HRP20170287T1 - Makrociklički derivati, namijenjeni liječenju proliferativnih bolesti - Google Patents
Makrociklički derivati, namijenjeni liječenju proliferativnih bolesti Download PDFInfo
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- HRP20170287T1 HRP20170287T1 HRP20170287TT HRP20170287T HRP20170287T1 HR P20170287 T1 HRP20170287 T1 HR P20170287T1 HR P20170287T T HRP20170287T T HR P20170287TT HR P20170287 T HRP20170287 T HR P20170287T HR P20170287 T1 HRP20170287 T1 HR P20170287T1
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- Prior art keywords
- nr9r10
- cr5r6
- nr9c
- alkyl
- cycloalkyl
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- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 36
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 34
- 229910052739 hydrogen Inorganic materials 0.000 claims 33
- 239000001257 hydrogen Substances 0.000 claims 33
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 30
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 27
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims 23
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 150000002431 hydrogen Chemical group 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 3
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 2
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- 206010023774 Large cell lung cancer Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical group C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical group C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical group C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- 201000009546 lung large cell carcinoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 150000003536 tetrazoles Chemical group 0.000 claims 1
- 150000003852 triazoles Chemical group 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (17)
1. Spoj formule (I)
[image]
,
naznačen time što:
X se bira iz skupine koju čine -(CR5R6)qO(CR5R6)r-, -(CR5R6)qN(R1)(CR5R6)r-, -(CR5R6)qC(O)N(R1)(CR5R6)r- i -(CR5R6)qN(R1)C(O)(CR5R6)r-;
svako od Y i Z je neovisno N ili CH, uz uvjet da kada je Y N, Z je CH i kada je Z N, Y je CH;
A je prsten, kojeg se bira između C6-C12 arila i 5-6-eročlanog heteroarila;
R1 se bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl i 5-6-eročlani heteroaril, gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R2 se neovisno bira iz skupine koju čine halogen, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl, 5-6-eročlani heteroaril, -S(O)tR7, -S(O)2NR7R8, -S(O)2OR7, -NO2, -(CR5R6)qNR7R8, -N(CR5R6)(CR5R6)qNR7R8, -OR7, -O(CR5R6)(CR5R6)qOR7, -O(CR5R6)(CR5R6)qR7, -CN, -C(O)R7, -OC(O)R7, -O(CR5R6)qR7, -NR7C(O)R8, -(CR5R6)qC(O)OR7, -(CR5R6)qNR7R8, -C(=NR7)NR7R8, -NR7C(O)NR7R8, -NR7S(O)2R8 i -(CR5R6)qC(O)NR7R8; gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH,-NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog od R3 i R4 se neovisno bira između vodika, C1-C6 alkila i C3-C6 cikloalkila, gdje svaki vodik na C1-C6 alkilu i C3-C6 cikloalkilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R5 i R6 se neovisno bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl, 5-6-eročlani heteroaril, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 i -C(O)NR9R10; gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R7 i R8 se neovisno bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl i 5-6-eročlani heteroaril, gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R9 i R10 se neovisno bira između vodika, C1-C6 alkila, C2-C6 alkenila, C2-C6 alkinila, C3-C6 cikloalkila, C6-C12 arila, 3-12-eročlanog heteroalicikla i 5-6-eročlanog heteroarila;
m je 0, 1, 2 ili 3;
n je 0, 1, 2 ili 3;
p je 0,1,2, 3 ili 4;
svaki q je neovisno 0, 1, 2 ili 3;
svaki r je neovisno 0, 1, 2 ili 3; i
svaki t je neovisno 0, 1 ili 2;
ili njegova farmaceutski prihvatljiva sol.
2. Spoj u skladu s patentnim zahtjevom 1 formule (V)
[image]
,
naznačen time što:
A je prsten, kojeg se bira između C6-C12 arila i 5-6-eročlanog heteroarila;
R1 se bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl i 5-6-eročlani heteroaril, gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2R9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, --C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R2 se neovisno bira iz skupine koju čine halogen, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl, 5-6-eročlani heteroaril, -S(O)tR7, -S(O)2NR7R8, -S(O)2OR7, -NO2, -(CR5R6)qNR7R8, -N(CR5R6)(CR5R6)qNR1R8, -OR7, -O(CR5R6)(CR5R6)qOR7, -O(CR5R6)(CR5R6)qR7, -CN, -C(O)R7, -OC(O)R7, -O(CR5R6)qR7, -NR7C(O)R8, -(CR5R6)qC(O)OR7, -(CR5R6)qNR7R8, -C(=NR7)NR7 R8, -NR7C(O)NR7R8, -NR7S(O)2R8 i -(CR5R6)qC(O)NR7R8; gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog od R3 i R4 se neovisno bira između vodika, C1-C6 alkila i C3-C6 cikloalkila, gdje svaki vodik na C1-C6 alkilu i C3-C6 cikloalkilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10);
svakog R5 i R6 se neovisno bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl, 5-6-eročlani heteroaril, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 i -C(O)NR9R10; gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R7 i R8 se neovisno bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl i 5-6-eročlani heteroaril, gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2 -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R9 i R10 se neovisno bira između vodika, C1-C6 alkila, C2-C6 alkenila, C2-C6 alkinila, C3-C6 cikloalkila, C6-C12 arila, 3-12-eročlanog heteroalicikla i 5-6-eročlanog heteroarila;
p je 0, 1, 2, 3 ili 4;
svaki q je neovisno 0, 1, 2 ili 3; i
svaki t je neovisno 0, 1 ili 2;
ili njegova farmaceutski prihvatljiva sol.
3. Spoj u skladu s patentnim zahtjevom 1 formule (VI)
[image]
,
naznačen time što:
A je prsten, kojeg se bira između C6-C12 arila i 5-6-eročlanog heteroarila;
R1 se bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl i 5-6-eročlani heteroaril, gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R2 se neovisno bira iz skupine koju čine halogen, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl, 5-6-eročlani heteroaril, -S(O)tR7, -S(O)2NR7R8, -S(O)3OR7, -NO2, -(CR5R6)qNR7R8, -N(CR5R6)(CR5R6)qNR7R8, -OR7, -O(CR5R6)(CR5R6)qOR7, -O(CR5R6)(CR5R6)qR7, -CN, -C(O)R7, -OC(O)R7, -O(CR5R6)qR7, -NR7C(O)R8, -(CR5R6)qC(O)OR7, -(CR5R6)qNR7R8, -C(=NR7)NR7R8, -NR7C(O)NR7R8, -NR7S(O)2R8 i -(CR5R6)qC(O)NR7R8; gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH,-NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog od R3 i R4 se neovisno bira između vodika, C1-C6 alkila i C3-C6 cikloalkila, gdje svaki vodik na C1-C6 alkilu i C3-C6 cikloalkilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R5 i R6 se neovisno bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl, 5-6-eročlani heteroaril, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 i -C(O)NR9R10; gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -CN, -OR9, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R7 i R8 se neovisno bira iz skupine koju čine vodik, C1-C6 alkil, C2-C6 alkenil, C2-C6 alkinil, C3-C6 cikloalkil, C6-C12 aril, 3-12-eročlani heteroalicikl i 5-6-eročlani heteroaril, gdje svaki vodik na navedenom C1-C6 alkilu, C2-C6 alkenilu, C2-C6 alkinilu, C3-C6 cikloalkilu, C6-C12 arilu, 3-12-eročlanom heteroaliciklu i 5-6-eročlanom heteroarilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10;
svakog R9 i R10 se neovisno bira između vodika, C1-C6 alkila, C2-C6 alkenila, C2-C6 alkinila, C3-C6 cikloalkila, C6-C12 arila, 3-12-eročlanog heteroalicikla i 5-6-eročlanog heteroarila;
p je 0, 1, 2, 3 ili 4;
svaki q je neovisno 0, 1, 2 ili 3; i
svaki t je neovisno 0, 1 ili 2;
ili njegova farmaceutski prihvatljiva sol.
4. Spoj u skladu s patentnim zahtjevom 1, 2 ili 3, naznačen time što se R1 bira iz skupine koju čine vodik, C1-C6 alkil i C3-C6 cikloalkil, ili njegova farmaceutski prihvatljiva sol.
5. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što svakog R2 se neovisno bira iz skupine koju čine C1-C6 alkil, C3-C6 cikloalkil, -S(O)tR7, -S(O)2NR7R8, -OR7, -O(CR5R6)(CR5R6)qOR7, -O(CR5R6)(CR5R6)qR7 i -CN; gdje svaki vodik na navedenom C1-C6 alkilu i C3-C6 cikloalkilu može biti neovisno izborno supstituiran halogenom, -OH, -NH2, -S(O)tR9, -S(O)2NR9R10, -S(O)2OR9, -NO2, -OR9, -CN, -C(O)R9, -OC(O)R9, -NR9C(O)R10, -C(O)OR9, -C(=NR9)NR9R10, -NR9C(O)NR9R10, -NR9S(O)2R10 ili -C(O)NR9R10, ili njegova farmaceutski prihvatljiva sol.
6. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što je A prsten kojeg se bira iz skupine koju čine fenil, piridin, pirimidin, piridazin, pirazin, triazin, pirazol, imidazol, triazol, tetrazol, tiazol, izotiazol, oksazol i izoksazol, ili njegova farmaceutski prihvatljiva sol.
7. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što se svakog od R3 i R4 neovisno bira iz skupine koju čine vodik i C1-C6 alkil, ili njegova farmaceutski prihvatljiva sol.
8. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je (10R)-7-amino-12-fluor-2,10,16-trimetil-15-okso-10,15,16,17-tetrahidro-2H-8,4-(meteno)pirazolo[4,3-h][2,5,11]benzoksadiazaciklotetradecin-3-karbonitril, ili njegova farmaceutski prihvatljiva sol.
9. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je (10R)-7-amino-12-fluor-2,10,16-trimetil-15-okso-10,15,16,17-tetrahidro-2H-8,4-(meteno)pirazolo[4,3-h][2,5,11]benzoksadiazaciklotetradecin-3-karbonitril.
10. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol, kao i farmaceutski prihvatljivu podlogu ili pomoćnu tvar.
11. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi kao medikament, po mogućnosti u liječenju raka kod sisavca.
12. Spoj u skladu s patentnim zahtjevom 11, naznačen time što je rak posredovan kinazom iz anaplastičnog limfoma (ALK).
13. Spoj u skladu s patentnim zahtjevom 11, naznačen time što je rak posredovan fuzijskim proteinom EML4-ALK.
14. Spoj u skladu s patentnim zahtjevom 11, naznačen time što je rak posredovan fuzijskim proteinom EML4-ALK, koji ima najmanje jednu mutaciju.
15. Spoj u skladu s patentnim zahtjevom 14, naznačen time što je navedena mutacija L1196M ili C1156Y.
16. Spoj u skladu s bilo kojim od patentnih zahtjeva 11 do 15, naznačen time što se rak bira iz skupine koju čine rak velikih stanica pluća (NSCLC), karcinom pločastih stanica, rak prostate neosjetljiv na hormone, karcinom papilarnih stanica bubrega, kolorektalni adenokarcinom, neuroblastomi, anaplastični limfom velikih stanica (ALCL) i rak želuca.
17. Kombinacija, naznačena time što je kombinacija spoja u skladu s bilo kojim od patentnih zahtjeva 1 do 9, ili njegove farmaceutski prihvatljive soli, s dodatnim sredstvom protiv raka.
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