BRPI0617787A2 - derivados de piperidin-4-il-piridazin-3-ilamina como antagonistas de receptores de dopamina-2 de dissociação rápida - Google Patents

derivados de piperidin-4-il-piridazin-3-ilamina como antagonistas de receptores de dopamina-2 de dissociação rápida

Info

Publication number
BRPI0617787A2
BRPI0617787A2 BRPI0617787-5A BRPI0617787A BRPI0617787A2 BR PI0617787 A2 BRPI0617787 A2 BR PI0617787A2 BR PI0617787 A BRPI0617787 A BR PI0617787A BR PI0617787 A2 BRPI0617787 A2 BR PI0617787A2
Authority
BR
Brazil
Prior art keywords
pyridazin
piperidin
compounds
receptor antagonists
dopamine
Prior art date
Application number
BRPI0617787-5A
Other languages
English (en)
Inventor
Bruyn Marcel Frans Leopold De
Gregor James Macdonald
Ludo Edmond Josephine Kennis
Xavier Jean Michel Langlois
Den Keybus Frans Maria Alfons Van
Roosbroeck Yves Emiel Maria Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0617787A2 publication Critical patent/BRPI0617787A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVADOS DE PIPERIDIN-4-IL-PIRIDAZIN-3-ILAMINA COMO ANTAGONISTAS DE RECEPTORES DE DOPAMINA-2 DE DISSOCIAçãO RáPIDA. A presente invenção refere-se a compostos que são antagonistas de receptores de dopamina 2 de dissociação rápida, a processos para a preparação destes compostos, a composições farmacêuticas compreendendo estes compostos como componente ativo. Os compostos são úteis como medicamentos para o tratamento ou a prevenção de distúrbios do sistema nervoso central, por exemplo esquizofrenia, exercendo um efeito antipsicótico sem efeitos colaterais motores.
BRPI0617787-5A 2005-10-26 2006-10-24 derivados de piperidin-4-il-piridazin-3-ilamina como antagonistas de receptores de dopamina-2 de dissociação rápida BRPI0617787A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05110028 2005-10-26
EP06100209 2006-01-10
EP06101545 2006-02-10
PCT/EP2006/067696 WO2007048779A1 (en) 2005-10-26 2006-10-24 Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0617787A2 true BRPI0617787A2 (pt) 2009-12-01

Family

ID=35734993

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0617787-5A BRPI0617787A2 (pt) 2005-10-26 2006-10-24 derivados de piperidin-4-il-piridazin-3-ilamina como antagonistas de receptores de dopamina-2 de dissociação rápida

Country Status (35)

Country Link
US (3) US8940743B2 (pt)
EP (1) EP1943242B1 (pt)
JP (1) JP5140598B2 (pt)
KR (1) KR101351910B1 (pt)
CN (1) CN101291925B (pt)
AP (1) AP2607A (pt)
AR (1) AR058151A1 (pt)
AT (1) ATE495167T1 (pt)
AU (1) AU2006307930B2 (pt)
BR (1) BRPI0617787A2 (pt)
CA (1) CA2623160C (pt)
CR (1) CR10020A (pt)
CY (1) CY1111977T1 (pt)
DE (1) DE602006019624D1 (pt)
DK (1) DK1943242T3 (pt)
EA (1) EA015681B1 (pt)
EC (1) ECSP088396A (pt)
ES (1) ES2359020T3 (pt)
GT (1) GT200800033A (pt)
HK (1) HK1124317A1 (pt)
HN (1) HN2008000646A (pt)
HR (1) HRP20110226T1 (pt)
IL (1) IL191016A (pt)
JO (1) JO2769B1 (pt)
MY (1) MY145609A (pt)
NO (1) NO20082350L (pt)
NZ (1) NZ566785A (pt)
PL (1) PL1943242T3 (pt)
PT (1) PT1943242E (pt)
RS (1) RS51674B (pt)
SI (1) SI1943242T1 (pt)
TW (1) TWI399373B (pt)
UA (1) UA94058C2 (pt)
WO (1) WO2007048779A1 (pt)
ZA (1) ZA200803668B (pt)

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JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
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US8653262B2 (en) 2007-05-31 2014-02-18 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists and uses thereof
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LT2307374T (lt) 2008-07-31 2017-04-25 Janssen Pharmaceutica Nv Piperazin-1-il-trifluormetil-pakeistieji piridinai kaip greitai disocijuojantys dopamino 2 receptoriaus antagonistai

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CN101291925A (zh) 2008-10-22
CA2623160A1 (en) 2007-05-03
DK1943242T3 (da) 2011-04-26
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