HRP20200887T1 - Smjese za inhibiciju masp-2 ovisne aktivacije komplementa - Google Patents
Smjese za inhibiciju masp-2 ovisne aktivacije komplementa Download PDFInfo
- Publication number
- HRP20200887T1 HRP20200887T1 HRP20200887TT HRP20200887T HRP20200887T1 HR P20200887 T1 HRP20200887 T1 HR P20200887T1 HR P20200887T T HRP20200887T T HR P20200887TT HR P20200887 T HRP20200887 T HR P20200887T HR P20200887 T1 HRP20200887 T1 HR P20200887T1
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- Prior art keywords
- antibody
- masp
- fragment
- antigen
- nucleic acid
- Prior art date
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- 230000001419 dependent effect Effects 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title claims 2
- 230000000295 complement effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000012634 fragment Substances 0.000 claims 9
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 claims 4
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 101001056015 Homo sapiens Mannan-binding lectin serine protease 2 Proteins 0.000 claims 1
- -1 according to claim 1 Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000054960 human MASP2 Human genes 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (11)
1. Izolirano humano monoklonsko protutijelo, ili njegov antigen vezujući fragment, koji veže humani MASP-2 i inhibira MASP-2 ovisnu aktivaciju komplementa, pri čemu protutijelo ili njegov antigen vezujući fragment sadrži:
a) varijabilno područje teškog lanca koji sadrži aminokiselinu navedenu u SEQ ID NO: 20; i
b) varijabilno područje lakog lanca koji sadrži aminokiselinsku sekvencu navedenu u SEQ ID NO: 24.
2. Protutijelo ili njegov fragment sukladno zahtjevu 1, pri čemu su protutijelo ili njegov antigen vezujući fragment izabrani iz skupine sastavljene od Fv, Fab, Fab’, F(ab)2, F(ab’)2, jednolančanog protutijela, ScFv, univalentnog protutijela kojem nedostaje područje zgloba i cijelog protutijela.
3. Protutijelo ili njegov fragment sukladno zahtjevu 1, pri čemu je navedeno protutijelo izabrano iz skupine sastavljene od IgG2 molekula, i IgG1 molekula i IgG4 molekula.
4. Protutijelo ili njegov fragment sukladno zahtjevu 3, pri čemu IgG4 molekula sadrži S228P mutaciju.
5. Molekula nukleinske kiseline koji kodira aminokiselinsku sekvencu MASP-2 protutijela, ili njegov antigen vezujući fragment, sukladno zahtjevu 1.
6. Ekspresijska traka koja sadrži molekulu nukleinske kiseline koji kodira MASP-2 protutijelo sukladno pronalasku u patentnom zahtjevu 5.
7. Stanica koja sadrži najmanje jednu od molekula nukleinske kiseline koji kodiraju MASP-2 protutijelo sukladno zahtjevu 1, sukladno zahtjevu 5 ili zahtjevu 6.
8. Postupak za generiranje izoliranje anti-MASP-2 protutijela koji sadrži kultivaciju stanice sukladno zahtjevu 7 pod uvjetima koji dozvoljavaju ekspresiju molekula nukleinske kiseline koji kodiraju anti-MASP-2 protutijelo sukladno zahtjevu 1 i izoliranje navedenog anti-MASP-2 protutijela.
9. Farmaceutski sastav koja sadrži humano monoklonsko anti-MASP-2 protutijelo, ili njegov fragment, sukladno zahtjevu 1, i farmaceutski prihvatljiv ekscipijens.
10. Farmaceutski sastav sukladno zahtjevu 9, pri čemu je sastav formuliran za intra-arterijsku, intravensku, intrakranijalnu, intramuskularnu, inhalacijsku, nazalnu ili subkutanu primjenu.
11. Farmaceutski sastav sukladno zahtjevu 9 koja sadrži jediničnu dozu od 1 mg do 1000 mg izoliranog protutijela ili njegovog fragmenta sukladno zahtjevu 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482567P | 2011-05-04 | 2011-05-04 | |
| PCT/US2012/036509 WO2012151481A1 (en) | 2011-05-04 | 2012-05-04 | Compositions for inhibiting masp-2 dependent complement acitivation |
| EP12779347.9A EP2704743B1 (en) | 2011-05-04 | 2012-05-04 | Compositions for inhibiting masp-2 dependent complement acitivation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200887T1 true HRP20200887T1 (hr) | 2020-09-04 |
Family
ID=47090380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200887TT HRP20200887T1 (hr) | 2011-05-04 | 2020-06-02 | Smjese za inhibiciju masp-2 ovisne aktivacije komplementa |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US9011860B2 (hr) |
| EP (2) | EP3725811A3 (hr) |
| JP (5) | JP5891298B2 (hr) |
| KR (3) | KR101641057B1 (hr) |
| CN (2) | CN107011443B (hr) |
| AU (1) | AU2012250627B2 (hr) |
| BR (1) | BR112013028429B1 (hr) |
| CA (3) | CA3131223C (hr) |
| CL (1) | CL2013003140A1 (hr) |
| CY (1) | CY1123212T1 (hr) |
| DK (1) | DK2704743T3 (hr) |
| ES (1) | ES2795667T3 (hr) |
| HR (1) | HRP20200887T1 (hr) |
| HU (1) | HUE049154T2 (hr) |
| IL (4) | IL229208B (hr) |
| LT (1) | LT2704743T (hr) |
| ME (1) | ME03755B (hr) |
| MX (3) | MX361175B (hr) |
| PL (1) | PL2704743T3 (hr) |
| PT (1) | PT2704743T (hr) |
| RS (1) | RS60541B1 (hr) |
| RU (3) | RU2636038C2 (hr) |
| SI (1) | SI2704743T1 (hr) |
| WO (1) | WO2012151481A1 (hr) |
| ZA (1) | ZA201308943B (hr) |
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| AU2008304778B9 (en) | 2007-09-26 | 2014-05-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
| EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| WO2012073992A1 (ja) | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | 複数分子の抗原に繰り返し結合する抗原結合分子 |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| CA3237802A1 (en) | 2011-04-08 | 2012-10-11 | Omeros Corporation | Methods for treating conditions associated with masp-2 dependent complement activation |
| MX361175B (es) * | 2011-05-04 | 2018-11-29 | Omeros Corp | Composiciones para inhibir la activación del complemento dependiente de la masp-2. |
| EP2889376A4 (en) | 2012-08-24 | 2016-11-02 | Chugai Pharmaceutical Co Ltd | ANTIBODIES Fc SPECIFIC TO FCTRII OF MOUSE |
| CN110818798A (zh) | 2012-10-25 | 2020-02-21 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
| HRP20220637T1 (hr) | 2012-11-02 | 2022-06-24 | Bioverativ Usa Inc. | Protutijela anti-komplementa c1s i njihova upotreba |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| NZ729747A (en) * | 2013-03-15 | 2020-03-27 | Omeros Corp | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| CN113621057A (zh) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc区变体 |
| HUE051746T2 (hu) * | 2013-10-17 | 2021-03-29 | Omeros Corp | Eljárások MASP-2-függõ komplement aktiválással kapcsolatos állapotok kezelésére |
| UA127961C2 (uk) | 2014-12-19 | 2024-02-28 | Чугей Сейяку Кабусікі Кайся | Антитіло до латентного міостатину |
| JP2018510842A (ja) | 2015-02-05 | 2018-04-19 | 中外製薬株式会社 | イオン濃度依存的抗原結合ドメインを含む抗体、Ｆｃ領域改変体、ＩＬ−８に結合する抗体、およびその使用 |
| EA201792080A1 (ru) | 2015-04-06 | 2018-03-30 | БИОВЕРАТИВ ЮЭсЭй ИНК. | Гуманизированные анти-c1s антитела и способы их применения |
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| IL259225B (en) | 2015-11-09 | 2022-09-01 | Omeros Corp | Preparations containing antibodies that suppress masp-2 and antigen-binding fragments for use in the treatment of tma associated with hematopoietic stem cell transplantation |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN117503923A (zh) | 2016-01-05 | 2024-02-06 | 莱斯特大学 | 用于抑制有需要的受试者的纤维化的方法 |
| WO2017173290A1 (en) | 2016-03-31 | 2017-10-05 | Omeros Corporation | Methods for inhibiting angiogenesis in a subject in need thereof |
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| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
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| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| TR201708554T4 (tr) | 2004-06-10 | 2019-02-21 | Omeros Corp | Masp-2 ye bağlı tamamlayıcı aktivasyon ile ilişkili durumların tedavisi için yöntemler. |
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| MX361175B (es) * | 2011-05-04 | 2018-11-29 | Omeros Corp | Composiciones para inhibir la activación del complemento dependiente de la masp-2. |
| NZ781091A (en) * | 2012-04-06 | 2022-04-29 | Omeros Corp | Compositions and methods of inhibiting masp-1, masp-2 and/or masp-3 for treatment of paroxysmal nocturnal hemoglobinuria |
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