SI1252151T1 - A process for the preparation of quetiapine and intermediates therefor - Google Patents

A process for the preparation of quetiapine and intermediates therefor

Info

Publication number
SI1252151T1
SI1252151T1 SI200130107T SI200130107T SI1252151T1 SI 1252151 T1 SI1252151 T1 SI 1252151T1 SI 200130107 T SI200130107 T SI 200130107T SI 200130107 T SI200130107 T SI 200130107T SI 1252151 T1 SI1252151 T1 SI 1252151T1
Authority
SI
Slovenia
Prior art keywords
quetiapine
preparation
intermediates therefor
formula
thiazepine
Prior art date
Application number
SI200130107T
Other languages
English (en)
Slovenian (sl)
Inventor
Daniel Bozsing
LAX Gy�rgyi KOVANYINE
Gyula Simig
Gy�rgyne RAKOCZY
Peter T�MPE
Gyrgy KRASZNAI
DONATH Gy�rgyi VERECZKEYNE
Kalman Nagy
Original Assignee
Egis Gyogyszergyar Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Reszvenytarsasag filed Critical Egis Gyogyszergyar Reszvenytarsasag
Publication of SI1252151T1 publication Critical patent/SI1252151T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
SI200130107T 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor SI1252151T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor
EP01904235A EP1252151B1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Publications (1)

Publication Number Publication Date
SI1252151T1 true SI1252151T1 (en) 2004-08-31

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130107T SI1252151T1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Country Status (16)

Country Link
EP (1) EP1252151B1 (hu)
CN (2) CN1177839C (hu)
AT (1) ATE261949T1 (hu)
AU (1) AU3214601A (hu)
CZ (1) CZ301236B6 (hu)
DE (1) DE60102357T2 (hu)
DK (1) DK1252151T3 (hu)
ES (1) ES2217115T3 (hu)
HR (1) HRP20020579B1 (hu)
HU (1) HU227039B1 (hu)
PL (1) PL211338B1 (hu)
RU (1) RU2258067C2 (hu)
SI (1) SI1252151T1 (hu)
SK (1) SK287171B6 (hu)
UA (1) UA73547C2 (hu)
WO (1) WO2001055125A1 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539192A (ja) 1999-03-15 2002-11-19 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼ阻害剤としての新規な化合物及び組成物
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
CN1324008C (zh) 2001-09-14 2007-07-04 安万特药物公司 作为组织蛋白酶抑制剂的新化合物和组合物
WO2003042197A1 (en) 2001-11-14 2003-05-22 Aventis Pharmaceuticals Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
US7071331B2 (en) 2003-02-22 2006-07-04 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
AU2004233346B2 (en) 2003-04-23 2008-03-06 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
EP1664007B1 (en) * 2003-09-23 2009-12-23 Fermion Oy Preparation of quetiapine
US7858777B2 (en) 2003-09-23 2010-12-28 Fermion Oy Preparation method for quetiapine
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
WO2006113425A1 (en) 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
WO2007036599A1 (en) 2005-09-30 2007-04-05 Fermion Oy New crystallization process of quetiapine hemifumarate
DE202009018024U1 (de) 2008-08-01 2010-12-09 Krka Tovarna Zdravil, D.D., Novo Mesto Quetiapin-Zusammensetzung
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
US20120071649A1 (en) 2009-03-04 2012-03-22 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476743A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von Amidinen der Dibenzo (b,e) (1,4)-diazepin-Reihe
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
HRP20020579B1 (en) 2005-08-31
PL355726A1 (en) 2004-05-17
HUP0000283A2 (hu) 2002-04-29
HUP0000283A3 (en) 2002-11-28
SK287171B6 (sk) 2010-02-08
CN1177839C (zh) 2004-12-01
RU2258067C2 (ru) 2005-08-10
HRP20020579A2 (en) 2004-08-31
UA73547C2 (uk) 2005-08-15
EP1252151B1 (en) 2004-03-17
RU2002122723A (ru) 2004-01-10
EP1252151A1 (en) 2002-10-30
AU3214601A (en) 2001-08-07
DK1252151T3 (da) 2004-07-12
DE60102357T2 (de) 2005-01-13
CZ301236B6 (cs) 2009-12-16
CZ20022463A3 (cs) 2002-10-16
ES2217115T3 (es) 2004-11-01
CN1396916A (zh) 2003-02-12
WO2001055125A1 (en) 2001-08-02
HU0000283D0 (en) 2000-03-28
HU227039B1 (en) 2010-05-28
ATE261949T1 (de) 2004-04-15
PL211338B1 (pl) 2012-05-31
CN1537847A (zh) 2004-10-20
CN1239487C (zh) 2006-02-01
DE60102357D1 (de) 2004-04-22
SK10602002A3 (sk) 2002-11-06

Similar Documents

Publication Publication Date Title
PL355726A1 (en) A process for the preparation of quetiapine and intermediates therefor
HUP0300567A3 (en) Process for preparation of novel piperazine derivatives
NZ504106A (en) Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them
NO20075071L (no) Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005
IL150982A0 (en) Process for the preparation of donepezil
EP0447135B1 (en) Process for preparing 1,5-benzothiazepine derivatives
YU76500A (sh) Hemijska sinzeza morfolinskih derivata
AU3354095A (en) Process for producing alkoxyiminoacetamide derivative
ATE367383T1 (de) Verfahren zur herstellung von 11-(4-(2-(2- hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo(b,f) 1,4)thiazepin
IL141394A0 (en) Process for the preparation of imidazodiazepine intermediates
PL1660469T3 (pl) Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina
BR9917400A (pt) Processo para a preparação de um derivado de dibenzotiazepina, e, derivado de 2-nitro - 2' - carboxi - difenilsulfeto
HU0201262D0 (hu)
AU3590801A (en) One-pot synthesis of alkyl 3-cyclopropylamino-2-(2,4-dibromo-3-(difluoromethoxy)benzoyl -2-propenoate as a useful intermediate for antibacterial quinolone medicaments
HRP20020021B1 (en) Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates
PL354677A1 (en) A process for the preparation of {2-[4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid and novel intermediates therefor
AU2001253602A1 (en) Synthesis of intermediates useful in preparing tricyclic compounds
AU2639999A (en) Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives
MY120806A (en) Improved process for preparing pharmaceutically valuable norbenzomorphane derivatives.
WO2004089890A3 (en) Process and intermediates for preparing benzazepines
MXPA04003628A (es) Derivados de benzoxanina y benzotiazina y composiciones farmaceuticas que los contienen.
AU1499902A (en) Method for producing 1 substituted 5-chloro-4 methyl pyrazoles
ZA200200158B (en) Process for producing dibenzothiazepine derivatives.
AU2000275433A1 (en) Process for the preparation of alkyl n-alkylanthranilate