PL1660469T3 - Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina - Google Patents

Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina

Info

Publication number
PL1660469T3
PL1660469T3 PL04766244T PL04766244T PL1660469T3 PL 1660469 T3 PL1660469 T3 PL 1660469T3 PL 04766244 T PL04766244 T PL 04766244T PL 04766244 T PL04766244 T PL 04766244T PL 1660469 T3 PL1660469 T3 PL 1660469T3
Authority
PL
Poland
Prior art keywords
thiazepine
dibenzo
piperazinyl
synthesis
preparation
Prior art date
Application number
PL04766244T
Other languages
English (en)
Inventor
Łukasz Kaczmarek
Katarzyna Badowska-Rosłonek
Elżbieta Stolarczyk
Wiesław Szelejewski
Original Assignee
Helm Ag
Inst Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helm Ag, Inst Farmaceutyczny filed Critical Helm Ag
Publication of PL1660469T3 publication Critical patent/PL1660469T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL04766244T 2003-07-18 2004-07-16 Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina PL1660469T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL361347A PL195728B1 (pl) 2003-07-18 2003-07-18 Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
PCT/EP2004/051520 WO2005012274A1 (en) 2003-07-18 2004-07-16 Process for the preparation of 11-(1-piperazinyl)dibenzo `b, f! `1 ,4!-thiazepine, an intermediate in the synthesis of the antipsychotic drug quetiapine
EP04766244A EP1660469B1 (en) 2003-07-18 2004-07-16 Process for the preparation of 11-(1-piperazinyl)dibenzo 'b, f! '1 ,4!-thiazepine, an intermediate in the synthesis of the antipsychotic drug quetiapine

Publications (1)

Publication Number Publication Date
PL1660469T3 true PL1660469T3 (pl) 2008-02-29

Family

ID=34114486

Family Applications (2)

Application Number Title Priority Date Filing Date
PL361347A PL195728B1 (pl) 2003-07-18 2003-07-18 Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
PL04766244T PL1660469T3 (pl) 2003-07-18 2004-07-16 Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL361347A PL195728B1 (pl) 2003-07-18 2003-07-18 Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny

Country Status (7)

Country Link
EP (1) EP1660469B1 (pl)
AT (1) ATE371654T1 (pl)
DE (1) DE602004008652D1 (pl)
ES (1) ES2291922T3 (pl)
PL (2) PL195728B1 (pl)
PT (1) PT1660469E (pl)
WO (1) WO2005012274A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113425A1 (en) 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
RU2008137615A (ru) 2006-02-22 2010-03-27 АСТРАЗЕНЕКА ЮКей ЛИМИТЕД (GB) Способ получения дибензотиазепиновых соединений
US8101597B2 (en) 2007-05-07 2012-01-24 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
PT2307389E (pt) 2008-06-20 2013-03-28 Astrazeneca Ab Derivados de dibenzotiazepina e sua utilização
US20120071649A1 (en) 2009-03-04 2012-03-22 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
PL395468A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego
CN103396382B (zh) * 2013-07-29 2015-05-20 太仓市茜泾化工有限公司 一种喹硫平中间体的制备方法
CN113698363A (zh) * 2021-09-15 2021-11-26 苏州敬业医药化工有限公司 一种11-哌嗪-二苯并[b,f][1,4]硫氮杂卓盐酸盐的纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458516A (en) * 1968-02-16 1969-07-29 American Cyanamid Co 11-(piperazinyl)dibenz(b,f)(1,4)oxazepines and analogous thiazepines
HU227039B1 (en) * 2000-01-25 2010-05-28 Egis Gyogyszergyar Nyilvanosan New process for the production of quetiapine and intermediates therefor

Also Published As

Publication number Publication date
ES2291922T3 (es) 2008-03-01
WO2005012274A1 (en) 2005-02-10
PT1660469E (pt) 2007-10-11
ATE371654T1 (de) 2007-09-15
DE602004008652D1 (de) 2007-10-11
EP1660469A1 (en) 2006-05-31
PL361347A1 (pl) 2005-01-24
PL195728B1 (pl) 2007-10-31
EP1660469B1 (en) 2007-08-29

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