HRP20161630T1 - Citotoksični imunoglobulin - Google Patents
Citotoksični imunoglobulin Download PDFInfo
- Publication number
- HRP20161630T1 HRP20161630T1 HRP20161630TT HRP20161630T HRP20161630T1 HR P20161630 T1 HRP20161630 T1 HR P20161630T1 HR P20161630T T HRP20161630T T HR P20161630TT HR P20161630 T HRP20161630 T HR P20161630T HR P20161630 T1 HRP20161630 T1 HR P20161630T1
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- Prior art keywords
- modular
- antibody
- modular antibody
- pharmaceutical composition
- antibody according
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- 108060003951 Immunoglobulin Proteins 0.000 title claims 2
- 231100000433 cytotoxic Toxicity 0.000 title claims 2
- 230000001472 cytotoxic effect Effects 0.000 title claims 2
- 102000018358 immunoglobulin Human genes 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 101150029707 ERBB2 gene Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000001640 apoptogenic effect Effects 0.000 claims 2
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 1
- 101710204410 Scaffold protein Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000012931 lyophilized formulation Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011285 therapeutic regimen Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (20)
1. Citotoksično modularno antitijelo sa molekulskom masom do 60kD, specifično se vezuje za humani Her2 sa afinitetom vezivanja Kd <10-8 M, gdje antitijelo sadrži fragment teškog lanca humanog IgG1 koji sadrži CH2 domenu i CH3 domenu i gdje antitijelo sadrži vezujuće mjesto koje se specifično vezuje za Her2 koji je projektiran u strukturnoj regiji petlje CH3 domena i sadrži amino-kiselinske sekvence sa identifikacijskim brojevima sekvenci (SEQ ID NO) 191, 241 i 370, gdje SEQ ID NO: 191 je sadržana unutar AB petlje, SEQ ID NO: 241 je sadržana unutar CD petlje, i SEQ ID NO: 370 je sadržana unutar EF petlje strukturne regije petlje.
2. Modularno antitijelo prema patentnom zahtjevu 1, koje ima najmanje jedno od – stanično posredovana citotoksičnost zavisna od antitijela (ADCC), stanična fagocitoza zavisna od antitijela (ADCP), citotoksičnost zavisna od komplementa (CDC) ili apoptotična aktivnost.
3. Modularno antitijelo prema patentnom zahtjevu 2, koje ima apoptotičnu aktivnost.
4. Modularno antitijelo prema patentnim zahtjevima 1 do 3, gdje je spomenuto antitijelo antigen-vezujući Fc.
5. Modularno antitijelo prema patentnom zahtjevu 4, gdje je spomenuto antitijelo antigen-vezujući IgG1 Fc.
6. Kombinirano modularno antitijelo koje sadrži modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 5, dalje kombinirano sa jednim ili više modificiranih modularnih antitijela ili sa nemodificiranim modularnim antitijelima ili njihovim dijelovima.
7. Kombinirano modularno antitijelo prema patentnom zahtjevu 6, koje je potpun molekula antitijela.
8. Modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 7, gdje je modularno antitijelo fuzioni protein u kome je domena modularnog antitijela fuzionirana za jedan ili više drugih proteina.
9. Modularno antitijelo prema patentnom zahtjevu 8, gdje je protein fuzioniran za modularno antitijelo odabran iz grupe koja se sastoji od drugih modularnih antitijela, imunoglobulina, laganada, proteina skele (“scaffold”), enzima, i toksina.
10. Modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 9 za primjenu u terapiji.
11. Modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 10, za primjenu u liječenju pacijenta koji boluje od solidnog tumora, čiji tumor eksprimira receptor erbB klase, gdje receptor je Her2.
12. Modularno antitijelo za primjenu prema patentnim zahtjevima 10 ili 11, gdje je modularno antitijelo administrirano u kombinaciji sa jednim ili više drugih terapijskih agenasa.
13. Modularno antitijelo za primjenu prema patentnim zahtjevima 10 ili 11, gdje je modularno antitijelo administrirano istovremeno sa jednim ili više terapijskih režima.
14. Farmaceutska kompozicija koja sadrži modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 9.
15. Farmaceutska kompozicija prema patentnom zahtjevu 14, koja sadrži modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 9 i jedan ili više dodatnih terapijskih aktivnih agenasa.
16. Farmaceutska kompozicija prema patentnom zahtjevu 14 ili 15, gdje farmaceutska kompozicija dalje sadrži farmaceutski prihvatljiv nosač, ekscipijens ili stabilizator.
17. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 14 do 16, gdje farmaceutska kompozicija je liofilizovana formulacija, ili vodena otopina.
18. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 14 do 16, gdje je farmaceutska kompozicija za oralnu, subkutanu, intravensku, intranazalnu, intraotičku, transdermalnu, mukoznu, topikalnu, intraperitonealnu, intramuskularnu, intrapulmonarnu, vaginalnu, parenteralnu, rektalnu, ili intraokularnu administraciju.
19. Molekul nukleinske kiseline sadrži sekvencu koja kodira modularno antitijelo prema bilo kojem od patentnih zahtjeva 1 do 7 i kontrolne sekvence u operabilnom spoju, gdje je domaćin transformiran ili transfektiran sa spomenutim sekvencama sposoban da proizvode kodirano modularno antitijelo.
20. Vektor koji sadrži molekulu nukleinske kiseline iz patentnog zahtjeva 19.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08450068A EP2113255A1 (en) | 2008-05-02 | 2008-05-02 | Cytotoxic immunoglobulin |
| EP13167714.8A EP2630970B1 (en) | 2008-05-02 | 2009-03-03 | Cytotoxic immunoglobulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161630T1 true HRP20161630T1 (hr) | 2017-02-10 |
Family
ID=39745473
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140760AT HRP20140760T1 (hr) | 2008-05-02 | 2014-08-11 | Citotoksiäśni imunoglobulin |
| HRP20161630TT HRP20161630T1 (hr) | 2008-05-02 | 2016-12-05 | Citotoksični imunoglobulin |
| HRP20181267TT HRP20181267T1 (hr) | 2008-05-02 | 2018-08-03 | Citotoksični imunoglobulin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140760AT HRP20140760T1 (hr) | 2008-05-02 | 2014-08-11 | Citotoksiäśni imunoglobulin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181267TT HRP20181267T1 (hr) | 2008-05-02 | 2018-08-03 | Citotoksični imunoglobulin |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8859738B2 (hr) |
| EP (4) | EP2113255A1 (hr) |
| JP (2) | JP5693447B2 (hr) |
| CN (2) | CN102083464B (hr) |
| CA (1) | CA2721614C (hr) |
| CY (1) | CY1119508T1 (hr) |
| DK (3) | DK2274012T3 (hr) |
| ES (3) | ES2609359T3 (hr) |
| HR (3) | HRP20140760T1 (hr) |
| HU (2) | HUE039975T2 (hr) |
| LT (2) | LT2630970T (hr) |
| PL (3) | PL2630970T3 (hr) |
| PT (1) | PT2630970T (hr) |
| SI (2) | SI2274012T1 (hr) |
| WO (1) | WO2009132876A1 (hr) |
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| KR101404512B1 (ko) | 2005-01-05 | 2015-01-29 | 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. | 상보성 결정부위와 다른 분자의 부위에서 처리된 결합성을갖는 합성 면역글로불린 영역 |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| US7989160B2 (en) | 2006-02-13 | 2011-08-02 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| AT503902B1 (de) * | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
| EP3241842B1 (en) | 2007-06-26 | 2024-01-31 | F-star Therapeutics Limited | Display of binding agents |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| WO2009088805A2 (en) | 2008-01-03 | 2009-07-16 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| EP2113255A1 (en) * | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| US20120010388A1 (en) * | 2010-04-16 | 2012-01-12 | Gottfried Himmler | LeY SPECIFIC BIOTHERAPEUTIC |
| EP2407487A1 (en) * | 2010-07-14 | 2012-01-18 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Multispecific modular antibody |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| EP2546268A1 (en) | 2011-07-13 | 2013-01-16 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Internalising immunoglobulin |
| US20140050720A1 (en) | 2012-01-09 | 2014-02-20 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
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| US9644021B2 (en) | 2013-01-11 | 2017-05-09 | The California Institute For Biomedical Research | Bovine fusion antibodies |
| WO2014144600A2 (en) | 2013-03-15 | 2014-09-18 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
| KR102361237B1 (ko) | 2013-07-11 | 2022-02-09 | 더 스크립스 리서치 인스티튜트 | 코일드 코일 면역글로불린 융합 단백질 및 이것의 조성물 |
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| GB201317622D0 (en) * | 2013-10-04 | 2013-11-20 | Star Biotechnology Ltd F | Cancer biomarkers and uses thereof |
| TWI707872B (zh) | 2014-05-29 | 2020-10-21 | 美商宏觀基因股份有限公司 | 特異性結合多種癌症抗原的三特異性結合分子和其使用方法 |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| CR20170109A (es) | 2014-09-26 | 2017-07-26 | Macrogenics Inc | Diacuerpos monovalentes biespecificos que son capaces de unir cd19 y cd3, y usos de los mismos |
| TWI565712B (zh) * | 2014-10-20 | 2017-01-11 | 福又達生物科技股份有限公司 | 增進神經元生長的胜肽及其應用 |
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