MD20140086A2 - Derivaţi macrociclici pentru tratamentul bolilor proliferative - Google Patents

Derivaţi macrociclici pentru tratamentul bolilor proliferative Download PDF

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Publication number
MD20140086A2
MD20140086A2 MDA20140086A MD20140086A MD20140086A2 MD 20140086 A2 MD20140086 A2 MD 20140086A2 MD A20140086 A MDA20140086 A MD A20140086A MD 20140086 A MD20140086 A MD 20140086A MD 20140086 A2 MD20140086 A2 MD 20140086A2
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MD
Moldova
Prior art keywords
treatment
compounds
proliferative diseases
salts
macrocyclic derivatives
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MDA20140086A
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English (en)
Moldavian (mo)
Russian (ru)
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MD4590B1 (ro
MD4590C1 (ro
Inventor
Саймон Бейли
Бенджамин Джозеф БЁРК
Майкл Раймонд КОЛЛИНС
Цзинжун Джин Цуй
Джудит Гейл Дил
Роберт Луис Хоффман
Циньхуа Хуан
Тед Уильям ДЖОНСОН
Роберт Стивен Кания
Джон Чарльз Кат
Фыонг Тхи Куи Ле
Мишель Энн Мактиг
Синтия Луиза Палмер
Пол Фрэнсис Ричардсон
Нил Уильям СЕЙЧ
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Pfizer Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48142828&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20140086(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20140086A2 publication Critical patent/MD20140086A2/ro
Publication of MD4590B1 publication Critical patent/MD4590B1/ro
Publication of MD4590C1 publication Critical patent/MD4590C1/ro

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Invenţia se referă la compuşi cu formula (Φ)cu semnificaţiile definite în continuare în documentul dat şi la sărurile farmaceutice acceptabile ale acestora, la compoziţii farmaceutice ce conţin compuşii (Φ) şi sărurile lor şi la utilizarea acestora. Compuşii şi sărurile (Φ) inhibă kinaza limfomului anaplastic (ALK) şi/sau EML4-ALK şi sunt utili pentru tratamentul sau ameliorarea tulburarilor proliferative celulare anormale, cum ar fi cancerul.
MDA20140086A 2012-03-06 2013-02-20 Derivaţi macrociclici pentru tratamentul bolilor proliferative MD4590C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261607485P 2012-03-06 2012-03-06
US201361759307P 2013-01-31 2013-01-31
PCT/IB2013/051391 WO2013132376A1 (en) 2012-03-06 2013-02-20 Macrocyclic derivatives for the treatment of proliferative diseases

Publications (3)

Publication Number Publication Date
MD20140086A2 true MD20140086A2 (ro) 2015-01-31
MD4590B1 MD4590B1 (ro) 2018-08-31
MD4590C1 MD4590C1 (ro) 2019-03-31

Family

ID=48142828

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140086A MD4590C1 (ro) 2012-03-06 2013-02-20 Derivaţi macrociclici pentru tratamentul bolilor proliferative

Country Status (45)

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US (2) US8680111B2 (ro)
EP (1) EP2822953B9 (ro)
JP (2) JP5823066B2 (ro)
KR (1) KR101692600B1 (ro)
CN (1) CN104169286B (ro)
AP (1) AP2014007881A0 (ro)
AR (1) AR090230A1 (ro)
AU (1) AU2013229173B2 (ro)
BR (1) BR112014022106B1 (ro)
CA (1) CA2863892C (ro)
CL (1) CL2014002084A1 (ro)
CO (1) CO7061081A2 (ro)
CR (1) CR20140370A (ro)
CY (2) CY1118771T1 (ro)
DK (1) DK2822953T5 (ro)
DO (1) DOP2014000188A (ro)
EA (1) EA026155B9 (ro)
ES (1) ES2621220T3 (ro)
FR (1) FR19C1062I2 (ro)
GE (1) GEP201606560B (ro)
GT (1) GT201400187A (ro)
HR (1) HRP20170287T2 (ro)
HU (2) HUE034118T2 (ro)
IL (1) IL234062A (ro)
LT (2) LT2822953T (ro)
LU (1) LUC00131I2 (ro)
MD (1) MD4590C1 (ro)
ME (1) ME02630B (ro)
MX (1) MX350844B (ro)
MY (1) MY169142A (ro)
NI (1) NI201400102A (ro)
NL (1) NL301006I2 (ro)
NO (1) NO2019034I1 (ro)
NZ (1) NZ627900A (ro)
PE (1) PE20142339A1 (ro)
PH (1) PH12014501992B1 (ro)
PL (1) PL2822953T3 (ro)
PT (1) PT2822953T (ro)
RS (1) RS55814B1 (ro)
SG (1) SG11201404451TA (ro)
SI (1) SI2822953T1 (ro)
TW (1) TWI476199B (ro)
UY (1) UY34657A (ro)
WO (1) WO2013132376A1 (ro)
ZA (1) ZA201406244B (ro)

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