HRP930235B1 - ((benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines - Google Patents

((benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

Info

Publication number
HRP930235B1
HRP930235B1 HR07/842,560A HRP930235A HRP930235B1 HR P930235 B1 HRP930235 B1 HR P930235B1 HR P930235 A HRP930235 A HR P930235A HR P930235 B1 HRP930235 B1 HR P930235B1
Authority
HR
Croatia
Prior art keywords
benzodioxan
benzopyran
benzofuran
alkylamino
alkyl substituted
Prior art date
Application number
HR07/842,560A
Other languages
English (en)
Inventor
Walter Jacobus Joseph Janssens
Original Assignee
Walter Jacobus Joseph Janssens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walter Jacobus Joseph Janssens filed Critical Walter Jacobus Joseph Janssens
Publication of HRP930235A2 publication Critical patent/HRP930235A2/hr
Publication of HRP930235B1 publication Critical patent/HRP930235B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Pyrane Compounds (AREA)
HR07/842,560A 1992-02-27 1993-02-25 ((benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines HRP930235B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (2)

Publication Number Publication Date
HRP930235A2 HRP930235A2 (en) 1997-10-31
HRP930235B1 true HRP930235B1 (en) 1999-04-30

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
HR07/842,560A HRP930235B1 (en) 1992-02-27 1993-02-25 ((benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

Country Status (37)

Country Link
US (4) US5541180A (el)
EP (1) EP0639192B1 (el)
JP (1) JP2779268B2 (el)
KR (1) KR100190300B1 (el)
CN (1) CN1038032C (el)
AP (1) AP416A (el)
AT (1) ATE138064T1 (el)
AU (1) AU664237B2 (el)
BG (1) BG62052B1 (el)
CA (1) CA2117483C (el)
CZ (1) CZ282092B6 (el)
DE (1) DE69302687T2 (el)
DK (1) DK0639192T3 (el)
EE (1) EE03029B1 (el)
ES (1) ES2087721T3 (el)
FI (1) FI109122B (el)
GR (1) GR3019927T3 (el)
HR (1) HRP930235B1 (el)
HU (2) HU222495B1 (el)
IL (1) IL104868A (el)
LT (1) LT3049B (el)
LV (1) LV10715B (el)
MX (1) MX9301053A (el)
MY (1) MY110627A (el)
NO (1) NO306255B1 (el)
NZ (1) NZ249124A (el)
OA (1) OA10095A (el)
PH (1) PH31295A (el)
PL (1) PL174736B1 (el)
RO (1) RO115630B1 (el)
RU (1) RU2121999C1 (el)
SG (1) SG47763A1 (el)
SI (1) SI9300097B (el)
SK (1) SK280166B6 (el)
TW (1) TW225531B (el)
WO (1) WO1993017017A1 (el)
ZA (1) ZA931404B (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228673B1 (en) * 1993-08-19 2013-05-28 Janssen Pharmaceutica Nv Vasoconstrictive substituted dihydropyranopyridines, process for producing them and pharmaceutical compositions containing them
KR100330696B1 (ko) * 1993-08-19 2002-10-04 얀센 파마슈티카 엔.브이. 혈관수축성디하이드로벤조피란유도체
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
ATE210657T1 (de) * 1994-10-14 2001-12-15 Merck Patent Gmbh Zns wirksames (r)-(-)-2-(5-(4-fluorophenyl)-3- pyridylmethylaminomethyl)chroman
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
WO1996041632A1 (en) * 1995-06-08 1996-12-27 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
JP2003501427A (ja) 1999-06-02 2003-01-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノアルキル置換（ベンゾジオキサン、ベンゾフランもしくはベンゾピラン）誘導体
EA004648B1 (ru) 1999-06-02 2004-06-24 Янссен Фармацевтика Н.В. Пирролидинил-, пиперидинил- или гомопиперидинилзамещенные производные, способ их получения, их применение в медицине, содержащая их фармацевтическая композиция и способ ее получения
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
JP2004517081A (ja) * 2000-11-29 2004-06-10 イーライ・リリー・アンド・カンパニー １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物
IL157254A0 (en) * 2001-02-23 2004-02-19 Merck & Co Inc N-substituted nonaryl-heterocyclic nmda/mr2b antagonists
US7872030B2 (en) 2001-07-26 2011-01-18 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
ES2262840T3 (es) * 2001-09-19 2006-12-01 Merck Patent Gmbh Nuevo uso de los aminometil cromanos substituidos.
AU2004208821B2 (en) * 2003-01-31 2009-01-15 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
ZA200507112B (en) * 2003-03-31 2007-03-28 Taisho Pharmaceutical Co Ltd Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
PL1976509T3 (pl) * 2006-01-18 2015-07-31 Evolva Sa Modulatory PPAR
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL296841A (el) * 1962-08-20
FR1366479A (fr) * 1962-08-20 1964-07-10 Res Lab Dr C Janssen Nv Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
GR71865B (el) * 1978-03-20 1983-07-07 Ciba Geigy
US4405922A (en) * 1979-05-23 1983-09-20 Hitachi Koki Company, Limited Failure detection circuit for impact printers or the like
US4405622A (en) * 1980-10-16 1983-09-20 Syntex (U.S.A.) Inc. [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
FR2524887A1 (fr) * 1982-04-08 1983-10-14 Bouchara Emile Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
CA2011899A1 (en) * 1989-03-13 1990-09-13 Masaaki Toda Benzopyran derivatives
WO1994017017A1 (en) * 1991-07-15 1994-08-04 Exxon Research And Engineering Company Benzene removal from gasoline boiling range streams
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
AP9300493A0 (en) 1993-04-30
IL104868A0 (en) 1993-06-10
NO943186L (no) 1994-08-29
BG98870A (bg) 1995-03-31
DK0639192T3 (da) 1996-08-19
EP0639192B1 (en) 1996-05-15
IL104868A (en) 1998-01-04
MX9301053A (es) 1994-03-31
AP416A (en) 1995-09-29
FI943928A0 (fi) 1994-08-26
FI943928A (fi) 1994-08-26
BG62052B1 (bg) 1999-01-29
KR100190300B1 (ko) 1999-06-01
CS202094A3 (en) 1995-01-18
TW225531B (el) 1994-06-21
RU2121999C1 (ru) 1998-11-20
AU664237B2 (en) 1995-11-09
NZ249124A (en) 1995-08-28
WO1993017017A1 (en) 1993-09-02
PH31295A (en) 1998-07-06
CA2117483A1 (en) 1993-09-02
DE69302687D1 (de) 1996-06-20
HU9402464D0 (en) 1994-10-28
LV10715B (en) 1995-12-20
SI9300097A (en) 1993-09-30
CN1079470A (zh) 1993-12-15
ZA931404B (en) 1994-08-26
NO943186D0 (no) 1994-08-29
HU222495B1 (hu) 2003-07-28
SK102994A3 (en) 1995-07-11
EE03029B1 (et) 1997-08-15
CA2117483C (en) 2001-01-09
LTIP367A (lt) 1994-04-25
CZ282092B6 (cs) 1997-05-14
US5688952A (en) 1997-11-18
RU94041210A (ru) 1996-07-10
US5541180A (en) 1996-07-30
LV10715A (lv) 1995-06-20
US5624952A (en) 1997-04-29
HUT71129A (en) 1995-11-28
DE69302687T2 (de) 1996-11-14
LT3049B (en) 1994-10-25
CN1038032C (zh) 1998-04-15
JP2779268B2 (ja) 1998-07-23
JPH07504408A (ja) 1995-05-18
GR3019927T3 (en) 1996-08-31
EP0639192A1 (en) 1995-02-22
HU211742A9 (en) 1995-12-28
AU3499193A (en) 1993-09-13
MY110627A (en) 1998-09-30
HRP930235A2 (en) 1997-10-31
ATE138064T1 (de) 1996-06-15
OA10095A (en) 1996-12-18
RO115630B1 (ro) 2000-04-28
SG47763A1 (en) 1998-04-17
NO306255B1 (no) 1999-10-11
US5607949A (en) 1997-03-04
FI109122B (fi) 2002-05-31
SK280166B6 (sk) 1999-09-10
ES2087721T3 (es) 1996-07-16
SI9300097B (en) 2001-12-31
PL174736B1 (pl) 1998-09-30

Similar Documents

Publication Publication Date Title
HRP930235B1 (en) ((benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
EP0434249A3 (en) Benzofuran derivatives
GR3035089T3 (en) Analogs of pth.
ZA946470B (en) Benzofuran derivatives
ZA926334B (en) Benzodioxane derivatives.
GR3036577T3 (en) Novel carbocyclic adenosine analogs useful as immunosuppressants.
AU6346790A (en) Inertial stabilizing system
ZA926549B (en) Novel benzopyran derivatives
ZA918670B (en) Antifoam ingredient.
AR243522A1 (es) Compuesto de benzofurano substituido por n-heterociclo,procedimiento para prepararlo,compuestos intermedios empleados,procedimiento para su preparacion y composicion herbicida.
IT9082518A0 (it) Attacco di sicurezza, particolarmente per sci
AU5872590A (en) 4-pyridone-substituted chromans or chromenes
ZA937633B (en) Benzofuran derivatives
EP0435322A3 (en) Benzofuran derivatives
GB8812964D0 (en) Pyran compounds
GB8621036D0 (en) Laser & control system
IT8982600A0 (it) Attacco di sicurezza, particolarmente per sci
ZA923547B (en) Benzofuran derivatives
DE59006488D1 (de) Skibremse.
EP0420470A3 (en) Naphthopyran compounds
IE901319L (en) Antihypertensive benzopyrans
IT9082542A0 (it) Attacco di sicurezza,particolarmente per sci
GB9025068D0 (en) Lactone compounds
ZA925060B (en) Benzofuran derivatives.
GB9005538D0 (en) Novel antihypertensive benzopyran derivatives

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20120113

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20130226