SG11201809554VA - Methods of treating skin cancer by administering a pd-1 inhibitor - Google Patents
Methods of treating skin cancer by administering a pd-1 inhibitorInfo
- Publication number
- SG11201809554VA SG11201809554VA SG11201809554VA SG11201809554VA SG11201809554VA SG 11201809554V A SG11201809554V A SG 11201809554VA SG 11201809554V A SG11201809554V A SG 11201809554VA SG 11201809554V A SG11201809554V A SG 11201809554VA SG 11201809554V A SG11201809554V A SG 11201809554VA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- tarrytown
- regeneron
- methods
- saw mill
- Prior art date
Links
- 208000000453 Skin Neoplasms Diseases 0.000 title abstract 3
- 201000000849 skin cancer Diseases 0.000 title abstract 3
- 239000012270 PD-1 inhibitor Substances 0.000 title abstract 2
- 239000012668 PD-1-inhibitor Substances 0.000 title abstract 2
- 229940121655 pd-1 inhibitor Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 4
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 206010004146 Basal cell carcinoma Diseases 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 November 2017 (16.11.2017) WIPO I PCT omit VIII Hot 0 Oil mom VIII 10110111110 oimIE (10) International Publication Number WO 2017/197263 Al (51) International Patent Classification: C07K 16/28 (2006.01) A61N 5/10 (2006.01) A61N 5/00 (2006.01) (21) International Application Number: PCT/US2017/032408 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 12 May 2017 (12.05.2017) with international search report (Art. 21(3)) (25) Filing Language: English with sequence listing part of description (Rule 5.2(a)) (26) Publication Language: English (30) Priority Data: 62/335,743 13 May 2016 (13.05.2016) US 62/340,142 23 May 2016 (23.05.2016) US 62/348,546 10 June 2016 (10.06.2016) US 62/350,305 15 June 2016 (15.06.2016) US 62/364,920 21 July 2016 (21.07.2016) US 62/374,020 12 August 2016 (12.08.2016) US 62/451,274 27 January 2017 (27.01.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (72) Inventors: LOWY, Israel; c/o Regeneron Pharmaceuti- cals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). SIMS, Tasha, N.; c/o Regeneron Pharmaceu- ticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). FURY, Matthew, G.; c/o Regeneron Pharma- ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (74) Agent: KOWALCHYK, Katherine, M.; Merchant & Gould P.C., P.O. Box 2903, Minneapolis, MN 55402-0903 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, N 1-1 (54) Title: METHODS OF TREATING SKIN CANCER BY ADMINISTERING A PD-1 INHIBITOR (57) : The present disclosure provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin O cancer). The methods of the present disclosure comprise administering to a subject in need thereof a therapeutically effective amount of \" a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous 0 cell carcinoma or basal cell carcinoma.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662335743P | 2016-05-13 | 2016-05-13 | |
US201662340142P | 2016-05-23 | 2016-05-23 | |
US201662348546P | 2016-06-10 | 2016-06-10 | |
US201662350305P | 2016-06-15 | 2016-06-15 | |
US201662364920P | 2016-07-21 | 2016-07-21 | |
US201662374020P | 2016-08-12 | 2016-08-12 | |
US201762451274P | 2017-01-27 | 2017-01-27 | |
PCT/US2017/032408 WO2017197263A1 (en) | 2016-05-13 | 2017-05-12 | Methods of treating skin cancer by administering a pd-1 inhibitor |
Publications (1)
Publication Number | Publication Date |
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SG11201809554VA true SG11201809554VA (en) | 2018-11-29 |
Family
ID=58800911
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202011110PA SG10202011110PA (en) | 2016-05-13 | 2017-05-12 | Methods of treating skin cancer by administering a pd-1 inhibitor |
SG11201809554VA SG11201809554VA (en) | 2016-05-13 | 2017-05-12 | Methods of treating skin cancer by administering a pd-1 inhibitor |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202011110PA SG10202011110PA (en) | 2016-05-13 | 2017-05-12 | Methods of treating skin cancer by administering a pd-1 inhibitor |
Country Status (31)
Country | Link |
---|---|
US (4) | US20170327567A1 (en) |
EP (4) | EP4180459A1 (en) |
JP (4) | JP6999577B2 (en) |
KR (5) | KR102349056B1 (en) |
CN (4) | CN109153724B (en) |
AU (2) | AU2017264959A1 (en) |
BR (1) | BR112018073291A2 (en) |
CA (2) | CA3023985A1 (en) |
CL (1) | CL2018003207A1 (en) |
CY (1) | CY1124901T1 (en) |
DK (3) | DK3932951T3 (en) |
ES (3) | ES2899954T3 (en) |
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Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180040138A (en) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of using them |
EP3740506A1 (en) * | 2018-01-16 | 2020-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
MX2020011588A (en) * | 2018-05-03 | 2020-12-07 | Shanghai Epimab Biotherapeutics Co Ltd | High affinity antibodies to pd-1 and lag-3 and bispecific binding proteins made therefrom. |
TW202005985A (en) * | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | Methods for treating cancer with bispecific anti-CD3xMUC16 antibodies and anti-PD-1 antibodies |
SG11202100344WA (en) | 2018-07-23 | 2021-02-25 | Guardant Health Inc | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
SG11202101400UA (en) | 2018-08-31 | 2021-03-30 | Guardant Health Inc | Microsatellite instability detection in cell-free dna |
KR20210079313A (en) * | 2018-10-19 | 2021-06-29 | 센화 바이오사이언시즈 인코포레이티드 | Combinations for Immunomodulation in Cancer Treatment |
US20210388091A1 (en) * | 2018-11-14 | 2021-12-16 | Regeneron Pharmaceuticals, Inc. | Intralesional administration of pd-1 inhibitors for treating skin cancer |
CA3119341A1 (en) * | 2018-11-16 | 2020-05-22 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
JP2022513700A (en) * | 2018-12-03 | 2022-02-09 | フュージョン ファーマシューティカルズ インコーポレイテッド | Combination therapy of radioactive immune complex and checkpoint inhibitor |
KR20210102331A (en) * | 2018-12-08 | 2021-08-19 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Identification and targeting of tumor-promoting carcinoma-associated fibroblasts for diagnosis and treatment of cancer and other diseases |
BR112021013887A2 (en) * | 2019-01-21 | 2021-09-21 | Sanofi | THERAPEUTIC RNA FOR ADVANCED STAGE SOLID TUMOR CANCER |
CN113365659B (en) * | 2019-01-31 | 2023-08-18 | 正大天晴药业集团股份有限公司 | Use of anti-PD-L1 antibodies for the treatment of head and neck cancer |
WO2020176699A1 (en) | 2019-02-28 | 2020-09-03 | Regeneron Pharmaceuticals, Inc. | Administration of pd-1 inhibitors for treating skin cancer |
CA3138459A1 (en) * | 2019-04-28 | 2020-11-05 | Institut Pasteur De Montevideo | Ionic channel modulation as a method for treating tumors through inflammasome activation |
JP2022532490A (en) * | 2019-05-13 | 2022-07-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Combination of PD-1 and LAG-3 inhibitors to enhance efficacy in the treatment of cancer |
US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
KR102195221B1 (en) | 2019-12-31 | 2020-12-24 | 서울대학교산학협력단 | Pharmaceutical composition for combination of radiotherapy for treating triple negative breast cancer comprising phosphatidylinositol 3-kinase inhibitor and programmed cell death protein 1 inhibitor |
AU2021212659A1 (en) | 2020-01-28 | 2022-08-04 | Reflexion Medical, Inc. | Joint optimization of radionuclide and external beam radiotherapy |
CN111840585B (en) * | 2020-07-20 | 2022-05-03 | 厦门大学 | Pharmaceutical composition for tumor immunotherapy |
IL300975A (en) * | 2020-09-03 | 2023-04-01 | Regeneron Pharma | Methods of treating cancer pain by administering a pd-1 inhibitor |
KR20230141869A (en) * | 2021-02-11 | 2023-10-10 | 리제너론 파마슈티칼스 인코포레이티드 | Method for treating cancer by administration of PD-1 inhibitor as neoadjuvant therapy |
CN115125211A (en) * | 2021-03-24 | 2022-09-30 | 核工业总医院 | Colon cancer peritoneal metastasis mouse model for evaluating curative effect of immunotherapy |
CN113368226B (en) * | 2021-06-30 | 2021-11-30 | 上海力沃生物科技有限公司 | Pharmaceutical composition containing DC tumor vaccine and application thereof in treating cancer |
WO2023014206A1 (en) * | 2021-08-06 | 2023-02-09 | 알지노믹스 주식회사 | Cancer-specific trans-splicing ribozyme as gene therapy product combined with radiotherapy |
US20230250176A1 (en) * | 2022-02-09 | 2023-08-10 | Dragonfly Therapeutics, Inc. | Ppharmaceutical formulations and therapeutic uses of multi-specific binding proteins that bind egfr, nkg2d, and cd16 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2143491C (en) | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
CA2383424C (en) | 1999-08-23 | 2011-02-15 | Gordon Freeman | Novel b7-4 molecules and uses therefor |
US6808710B1 (en) | 1999-08-23 | 2004-10-26 | Genetics Institute, Inc. | Downmodulating an immune response with multivalent antibodies to PD-1 |
PT1234031T (en) | 1999-11-30 | 2017-06-26 | Mayo Foundation | B7-h1, a novel immunoregulatory molecule |
WO2002000730A2 (en) | 2000-06-28 | 2002-01-03 | Genetics Institute, Llc. | Pd-l2 molecules: novel pd-1 ligands and uses therefor |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
AR036993A1 (en) | 2001-04-02 | 2004-10-20 | Wyeth Corp | USE OF AGENTS THAT MODULATE THE INTERACTION BETWEEN PD-1 AND ITS LINKS IN THE SUBMODULATION OF IMMUNOLOGICAL ANSWERS |
AU2002258941A1 (en) | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
FI2206517T3 (en) | 2002-07-03 | 2023-10-19 | Ono Pharmaceutical Co | Immunopotentiating compositions comprising anti-PD-L1 antibodies |
JP2004104681A (en) | 2002-09-12 | 2004-04-02 | Renesas Technology Corp | Input buffer circuit |
US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
JP4511943B2 (en) | 2002-12-23 | 2010-07-28 | ワイス エルエルシー | Antibody against PD-1 and use thereof |
ES2729974T3 (en) | 2003-01-23 | 2019-11-07 | Ono Pharmaceutical Co | Specific antibody of human PD-1 and CD3 |
EP2053062A1 (en) | 2004-03-24 | 2009-04-29 | Xencor, Inc. | Immunoglobin variants outside the Fc region |
CA2885854C (en) | 2004-04-13 | 2017-02-21 | F. Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
JP5848861B2 (en) | 2004-04-20 | 2016-01-27 | ジェンマブ エー/エスGenmab A/S | Human monoclonal antibody against CD20 |
US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
EP1866339B8 (en) | 2005-03-25 | 2021-12-01 | GITR, Inc. | Gitr binding molecules and uses therefor |
LT2439273T (en) | 2005-05-09 | 2019-05-10 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
JP4663394B2 (en) | 2005-05-11 | 2011-04-06 | ダイセルポリマー株式会社 | Difficult-plating coating material and plating pretreatment method |
CA2611814A1 (en) | 2005-06-20 | 2007-01-04 | Medarex, Inc. | Cd19 antibodies and their uses |
CN105330741B (en) | 2005-07-01 | 2023-01-31 | E.R.施贵宝&圣斯有限责任公司 | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
CN102875681A (en) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | Anti-alpha v beta 6 antibodies and uses thereof |
EP1820513A1 (en) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies |
US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
MX2008014804A (en) | 2006-06-02 | 2009-01-27 | Regeneron Pharma | High affinity antibodies to human il-6 receptor. |
DK2170959T3 (en) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | ANTIBODIES AGAINST HUMAN PROGRAMMED DEATH RECEPTOR PD-1 |
ES2591281T3 (en) | 2007-07-12 | 2016-11-25 | Gitr, Inc. | Combination therapies that employ GITR binding molecules |
US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
US9243052B2 (en) | 2007-08-17 | 2016-01-26 | Daniel Olive | Method for treating and diagnosing hematologic malignancies |
AU2007358569B2 (en) | 2007-09-07 | 2014-09-04 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
BRPI0907718A2 (en) | 2008-02-11 | 2017-06-13 | Curetech Ltd | method for treating a tumor, method for improving tolerability to at least one chemotherapeutic agent, method for increasing survival of an individual having a tumor, method for reducing or preventing tumor recurrence, use of a humanized monoclonal antibody or fragment and antibody thereof humanized monoclonal or fragment thereof |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Pd-1 binding proteins |
NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
WO2010029434A1 (en) | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
AU2009290544B2 (en) | 2008-09-12 | 2015-07-16 | Oxford University Innovation Limited | PD-1 specific antibodies and uses thereof |
ES2592216T3 (en) | 2008-09-26 | 2016-11-28 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1 and PD-L2 antibodies and their uses |
KR101050829B1 (en) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | Anticancer agents comprising an anti-PD-1 antibody or an anti-PD-L1 antibody |
SI2376535T1 (en) | 2008-12-09 | 2017-07-31 | F. Hoffmann-La Roche Ag | Anti-pd-l1 antibodies and their use to enhance t-cell function |
JP5844159B2 (en) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | PD-1 antibody and PD-L1 antibody and use thereof |
AU2010265933B2 (en) | 2009-06-26 | 2015-05-14 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
LT3023438T (en) | 2009-09-03 | 2020-05-11 | Merck Sharp & Dohme Corp. | Anti-gitr antibodies |
ES2681214T3 (en) | 2009-09-30 | 2018-09-12 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for cancer treatment |
JP2013512251A (en) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Simultaneous inhibition of PD-L1 / PD-L2 |
NZ599405A (en) | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
EP3095871B1 (en) | 2010-02-08 | 2019-04-10 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
JP5920929B2 (en) | 2010-03-11 | 2016-05-18 | ユセベ ファルマ ソシエテ アノニム | PD-1 antibody |
JP2013532153A (en) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | Bispecific antibodies against TIM-3 and PD-1 for immunotherapy against chronic immune disease |
EP2910572B1 (en) | 2010-11-11 | 2017-09-06 | Versitech Limited | Soluble pd-1 variants, fusion constructs, and uses thereof |
LT2699264T (en) | 2011-04-20 | 2018-07-10 | Medimmune, Llc | Antibodies and other molecules that bind b7-h1 and pd-1 |
US8686119B2 (en) | 2011-07-24 | 2014-04-01 | Curetech Ltd. | Variants of humanized immunomodulatory monoclonal antibodies |
TW201840336A (en) | 2011-08-01 | 2018-11-16 | 美商建南德克公司 | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
KR101981873B1 (en) | 2011-11-28 | 2019-05-23 | 메르크 파텐트 게엠베하 | Anti-pd-l1 antibodies and uses thereof |
GB201120527D0 (en) | 2011-11-29 | 2012-01-11 | Ucl Business Plc | Method |
CA2899433A1 (en) | 2012-01-27 | 2013-08-01 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
AU2013256010B2 (en) | 2012-05-04 | 2018-01-04 | Dana-Farber Cancer Institute, Inc. | Affinity matured anti-CCR4 humanized monoclonal antibodies and methods of use |
WO2013169693A1 (en) | 2012-05-09 | 2013-11-14 | Bristol-Myers Squibb Company | Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody |
US20130303250A1 (en) | 2012-05-11 | 2013-11-14 | Ryan Moore | Method of Playing a Card Game |
US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
EP3556776A1 (en) | 2012-05-31 | 2019-10-23 | F. Hoffmann-La Roche AG | Methods of treating cancer using pd-1 axis binding antagonists and vegf antagonists |
JOP20200236A1 (en) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof |
EA038920B1 (en) | 2012-10-02 | 2021-11-10 | Бристол-Майерс Сквибб Компани | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
WO2014066834A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
TWI682941B (en) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | Antibodies comprising chimeric constant domains |
CN109045289A (en) | 2013-02-22 | 2018-12-21 | 库瑞瓦格股份公司 | Vaccine inoculation and the combination for inhibiting PD-1 approach |
PL2970473T3 (en) | 2013-03-14 | 2018-01-31 | Bristol Myers Squibb Co | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
EP2972373B1 (en) | 2013-03-15 | 2019-10-09 | F.Hoffmann-La Roche Ag | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
RS61400B1 (en) | 2013-05-02 | 2021-02-26 | Anaptysbio Inc | Antibodies directed against programmed death-1 (pd-1) |
WO2014194293A1 (en) | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
WO2014209804A1 (en) | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
KR20160030936A (en) | 2013-07-16 | 2016-03-21 | 제넨테크, 인크. | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
JP2016531907A (en) | 2013-08-02 | 2016-10-13 | アデュロ・バイオテック・ホールディングス・ヨーロッパ・ベスローテン・フエンノートシャップAduro Biotech Holdings, Europe B.V. | Combination of CD27 agonist and immune checkpoint inhibition for immune stimulation |
AR097306A1 (en) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | MODULATION OF TUMOR IMMUNITY |
JP6586087B2 (en) | 2013-08-20 | 2019-10-02 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Cancer treatment with a combination of a PD-1 antagonist and dinacribib |
EP3178849B1 (en) | 2013-09-20 | 2019-03-20 | Bristol-Myers Squibb Company | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
SG11201602283UA (en) | 2013-09-27 | 2016-04-28 | Genentech Inc | Anti-pdl1 antibody formulations |
US10241115B2 (en) | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
DK3083689T3 (en) | 2013-12-17 | 2020-08-03 | Genentech Inc | Anti-CD3 antibodies and methods of use |
TWI680138B (en) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | Human antibodies to pd-l1 |
TWI681969B (en) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | Human antibodies to pd-1 |
JOP20200094A1 (en) * | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
TWI701042B (en) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | Methods and antibody compositions for tumor treatment |
BR112016026559A8 (en) | 2014-05-15 | 2021-07-13 | Bristol Myers Squibb Co | use of an anti-pd-1 antibody and another anticancer agent in combination with dual platinum-based (pt-dc) chemotherapy and kit |
MA47849A (en) | 2014-05-28 | 2020-01-29 | Agenus Inc | ANTI-GITR ANTIBODIES AND THEIR METHODS OF USE |
EA037006B1 (en) | 2014-06-06 | 2021-01-26 | Бристол-Майерс Сквибб Компани | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
US10092645B2 (en) * | 2014-06-17 | 2018-10-09 | Medimmune Limited | Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy |
BR112016029650A2 (en) | 2014-06-19 | 2017-10-24 | Regeneron Pharma | rodent, pd-1 polypeptide, isolated cell or rodent tissue, rodent embryonic stem cell, methods of producing a rodent, reducing tumor growth in a rodent, killing tumor cells in a rodent, and evaluating pharmacokinetic properties of a drug that targets human pd-1, and, rodent tumor model? |
TWI693232B (en) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
CU20170052A7 (en) | 2014-10-14 | 2017-11-07 | Dana Farber Cancer Inst Inc | ANTIBODY MOLECULES THAT JOIN PD-L1 |
WO2016124558A1 (en) | 2015-02-03 | 2016-08-11 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
US20180155429A1 (en) | 2015-05-28 | 2018-06-07 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
KR20180040138A (en) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of using them |
ES2954153T3 (en) | 2015-12-22 | 2023-11-20 | Regeneron Pharma | Combination of anti-PD-1 antibodies and anti-CD20/anti-CD3 bispecific antibodies to treat cancer |
US20190048085A1 (en) | 2016-02-25 | 2019-02-14 | Cell Medica Switzerland Ag | Modified cells for immunotherapy |
MX2019006448A (en) | 2016-12-01 | 2020-02-05 | Regeneron Pharma | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging. |
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