HRP20190475T1 - Antitijela koja sadrže ne-prirodne aminokiselinske ostatke specifične za mjesto, metode njihovog pripremanja i metode njihove primjene - Google Patents
Antitijela koja sadrže ne-prirodne aminokiselinske ostatke specifične za mjesto, metode njihovog pripremanja i metode njihove primjene Download PDFInfo
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- HRP20190475T1 HRP20190475T1 HRP20190475TT HRP20190475T HRP20190475T1 HR P20190475 T1 HRP20190475 T1 HR P20190475T1 HR P20190475T T HRP20190475T T HR P20190475TT HR P20190475 T HRP20190475 T HR P20190475T HR P20190475 T1 HRP20190475 T1 HR P20190475T1
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- Prior art keywords
- antibody
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- amino acid
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- therapeutic
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- 125000000539 amino acid group Chemical group 0.000 title claims 5
- -1 amino, carboxy, acetyl Chemical group 0.000 claims 4
- 238000002372 labelling Methods 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 230000006334 disulfide bridging Effects 0.000 claims 2
- 125000004474 heteroalkylene group Chemical group 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 2
- 229940127121 immunoconjugate Drugs 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000001439 semicarbazido group Chemical group [H]N([H])C(=O)N([H])N([H])* 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 230000004989 O-glycosylation Effects 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 238000004873 anchoring Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 230000029226 lipidation Effects 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000004481 post-translational protein modification Effects 0.000 claims 1
- 230000013823 prenylation Effects 0.000 claims 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (13)
1. Antitijelo IgG klase koje sadrži polipeptidni lanac koji ima jedan ili više ne-prirodnih aminokiselinskih ostataka na specifičnim mjestima odabranih iz grupe koja se sastoji od ostatka L7 lakog lanca u skladu sa Kabat ili Chothia shemom numeriranja, ostataka H404, H121, H180, i H136 teškog lanca u skladu sa EU shemom numeriranja, ili njihove post-translacijske modificirane varijante, gdje post-translacijska modifikacija je međulančano disulfidno vezivanje, međulančano disulfidno vezivanje, N-vezana glikozilacija, fosforilacija, O-vezana glikozilacija, metilacija, acetilacija, lipidacija, GPI usidravanje, miristilacija ili prenilacija.
2. Antitijelo iz patentnog zahtjeva 1, koje sadrži polipeptidni lanac koji ima najmanje 70%, 80% ili 90% homologije sa SEK ID BR:1 i koji ima jedan ili više ne-prirodnih aminokiselinskih ostataka na specifičnim mjestima odabranim iz grupe koja se sastoji od mjesta koja odgovaraju ostacima 407, 124, 183, i 139 reprezentativnog polipeptida teškog lanca u skladu sa SEK ID BR:1, ili njihovu post-translacijsku modificiranu varijantu, kao što je definirano u patentnom zahtjevu 1.
3. Antitijelo iz bilo kojeg od prethodnih patentnih zahtjeva gdje spomenuti polipeptidni lanac je laki lanac tipa odabranog od λ i κ.
4. Antitijelo iz bilo kojeg od prethodnih patentnih zahtjeva koje je podklase odabrane iz grupe koja se sastoji od IgG1, IgG2, IgG3, i IgG4.
5. Antitijelo iz bilo kojeg od prethodnih patentnih zahtjeva gdje spomenuti ne-prirodni aminokiselinski ostatak sadrži segment odabran iz grupe koja se sastoji od amino, karboksi, acetil, hidrazino, hidrazido, semikarbazido, sulfanil, azido i alkinil.
6. Antitijelo iz bilo kojeg od prethodnih patentnih zahtjeva gdje svaki ne-prirodni aminokiselinski ostatak je u skladu sa formulom
gdje svako L je nezavisno divalentni veznik; i
svako R je nezavisno funkcionalna grupa.
7. Antitijelo iz patentnog zahtjeva 6 gdje R je reaktivna grupa, terapijski segment ili segment za obilježavanje, opcionalno gdje svako R je reaktivna grupa odabrana od grupe koja se sastoji od amino, karboksi, acetil, hidrazino, hidrazido, semikarbazido, sulfanil, azido i alkinil, opcionalno gdje svako L je divalentni veznik odabran od grupe koja se sastoji od veze, alkilena, supstituisanog alkilena, heteroalkilena, supstituisanog heteroalkilena, arilena, supstituisanog arilena, heteroarilena i supstituisanog heteroarilena.
8. Antitijelo iz bilo kojeg od patentnih zahtjeva 1 do 7, gdje antitijelo je humano ili humanizirano antitijelo.
9. Konjugat antitijela koji sadrži antitijelo iz bilo kojeg od prethodnih patentnih zahtjeva vezano za jedan ili više terapijskih segmenata ili segmenata za obilježavanje.
10. Konjugat antitijela iz patentnog zahtjeva 9 koji sadrži spomenuto antitijelo vezano za jedan ili više lijekova ili polimera, jedan ili više terapijskih segmenata ili segmenata za obilježavanje, ili jedan ili više jednolančanih vezujućih domena (scFv), opcionalno gdje spomenuto antitijelo je vezano za spomenuti jedan ili više terapijskih segmenata ili segmenata za obilježavanje preko jednog ili više veznika.
11. Kompozicija koja sadrži antitijelo iz bilo kojeg od patentnih zahtjeva 1 do 8, gdje spomenuta kompozicija je suštinski čista.
12. Kompozicija koja sadrži antitijelo iz bilo kojeg od patentnih zahtjeva 1 do 8 gdje spomenuto antitijelo je najmanje 95% po masi ukupne mase antitijela spomenute kompozicije.
13. Antitijelo u skladu sa bilo kojim od patentnih zahtjeva 1 do 8, za primjenu u terapiji.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261657556P | 2012-06-08 | 2012-06-08 | |
US201261725433P | 2012-11-12 | 2012-11-12 | |
PCT/US2013/044843 WO2013185115A1 (en) | 2012-06-08 | 2013-06-07 | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
EP13730764.1A EP2859017B1 (en) | 2012-06-08 | 2013-06-07 | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
Publications (1)
Publication Number | Publication Date |
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HRP20190475T1 true HRP20190475T1 (hr) | 2019-05-31 |
Family
ID=48670845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190475TT HRP20190475T1 (hr) | 2012-06-08 | 2019-03-11 | Antitijela koja sadrže ne-prirodne aminokiselinske ostatke specifične za mjesto, metode njihovog pripremanja i metode njihove primjene |
Country Status (18)
Country | Link |
---|---|
US (3) | US9738724B2 (hr) |
EP (2) | EP2859017B1 (hr) |
JP (1) | JP6498600B2 (hr) |
KR (1) | KR102172897B1 (hr) |
CN (1) | CN104583235B (hr) |
AU (1) | AU2013270684B2 (hr) |
BR (1) | BR112014030278A2 (hr) |
CA (1) | CA2875989A1 (hr) |
DK (1) | DK2859017T3 (hr) |
ES (1) | ES2718478T3 (hr) |
HK (1) | HK1203518A1 (hr) |
HR (1) | HRP20190475T1 (hr) |
HU (1) | HUE043552T2 (hr) |
IL (1) | IL236111B (hr) |
PL (1) | PL2859017T3 (hr) |
SG (1) | SG11201408161RA (hr) |
SI (1) | SI2859017T1 (hr) |
WO (1) | WO2013185115A1 (hr) |
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KR20150008171A (ko) * | 2012-05-10 | 2015-01-21 | 자임워크스 인코포레이티드 | 단일군 일가 항체 구조물 및 그의 용도 |
EP2859017B1 (en) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
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WO2014036492A1 (en) | 2012-08-31 | 2014-03-06 | Sutro Biopharma, Inc. | Modified amino acids comprising an azido group |
AU2014214751B2 (en) | 2013-02-08 | 2017-06-01 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
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HUE043552T2 (hu) | 2019-09-30 |
EP3505534A1 (en) | 2019-07-03 |
IL236111A0 (en) | 2015-01-29 |
AU2013270684B2 (en) | 2018-04-19 |
JP6498600B2 (ja) | 2019-04-10 |
CN104583235B (zh) | 2019-03-01 |
DK2859017T3 (da) | 2019-05-13 |
US20170362334A1 (en) | 2017-12-21 |
EP2859017A1 (en) | 2015-04-15 |
BR112014030278A2 (pt) | 2017-06-27 |
KR102172897B1 (ko) | 2020-11-02 |
US10669347B2 (en) | 2020-06-02 |
WO2013185115A1 (en) | 2013-12-12 |
US9738724B2 (en) | 2017-08-22 |
IL236111B (en) | 2019-03-31 |
SI2859017T1 (sl) | 2019-05-31 |
JP2015518905A (ja) | 2015-07-06 |
US11958909B2 (en) | 2024-04-16 |
SG11201408161RA (en) | 2015-01-29 |
KR20150023630A (ko) | 2015-03-05 |
ES2718478T3 (es) | 2019-07-02 |
PL2859017T3 (pl) | 2019-07-31 |
HK1203518A1 (en) | 2015-10-30 |
EP2859017B1 (en) | 2019-02-20 |
AU2013270684A1 (en) | 2015-01-22 |
CA2875989A1 (en) | 2013-12-12 |
US20200299403A1 (en) | 2020-09-24 |
US20140046030A1 (en) | 2014-02-13 |
CN104583235A (zh) | 2015-04-29 |
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