151 T1 SI1252151 T1 SI 1252151T1
- Authority
- SI
- Slovenia
- Prior art keywords
- quetiapine
- preparation
- intermediates therefor
- formula
- thiazepine
- Prior art date
Links
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004431 quetiapine Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0000283A HU227039B1 (en) | 2000-01-25 | 2000-01-25 | New process for the production of quetiapine and intermediates therefor |
PCT/HU2001/000010 WO2001055125A1 (en) | 2000-01-25 | 2001-01-24 | A process for the preparation of quetiapine and intermediates therefor |
EP01904235A EP1252151B1 (en) | 2000-01-25 | 2001-01-24 | A process for the preparation of quetiapine and intermediates therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1252151T1 true SI1252151T1 (en) | 2004-08-31 |
Family
ID=89978038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200130107T SI1252151T1 (en) | 2000-01-25 | 2001-01-24 | A process for the preparation of quetiapine and intermediates therefor |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1252151B1 (xx) |
CN (2) | CN1239487C (xx) |
AT (1) | ATE261949T1 (xx) |
AU (1) | AU3214601A (xx) |
CZ (1) | CZ301236B6 (xx) |
DE (1) | DE60102357T2 (xx) |
DK (1) | DK1252151T3 (xx) |
ES (1) | ES2217115T3 (xx) |
HR (1) | HRP20020579B1 (xx) |
HU (1) | HU227039B1 (xx) |
PL (1) | PL211338B1 (xx) |
RU (1) | RU2258067C2 (xx) |
SI (1) | SI1252151T1 (xx) |
SK (1) | SK287171B6 (xx) |
UA (1) | UA73547C2 (xx) |
WO (1) | WO2001055125A1 (xx) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1178958B1 (en) | 1999-03-15 | 2004-02-18 | Axys Pharmaceuticals, Inc. | N-cyanomethyl amides as protease inhibitors |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
MXPA04002282A (es) | 2001-09-14 | 2005-03-07 | Axis Pharmaceutical Inc | Nuevos compuestos y preparaciones como inhibidores de la catepsina. |
RU2004117877A (ru) | 2001-11-14 | 2006-01-10 | Авентис Фармасьютикалз Инк. (Us) | Олигопептиды и композиции, содержащие их, в качестве ингибиторов катепсина s |
US7071331B2 (en) | 2003-02-22 | 2006-07-04 | Teva Pharmaceutical Industries Ltd. | Synthesis of quetiapine and pharmaceutically acceptable salts thereof |
EP2404615A1 (en) | 2003-04-23 | 2012-01-11 | Medarex, Inc. | Humanized antibodies to interferon alpha receptor-1 (IFNAR-1) |
PL195728B1 (pl) * | 2003-07-18 | 2007-10-31 | Helm Ag | Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny |
ES2223294B2 (es) * | 2003-08-08 | 2005-10-01 | Vita Cientifica, S.L. | Procedimiento de preparacion de un compuesto farmaceuticamente activo. |
CA2538866A1 (en) | 2003-09-23 | 2005-03-31 | Fermion Oy | Preparation of quetiapine |
JP2007505864A (ja) * | 2003-09-23 | 2007-03-15 | フェルミオン オサケ ユキチュア | クエチアピンの製造 |
KR101038389B1 (ko) * | 2004-06-23 | 2011-06-01 | 에스케이바이오팜 주식회사 | 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[b,f][1,4]티아제핀의 제조방법 |
WO2006035293A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Polymorphic forms of quetiapine hemifumarate |
GB0425729D0 (en) * | 2004-11-23 | 2004-12-22 | Pliva Res & Dev Ltd | Heterocyclic compounds |
WO2006056772A2 (en) * | 2004-11-23 | 2006-06-01 | Pliva Hrvatska D.O.O. | Salts of quetiapine |
ES2234447B1 (es) * | 2005-03-07 | 2006-03-01 | Union Quimico-Farmaceutica S.A. | Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina. |
JP2008502707A (ja) | 2005-04-14 | 2008-01-31 | テバ ファーマシューティカル インダストリーズ リミティド | クエチアピンフマレートの調製方法 |
EP1928849A1 (en) | 2005-09-30 | 2008-06-11 | Fermion Oy | New crystallization process of quetiapine hemifumarate |
SI2262486T1 (sl) | 2008-08-01 | 2013-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Sestavek kvetiapina |
CN101676275B (zh) * | 2008-09-17 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 一种富马酸喹硫平的制备方法 |
US20120071649A1 (en) | 2009-03-04 | 2012-03-22 | Ranbaxy Laboratories Limited | Process for the preparation of quetiapine fumarate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH422793A (de) * | 1961-07-20 | 1966-10-31 | Wander Ag Dr A | Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine |
CH476743A (de) * | 1962-06-08 | 1969-08-15 | Wander Ag Dr A | Verfahren zur Herstellung von Amidinen der Dibenzo (b,e) (1,4)-diazepin-Reihe |
US3539573A (en) * | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
US3560622A (en) * | 1967-10-13 | 1971-02-02 | American Cyanamid Co | Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents |
-
2000
- 2000-01-25 HU HU0000283A patent/HU227039B1/hu not_active IP Right Cessation
-
2001
- 2001-01-24 EP EP01904235A patent/EP1252151B1/en not_active Expired - Lifetime
- 2001-01-24 DE DE2001602357 patent/DE60102357T2/de not_active Expired - Lifetime
- 2001-01-24 AU AU32146/01A patent/AU3214601A/en not_active Abandoned
- 2001-01-24 SK SK1060-2002A patent/SK287171B6/sk not_active IP Right Cessation
- 2001-01-24 DK DK01904235T patent/DK1252151T3/da active
- 2001-01-24 WO PCT/HU2001/000010 patent/WO2001055125A1/en active IP Right Grant
- 2001-01-24 CN CNB2004100027829A patent/CN1239487C/zh not_active Expired - Fee Related
- 2001-01-24 ES ES01904235T patent/ES2217115T3/es not_active Expired - Lifetime
- 2001-01-24 SI SI200130107T patent/SI1252151T1/xx unknown
- 2001-01-24 RU RU2002122723/04A patent/RU2258067C2/ru not_active IP Right Cessation
- 2001-01-24 CZ CZ20022463A patent/CZ301236B6/cs not_active IP Right Cessation
- 2001-01-24 PL PL355726A patent/PL211338B1/pl unknown
- 2001-01-24 CN CNB018040993A patent/CN1177839C/zh not_active Expired - Fee Related
- 2001-01-24 AT AT01904235T patent/ATE261949T1/de active
- 2001-01-24 UA UA2002086977A patent/UA73547C2/uk unknown
-
2002
- 2002-07-05 HR HR20020579A patent/HRP20020579B1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HRP20020579A2 (en) | 2004-08-31 |
RU2002122723A (ru) | 2004-01-10 |
HRP20020579B1 (en) | 2005-08-31 |
EP1252151B1 (en) | 2004-03-17 |
PL355726A1 (en) | 2004-05-17 |
DK1252151T3 (da) | 2004-07-12 |
HU0000283D0 (en) | 2000-03-28 |
WO2001055125A1 (en) | 2001-08-02 |
DE60102357T2 (de) | 2005-01-13 |
DE60102357D1 (de) | 2004-04-22 |
CZ301236B6 (cs) | 2009-12-16 |
CN1177839C (zh) | 2004-12-01 |
ES2217115T3 (es) | 2004-11-01 |
CN1396916A (zh) | 2003-02-12 |
UA73547C2 (uk) | 2005-08-15 |
PL211338B1 (pl) | 2012-05-31 |
SK287171B6 (sk) | 2010-02-08 |
CN1239487C (zh) | 2006-02-01 |
HU227039B1 (en) | 2010-05-28 |
RU2258067C2 (ru) | 2005-08-10 |
EP1252151A1 (en) | 2002-10-30 |
HUP0000283A3 (en) | 2002-11-28 |
CN1537847A (zh) | 2004-10-20 |
HUP0000283A2 (hu) | 2002-04-29 |
AU3214601A (en) | 2001-08-07 |
SK10602002A3 (sk) | 2002-11-06 |
CZ20022463A3 (cs) | 2002-10-16 |
ATE261949T1 (de) | 2004-04-15 |
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