HRP20202082T1 - Transtiretin (ttr) irna pripravci i postupci njihove upotrebe za liječenje ili sprječavanje bolesti povezanih s ttr - Google Patents

Transtiretin (ttr) irna pripravci i postupci njihove upotrebe za liječenje ili sprječavanje bolesti povezanih s ttr Download PDF

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Publication number
HRP20202082T1
HRP20202082T1 HRP20202082TT HRP20202082T HRP20202082T1 HR P20202082 T1 HRP20202082 T1 HR P20202082T1 HR P20202082T T HRP20202082T T HR P20202082TT HR P20202082 T HRP20202082 T HR P20202082T HR P20202082 T1 HRP20202082 T1 HR P20202082T1
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HR
Croatia
Prior art keywords
subject
double
ttr
rnai agent
nucleotide
Prior art date
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HRP20202082TT
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English (en)
Croatian (hr)
Inventor
Tracy Zimmermann
Amy Chan
Vasant Jadhav
Martin Maier
Kallanthottathil G. Rajeev
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Alnylam Pharmaceuticals, Inc.
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Application filed by Alnylam Pharmaceuticals, Inc. filed Critical Alnylam Pharmaceuticals, Inc.
Publication of HRP20202082T1 publication Critical patent/HRP20202082T1/hr

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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HRP20202082TT 2015-07-31 2016-07-28 Transtiretin (ttr) irna pripravci i postupci njihove upotrebe za liječenje ili sprječavanje bolesti povezanih s ttr HRP20202082T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562199563P 2015-07-31 2015-07-31
US201662287518P 2016-01-27 2016-01-27
PCT/US2016/044359 WO2017023660A1 (en) 2015-07-31 2016-07-28 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES
EP16750567.6A EP3329002B1 (en) 2015-07-31 2016-07-28 Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated diseases

Publications (1)

Publication Number Publication Date
HRP20202082T1 true HRP20202082T1 (hr) 2021-02-19

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HRP20202082TT HRP20202082T1 (hr) 2015-07-31 2016-07-28 Transtiretin (ttr) irna pripravci i postupci njihove upotrebe za liječenje ili sprječavanje bolesti povezanih s ttr

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US (5) US10208307B2 (enExample)
EP (1) EP3329002B1 (enExample)
JP (4) JP6896703B2 (enExample)
KR (2) KR102667020B1 (enExample)
CN (2) CN108138182B (enExample)
BR (1) BR112018000542B1 (enExample)
CA (1) CA2994285A1 (enExample)
CL (1) CL2018000198A1 (enExample)
CY (1) CY1124545T1 (enExample)
DK (1) DK3329002T3 (enExample)
EA (1) EA201890394A1 (enExample)
ES (1) ES2842300T3 (enExample)
FI (1) FIC20230006I1 (enExample)
FR (1) FR23C1008I2 (enExample)
HK (1) HK1256683A1 (enExample)
HR (1) HRP20202082T1 (enExample)
HU (2) HUE051998T2 (enExample)
IL (4) IL296476B2 (enExample)
LT (2) LT3329002T (enExample)
LU (1) LUC00297I2 (enExample)
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MX (2) MX2018000981A (enExample)
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RS (1) RS61297B1 (enExample)
SG (1) SG10201912341SA (enExample)
SI (1) SI3329002T1 (enExample)
SM (1) SMT202100020T1 (enExample)
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UA (1) UA126276C2 (enExample)
WO (1) WO2017023660A1 (enExample)
ZA (2) ZA201800571B (enExample)

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WO2013075035A1 (en) 2011-11-18 2013-05-23 Alnylam Pharmaceuticals Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
HK1200191A1 (en) 2011-11-18 2015-07-31 Alnylam Pharmaceuticals, Inc. Modified rnai agents
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
KR20240148947A (ko) 2012-07-13 2024-10-11 웨이브 라이프 사이언시스 리미티드 키랄 제어
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
ES2917473T3 (es) 2014-01-16 2022-07-08 Wave Life Sciences Ltd Diseño quiral
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JOP20210043A1 (ar) * 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
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BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
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JP2023548005A (ja) * 2020-10-28 2023-11-15 ノヴォ ノルディスク アー／エス 抗トランスサイレチン抗体およびその使用方法
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EP4351541A2 (en) 2021-06-08 2024-04-17 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders
CA3227852A1 (en) 2021-08-03 2023-02-09 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof
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