MD3455259T2 - Combinație de anticorpi anti-PD-1 și radiație pentru tratarea cancerului - Google Patents
Combinație de anticorpi anti-PD-1 și radiație pentru tratarea canceruluiInfo
- Publication number
- MD3455259T2 MD3455259T2 MDE20190335T MDE20190335T MD3455259T2 MD 3455259 T2 MD3455259 T2 MD 3455259T2 MD E20190335 T MDE20190335 T MD E20190335T MD E20190335 T MDE20190335 T MD E20190335T MD 3455259 T2 MD3455259 T2 MD 3455259T2
- Authority
- MD
- Moldova
- Prior art keywords
- combination
- methods
- radiation
- antibodies
- treat cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000005855 radiation Effects 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Optics & Photonics (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prezenta invenţie se referă la metode pentru tratarea, reducerea severităţii sau inhibarea creşterii cancerului (de exemplu, tumorilor solide). Metodele prezentei invenţii cuprind administrarea la un subiect, care are nevoie de aceasta, a unei cantităţi terapeutic eficiente de un antagonist al morţii programate 1 (PD-1) (de exemplu, un anticorp anti-PD-1), opţional, оn combinaţie cu radioterapie. Оn anumite variante de realizare, metodele cuprind administrarea radiaţiei hipo-fracţionate оn combinaţie cu un anticorp anti-PD-1 sau un fragment al acestuia pentru a obţine un efect abscopal prelungit оn inhibarea tumorii.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662335743P | 2016-05-13 | 2016-05-13 | |
US201662340142P | 2016-05-23 | 2016-05-23 | |
US201662348546P | 2016-06-10 | 2016-06-10 | |
US201662350305P | 2016-06-15 | 2016-06-15 | |
US201662364920P | 2016-07-21 | 2016-07-21 | |
US201662374020P | 2016-08-12 | 2016-08-12 | |
US201762451274P | 2017-01-27 | 2017-01-27 | |
PCT/US2017/032397 WO2017197259A1 (en) | 2016-05-13 | 2017-05-12 | Combination of anti-pd-1 antibodies and radiation to treat cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3455259T2 true MD3455259T2 (ro) | 2023-07-31 |
Family
ID=58800911
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20190333T MD3455258T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea unui inhibitor PD-1 |
MDE20190335T MD3455259T2 (ro) | 2016-05-13 | 2017-05-12 | Combinație de anticorpi anti-PD-1 și radiație pentru tratarea cancerului |
MDE20220619T MD3932951T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea inhibitorului PD-1 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20190333T MD3455258T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea unui inhibitor PD-1 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20220619T MD3932951T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea inhibitorului PD-1 |
Country Status (30)
Country | Link |
---|---|
US (4) | US20170327567A1 (ro) |
EP (4) | EP4180459A1 (ro) |
JP (4) | JP7054680B2 (ro) |
KR (5) | KR102349056B1 (ro) |
CN (4) | CN116407627A (ro) |
AU (2) | AU2017264959B2 (ro) |
BR (1) | BR112018073291A2 (ro) |
CA (2) | CA3023984A1 (ro) |
CL (1) | CL2018003207A1 (ro) |
CY (1) | CY1124901T1 (ro) |
DK (3) | DK3455258T3 (ro) |
ES (3) | ES2943640T3 (ro) |
FI (2) | FI3932951T3 (ro) |
HR (3) | HRP20220014T1 (ro) |
HU (3) | HUE061417T2 (ro) |
IL (3) | IL262562B2 (ro) |
LT (2) | LT3932951T (ro) |
MD (3) | MD3455258T2 (ro) |
MX (4) | MX2018013848A (ro) |
MY (1) | MY194085A (ro) |
PH (1) | PH12018502263A1 (ro) |
PL (3) | PL3932951T3 (ro) |
PT (3) | PT3932951T (ro) |
RS (3) | RS64014B1 (ro) |
SG (2) | SG10202011110PA (ro) |
SI (3) | SI3932951T1 (ro) |
TW (4) | TWI755395B (ro) |
UA (1) | UA124151C2 (ro) |
WO (2) | WO2017197259A1 (ro) |
ZA (2) | ZA201807050B (ro) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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