HUE030881T2 - Meningitisz/szepszis-asszociált escherichia coliból származó fehérjék és nukleinsavak - Google Patents

Meningitisz/szepszis-asszociált escherichia coliból származó fehérjék és nukleinsavak Download PDF

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Publication number
HUE030881T2
HUE030881T2 HUE11150423A HUE11150423A HUE030881T2 HU E030881 T2 HUE030881 T2 HU E030881T2 HU E11150423 A HUE11150423 A HU E11150423A HU E11150423 A HUE11150423 A HU E11150423A HU E030881 T2 HUE030881 T2 HU E030881T2
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HU
Hungary
Prior art keywords
vol
vaccine
antigen
polypeptides
cells
Prior art date
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HUE11150423A
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English (en)
Inventor
Scorza Francesco Berlanda
Mariagrazia Pizza
Laura Serino
Vega Masignani
Herve Tettelin
Moriel Danilo Gomes
Nathalie Norais
Maria Rita Fontana
Original Assignee
Glaxosmithkline Biologicals Sa
J Craig Venter Inst Inc
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Publication of HUE030881T2 publication Critical patent/HUE030881T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (7)

  1. MSKPiBÇj0tSM^E:^SZIS..ASSZOÇ|ÎÂ.LT EWffiCHîA COLIBÓL EZÂRMAEO: FEHÉRJÉK &amp; mmMim&amp;VAK ígénypimnU jl, FöHpepö4í (s) 8EQ © MO: 2 szoBísti (b) SEQ M2 NO: 2 szs» Âii «wkvwtiàvs! UîgsEibb ^¾.½¾. axostos ajaiöuw'-sxefcveactikt, {c) aniWKís&amp;v-saek'vcttctát, amaîy SEQ II> NO: 2 sssrsöE Mxtemnh. Rplább i 0S <gÄ: kövNÖ éld iigpiej* v&amp;gy (d). SEO © 'MO:: :2 sxatPib .8æekv«8«fêN^ tegdéfeb 8ö%4aa: posa»; s^íö#Só'^Sig&amp;kvpeii|í, aiseiy sma!s»sx ÉBQ ID NO: 2 süteti szekvapda tegäMbh !(s, «gyggEt: Μ«δ sspmössväbb! álló b&amp;gspensk ExFEO (ex5íJsm«ss:Esálfe paOgéa Exhcnchid edit) baktsdum okozta betegség étvágy önözés kvsstáséhes:. vagy megdbsésébass történd askal-ösasáspe
  2. 2. Az ! · ígótyppítt «ÄerInO poHpeptk; as ott roegÉsnár-asoít dkatataxásra, shoí a Ragæsss SBQ !D NO: 2 szedhU B*»gt gépjét taslaimasxa.
  3. 3> As 1. vsgy 2. sgénypoat sxertnb pobpeptid as 0« iTseghatámsott sbkatmasávra, «ho! a iEsgsseitsa ko· vatisvzÖk MU C# a pöBpvpíkt K-taAntnáEs vzigsálixpfbtjö φό s p$p«piM as »«»&amp; sslgnâlgpnsbeFalaÜ vsgy (s) a poHpqxkt as i · 20 N-ïsœsMbs amínosava nélkül.
  4. 4:. Oyőgyásaaö k&amp;ÉtStey, ætndy as 54. iaéísyponíok nàsrmelyikébvn meghatározod. psOspaptisfet uíy-Olasas gyPgyáa^kdsg s!%adEatô hordozóvá Össsakaverve, Ex PEC bafctézbsp}. okcszta baíagaJg ésOagy teNö·· zé% ksxesPsébess vagy biagatóxésábP tmÈ0 túk^tzám*
  5. 5. Qyögyasssrt* késsibpény, asbdÿ 'két vagy többi m Î-3, igéOÿpogok bSnseíyik^to. mogtsatázösoP golipegBíkst íamissas gyögvészsiSag d:Og&amp;íÉaíó boniozÓYa! ësïSzakeverve, BxPBC bákíéybíöí. oksisia Biitegség és/v&amp;gy tèridzés kezstésébvst vagy psegélösésébap történd ídkalnnízásta.
  6. 6. A '4. xagy 5. igánypoKí «.«esfitHi't lészíOxény as öE msgiotarozoib alktkbpazsspn amely plfcteyag-sdiaváast: äs tartaissaz.
  7. 7. !snsnaüogBn készt tm.é.ny, arsaty 8S 54. igénypontokba» meghatározott polipeptisfct tartalmaz, £sPBC tökíérgígt ökbSta hatagseg éaóagy önözés keseljsébas vagy msgdözésibép mUíéé alksbibiRiSO·: % Μ 14« igéíiy|Xsaíök báíáíalyskesssedab poMpplkissk: :Ok ppjKstslísssxoP alkalmazásra vagy a 7. jgaóypöSt Spsipij inmhmogéö Msztitntmy as ott gmgbstateiaxoti, siikalaijgJstsb alól M BkPBO békíéHstnt MNEC OtRbkîkWissAgspsxiS'asssoasàlî Mwb&amp;icMMs e&amp;ïi} b^tâmm. % M: S 4, lgtbyF«P#fe;fetesb/fií#8e êi$0$éwt<M P>l!ps^t!á vagy a J.ssgOsypoátiats msgbasatpsssß lîïppuiîpgép: késattisiböv afaimasáxa pSoíeSKibess îaüïiaavàlass kiváliasass ssolgalb gyögyissar gMÄÄtw»* ahp! ss: vési ExFECESírE^s élte. 10. A 0. igíOypostí ssviástü alkalnstiXáSi ab.ol .az BxFFC baktásiiss MKEC baktéritssss.
HUE11150423A 2005-02-18 2006-02-17 Meningitisz/szepszis-asszociált escherichia coliból származó fehérjék és nukleinsavak HUE030881T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65463205P 2005-02-18 2005-02-18
US71272005P 2005-08-29 2005-08-29

Publications (1)

Publication Number Publication Date
HUE030881T2 true HUE030881T2 (hu) 2017-06-28

Family

ID=36917149

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE11150423A HUE030881T2 (hu) 2005-02-18 2006-02-17 Meningitisz/szepszis-asszociált escherichia coliból származó fehérjék és nukleinsavak
HUE06748228A HUE027400T2 (hu) 2005-02-18 2006-02-17 Fehérjék és nukleinsavak agyhártyagyulladással/szepszissel kapcsolt Escherichia coliból

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE06748228A HUE027400T2 (hu) 2005-02-18 2006-02-17 Fehérjék és nukleinsavak agyhártyagyulladással/szepszissel kapcsolt Escherichia coliból

Country Status (18)

Country Link
US (4) US8758764B2 (hu)
EP (2) EP1858920B1 (hu)
JP (2) JP2008529558A (hu)
AU (1) AU2006214064B2 (hu)
CA (1) CA2601924A1 (hu)
CY (2) CY1117732T1 (hu)
DK (2) DK2351772T3 (hu)
ES (2) ES2569654T3 (hu)
HU (2) HUE030881T2 (hu)
IL (2) IL185359A0 (hu)
LT (1) LT2351772T (hu)
MX (1) MX306302B (hu)
NZ (3) NZ597685A (hu)
PL (2) PL1858920T3 (hu)
PT (1) PT2351772T (hu)
SG (1) SG160329A1 (hu)
SI (2) SI1858920T1 (hu)
WO (1) WO2006089264A2 (hu)

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