HRP930700A2 - Process for the purification of chymopapain, purified chymopapain and preparations containing the same - Google Patents

Process for the purification of chymopapain, purified chymopapain and preparations containing the same Download PDF

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Publication number
HRP930700A2
HRP930700A2 HR930700A HRP930700A HRP930700A2 HR P930700 A2 HRP930700 A2 HR P930700A2 HR 930700 A HR930700 A HR 930700A HR P930700 A HRP930700 A HR P930700A HR P930700 A2 HRP930700 A2 HR P930700A2
Authority
HR
Croatia
Prior art keywords
chymopapain
solution
added
minutes
mixture
Prior art date
Application number
HR930700A
Other languages
English (en)
Croatian (hr)
Inventor
Alan John Barrett
David John Buttle
Daniel Hulbert Rich
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of HRP930700A2 publication Critical patent/HRP930700A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HR930700A 1989-04-28 1993-04-02 Process for the purification of chymopapain, purified chymopapain and preparations containing the same HRP930700A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898909836A GB8909836D0 (en) 1989-04-28 1989-04-28 Therapeutic agent
YU87090A YU87090A (sh) 1989-04-28 1990-05-04 Postupak za prečišćavanje himopapaina

Publications (1)

Publication Number Publication Date
HRP930700A2 true HRP930700A2 (en) 1995-06-30

Family

ID=10655944

Family Applications (1)

Application Number Title Priority Date Filing Date
HR930700A HRP930700A2 (en) 1989-04-28 1993-04-02 Process for the purification of chymopapain, purified chymopapain and preparations containing the same

Country Status (34)

Country Link
US (2) US5380656A (enFirst)
EP (1) EP0470136B1 (enFirst)
JP (1) JPH04506003A (enFirst)
KR (1) KR920701241A (enFirst)
CN (1) CN1047340A (enFirst)
AT (1) ATE107660T1 (enFirst)
AU (1) AU631641B2 (enFirst)
BG (1) BG60916B1 (enFirst)
CA (1) CA2056402C (enFirst)
DD (1) DD296960A5 (enFirst)
DE (1) DE69010199T2 (enFirst)
DK (1) DK0470136T3 (enFirst)
EG (1) EG19583A (enFirst)
ES (1) ES2055427T3 (enFirst)
FI (1) FI914995A7 (enFirst)
GB (1) GB8909836D0 (enFirst)
GR (1) GR1001011B (enFirst)
HR (1) HRP930700A2 (enFirst)
HU (2) HUT58345A (enFirst)
IE (1) IE64351B1 (enFirst)
IL (1) IL94227A (enFirst)
IN (2) IN170683B (enFirst)
LT (1) LT3827B (enFirst)
LV (1) LV10200B (enFirst)
MX (1) MX20503A (enFirst)
NO (1) NO914206L (enFirst)
NZ (1) NZ233475A (enFirst)
PL (1) PL166810B1 (enFirst)
PT (1) PT93921B (enFirst)
RO (1) RO112032B1 (enFirst)
RU (1) RU2074891C1 (enFirst)
WO (1) WO1990013561A1 (enFirst)
YU (1) YU87090A (enFirst)
ZA (1) ZA903228B (enFirst)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent
AU1531092A (en) * 1991-02-22 1992-09-15 Du Pont Merck Pharmaceutical Company, The Substituted alpha-aminoaldehydes and derivatives
CA2061861A1 (en) * 1991-03-04 1992-09-05 Jonathan Duvick Plant polypeptides with inhibitory activity towards pathogenic microorganisms
CN1060519C (zh) * 1991-05-09 2001-01-10 广西亚热带作物研究所 桄榔植物蛋白酶的提取方法
AU668110B2 (en) * 1991-10-14 1996-04-26 Cash Engineering Research Pty Ltd Inlet control combination for a compressor system
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
WO1994028012A1 (en) * 1993-05-28 1994-12-08 Warner-Lambert Company Hydroxamate inhibitors of endothelin converting enzyme
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
EP1161415B1 (en) 1999-03-15 2005-07-13 Axys Pharmaceuticals, Inc. N-cyanomethylamides as protease inhibitors
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6703040B2 (en) 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
US7935337B2 (en) 2002-12-25 2011-05-03 Hiromichi Komori Method of therapy for degenerative intervertebral discs
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20080069907A1 (en) * 2004-07-06 2008-03-20 Chikao Morimoto Compositions for Cancer Prevention, Treatment, or Amelioration Comprising Papaya Extract
CN1320111C (zh) * 2004-08-09 2007-06-06 王美岭 一种制备木瓜凝乳酶的方法
US20060241566A1 (en) * 2005-04-11 2006-10-26 Orthox, Llc Nucleus Extraction from Spine Intervertebral Disc
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US20070265633A1 (en) * 2006-05-11 2007-11-15 Moon Jon K Implement and method to extract nucleus from spine intervertebral disc
US8257938B2 (en) * 2009-02-27 2012-09-04 Medical Diagnostic Laboratories, Llc Hemolysin and its protein fragments in sero-detection of Anaplasma phagocytophilum
JPWO2013038936A1 (ja) * 2011-09-13 2015-03-26 タカラバイオ株式会社 ペルオキシダーゼ反応の停止方法及び反応停止剤
WO2014004512A1 (en) 2012-06-25 2014-01-03 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses
CN118878631B (zh) * 2024-06-05 2025-04-04 中国海洋大学 一种基于配体垂钓筛选合成牡蛎ace抑制肽的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE270723C (enFirst) *
US2313875A (en) * 1940-12-17 1943-03-16 Eugene F Jansen Proteolytic enzyme process
US3320131A (en) * 1964-10-23 1967-05-16 Baxter Laboratories Inc Method for the treatment of herniation of intervertebral discs
US3558433A (en) * 1967-11-07 1971-01-26 Baxter Laboratories Inc Process for purification of chymopapain
YU40433B (en) * 1975-02-20 1986-02-28 Lek Tovarna Farmacevtskih Process for obtaining pure, proteolytically active anzymes
DE3212846A1 (de) 1981-04-13 1982-11-04 Sintokogio, Ltd., Nagoya, Aichi Apparat und verfahren zum herstellen eines kerns
US4374926A (en) * 1981-05-13 1983-02-22 Smith Laboratories, Inc. Method for the production of improved chymopapain
EP0065395B1 (en) * 1981-05-13 1988-08-24 BOOTS-FLINT, INC. (a Delaware corp.) Improved chymopapain and method for its production and use
US4439423A (en) * 1981-05-13 1984-03-27 Smith Laboratories, Inc. Chymopapain and method for its use
US4719108A (en) * 1981-05-13 1988-01-12 Smith Laboratories, Inc. Chymopapain composition and method for its use
GB2124233B (en) * 1982-07-19 1985-09-18 Nat Res Dev Synthetic peptides and their preparation
GB2156821A (en) * 1984-04-03 1985-10-16 Simmons James W Process for purifying chymopapain
HU196624B (en) * 1986-12-08 1988-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing chymopapain with high specific activity
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent

Also Published As

Publication number Publication date
BG95362A (bg) 1993-12-24
GR900100315A (en) 1991-09-27
NZ233475A (en) 1991-10-25
CN1047340A (zh) 1990-11-28
PL166810B1 (pl) 1995-06-30
LT3827B (en) 1996-03-25
FI914995A0 (fi) 1991-10-23
RU2074891C1 (ru) 1997-03-10
AU5547290A (en) 1990-11-29
MX20503A (es) 1993-12-01
JPH04506003A (ja) 1992-10-22
AU631641B2 (en) 1992-12-03
ZA903228B (en) 1990-12-28
DE69010199D1 (de) 1994-07-28
EP0470136A1 (en) 1992-02-12
EP0470136B1 (en) 1994-06-22
NO914206L (no) 1991-12-17
IE901538L (en) 1990-10-28
CA2056402C (en) 1999-11-16
CA2056402A1 (en) 1990-10-29
KR920701241A (ko) 1992-08-11
HUT58345A (en) 1992-02-28
DE69010199T2 (de) 1994-10-13
PT93921B (pt) 1996-10-31
LTIP1645A (en) 1995-07-25
YU87090A (sh) 1992-09-07
LV10200A (lv) 1994-10-20
LV10200B (en) 1995-04-20
RO112032B1 (ro) 1997-04-30
DK0470136T3 (da) 1994-08-01
US5380656A (en) 1995-01-10
IN170683B (enFirst) 1992-05-02
HU903342D0 (en) 1992-01-28
ATE107660T1 (de) 1994-07-15
ES2055427T3 (es) 1994-08-16
BG60916B1 (bg) 1996-06-28
US5468480A (en) 1995-11-21
IL94227A0 (en) 1991-01-31
HU211746A9 (en) 1995-12-28
NO914206D0 (no) 1991-10-25
GR1001011B (el) 1993-03-31
DD296960A5 (de) 1991-12-19
PT93921A (pt) 1990-11-20
EG19583A (en) 1995-09-30
FI914995A7 (fi) 1991-10-23
IN173230B (enFirst) 1994-03-12
WO1990013561A1 (en) 1990-11-15
IL94227A (en) 1994-12-29
GB8909836D0 (en) 1989-06-14
IE64351B1 (en) 1995-07-26

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