HRP20121021T1 - SPOJ 3-FENILPIRAZOLO[5,1-b]TIAZOLA - Google Patents
SPOJ 3-FENILPIRAZOLO[5,1-b]TIAZOLA Download PDFInfo
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- HRP20121021T1 HRP20121021T1 HRP20121021AT HRP20121021T HRP20121021T1 HR P20121021 T1 HRP20121021 T1 HR P20121021T1 HR P20121021A T HRP20121021A T HR P20121021AT HR P20121021 T HRP20121021 T HR P20121021T HR P20121021 T1 HRP20121021 T1 HR P20121021T1
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- methoxy
- salt
- thiazol
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- -1 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND Chemical class 0.000 title claims 10
- 150000001875 compounds Chemical class 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 11
- 208000019901 Anxiety disease Diseases 0.000 claims 4
- 230000036506 anxiety Effects 0.000 claims 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 206010008190 Cerebrovascular accident Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000030814 Eating disease Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000033463 Ischaemic neuropathy Diseases 0.000 claims 2
- 206010054048 Postoperative ileus Diseases 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000022531 anorexia Diseases 0.000 claims 2
- 230000036461 convulsion Effects 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 230000001079 digestive effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 235000014632 disordered eating Nutrition 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 231100000318 excitotoxic Toxicity 0.000 claims 2
- 230000003492 excitotoxic effect Effects 0.000 claims 2
- 206010022437 insomnia Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- IFYKMCAPVKAGQX-UHFFFAOYSA-N 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-n-(oxan-4-yl)-n-propylpyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=NN2C(C=3C(=CC(COC)=CC=3OC)OC)=CSC2=C1N(CCC)C1CCOCC1 IFYKMCAPVKAGQX-UHFFFAOYSA-N 0.000 claims 1
- ZOEBQJWEMYNPDT-UHFFFAOYSA-N 3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-n-(oxan-4-yl)-n-propylpyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=NN2C(C=3C(=CC(COC)=CC=3Cl)OC)=CSC2=C1N(CCC)C1CCOCC1 ZOEBQJWEMYNPDT-UHFFFAOYSA-N 0.000 claims 1
- REEHHYCKBNOQNI-UHFFFAOYSA-N 3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-n-(oxan-3-yl)-n-propylpyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=NN2C(C=3C(=CC(COCC)=CC=3OC)OC)=CSC2=C1N(CCC)C1CCCOC1 REEHHYCKBNOQNI-UHFFFAOYSA-N 0.000 claims 1
- JLSWTZVCHXNYGF-UHFFFAOYSA-N 4-[7-[cyclopropylmethyl(oxolan-3-ylmethyl)amino]-6-methoxypyrazolo[5,1-b][1,3]thiazol-3-yl]-3,5-dimethoxybenzonitrile Chemical compound COC1=NN2C(C=3C(=CC(=CC=3OC)C#N)OC)=CSC2=C1N(CC1COCC1)CC1CC1 JLSWTZVCHXNYGF-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 206010054089 Depressive symptom Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000029650 alcohol withdrawal Diseases 0.000 claims 1
- 229910052801 chlorine Chemical group 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- CIEVCSWHRZMADV-UHFFFAOYSA-N n-(2-cyclopropylethyl)-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-n-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=CC(COCC)=CC(OC)=C1C(N1N=C2OC)=CSC1=C2N(C1CCOCC1)CCC1CC1 CIEVCSWHRZMADV-UHFFFAOYSA-N 0.000 claims 1
- DVZMOOXPINUDLM-UHFFFAOYSA-N n-(cyclobutylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-n-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=CC(COC)=CC(OC)=C1C(N1N=C2OC)=CSC1=C2N(C1CCOCC1)CC1CCC1 DVZMOOXPINUDLM-UHFFFAOYSA-N 0.000 claims 1
- NFOXKSLQJXDWGK-UHFFFAOYSA-N n-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-n-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=CC(COC)=CC(OC)=C1C(N1N=C2OC)=CSC1=C2N(C1CCOCC1)CC1CC1 NFOXKSLQJXDWGK-UHFFFAOYSA-N 0.000 claims 1
- SZHOIIKHFGGEKW-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-methoxy-n-(oxan-4-ylmethyl)-3-(2,4,6-trimethoxyphenyl)pyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=NN2C(C=3C(=CC(OC)=CC=3OC)OC)=CSC2=C1N(CC1CCOCC1)CC1CC1 SZHOIIKHFGGEKW-UHFFFAOYSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- COWJNZFMPUADKV-UHFFFAOYSA-N n-butyl-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-n-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=NN2C(C=3C(=CC(COC)=CC=3OC)OC)=CSC2=C1N(CCCC)C1CCOCC1 COWJNZFMPUADKV-UHFFFAOYSA-N 0.000 claims 1
- MKMSLJYQGXJIQH-UHFFFAOYSA-N n-butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-n-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine Chemical compound COC1=NN2C(C=3C(=CC(COCC)=CC=3OC)OC)=CSC2=C1N(CCCC)C1CCOCC1 MKMSLJYQGXJIQH-UHFFFAOYSA-N 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000006173 tetrahydropyranylmethyl group Chemical group 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (18)
1. Spoj prikazan sa formulom (I) ili njegova sol:
[image]
naznačen time da
R1 predstavlja formulu -A11-A12;
R2 predstavlja tetrahidrofurilmetil, tetrahidropiranilmetil ili tetrahidropiranil; A11 predstavlja jednostruku vezu, metilen ili 1,2-etilen;
A12 predstavlja C1-6 alkil, C3-6 cikloalkil, ili C3-6 cikloalkil supstituiran sa metilnom skupinom;
R3 predstavlja metoksi, cijano, ciklobutiloksimetil, metoksimetil ili etoksimetil; i
R4 predstavlja metoksi ili klor.
2. Spoj prema zahtjevu 1, naznačen time da R2 je tetrahidropiran-4-il, tetrahidropiran-3-il, (tetrahidropiran-4-il)metil ili (tetrahidrofuran-3-il)metil.
3. Spoj prema zahtjevu 1 ili zahtjevu 2, naznačen time da R1 je n-propil, n-butil, n-pentil, ciklopropilmetil, ciklobutilmetil, 2-(ciklopropil)etil ili (2-metilciklopropil)metil.
4. Spoj prema zahtjevu 1, naznačen time da spoj je N-butil-3-[2,6-dimetoksi-4-(metoksimetil)fenil]-6-metoksi-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
5. Spoj prema zahtjevu 1, naznačen time da spoj je N-butil-3-[4-(etoksimetil)-2,6-dimetoksifenil]-6-metoksi-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
6. Spoj prema zahtjevu 1, naznačen time da spoj je N-(2-ciklopropiletil)-3-[4-(etoksimetil)-2,6-dimetoksifenil]-6-metoksi-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
7. Spoj prema zahtjevu 1, naznačen time da spoj je 3-[4-(etoksimetil)-2,6-dimetoksifenil]-6-metoksi-N-propil-N-(tetrahidro-2H-piran-3-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
8. Spoj prema zahtjevu 1, naznačen time da spoj je N-(ciklobutilmetil)-3-[2,6-dimetoksi-4-(metoksimetil)fenil]-6-metoksi-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
9. Spoj prema zahtjevu 1, naznačen time da spoj je N-(ciklopropilmetil)-3-[2,6-dimetoksi-4-(metoksimetil)fenil]-6-metoksi-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
10. Spoj prema zahtjevu 1, naznačen time da spoj je 3-[2,6-dimetoksi-4-(metoksimetil)fenil]-6-metoksi-N-propil-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
11. Spoj prema zahtjevu 1, naznačen time da spoj je 3-[2-chloro-6-metoksi-4-(metoksimetil)fenil]-6-metoksi-N-propil-N-(tetrahidro-2H-piran-4-il)pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
12. Spoj prema zahtjevu 1, naznačen time da spoj je 4-{7-[(ciklopropilmetil)(tetrahidrofuran-3-ilmetil)amino]-6-metoksipirazolo[5,1-b][1,3]tiazol-3-il}-3,5-dimetoksibenzonitril ili njegova sol.
13. Spoj prema zahtjevu 1, naznačen time da spoj je N-(ciklopropilmetil)-6-metoksi-N-(tetrahidro-2H-piran-4-ilmetil)-3-(2,4,6-trimetoksifenil)-pirazolo[5,1-b][1,3]tiazol-7-amin ili njegova sol.
14. Farmaceutski pripravak naznačen time da sadrži spoj prema bilo kojem od zahtjeva 1-13 kao aktivni sastojak.
15. Terapeutsko ili profilaktičko sredstvo koje sadrži spoj prema bilo kojem od zahtjeva 1-13 naznačeno time da je za uporabu kod liječenja ili sprečavanja depresije, simptoma depresije, tjeskobe, sindroma iritabilnog crijeva, poremećaja spavanja, nesanice, ovisnosti o alkoholu, simptoma odvikavanja od alkohola, ovisnosti o drogama, simptoma odvikavanja od droga, probavnih poremećaja vezanih uz stres, anoreksije, poremećaja prehrane, postoperativnog ileusa, ishemijske neuropatije, apopleksije, ekscitotoksične neuropatije, konvulzija, epilepsije, hipertenzije, shizofrenije, bipolarnog poremećaja ili demencije.
16. Terapeutsko ili profilaktičko sredstvo za uporabu prema zahtjevu 15, naznačeno time da terapeutsko ili profilaktičko sredstvo je za uporabu kod liječenja ili sprečavanja depresije, simptoma depresije, tjeskobe ili sindroma iritabilnog crijeva.
17. Spoj prema bilo kojem od zahtjeva 1-13 naznačen time da je za uporabu kod liječenja ili sprečavanja depresije, simptoma depresije, tjeskobe, sindroma iritabilnog crijeva, poremećaja spavanja, nesanice, ovisnosti o alkoholu, simptoma odvikavanja od alkohola, ovisnosti o drogama, simptoma odvikavanja od droga, probavnih poremećaja vezanih uz stres, anoreksije, poremećaja prehrane, postoperativnog ileusa, ishemijske neuropatije, apopleksije, ekscitotoksične neuropatije, konvulzija, epilepsije, hipertenzije, shizofrenije, bipolarnog poremećaja ili demencije.
18. Spoj za uporabu prema zahtjevu 17, naznačen time da je spoj za uporabu kod liječenja ili sprečavanja depresije, simptoma depresije, tjeskobe ili sindroma iritabilnog crijeva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4508408P | 2008-04-15 | 2008-04-15 | |
JP2008106080 | 2008-04-15 | ||
PCT/JP2009/057270 WO2009128383A1 (ja) | 2008-04-15 | 2009-04-09 | 3-フェニルピラゾロ[5,1-b]チアゾール化合物 |
Publications (1)
Publication Number | Publication Date |
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HRP20121021T1 true HRP20121021T1 (hr) | 2013-01-31 |
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ID=41164535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20121021AT HRP20121021T1 (hr) | 2008-04-15 | 2012-12-12 | SPOJ 3-FENILPIRAZOLO[5,1-b]TIAZOLA |
Country Status (29)
Country | Link |
---|---|
US (1) | US8431603B2 (hr) |
EP (1) | EP2266990B1 (hr) |
JP (1) | JP4654325B2 (hr) |
KR (1) | KR101601994B1 (hr) |
CN (1) | CN102007133B (hr) |
AR (1) | AR071655A1 (hr) |
AU (1) | AU2009237050B2 (hr) |
BR (1) | BRPI0911659B8 (hr) |
CA (1) | CA2721670C (hr) |
CL (1) | CL2009000896A1 (hr) |
CY (1) | CY1113484T1 (hr) |
DK (1) | DK2266990T3 (hr) |
ES (1) | ES2396126T3 (hr) |
HK (2) | HK1150310A1 (hr) |
HR (1) | HRP20121021T1 (hr) |
IL (1) | IL208393A (hr) |
MX (1) | MX2010011089A (hr) |
MY (1) | MY152687A (hr) |
NZ (1) | NZ588376A (hr) |
PE (1) | PE20091890A1 (hr) |
PL (1) | PL2266990T3 (hr) |
PT (1) | PT2266990E (hr) |
RS (1) | RS52561B (hr) |
RU (1) | RU2482120C2 (hr) |
SI (1) | SI2266990T1 (hr) |
TW (1) | TW201004964A (hr) |
UA (1) | UA101836C2 (hr) |
WO (1) | WO2009128383A1 (hr) |
ZA (1) | ZA201006764B (hr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2266990E (pt) | 2008-04-15 | 2012-12-27 | Eisai R&D Man Co Ltd | Composto de 3-fenilpirazolo[5,1-b]tiazole |
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