JP2018523655A5 - - Google Patents
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- JP2018523655A5 JP2018523655A5 JP2018504819A JP2018504819A JP2018523655A5 JP 2018523655 A5 JP2018523655 A5 JP 2018523655A5 JP 2018504819 A JP2018504819 A JP 2018504819A JP 2018504819 A JP2018504819 A JP 2018504819A JP 2018523655 A5 JP2018523655 A5 JP 2018523655A5
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- Prior art keywords
- double
- rnai agent
- nucleotide
- stranded rnai
- seq
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021096344A JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2023199064A JP7711150B2 (ja) | 2015-07-31 | 2023-11-24 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2025115513A JP2025165939A (ja) | 2015-07-31 | 2025-07-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199563P | 2015-07-31 | 2015-07-31 | |
| US62/199,563 | 2015-07-31 | ||
| US201662287518P | 2016-01-27 | 2016-01-27 | |
| US62/287,518 | 2016-01-27 | ||
| PCT/US2016/044359 WO2017023660A1 (en) | 2015-07-31 | 2016-07-28 | TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096344A Division JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523655A JP2018523655A (ja) | 2018-08-23 |
| JP2018523655A5 true JP2018523655A5 (enExample) | 2019-08-29 |
| JP6896703B2 JP6896703B2 (ja) | 2021-06-30 |
Family
ID=56682264
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504819A Active JP6896703B2 (ja) | 2015-07-31 | 2016-07-28 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2021096344A Active JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2023199064A Active JP7711150B2 (ja) | 2015-07-31 | 2023-11-24 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2025115513A Pending JP2025165939A (ja) | 2015-07-31 | 2025-07-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096344A Active JP7417559B2 (ja) | 2015-07-31 | 2021-06-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2023199064A Active JP7711150B2 (ja) | 2015-07-31 | 2023-11-24 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
| JP2025115513A Pending JP2025165939A (ja) | 2015-07-31 | 2025-07-09 | ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法 |
Country Status (35)
Families Citing this family (35)
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| TWI865997B (zh) | 2016-12-16 | 2024-12-11 | 美商阿尼拉製藥公司 | 使用甲狀腺素運載蛋白（ＴＴＲ）ｉＲＮＡ組成物於治療或預防ＴＴＲ相關疾病之方法 |
| EP3684931A1 (en) | 2017-09-19 | 2020-07-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating transthyretin (ttr) mediated amyloidosis |
| CA3114396A1 (en) | 2018-09-28 | 2020-04-02 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| EP4022062A1 (en) | 2019-08-30 | 2022-07-06 | Alnylam Pharmaceuticals, Inc. | Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy |
| EP4055165A1 (en) | 2019-11-06 | 2022-09-14 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| AU2021232029A1 (en) | 2020-03-06 | 2022-10-06 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin (TTR) |
| JP2024518374A (ja) | 2021-05-03 | 2024-05-01 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | トランスサイレチン（ｔｔｒ）媒介性アミロイドーシスを治療するための組成物および方法 |
| JP2024523000A (ja) | 2021-06-08 | 2024-06-25 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | シュタルガルト病及び／又は網膜結合タンパク質４（ｒｂｐ４）関連障害を治療又は予防するための組成物及び方法 |
| AR126675A1 (es) | 2021-08-03 | 2023-11-01 | Alnylam Pharmaceuticals Inc | COMPOSICIONES DE ARNi CONTRA LA TRANSTIRRETINA (TTR) Y SUS MÉTODOS DE USO |
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