HRP20230236T1 - Postupci liječenja raka kože primjenom inhibitora pd-1 - Google Patents
Postupci liječenja raka kože primjenom inhibitora pd-1 Download PDFInfo
- Publication number
- HRP20230236T1 HRP20230236T1 HRP20230236TT HRP20230236T HRP20230236T1 HR P20230236 T1 HRP20230236 T1 HR P20230236T1 HR P20230236T T HRP20230236T T HR P20230236TT HR P20230236 T HRP20230236 T HR P20230236T HR P20230236 T1 HRP20230236 T1 HR P20230236T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- antigen
- binding fragment
- amino acid
- acid sequence
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 19
- 239000012270 PD-1 inhibitor Substances 0.000 title 1
- 239000012668 PD-1-inhibitor Substances 0.000 title 1
- 208000000453 Skin Neoplasms Diseases 0.000 title 1
- 229940121655 pd-1 inhibitor Drugs 0.000 title 1
- 201000000849 skin cancer Diseases 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 239000003112 inhibitor Substances 0.000 claims 15
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 230000001394 metastastic effect Effects 0.000 claims 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims 4
- 230000004614 tumor growth Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 229940121827 Hedgehog pathway inhibitor Drugs 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 102100034608 Angiopoietin-2 Human genes 0.000 claims 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 241000289669 Erinaceus europaeus Species 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 108010048036 Angiopoietin-2 Proteins 0.000 claims 1
- 101710144268 B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 229940126634 CD38 inhibitor Drugs 0.000 claims 1
- VJQALSOBHVEJQM-UHFFFAOYSA-N COCCOC1CCC(CC1)Nc1cc(=O)n(C)c2ccc(cc12)-c1cncs1 Chemical compound COCCOC1CCC(CC1)Nc1cc(=O)n(C)c2ccc(cc12)-c1cncs1 VJQALSOBHVEJQM-UHFFFAOYSA-N 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- 208000012766 Growth delay Diseases 0.000 claims 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 239000000611 antibody drug conjugate Substances 0.000 claims 1
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- 229940028885 interleukin-4 Drugs 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108091006082 receptor inhibitors Proteins 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
- 238000005549 size reduction Methods 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 229960004449 vismodegib Drugs 0.000 claims 1
- BPQMGSKTAYIVFO-UHFFFAOYSA-N vismodegib Chemical group ClC1=CC(S(=O)(=O)C)=CC=C1C(=O)NC1=CC=C(Cl)C(C=2N=CC=CC=2)=C1 BPQMGSKTAYIVFO-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39575—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from other living beings excluding bacteria and viruses, e.g. protozoa, fungi, plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0604—Lungs and/or airways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0605—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0606—Mouth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0607—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0608—Rectum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0609—Stomach and/or esophagus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/061—Bladder and/or urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0611—Vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (18)
1. Antitijelo ili njegov fragment koji veže antigen koji se specifično veže za programiranu staničnu smrt-1 (PD-1) za upotrebu u postupku liječenja ili inhibicije rasta tumora, navedena metoda obuhvaća:
(a) odabir pacijenta koji ima tumor bazalnih stanica (BCC); i
(b) davanje pacijentu kojem je potrebno terapeutski efikasne količine antitijela ili njegovog fragmenta koji veže antigen;
pri čemu antitijelo ili njegov fragment koji se veže za antigen sadrži tri regije koje određuju komplementarnost teškog lanca (HCDR1, HCDR2 i HCDR3) varijabilne regije teškog lanca (HCVR) i tri regije koje određuju komplementarnost lakog lanca (LCDR1, LCDR2 i LCDR3) varijabilne regije lakog lanca (LCVR); pri čemu HCDR1 sadrži aminokiselinsku sekvencu SEQ ID NO: 3; HCDR2 sadrži aminokiselinsku sekvencu SEQ ID NO: 4; HCDR3 sadrži aminokiselinsku sekvencu SEQ ID NO: 5; LCDR1 sadrži aminokiselinsku sekvencu SEQ ID NO: 6; LCDR2 sadrži aminokiselinsku sekvencu SEQ ID NO: 7; i LCDR3 sadrži aminokiselinsku sekvencu SEQ ID NO: 8.
2. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema zahtjevu 1, pri čemu je BCC metastatski, neoperabilnii/ili lokalno napredni.
3. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema zahtjevu 1 ili 2, u kojem:
(a) navedeni pacijent je liječen barem jednom prethodnom terapijom protiv tumora
(b) pacijent je rezistentan ili neadekvatno reagirana ili ima recidiv nakon prethodne terapije.
4. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema zahtjevu 3, gdje je terapija protiv tumora izabrana između operacije, zračenja, kemoterapije, inhibitora “hedgehog“ puta i drugog anti-PD-1 antitijela.
5. Antitijelo ili njegov fragment koji veže antigen za upotrebu prema bilo kojem od zahtjeva 1-4, gdje BCC je napredovao poslije ranijeg tretmana s, ili je pacijent intolerantan, na inhibitor “hedgehog“ puta.
6. Antitijelo ili njegov fragment koji se veže za antigen za upotrebu u postupku prema zahtjevu 4 ili 5, gdje je inhibitor “hedgehog“ puta izabran između vismodegiba i sonedegiba.
7. Antitijelo ili njegov fragment koji se veže za antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-6, gdje se antitijelo ili njegov fragment za vezivanje antigena daje u jednoj ili više doza, gdje:
(a) svaka doza je davana 0,5 do 4 tjedna neposredno nakon prethodne doze;
(b) svaka doza je davana 2 tjedna neposredno nakon prethodne doze; ili
(c) svaka doza je davana 3 tjedna neposredno nakon prethodne doze
8. Antitijelo ili njegov fragment koji se veže za antigen za upotrebu u postupku prema zahtjevu 7, gdje svaka doza obuhvaća anti-PD-1 antitijelo ili njegov fragment koji se veže za antigen u količini od
(a) 1, 3 ili 10 mg/kg tjelesne mase pacijenta, opcionalno 3 mg/kg tjelesne mase pacijenta; ili
(b) 50 - 600 mg; opcionalno 200, 250 ili 350 mg .
9. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-8, pri čemu je davano kao monoterapija.
10. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-9, gdje davanje dovodi do bar jednog efekta koji je izabran iz grupe koja se sastoji od inhibicije rasta tumora, regresije tumora, smanjenja veličine tumora, smanjenja broja tumorskih stanica, odlaganja rasta tumora, apskopalnom efektu, inhibiciji tumorskih metastaza, smanjenju metastatskih lezija tijekom vremena, smanjenoj upotrebi kemoterapeutika ili citotoksičnih sredstava, smanjenju u opterećenju tumora, porastu preživljavanja bez progresije, porasta u sveukupnom preživljavanju, potpunom odgovoru, parcijalnom odgovoru, i stabilnoj bolesti.
11. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-8 i 10, dalje obuhvaća davanje pacijentu dodatnog terapeutskog sredstva ili terapije, pri čemu je dodatno terapeutsko sredstvo ili terapija izabrano iz grupe koja se sastoji od inhibitora “hedgehog“ puta, operacije, zračenja, kemoterapeutskog sredstva, cjepiva protiv raka, inhibitora liganda 1 programirane smrti (PD-L1), inhibitora limfocitnog aktivirajućeg gena 3 (LAG3), inhibitora citotoksičnog T-limfocit-povezanog proteina 4 (CTLA-4), inhibitora T-ćelijskog imunoglobulina i domena mucina koji sadrži-3 (TIM3), inhibitora atenuatora B- i T-limfocita (BTLA), inhibitora T stanični imunoreceptora s Ig i ITIM domenima (TIGIT), CD47 inhibitora, inhibitora indolamin-2,3-dioksigenaze (IDO), bispecifičnog anti-CD3/anti-CD20 antitijela, antagonist vaskularnog endotelnog faktora rasta (VEGF), inhibitora angiopoietina-2 (Ang2), inhibitora transformirajućeg faktora rasta beta(TGFβ), inhibitor CD38, inhibitora receptora epidermalnog faktora rasta (EGFR), faktora koji stimulira koloniju granulocita-makrofaga (GM-CSF), ciklofosfamida, antitijela specifičnog za tumor-specifični antigen, Bacillus Calmette-Guerin cjepiva, citotoksina, inhibitora receptora za interleukin 6 (IL-6R), inhibitora receptora za interleukin 4 (IL-4R), inhibitor IL-10, IL-2, IL-7, IL-21, IL-15, konjugata antitijela s lijekom, antiinflamatornog lijeka, i dodatka prehrani .
12. Antitijelo ili njegov fragment koji se veže za antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-11, pri čemu je anti-PD-1 antitijelo ili njegov fragment koji se veže na antigen primijenjen intravenozno, supkutano, ili intraperitonealno.
13. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-12, pri čemu se anti-PD-1 antitijelo ili njegov fragment koji veže antigen se sastoji od HCVR koja je bar 90% identična u sekvenci sa SEQ ID NO: 1 i/ili LCVR koja je bar 90% identična u sekvenci sa SEQ ID NO: 2.
14. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-13, gdje se HCVR sastoji od aminokiselinske sekvence SEQ ID NO: 1 i LCVR se sastoji od aminokiselinske sekvence SEQ ID NO: 2.
15. Antitijelo ili njegov fragment koji veže antigen za upotrebu u postupku prema bilo kojem od zahtjeva 1-14, pri čemu se antitijelo sastoji od teškog lanca koji se sastoji od aminokiselinske sekvence SEQ ID NO: 9 i lakog lanca koji se sastoji iz aminokiselinske sekvence SEQ ID NO: 10.
16. Antitijelo koje se specifično veže za programiranu staničnu smrt-1 (PD-1) za upotrebu u postupku liječenja ili inhibicije rasta tumora, pri čemu spomenuti postupak obuhvaća:
(a) odabir pacijenta s metastatskim karcinomom baznih stanica (BCC) ili metastatskim BCC, pri čemu je pacijent napredovao na ili je intolerantan na inhibitor “hedgehog“ puta; i
(b) intravenozno davanje pacijentu kojem je potrebno svaka tri tjedna doze 350 mg antitijela koje se specifično vezuje za PD-1;
pri čemu se anti-PD-1 antitijelo sastoji iz tri regije koje određuju komplementarnost teškog lanca (HCDR1, HCDR2 i HCDR3) varijabilne regije teškog lanca (HCVR) i tri regije koje određuju komplementarnost lakog lanca (LCDR1, LCDR2 i LCDR3) varijabilne regije lakog lanca (LCVR), gdje se HCDR1 sastoji iz aminokiselinske sekvence SEQ ID NO: 3; HCDR2 se sastoji iz aminokiselinske sekvence SEQ ID NO: 4; HCDR3 se sastoji iz aminokiselinske sekvence SEQ ID NO: 5; LCDR1 se sastoji iz aminokiselinske sekvence SEQ ID NO: 6; LCDR2 se sastoji iz aminokiselinske sekvence SEQ ID NO: 7; i LCDR3 se sastoji iz aminokiselinske sekvence SEQ ID NO: 8.
17. Antitijelo za upotrebu u postupku prema zahtjevu 16, u kojem se anti-PD-1 antitijelo sastoji od HCVR koji se sastoji od aminokiselinske sekvence SEQ ID NO: 1 i LCVR koja se sastoji od aminokiselinske sekvence SEQ ID NO: 2.
18. Antitijelo za upotrebu u postupku prema bilo kojem od zahtjeva 16 ili 17, u kojem se anti-PD-1 antitijelo sastoji od teškog lanca koji se sastoji od aminokiselinske sekvence SEQ ID NO: 9 i laki lanac koji se sastoji iz aminokiselinske sekvence SEQ ID NO: 10.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662335743P | 2016-05-13 | 2016-05-13 | |
US201662340142P | 2016-05-23 | 2016-05-23 | |
US201662348546P | 2016-06-10 | 2016-06-10 | |
US201662350305P | 2016-06-15 | 2016-06-15 | |
US201662364920P | 2016-07-21 | 2016-07-21 | |
US201662374020P | 2016-08-12 | 2016-08-12 | |
US201762451274P | 2017-01-27 | 2017-01-27 | |
EP21191931.1A EP3932951B1 (en) | 2016-05-13 | 2017-05-12 | Methods of treating skin cancer by administering a pd-1 inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20230236T1 true HRP20230236T1 (hr) | 2023-04-14 |
Family
ID=58800911
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20230517TT HRP20230517T1 (hr) | 2016-05-13 | 2017-05-12 | Kombinacija anti-pd-1 antitijela i radijacijske terapije za liječenje raka |
HRP20220014TT HRP20220014T1 (hr) | 2016-05-13 | 2017-05-12 | Postupci liječenja raka kože davanjem inhibitora pd-1 |
HRP20230236TT HRP20230236T1 (hr) | 2016-05-13 | 2017-05-12 | Postupci liječenja raka kože primjenom inhibitora pd-1 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20230517TT HRP20230517T1 (hr) | 2016-05-13 | 2017-05-12 | Kombinacija anti-pd-1 antitijela i radijacijske terapije za liječenje raka |
HRP20220014TT HRP20220014T1 (hr) | 2016-05-13 | 2017-05-12 | Postupci liječenja raka kože davanjem inhibitora pd-1 |
Country Status (31)
Country | Link |
---|---|
US (4) | US10457725B2 (hr) |
EP (4) | EP3932951B1 (hr) |
JP (4) | JP7054680B2 (hr) |
KR (5) | KR102470294B1 (hr) |
CN (4) | CN109153724B (hr) |
AU (2) | AU2017264959A1 (hr) |
BR (1) | BR112018073291A2 (hr) |
CA (2) | CA3023984A1 (hr) |
CL (1) | CL2018003207A1 (hr) |
CY (1) | CY1124901T1 (hr) |
DK (3) | DK3455259T3 (hr) |
ES (3) | ES2938321T3 (hr) |
FI (2) | FI3932951T3 (hr) |
HR (3) | HRP20230517T1 (hr) |
HU (3) | HUE061874T2 (hr) |
IL (3) | IL262562B2 (hr) |
LT (2) | LT3455258T (hr) |
MD (3) | MD3932951T2 (hr) |
MX (4) | MX2018013848A (hr) |
MY (1) | MY194085A (hr) |
NZ (1) | NZ748192A (hr) |
PH (1) | PH12018502263A1 (hr) |
PL (3) | PL3455258T3 (hr) |
PT (3) | PT3455259T (hr) |
RS (3) | RS64218B1 (hr) |
SG (2) | SG10202011110PA (hr) |
SI (3) | SI3455259T1 (hr) |
TW (3) | TWI755395B (hr) |
UA (1) | UA124151C2 (hr) |
WO (2) | WO2017197259A1 (hr) |
ZA (2) | ZA201807050B (hr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016294440B2 (en) | 2015-07-13 | 2022-10-13 | Cytomx Therapeutics, Inc | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof |
EP3740506A1 (en) * | 2018-01-16 | 2020-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
BR112020022371A2 (pt) * | 2018-05-03 | 2021-02-02 | Shanghai Epimab Biotherapeutics Co., Ltd. | anticorpos de alta afinidade para pd-1 e lag-3 e proteínas de ligação biespecífica produzidas a partir dos mesmos |
TW202005985A (zh) * | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法 |
SG11202100344WA (en) | 2018-07-23 | 2021-02-25 | Guardant Health Inc | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
AU2019328344A1 (en) | 2018-08-31 | 2021-04-08 | Guardant Health, Inc. | Microsatellite instability detection in cell-free DNA |
AU2019362050A1 (en) * | 2018-10-19 | 2021-05-13 | Senhwa Biosciences, Inc. | Combinations for immune-modulation in cancer treatment |
WO2020102375A1 (en) * | 2018-11-14 | 2020-05-22 | Regeneron Pharmaceuticals, Inc. | Intralesional administration of pd-1 inhibitors for treating skin cancer |
US20220008515A1 (en) * | 2018-11-16 | 2022-01-13 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
JP2022511471A (ja) * | 2018-12-03 | 2022-01-31 | フュージョン ファーマシューティカルズ インコーポレイテッド | 放射性免疫複合体とdnaの損傷および修復阻害剤の併用療法 |
EP3890802A4 (en) * | 2018-12-08 | 2023-03-22 | Board of Regents, The University of Texas System | IDENTIFICATION AND TARGETING OF TUMOR-FOSTERING CARCINOMA-ASSOCIATED FIBROBLASTS FOR THE DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES |
MX2021008604A (es) * | 2019-01-21 | 2021-10-26 | Sanofi Sa | Arn terapeutico para tumores solidos cancerigenos en etapa avanzada. |
WO2020156500A1 (zh) * | 2019-01-31 | 2020-08-06 | 正大天晴药业集团股份有限公司 | 抗pd-l1抗体治疗头颈癌的用途 |
MA55084A (fr) * | 2019-02-28 | 2022-01-05 | Regeneron Pharma | Administration d'inhibiteurs de pd-1 pour le traitement du cancer de la peau |
WO2020222231A1 (en) * | 2019-04-28 | 2020-11-05 | Institut Pasteur De Montevideo. | Ionic channel modulation as a method for treating tumors through inflammasome activation |
JP2022532490A (ja) * | 2019-05-13 | 2022-07-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 癌の治療における有効性の増強のためのpd-1阻害剤とlag-3阻害剤の組み合わせ |
US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
KR102195221B1 (ko) | 2019-12-31 | 2020-12-24 | 서울대학교산학협력단 | 포스파티딜이노시톨 3-키나아제 억제제 및 프로그램화 세포 사멸 단백질 1 억제제를 포함하는, 삼중음성 유방암의 방사선 병용 치료용 약학적 조성물 |
JP2023512214A (ja) | 2020-01-28 | 2023-03-24 | リフレクション メディカル, インコーポレイテッド | 放射性核種および外部ビーム放射線療法の共同最適化 |
CN111840585B (zh) * | 2020-07-20 | 2022-05-03 | 厦门大学 | 一种用于肿瘤免疫治疗的药物组合 |
CN116194142A (zh) * | 2020-09-03 | 2023-05-30 | 瑞泽恩制药公司 | 通过施用pd-1抑制剂治疗癌症疼痛的方法 |
AU2022219955A1 (en) * | 2021-02-11 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer by administering a neoadjuvant pd-1 inhibitor |
CN115125211A (zh) * | 2021-03-24 | 2022-09-30 | 核工业总医院 | 免疫治疗疗效评价用结肠癌腹膜转移小鼠模型 |
CN113368226B (zh) * | 2021-06-30 | 2021-11-30 | 上海力沃生物科技有限公司 | 含有dc瘤苗的药物组合物及其在治疗癌症中的应用 |
WO2023014206A1 (ko) * | 2021-08-06 | 2023-02-09 | 알지노믹스 주식회사 | 방사선 치료와 병용되는 유전자 치료제로서 암 특이적 트랜스-스플라이싱 리보자임 |
US20230250176A1 (en) * | 2022-02-09 | 2023-08-10 | Dragonfly Therapeutics, Inc. | Ppharmaceutical formulations and therapeutic uses of multi-specific binding proteins that bind egfr, nkg2d, and cd16 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07291996A (ja) | 1994-03-01 | 1995-11-07 | Yuu Honshiyo | ヒトにおけるプログラムされた細胞死に関連したポリペプチド、それをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのポリペプチドまたはその抗体を含有する薬学的組成物 |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
WO2001014556A1 (en) | 1999-08-23 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Novel b7-4 molecules and uses therefor |
WO2001014557A1 (en) | 1999-08-23 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
WO2001039722A2 (en) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
AU2001271731A1 (en) | 2000-06-28 | 2002-01-08 | Dana-Farber Cancer Institute, Inc. | PD-L2 molecules: novel PD-1 ligands and uses therefor |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
AU2002258941A1 (en) | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
EP1456652A4 (en) | 2001-11-13 | 2005-11-02 | Dana Farber Cancer Inst Inc | IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR |
EP2243493A1 (en) | 2002-07-03 | 2010-10-27 | Ono Pharmaceutical Co., Ltd. | Immunopotentiative composition |
JP2004104681A (ja) | 2002-09-12 | 2004-04-02 | Renesas Technology Corp | 入力バッファ回路 |
US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
MXPA05006828A (es) | 2002-12-23 | 2005-09-08 | Wyeth Corp | Anticuerpos contra pd-1, y sus usos. |
EP2270051B1 (en) | 2003-01-23 | 2019-05-15 | Ono Pharmaceutical Co., Ltd. | Antibody specific for human PD-1 and CD3 |
WO2005092925A2 (en) | 2004-03-24 | 2005-10-06 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
DK1737891T3 (da) | 2004-04-13 | 2013-03-25 | Hoffmann La Roche | Anti-p-selectin-antistoffer |
US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
WO2006105021A2 (en) | 2005-03-25 | 2006-10-05 | Tolerrx, Inc. | Gitr binding molecules and uses therefor |
SI2161336T1 (sl) | 2005-05-09 | 2013-11-29 | Ono Pharmaceutical Co., Ltd. | Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki |
US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
JP4663394B2 (ja) | 2005-05-11 | 2011-04-06 | ダイセルポリマー株式会社 | 難めっき性被覆剤及びめっきの前処理方法 |
EP1899379B1 (en) | 2005-06-20 | 2018-04-11 | E. R. Squibb & Sons, L.L.C. | Cd19 antibodies and their uses |
BRPI0613361A2 (pt) | 2005-07-01 | 2011-01-04 | Medarex Inc | anticorpo monoclonal humano isolado, composição, imunoconjugado, molécula biespecìfica, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, camundongo transgênico, método para modular uma resposta imune num indivìduo, método para inibir crescimento de células tumorais num indivìduo, método para tratar uma doença infecciosa num indivìduo, método para aumentar uma resposta imune a um antìgeno num indivìduo, método para tratar ou prevenir uma doença inflamatória num indivìduo e método para preparar o anticorpo anti-pd-l1 |
CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
EP1820513A1 (en) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies |
US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
MY159787A (en) | 2006-06-02 | 2017-01-31 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
EP2535354B1 (en) | 2007-06-18 | 2017-01-11 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
ES2591281T3 (es) | 2007-07-12 | 2016-11-25 | Gitr, Inc. | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
WO2009014708A2 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
US9243052B2 (en) | 2007-08-17 | 2016-01-26 | Daniel Olive | Method for treating and diagnosing hematologic malignancies |
AU2007358569B2 (en) | 2007-09-07 | 2014-09-04 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
CN104548091A (zh) | 2008-02-11 | 2015-04-29 | 治疗科技公司 | 用于肿瘤治疗的单克隆抗体 |
US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
ES2545609T3 (es) | 2008-08-25 | 2015-09-14 | Amplimmune, Inc. | Composiciones de antagonistas de PD-1 y métodos de uso |
WO2010029434A1 (en) | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
US8927697B2 (en) | 2008-09-12 | 2015-01-06 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
AU2009296392B2 (en) | 2008-09-26 | 2016-06-02 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
KR101050829B1 (ko) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 항암제 |
KR20210060670A (ko) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도 |
WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
CN103833855A (zh) | 2009-06-26 | 2014-06-04 | 瑞泽恩制药公司 | 容易地分离的具有天然免疫球蛋白形式的双特异性抗体 |
PL3023438T3 (pl) | 2009-09-03 | 2020-07-27 | Merck Sharp & Dohme Corp. | Przeciwciała anty-gitr |
PL2482849T3 (pl) | 2009-09-30 | 2018-11-30 | Memorial Sloan-Kettering Cancer Center | Skojarzona immunoterapia w leczeniu nowotworu |
US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
BR122021025338B1 (pt) | 2009-11-24 | 2023-03-14 | Medimmune Limited | Anticorpo isolado ou fragmento de ligação do mesmo contra b7-h1, composição farmacêutica e seus usos |
US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
US8993731B2 (en) | 2010-03-11 | 2015-03-31 | Ucb Biopharma Sprl | PD-1 antibody |
US9163087B2 (en) | 2010-06-18 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions |
CN103261217B (zh) | 2010-11-11 | 2017-04-26 | 港大科桥有限公司 | 可溶性 pd‑1变体、融合构建体及其用途 |
KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들 |
BR112013032552A2 (pt) | 2011-07-24 | 2017-12-12 | Curetech Ltd | variantes de anticorpos monoclonais humanizados imunomoduladores |
WO2013019906A1 (en) | 2011-08-01 | 2013-02-07 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
HUE051954T2 (hu) | 2011-11-28 | 2021-03-29 | Merck Patent Gmbh | ANTI-PD-L1 ellenanyagok és alkalmazásaik |
GB201120527D0 (en) | 2011-11-29 | 2012-01-11 | Ucl Business Plc | Method |
US20140370012A1 (en) | 2012-01-27 | 2014-12-18 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
EP3511343A1 (en) | 2012-05-04 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use |
WO2013169693A1 (en) | 2012-05-09 | 2013-11-14 | Bristol-Myers Squibb Company | Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody |
US20130303250A1 (en) | 2012-05-11 | 2013-11-14 | Ryan Moore | Method of Playing a Card Game |
US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
AU2013267267B2 (en) | 2012-05-31 | 2017-10-26 | Genentech, Inc. | Methods of treating cancer using PD-L1 axis binding antagonists and VEGF antagonists |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
HUE035503T2 (en) | 2012-10-02 | 2018-05-02 | Bristol Myers Squibb Co | Combination of anti-anti-antibodies and anti-PD-1 antibodies to treat cancer |
US10034939B2 (en) | 2012-10-26 | 2018-07-31 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
CA2897858A1 (en) | 2013-02-22 | 2014-08-28 | Curevac Gmbh | Combination of vaccination and inhibition of the pd-1 pathway |
ES2644022T3 (es) | 2013-03-14 | 2017-11-27 | Bristol-Myers Squibb Company | Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso |
EP4356960A2 (en) | 2013-03-15 | 2024-04-24 | F. Hoffmann-La Roche AG | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
DK2992017T3 (da) | 2013-05-02 | 2021-01-25 | Anaptysbio Inc | Antistoffer rettet mod programmeret død-1 (pd-1) |
WO2014194293A1 (en) | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
WO2014209804A1 (en) | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
PT3021869T (pt) | 2013-07-16 | 2020-09-10 | Hoffmann La Roche | Métodos de tratamento do cancro com antagonistas da ligação ao eixo pd-1 e inibidores do tigit |
AU2014296887A1 (en) | 2013-08-02 | 2016-01-28 | Aduro Biotech Holdings, Europe B.V. | Combining CD27 agonists and immune checkpoint inhibition for immune stimulation |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
ES2827679T3 (es) | 2013-08-20 | 2021-05-24 | Merck Sharp & Dohme | Tratamiento del cáncer con una combinación de un antagonista de PD-1 y dinaciclib |
RS64268B1 (sr) | 2013-09-20 | 2023-07-31 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
PE20160541A1 (es) | 2013-09-27 | 2016-06-03 | Genentech Inc | Formulaciones de anticuerpos anti-pdl1 |
EP3079772B1 (en) | 2013-12-10 | 2020-02-05 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for pd-1 positive cells and pd-ligand positive cells in tumor tissue |
BR122021025087B1 (pt) | 2013-12-17 | 2023-04-04 | Genentech, Inc | Anticorpo anti-cd3, célula hospedeira procariótica, método de produção do anticorpo biespecífico, imunoconjugado, composição, uso do anticorpo biespecífico e kit |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
KR20170003692A (ko) | 2014-05-15 | 2017-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 사용한 폐암의 치료 |
CN108064242B (zh) | 2014-05-28 | 2022-10-21 | 阿吉纳斯公司 | 抗gitr抗体和其使用方法 |
HUE047385T2 (hu) | 2014-06-06 | 2020-04-28 | Bristol Myers Squibb Co | Antitestek glükokortikoid indukált tumornekrózis faktor receptor (GITR) ellen és annak felhasználásai |
US10092645B2 (en) * | 2014-06-17 | 2018-10-09 | Medimmune Limited | Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy |
RU2735958C2 (ru) | 2014-06-19 | 2020-11-11 | Регенерон Фармасьютикалз, Инк. | Животные, отличные от человека, имеющие гуманизированный ген 1 запрограммированной гибели клеток |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
ES2952717T3 (es) | 2014-10-14 | 2023-11-03 | Novartis Ag | Moléculas de anticuerpos contra PD-L1 y usos de las mismas |
ES2791950T3 (es) | 2015-02-03 | 2020-11-06 | Ventana Med Syst Inc | Ensayo histoquímico para evaluar la expresión del ligando de muerte programada 1 (PD-L1) |
MA42971A (fr) | 2015-03-13 | 2018-08-15 | Cytomx Therapeutics Inc | Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation |
WO2016191751A1 (en) | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
AU2016294440B2 (en) | 2015-07-13 | 2022-10-13 | Cytomx Therapeutics, Inc | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof |
CA3009161A1 (en) | 2015-12-22 | 2017-06-29 | Regeneron Pharmaceuticals, Inc. | Combination of anti-pd-1 antibodies and bispecific anti-cd20/anti-cd3 antibodies to treat cancer |
AU2017224843A1 (en) | 2016-02-25 | 2018-08-23 | Cell Medica Switzerland Ag | Binding members to PD-L1 |
CA3045466A1 (en) | 2016-12-01 | 2018-06-07 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
-
2017
- 2017-05-11 TW TW106115562A patent/TWI755395B/zh active
- 2017-05-11 TW TW111148425A patent/TWI822521B/zh active
- 2017-05-11 TW TW106115563A patent/TWI786044B/zh active
- 2017-05-12 SI SI201731342T patent/SI3455259T1/sl unknown
- 2017-05-12 KR KR1020187036323A patent/KR102470294B1/ko active IP Right Grant
- 2017-05-12 JP JP2018559739A patent/JP7054680B2/ja active Active
- 2017-05-12 US US15/593,915 patent/US10457725B2/en active Active
- 2017-05-12 EP EP21191931.1A patent/EP3932951B1/en active Active
- 2017-05-12 PL PL17726759T patent/PL3455258T3/pl unknown
- 2017-05-12 EP EP17727767.0A patent/EP3455259B1/en active Active
- 2017-05-12 KR KR1020187036322A patent/KR102349056B1/ko active IP Right Grant
- 2017-05-12 MD MDE20220619T patent/MD3932951T2/ro unknown
- 2017-05-12 CN CN201780028431.0A patent/CN109153724B/zh active Active
- 2017-05-12 PL PL17727767.0T patent/PL3455259T3/pl unknown
- 2017-05-12 WO PCT/US2017/032397 patent/WO2017197259A1/en unknown
- 2017-05-12 BR BR112018073291-5A patent/BR112018073291A2/pt not_active Application Discontinuation
- 2017-05-12 MD MDE20190333T patent/MD3455258T2/ro unknown
- 2017-05-12 RS RS20230397A patent/RS64218B1/sr unknown
- 2017-05-12 CN CN202310111383.9A patent/CN116407627A/zh active Pending
- 2017-05-12 SI SI201731309T patent/SI3932951T1/sl unknown
- 2017-05-12 FI FIEP21191931.1T patent/FI3932951T3/fi active
- 2017-05-12 CN CN202310111307.8A patent/CN116098997A/zh active Pending
- 2017-05-12 EP EP22203044.7A patent/EP4180459A1/en active Pending
- 2017-05-12 KR KR1020217040328A patent/KR102464774B1/ko active IP Right Grant
- 2017-05-12 PT PT177277670T patent/PT3455259T/pt unknown
- 2017-05-12 DK DK17727767.0T patent/DK3455259T3/da active
- 2017-05-12 FI FIEP17727767.0T patent/FI3455259T3/fi active
- 2017-05-12 MX MX2018013848A patent/MX2018013848A/es unknown
- 2017-05-12 CN CN201780028425.5A patent/CN109153723B/zh active Active
- 2017-05-12 EP EP17726759.8A patent/EP3455258B1/en active Active
- 2017-05-12 IL IL262562A patent/IL262562B2/en unknown
- 2017-05-12 AU AU2017264959A patent/AU2017264959A1/en active Pending
- 2017-05-12 MY MYPI2018703920A patent/MY194085A/en unknown
- 2017-05-12 PT PT211919311T patent/PT3932951T/pt unknown
- 2017-05-12 SG SG10202011110PA patent/SG10202011110PA/en unknown
- 2017-05-12 US US15/593,897 patent/US20170327567A1/en active Pending
- 2017-05-12 ES ES21191931T patent/ES2938321T3/es active Active
- 2017-05-12 MD MDE20190335T patent/MD3455259T2/ro unknown
- 2017-05-12 LT LTEPPCT/US2017/032408T patent/LT3455258T/lt unknown
- 2017-05-12 RS RS20211610A patent/RS62783B1/sr unknown
- 2017-05-12 HR HRP20230517TT patent/HRP20230517T1/hr unknown
- 2017-05-12 MX MX2018013847A patent/MX2018013847A/es unknown
- 2017-05-12 WO PCT/US2017/032408 patent/WO2017197263A1/en active Application Filing
- 2017-05-12 UA UAA201812344A patent/UA124151C2/uk unknown
- 2017-05-12 CA CA3023984A patent/CA3023984A1/en active Pending
- 2017-05-12 SG SG11201809554VA patent/SG11201809554VA/en unknown
- 2017-05-12 ES ES17726759T patent/ES2899954T3/es active Active
- 2017-05-12 LT LTEP21191931.1T patent/LT3932951T/lt unknown
- 2017-05-12 JP JP2018559738A patent/JP6999577B2/ja active Active
- 2017-05-12 KR KR1020227038606A patent/KR102595561B1/ko active IP Right Grant
- 2017-05-12 ES ES17727767T patent/ES2943640T3/es active Active
- 2017-05-12 RS RS20230164A patent/RS64014B1/sr unknown
- 2017-05-12 DK DK21191931.1T patent/DK3932951T3/da active
- 2017-05-12 IL IL302924A patent/IL302924A/en unknown
- 2017-05-12 CA CA3023985A patent/CA3023985A1/en active Pending
- 2017-05-12 NZ NZ748192A patent/NZ748192A/en unknown
- 2017-05-12 DK DK17726759.8T patent/DK3455258T3/da active
- 2017-05-12 HU HUE17727767A patent/HUE061874T2/hu unknown
- 2017-05-12 PT PT177267598T patent/PT3455258T/pt unknown
- 2017-05-12 HU HUE17726759A patent/HUE057781T2/hu unknown
- 2017-05-12 SI SI201730995T patent/SI3455258T1/sl unknown
- 2017-05-12 AU AU2017264955A patent/AU2017264955B2/en active Active
- 2017-05-12 PL PL21191931.1T patent/PL3932951T3/pl unknown
- 2017-05-12 HU HUE21191931A patent/HUE061417T2/hu unknown
- 2017-05-12 KR KR1020237036612A patent/KR20230152804A/ko not_active Application Discontinuation
- 2017-05-12 HR HRP20220014TT patent/HRP20220014T1/hr unknown
- 2017-05-12 HR HRP20230236TT patent/HRP20230236T1/hr unknown
-
2018
- 2018-10-23 ZA ZA2018/07050A patent/ZA201807050B/en unknown
- 2018-10-23 ZA ZA2018/07051A patent/ZA201807051B/en unknown
- 2018-10-24 PH PH12018502263A patent/PH12018502263A1/en unknown
- 2018-10-24 IL IL262561A patent/IL262561B/en unknown
- 2018-11-12 MX MX2022001123A patent/MX2022001123A/es unknown
- 2018-11-12 MX MX2022001120A patent/MX2022001120A/es unknown
- 2018-11-12 CL CL2018003207A patent/CL2018003207A1/es unknown
-
2019
- 2019-09-03 US US16/559,159 patent/US11505600B2/en active Active
-
2022
- 2022-01-10 CY CY20221100022T patent/CY1124901T1/el unknown
- 2022-01-14 JP JP2022004089A patent/JP7313493B2/ja active Active
- 2022-10-14 US US18/046,576 patent/US20230227542A1/en active Pending
-
2023
- 2023-07-07 JP JP2023112057A patent/JP2023123848A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20230236T1 (hr) | Postupci liječenja raka kože primjenom inhibitora pd-1 | |
JP2022050618A5 (hr) | ||
JP2019515008A5 (hr) | ||
JP7126941B2 (ja) | がんを治療するための抗pd-1抗体と二重特異性抗cd20/抗cd3抗体の組合せ | |
JP2019519499A5 (hr) | ||
JP6072854B2 (ja) | Cd38を特異的に認識する抗体とシタラビンを含有する抗腫瘍性組合せ剤 | |
TWI596116B (zh) | 包含專一性辨識cd38之抗體及硼替佐米(bortezomib)之抗腫瘤組合 | |
TWI457346B (zh) | 包含專一性辨識cd38之抗體及環磷醯胺(cyclophosphamide)之抗腫瘤組合 | |
JP7252627B2 (ja) | 制御性b10細胞を枯渇させる抗体および方法並びに免疫チェックポイント阻害剤との併用における使用 | |
JP2020508317A5 (hr) | ||
JP2022078265A5 (hr) | ||
JP2012510461A (ja) | Cd38を特異的に認識する抗体およびメルファランを含有する抗腫瘍性組合せ剤 | |
IL308805A (en) | Anti-PD-1 antibodies for the treatment of lung cancer | |
WO2018223923A1 (zh) | Pd-1抗体与vegf配体或vegf受体抑制剂联合在制备治疗肿瘤的药物中的用途 | |
KR102115203B1 (ko) | 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법 | |
AU2022202800B2 (en) | Combinations and uses thereof | |
AU2016266708A1 (en) | Combination of an anti-CD19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof | |
AU2020325981A1 (en) | Combination therapy involving antibodies against Claudin 18.2 and immune checkpoint inhibitors for treatment of cancer | |
JPWO2019246356A5 (hr) | ||
US20210277135A1 (en) | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a method of treating a cancer or a solid tumor | |
WO2020049534A1 (en) | Sting agonist and combination therapy thereof for the treatment of cancer | |
JPWO2020232019A5 (hr) | ||
RU2021128914A (ru) | Ингибиторы пути il-4/il-13 для повышенной эффективности при лечении злокачественных новообразований | |
CA3238750A1 (en) | Methods for treating cancer with bispecific anti-cd3 x muc16 antibodies and anti-ctla-4 antibodies | |
US20230235089A1 (en) | Methods for Treating Cancer with Bispecific Anti-CD3 x MUC16 Antibodies and Anti-CTLA-4 Antibodies |