SG11202101400UA - Microsatellite instability detection in cell-free dna - Google Patents
Microsatellite instability detection in cell-free dnaInfo
- Publication number
- SG11202101400UA SG11202101400UA SG11202101400UA SG11202101400UA SG11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA SG 11202101400U A SG11202101400U A SG 11202101400UA
- Authority
- SG
- Singapore
- Prior art keywords
- cell
- free dna
- microsatellite instability
- instability detection
- detection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Evolutionary Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Data Mining & Analysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Databases & Information Systems (AREA)
- Public Health (AREA)
- Evolutionary Computation (AREA)
- Epidemiology (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726182P | 2018-08-31 | 2018-08-31 | |
| US201962823578P | 2019-03-25 | 2019-03-25 | |
| US201962857048P | 2019-06-04 | 2019-06-04 | |
| PCT/US2019/048999 WO2020047378A1 (en) | 2018-08-31 | 2019-08-30 | Microsatellite instability detection in cell-free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202101400UA true SG11202101400UA (en) | 2021-03-30 |
Family
ID=67982149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202101400UA SG11202101400UA (en) | 2018-08-31 | 2019-08-30 | Microsatellite instability detection in cell-free dna |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11773451B2 (en) |
| EP (1) | EP3844761A1 (en) |
| JP (1) | JP2021535489A (en) |
| KR (1) | KR20210052511A (en) |
| CN (1) | CN112930569A (en) |
| AU (1) | AU2019328344A1 (en) |
| CA (1) | CA3109539A1 (en) |
| SG (1) | SG11202101400UA (en) |
| WO (1) | WO2020047378A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023521555A (en) * | 2020-03-12 | 2023-05-25 | パーソナル ゲノム ダイアグノスティクス インコーポレイテッド | Microsatellite instability signature |
| JP7498793B2 (en) | 2020-03-30 | 2024-06-12 | グレイル エルエルシー | Cancer Classification with Synthetic Training Samples |
| WO2022124575A1 (en) * | 2020-12-07 | 2022-06-16 | (주)디엑솜 | Method for diagnosing microsatellite instability using coefficient of variation of sequence lengths in microsatellite loci |
| WO2023287410A1 (en) * | 2021-07-14 | 2023-01-19 | Foundation Medicine, Inc. | Methods and systems for determining microsatellite instability |
| WO2023017402A1 (en) * | 2021-08-09 | 2023-02-16 | Canexia Health Inc. | Methods for identifying microsatellite instability high (msi-h) in dna samples |
| KR20230023276A (en) * | 2021-08-10 | 2023-02-17 | (주)디엑솜 | Method of diagnosing microsatellite instability using rate of change in sequence length at microsatellite locus |
| KR20230023278A (en) * | 2021-08-10 | 2023-02-17 | (주)디엑솜 | Method of diagnosing microsatellite instability using difference between maximum and minimum value of sequence length at microsatellite locus |
| CN113744251B (en) * | 2021-09-07 | 2023-08-29 | 上海桐树生物科技有限公司 | Method for predicting microsatellite instability from pathological pictures based on self-attention mechanism |
| WO2023225560A1 (en) | 2022-05-17 | 2023-11-23 | Guardant Health, Inc. | Methods for identifying druggable targets and treating cancer |
| CN117809744A (en) * | 2023-04-21 | 2024-04-02 | 苏州吉因加生物医学工程有限公司 | Method, device and storage medium for screening MSI characteristic sites |
| CN116312781B (en) * | 2023-05-17 | 2023-08-18 | 普瑞基准科技（北京）有限公司 | Genome instability assessment method and system based on machine learning |
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| US20030017081A1 (en) | 1994-02-10 | 2003-01-23 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| CA2195562A1 (en) | 1994-08-19 | 1996-02-29 | Pe Corporation (Ny) | Coupled amplification and ligation method |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| AR021833A1 (en) | 1998-09-30 | 2002-08-07 | Applied Research Systems | METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
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| JP4106026B2 (en) | 2001-11-28 | 2008-06-25 | アプレラ コーポレイション | Selective nucleic acid isolation methods and compositions |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| CN101914620B (en) | 2004-09-17 | 2014-02-12 | 加利福尼亚太平洋生命科学公司 | Method for analysis of molecules |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US7282337B1 (en) | 2006-04-14 | 2007-10-16 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
| EP2218794A1 (en) * | 2009-02-13 | 2010-08-18 | Alphagenics International SA | Detection of instability in regions of genomic DNA containing simple tandem repeats |
| US20120135874A1 (en) * | 2009-05-08 | 2012-05-31 | The Johns Hopkins University | Single molecule spectroscopy for analysis of cell-free nucleic acid biomarkers |
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| ES2788863T3 (en) | 2010-05-14 | 2020-10-23 | Massachusetts Gen Hospital | Compositions of tumor-specific neoantigens for use in treating tumors |
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| RU2014145017A (en) * | 2012-04-10 | 2016-05-27 | Виб Взв | NEW MARKERS FOR DETECTION OF MICROSATELITE INSTABILITY IN MALIGNANT TUMOR AND DETERMINATION OF SYNTHETIC LETALITY WITH INHIBITION OF EXCISIONAL REPAIR OF DNA BASES |
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-
2019
- 2019-08-30 AU AU2019328344A patent/AU2019328344A1/en active Pending
- 2019-08-30 EP EP19769633.9A patent/EP3844761A1/en active Pending
- 2019-08-30 CA CA3109539A patent/CA3109539A1/en active Pending
- 2019-08-30 KR KR1020217009381A patent/KR20210052511A/en active Search and Examination
- 2019-08-30 WO PCT/US2019/048999 patent/WO2020047378A1/en unknown
- 2019-08-30 CN CN201980071631.3A patent/CN112930569A/en active Pending
- 2019-08-30 JP JP2021510455A patent/JP2021535489A/en active Pending
- 2019-08-30 SG SG11202101400UA patent/SG11202101400UA/en unknown
-
2020
- 2020-06-19 US US16/907,034 patent/US11773451B2/en active Active
-
2023
- 2023-08-25 US US18/456,362 patent/US20230416843A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020047378A1 (en) | 2020-03-05 |
| US20210363586A1 (en) | 2021-11-25 |
| EP3844761A1 (en) | 2021-07-07 |
| US11773451B2 (en) | 2023-10-03 |
| CN112930569A (en) | 2021-06-08 |
| US20230416843A1 (en) | 2023-12-28 |
| CA3109539A1 (en) | 2020-03-05 |
| JP2021535489A (en) | 2021-12-16 |
| KR20210052511A (en) | 2021-05-10 |
| AU2019328344A1 (en) | 2021-04-08 |
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