AR058151A1 - Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion - Google Patents
Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacionInfo
- Publication number
- AR058151A1 AR058151A1 ARP060104659A ARP060104659A AR058151A1 AR 058151 A1 AR058151 A1 AR 058151A1 AR P060104659 A ARP060104659 A AR P060104659A AR P060104659 A ARP060104659 A AR P060104659A AR 058151 A1 AR058151 A1 AR 058151A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- halo
- hydrogen
- dopamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Reivindicacion 1: Un compuesto de formula (1) con su sal, hidrato o solvato aceptable para uso farmacéutico, o su forma estereoisomérica, en los cuales R es hidrogeno o alquilo C1-6; R1 es fenilo, fenilo sustituido con 1, 2 o 3 sustituyentes, cada uno de los cuales está seleccionado, en forma independiente, del grupo que consiste de hidrogeno, halo, ciano, alquilo C1-4, alquiloxi C1-4, perfluoro-alquilo C1-4, dialquil C1-4 amino; tienilo; tienilo sustituido con 1 o 2 sustituyentes seleccionados del grupo que consiste de halo y alquilo C1-4; cicloalquilo C3-8; o cicloalquenilo C5-7; R2 es hidrogeno o alquilo C1-6; R3 es halo, alquilo C1-4 o perfluoro- alquilo C1-4; y R4 y R5 son cada uno, en forma independiente, hidrogeno o halo. La presente invencion se refiere a compuestos que son antagonistas de los receptores 2 de dopamina de rápida disociacion, y a procesos para preparar dichos compuestos. Los compuestos son utiles como medicamentos para el tratamiento o la prevencion de trastornos del sistema nervioso central, por ejemplo esquizofrenia, eferciendo un efecto antipsicotico sin producir efectos colaterales motores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05110028 | 2005-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058151A1 true AR058151A1 (es) | 2008-01-23 |
Family
ID=35734993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104659A AR058151A1 (es) | 2005-10-26 | 2006-10-25 | Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US8940743B2 (es) |
| EP (1) | EP1943242B1 (es) |
| JP (1) | JP5140598B2 (es) |
| KR (1) | KR101351910B1 (es) |
| CN (1) | CN101291925B (es) |
| AP (1) | AP2607A (es) |
| AR (1) | AR058151A1 (es) |
| AT (1) | ATE495167T1 (es) |
| AU (1) | AU2006307930B2 (es) |
| BR (1) | BRPI0617787A2 (es) |
| CA (1) | CA2623160C (es) |
| CR (1) | CR10020A (es) |
| CY (1) | CY1111977T1 (es) |
| DE (1) | DE602006019624D1 (es) |
| DK (1) | DK1943242T3 (es) |
| EA (1) | EA015681B1 (es) |
| EC (1) | ECSP088396A (es) |
| ES (1) | ES2359020T3 (es) |
| GT (1) | GT200800033A (es) |
| HK (1) | HK1124317A1 (es) |
| HN (1) | HN2008000646A (es) |
| HR (1) | HRP20110226T1 (es) |
| IL (1) | IL191016A (es) |
| JO (1) | JO2769B1 (es) |
| MY (1) | MY145609A (es) |
| NO (1) | NO20082350L (es) |
| NZ (1) | NZ566785A (es) |
| PL (1) | PL1943242T3 (es) |
| PT (1) | PT1943242E (es) |
| RS (1) | RS51674B (es) |
| SI (1) | SI1943242T1 (es) |
| TW (1) | TWI399373B (es) |
| UA (1) | UA94058C2 (es) |
| WO (1) | WO2007048779A1 (es) |
| ZA (1) | ZA200803668B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体 |
| AU2008240729B2 (en) | 2007-04-23 | 2012-08-23 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| JP5431305B2 (ja) * | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体 |
| CA2687931C (en) * | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| CA2729313C (en) | 2008-07-03 | 2016-08-30 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| DK2307374T3 (en) * | 2008-07-31 | 2017-05-01 | Janssen Pharmaceutica Nv | PIPERAZIN-1-YLTRIFLUORMETHYL-SUBSTITUTED PYRIDINES AS QUICK DISSOCATING DOPAMIN-2 RECEPTOR ANTAGONISTS |
| PE20120061A1 (es) | 2008-12-19 | 2012-02-19 | Boehringer Ingelheim Int | Derivados de pirimidina como antagonistas del receptor ccr2 |
| MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
| PT3091012T (pt) | 2009-12-17 | 2018-06-27 | Centrexion Therapeutics Corp | Antagonistas do receptor ccr2 e suas utilizações |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
| CN104411312B (zh) | 2012-06-26 | 2018-03-06 | 詹森药业有限公司 | 包括pde2抑制剂例如1‑芳基‑4‑甲基‑[1,2,4]三唑[4,3‑a]‑喹喔啉化合物和pde10抑制剂的用于在治疗神经病学障碍或代谢障碍中使用的组合 |
| MX362197B (es) | 2012-07-09 | 2019-01-08 | Janssen Pharmaceutica Nv | Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos. |
| MX2017017177A (es) | 2015-07-02 | 2018-11-09 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidi n-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-piran-2-il)m etilamino)pirimidin-4il) metanona. |
| US20180350708A1 (en) * | 2017-06-06 | 2018-12-06 | Powertech Technology Inc. | Package structure and manufacturing method thereof |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933823A (en) | 1971-03-29 | 1976-01-20 | E. R. Squibb & Sons, Inc. | Isoxazolopyridine ketone derivatives |
| DE2341965C3 (de) | 1973-08-20 | 1979-01-25 | C.H. Boehringer Sohn, 6507 Ingelheim | 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen |
| NO147672C (no) | 1975-09-23 | 1983-05-25 | Janssen Pharmaceutica Nv | Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider |
| US4197304A (en) | 1975-09-23 | 1980-04-08 | Janssen Pharmaceutica N.V. | N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| DE3218482A1 (de) | 1982-05-15 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| ES8802151A1 (es) | 1985-07-31 | 1988-04-01 | Janssen Pharmaceutica Nv | Un procedimiento para la preparacion de nuevos piridazinaminas. |
| MX173362B (es) | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| US5461053A (en) | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
| PT93060B (pt) | 1989-02-07 | 1995-12-29 | Sanofi Sa | Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem |
| GB9008850D0 (en) * | 1990-04-19 | 1990-06-13 | Janssen Pharmaceutica Nv | Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones |
| GB9216298D0 (en) | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
| ATE182590T1 (de) | 1993-12-28 | 1999-08-15 | Upjohn Co | Heterozyklische verbindungen für die behandlung von kardiovaskular- und zentralnervensystem störungen |
| DE4425145A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung von Thiazol- und Thiadiazolverbindungen |
| TW406075B (en) | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
| US5560931A (en) | 1995-02-14 | 1996-10-01 | Nawosystems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
| US5753679A (en) | 1995-05-10 | 1998-05-19 | Hoffmann-La Roche Inc. | Benzyl-piperidine derivatives |
| MY116093A (en) | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
| TW504510B (en) | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| WO1999009025A2 (en) * | 1997-08-15 | 1999-02-25 | Pfizer Products Inc. | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor |
| KR100261139B1 (ko) | 1998-01-16 | 2000-08-01 | 황준수 | 신규한 알릴티오피리다진 유도체 및 그의 제조방법 |
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| EP1379520B2 (en) | 2001-02-23 | 2014-04-09 | Merck Sharp & Dohme Corp. | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists |
| EP1443046B1 (en) | 2001-10-09 | 2008-12-17 | Kyorin Pharmaceutical Co., Ltd. | Novel 4-(2furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same |
| GB0127832D0 (en) | 2001-11-20 | 2002-01-09 | Jagotec Ag | Method for the preparation of pharmaceutical nanosuspensions |
| WO2003049736A1 (en) | 2001-12-11 | 2003-06-19 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
| CA2474322A1 (en) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
| IL162859A0 (en) | 2002-02-05 | 2005-11-20 | Novo Nordisk As | Novel aryl-and heteroarylpiperazines |
| US20030236259A1 (en) | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| US6855709B2 (en) | 2002-02-22 | 2005-02-15 | Pharmacia & Upjohn Company | Pyridyl sulfone derivatives |
| SE0201544D0 (sv) | 2002-05-17 | 2002-05-17 | Biovitrum Ab | Novel compounds and thier use |
| ATE551053T1 (de) | 2002-09-26 | 2012-04-15 | Mandom Corp | Antiseptische bakterizide, und kosmetika, arzneimittel und lebensmittel, die die antiseptischen bakterizide enthalten |
| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| CA2524589A1 (en) | 2003-05-07 | 2004-11-18 | Ifac Gmbh & Co. Kg | Compositions for the targetted release of fragrances and aromas |
| JP4009303B2 (ja) | 2003-05-08 | 2007-11-14 | 杏林製薬株式会社 | 掻痒治療薬として有用な４−（２−フロイル）アミノピペリジン類 |
| WO2005005779A2 (en) | 2003-07-14 | 2005-01-20 | Genesis Mining Technologies (Pty) Ltd | Dual retention cutting arrangement |
| ATE461178T1 (de) | 2003-07-29 | 2010-04-15 | High Point Pharmaceuticals Llc | Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden |
| NZ545265A (en) | 2003-07-30 | 2009-11-27 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use for treating diseases mediated by stearoyl-CoA desaturase (SCD) enzymes |
| JP2007501801A (ja) | 2003-08-07 | 2007-02-01 | 日本たばこ産業株式会社 | ピロロ［１，２−ｂ］ピリダジン誘導体 |
| US7863044B2 (en) | 2003-10-24 | 2011-01-04 | Tao Cheng | p18 in stem cell manipulations |
| BRPI0506676A (pt) | 2004-02-10 | 2007-05-15 | Janssen Phamaceutica N V | piridazinona uréias como antagonistas de integrinas alfa4 |
| CN1934092A (zh) | 2004-03-23 | 2007-03-21 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| WO2005105779A1 (en) | 2004-04-28 | 2005-11-10 | Pfizer Limited | 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor |
| JP2008501031A (ja) | 2004-05-28 | 2008-01-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2251867B1 (es) | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| WO2006034440A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| AU2005307006B2 (en) | 2004-10-29 | 2012-05-03 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| WO2006105993A2 (en) | 2005-04-05 | 2006-10-12 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Method for shielding functional sites or epitopes on proteins |
| US7635705B2 (en) | 2005-06-20 | 2009-12-22 | Schering Corporation | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| CN101506165B (zh) | 2006-08-15 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | 苯基、吡啶和喹啉衍生物 |
| CA2606658A1 (en) | 2006-10-13 | 2008-04-13 | Mike Tyers | Compositions and methods for treating neurological disorders or damage |
| TW200829566A (en) | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| AU2008240729B2 (en) | 2007-04-23 | 2012-08-23 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| JP2010525013A (ja) | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体 |
| JP5431305B2 (ja) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体 |
| UY31346A1 (es) | 2007-09-20 | 2009-04-30 | Compuestos que tienen actividad en el receptor m1 y sus usos en medicina | |
| CA2729313C (en) | 2008-07-03 | 2016-08-30 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
| DK2307374T3 (en) | 2008-07-31 | 2017-05-01 | Janssen Pharmaceutica Nv | PIPERAZIN-1-YLTRIFLUORMETHYL-SUBSTITUTED PYRIDINES AS QUICK DISSOCATING DOPAMIN-2 RECEPTOR ANTAGONISTS |
-
2006
- 2006-10-12 JO JO2006368A patent/JO2769B1/en active
- 2006-10-24 SI SI200630966T patent/SI1943242T1/sl unknown
- 2006-10-24 WO PCT/EP2006/067696 patent/WO2007048779A1/en active Application Filing
- 2006-10-24 CN CN2006800389935A patent/CN101291925B/zh active Active
- 2006-10-24 KR KR1020087011462A patent/KR101351910B1/ko active IP Right Grant
- 2006-10-24 AU AU2006307930A patent/AU2006307930B2/en not_active Ceased
- 2006-10-24 BR BRPI0617787-5A patent/BRPI0617787A2/pt not_active IP Right Cessation
- 2006-10-24 NZ NZ566785A patent/NZ566785A/en not_active IP Right Cessation
- 2006-10-24 AP AP2008004441A patent/AP2607A/xx active
- 2006-10-24 UA UAA200803291A patent/UA94058C2/ru unknown
- 2006-10-24 JP JP2008537078A patent/JP5140598B2/ja active Active
- 2006-10-24 EA EA200801184A patent/EA015681B1/ru unknown
- 2006-10-24 ES ES06807495T patent/ES2359020T3/es active Active
- 2006-10-24 PL PL06807495T patent/PL1943242T3/pl unknown
- 2006-10-24 EP EP06807495A patent/EP1943242B1/en active Active
- 2006-10-24 CA CA2623160A patent/CA2623160C/en active Active
- 2006-10-24 DK DK06807495.4T patent/DK1943242T3/da active
- 2006-10-24 AT AT06807495T patent/ATE495167T1/de active
- 2006-10-24 RS RS20110153A patent/RS51674B/en unknown
- 2006-10-24 MY MYPI20081298A patent/MY145609A/en unknown
- 2006-10-24 DE DE602006019624T patent/DE602006019624D1/de active Active
- 2006-10-24 PT PT06807495T patent/PT1943242E/pt unknown
- 2006-10-24 US US12/091,219 patent/US8940743B2/en active Active
- 2006-10-25 AR ARP060104659A patent/AR058151A1/es unknown
- 2006-10-25 TW TW095139268A patent/TWI399373B/zh not_active IP Right Cessation
-
2008
- 2008-03-31 GT GT200800033A patent/GT200800033A/es unknown
- 2008-04-23 EC EC2008008396A patent/ECSP088396A/es unknown
- 2008-04-23 HN HN2008000646A patent/HN2008000646A/es unknown
- 2008-04-25 ZA ZA200803668A patent/ZA200803668B/xx unknown
- 2008-04-27 IL IL191016A patent/IL191016A/en active IP Right Grant
- 2008-05-26 CR CR10020A patent/CR10020A/es unknown
- 2008-05-26 NO NO20082350A patent/NO20082350L/no not_active Application Discontinuation
-
2009
- 2009-02-11 HK HK09101264.8A patent/HK1124317A1/xx not_active IP Right Cessation
-
2011
- 2011-03-29 HR HR20110226T patent/HRP20110226T1/hr unknown
- 2011-04-12 CY CY20111100375T patent/CY1111977T1/el unknown
-
2015
- 2015-01-26 US US14/605,873 patent/US9468640B2/en active Active
-
2016
- 2016-09-13 US US15/264,185 patent/US9751860B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR058151A1 (es) | Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion | |
| AR065333A1 (es) | Antagonistas del receptor de dopamina 2 de rapida disociacion | |
| AR056979A1 (es) | Derivados de dihidrobenzofuranos y usos de los mismos | |
| GT200600217A (es) | Proceso para la sintesis de compuestos organicos | |
| GT200400173A (es) | Compuestos de aril o heteroaril amida | |
| ECSP099461A (es) | Compuesto heteromonocíclico y uso del mismo | |
| AR079226A1 (es) | Espiroindolinona- pirrolidinas, procesos de preparacion y uso de los mismos para el tratamiento y profilaxis del cancer | |
| AR073622A1 (es) | Compuestos de benzo[d]isoxazol moduladores de receptores de dopamina d3 y de la serotonina 5-ht2a, proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos psicoticos | |
| AR091781A1 (es) | Antagonistas del receptor de 5-ht3 | |
| AR084553A1 (es) | DERIVADOS IMIDAZOLICOS HETEROCICLICOS INHIBIDORES DE b-SECRETASA, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y USO DE LOS MISMOS PARA TRATAR ENFERMEDADES NEURODEGENERATIVAS, EN PARTICULAR ALZHEIMER | |
| AR090203A1 (es) | Compuestos heterobiciclicos como inhibidores de pde10 | |
| GT200600030A (es) | 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2 | |
| GT200600107A (es) | Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos | |
| GT200500124A (es) | (4-metoxi-7-morfolin-4-il-benzotiazol-2-il) amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico | |
| AR059905A1 (es) | Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto | |
| AR087628A1 (es) | Inhibidores de pde10 de pirimidina | |
| AR064198A1 (es) | Piperidinilamino piridazinas como antagonistas del receptor de dopamina 2 de rapida disociacion. procesos de obtencion y composiciones farmaceuticas | |
| AR075531A1 (es) | Derivados de piperazin-ciclopropil benzamidas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del sistema nervioso central, tales como alzheimer y esquizofrenia, entre otros | |
| AR070885A1 (es) | Compuestos de azaindol para el tratamiento de trastornos del sistema nervioso central | |
| BR112013008675A2 (pt) | métodos e composições para o tratamento de diabetes e dislipidemia | |
| ECSP11011196A (es) | Derivados de piperidina | |
| AR066242A1 (es) | Tia(di)azoles como antagonistas del recpetor de dopamina 2 de disociacion rapida | |
| AR099071A1 (es) | Antagonistas selectivos de nr2b | |
| GT200300212A (es) | Piperazinas sustituidas heterociclicas para el tratamiento de la esquizofrenia | |
| AR081382A1 (es) | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |