HRP921226B1 - Morpholinyl derivatives of doxorubicin and process for their preparation - Google Patents

Morpholinyl derivatives of doxorubicin and process for their preparation

Info

Publication number
HRP921226B1
HRP921226B1 HRP-2379/90A HRP921226A HRP921226B1 HR P921226 B1 HRP921226 B1 HR P921226B1 HR P921226 A HRP921226 A HR P921226A HR P921226 B1 HRP921226 B1 HR P921226B1
Authority
HR
Croatia
Prior art keywords
doxorubicin
preparation
morpholinyl derivatives
morpholinyl
derivatives
Prior art date
Application number
HRP-2379/90A
Other languages
English (en)
Inventor
Antonio Suarato
Original Assignee
Antonio Suarato
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Antonio Suarato filed Critical Antonio Suarato
Publication of HRP921226A2 publication Critical patent/HRP921226A2/hr
Publication of HRP921226B1 publication Critical patent/HRP921226B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
HRP-2379/90A 1989-12-19 1992-11-11 Morpholinyl derivatives of doxorubicin and process for their preparation HRP921226B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation
YU237990A YU48136B (sh) 1989-12-19 1990-12-17 Morfolinil derivati doksorubicina i postupak za njihovo dobijanje

Publications (2)

Publication Number Publication Date
HRP921226A2 HRP921226A2 (en) 1995-12-31
HRP921226B1 true HRP921226B1 (en) 1998-10-31

Family

ID=26296395

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-2379/90A HRP921226B1 (en) 1989-12-19 1992-11-11 Morpholinyl derivatives of doxorubicin and process for their preparation

Country Status (28)

Country Link
EP (1) EP0434960B1 (fi)
JP (1) JP3300342B2 (fi)
KR (1) KR0183033B1 (fi)
CN (2) CN1024922C (fi)
AT (1) ATE143023T1 (fi)
AU (1) AU636429B2 (fi)
CA (1) CA2046857C (fi)
CZ (1) CZ281949B6 (fi)
DE (1) DE69028610T2 (fi)
DK (1) DK0434960T3 (fi)
ES (1) ES2094136T3 (fi)
FI (1) FI97389C (fi)
GR (1) GR3021557T3 (fi)
HR (1) HRP921226B1 (fi)
HU (2) HU209433B (fi)
IE (1) IE81174B1 (fi)
IL (3) IL96643A (fi)
MY (1) MY119192A (fi)
NO (2) NO175533C (fi)
NZ (1) NZ243695A (fi)
PT (1) PT96226B (fi)
RU (1) RU2100366C1 (fi)
SI (1) SI9012379B (fi)
SK (1) SK278994B6 (fi)
TW (1) TW208019B (fi)
UA (1) UA27108A1 (fi)
WO (1) WO1991009046A1 (fi)
YU (1) YU48136B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
ES2369640T3 (es) 2002-05-24 2011-12-02 Angiotech International Ag Composiciones y métodos para revestir implantes médicos.
MXPA05003183A (es) 2002-09-26 2005-06-08 Angiotech Int Ag Evolturas perivasculares.
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2519310A1 (en) * 2003-03-18 2004-09-30 Maria Adele Pacciarini Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
CN101490047A (zh) * 2006-07-12 2009-07-22 内尔维阿诺医学科学有限公司 晶体盐酸奈莫柔比星
WO2009124468A1 (zh) * 2008-04-11 2009-10-15 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
KR101897307B1 (ko) * 2010-12-02 2018-09-10 네르비아노 메디칼 사이언시스 에스.알.엘. 모르폴리닐 안트라사이클린 유도체의 제조 방법
CN105164138B (zh) 2013-04-29 2017-11-07 内尔维阿诺医学科学有限公司 新吗啉基蒽环类抗生素衍生物
CA2933579A1 (en) 2013-12-11 2015-06-18 University Of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)
EP3215513B1 (en) 2014-11-05 2019-05-08 Nerviano Medical Sciences S.r.l. Functionalized morpholinyl anthracycline derivatives
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
IE81174B1 (en) 2000-06-14
HU9200656D0 (en) 1992-05-28
KR0183033B1 (ko) 1999-04-01
AU636429B2 (en) 1993-04-29
SK621990A3 (en) 1998-05-06
CN1053238A (zh) 1991-07-24
CZ281949B6 (cs) 1997-04-16
NZ243695A (en) 1993-06-25
HUT60232A (en) 1992-08-28
AU6919491A (en) 1991-07-18
EP0434960A1 (en) 1991-07-03
NO175533B (no) 1994-07-18
PT96226B (pt) 1998-06-30
CN1079215A (zh) 1993-12-08
KR920701228A (ko) 1992-08-11
TW208019B (fi) 1993-06-21
CZ621990A3 (en) 1997-01-15
IL111527A0 (en) 1995-01-24
WO1991009046A1 (en) 1991-06-27
JPH04503679A (ja) 1992-07-02
MY119192A (en) 2005-04-30
ES2094136T3 (es) 1997-01-16
SI9012379B (sl) 2000-02-29
FI97389B (fi) 1996-08-30
CA2046857A1 (en) 1991-06-20
GR3021557T3 (en) 1997-02-28
PT96226A (pt) 1991-09-30
HU208148B (en) 1993-08-30
UA27108A1 (uk) 2000-02-28
IL96643A0 (en) 1991-09-16
HUT59693A (en) 1992-06-29
FI97389C (fi) 1996-12-10
ATE143023T1 (de) 1996-10-15
NO940831D0 (no) 1994-03-09
HRP921226A2 (en) 1995-12-31
IL111527A (en) 1998-02-22
NO176911C (no) 1995-06-21
HU209433B (en) 1994-06-28
IL96643A (en) 1995-01-24
NO913176D0 (no) 1991-08-14
EP0434960B1 (en) 1996-09-18
NO913176L (no) 1991-08-14
DE69028610D1 (de) 1996-10-24
YU237990A (sh) 1993-05-28
CA2046857C (en) 2001-06-12
HU912994D0 (en) 1992-01-28
SI9012379A (en) 1997-12-31
NO175533C (no) 1994-10-26
DK0434960T3 (da) 1996-10-14
JP3300342B2 (ja) 2002-07-08
IE904543A1 (en) 1991-06-19
SK278994B6 (sk) 1998-05-06
NO176911B (no) 1995-03-13
CN1024922C (zh) 1994-06-08
FI913887A0 (fi) 1991-08-16
YU48136B (sh) 1997-05-28
DE69028610T2 (de) 1997-02-06
CN1039708C (zh) 1998-09-09
RU2100366C1 (ru) 1997-12-27
NO940831L (no) 1991-08-14

Similar Documents

Publication Publication Date Title
HRP921226B1 (en) Morpholinyl derivatives of doxorubicin and process for their preparation
EP0163599A3 (en) Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
IL96272A0 (en) Polypeptide compounds,process for the preparation thereof and pharmaceutical compositions containing the same
IL97839A (en) Intermediates for preparing guanidine derivatives their preparation and use
GR3029847T3 (en) Benzothiadiazine derivative process for its preparation and pharmaceutical compositions containing it
UA21900A (uk) Похідhі глутатіоhу або їх фармацевтичhо прийhятhі солі, які проявляють протизапальhу, протиалергійhу та гепатотропhу активhість, і спосіб їх одержаhhя
DE69029781D1 (de) Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung
ATE63921T1 (de) 6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
HU901678D0 (en) Process for the production of new 4'-epi-4'-amino-antacyclines
GB8728314D0 (en) New compositions of matter
EP0443474A3 (en) 1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20071204

Year of fee payment: 18

PBON Lapse due to non-payment of renewal fee

Effective date: 20081218