US4032526A
(en)
|
1975-10-02 |
1977-06-28 |
American Cyanamid Company |
1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts
|
GB2068961B
(en)
|
1980-02-13 |
1983-11-30 |
Sankyo Co |
Quinazoline derivatives
|
DE3517617A1
(de)
|
1985-05-15 |
1986-11-20 |
Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München |
Neue pyridaziniumverbindungen, verfahren zu deren herstellung und diese enthaltende fungizide und algizide mittel
|
ES8802151A1
(es)
|
1985-07-31 |
1988-04-01 |
Janssen Pharmaceutica Nv |
Un procedimiento para la preparacion de nuevos piridazinaminas.
|
JPS61165445A
(ja)
|
1986-01-08 |
1986-07-26 |
株式会社巴組鐵工所 |
振動を減少しうる床構造
|
US5096916A
(en)
|
1990-05-07 |
1992-03-17 |
Aegis Technology, Inc. |
Treatment of chronic obstructive pulmonary disease (copd) by inhalation of an imidazoline
|
JPH08502508A
(ja)
|
1992-10-23 |
1996-03-19 |
メルク シヤープ エンド ドーム リミテツド |
ドーパミンレセプターサブタイプリガンド
|
JP3166376B2
(ja)
|
1993-02-03 |
2001-05-14 |
松下電器産業株式会社 |
熱利用装置
|
US5629235A
(en)
|
1995-07-05 |
1997-05-13 |
Winbond Electronics Corporation |
Method for forming damage-free buried contact
|
TW531537B
(en)
|
1995-12-27 |
2003-05-11 |
Janssen Pharmaceutica Nv |
1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
|
US6437138B1
(en)
|
1996-06-06 |
2002-08-20 |
Abbott Laboratories |
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
|
US5629325A
(en)
|
1996-06-06 |
1997-05-13 |
Abbott Laboratories |
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
BR9813279B1
(pt)
|
1997-10-27 |
2010-11-16 |
|
derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina.
|
ATE262523T1
(de)
|
1998-11-20 |
2004-04-15 |
Searle Llc |
Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane
|
US6248755B1
(en)
|
1999-04-06 |
2001-06-19 |
Merck & Co., Inc. |
Pyrrolidine modulators of chemokine receptor activity
|
CA2371583C
(en)
|
1999-05-04 |
2005-09-13 |
Schering Corporation |
Piperazine derivatives useful as ccr5 antagonists
|
US20020045613A1
(en)
|
2000-04-27 |
2002-04-18 |
Heinz Pauls |
1-aroyl-piperidinyl benzamidines
|
PL360495A1
(en)
|
2000-05-22 |
2004-09-06 |
Aventis Pharmaceuticals Inc. |
Arylmethylamine derivatives for use as tryptase inhibitors
|
US20050143372A1
(en)
|
2001-10-30 |
2005-06-30 |
Shomir Ghosh |
Compounds, pharmaceutical compositions and methods of use therefor
|
US6806279B2
(en)
|
2001-12-17 |
2004-10-19 |
Sunesis Pharmaceuticals, Inc. |
Small-molecule inhibitors of interleukin-2
|
CN1628109A
(zh)
|
2002-02-05 |
2005-06-15 |
诺沃挪第克公司 |
新颖的芳基-与杂芳基-哌嗪
|
JP2003240776A
(ja)
|
2002-02-13 |
2003-08-27 |
Horiba Ltd |
クロマトグラフリーダを用いる測定方法およびそれに用いる試験片ホルダ並びにクロマトグラフリーダを用いる検査/測定装置
|
HUP0200849A2
(hu)
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
US20030195192A1
(en)
|
2002-04-05 |
2003-10-16 |
Fortuna Haviv |
Nicotinamides having antiangiogenic activity
|
AU2003218738B2
(en)
|
2002-03-13 |
2009-01-08 |
Janssen Pharmaceutica N.V. |
Sulfonyl-derivatives as novel inhibitors of histone deacetylase
|
US20040014744A1
(en)
|
2002-04-05 |
2004-01-22 |
Fortuna Haviv |
Substituted pyridines having antiangiogenic activity
|
AU2003235097A1
(en)
|
2002-04-24 |
2003-11-10 |
Takeda Pharmaceutical Company Limited |
Use of compounds having ccr antagonism
|
AU2003231114B8
(en)
|
2002-04-29 |
2008-08-14 |
Merck Sharp & Dohme Corp. |
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
|
WO2003104223A1
(en)
|
2002-06-05 |
2003-12-18 |
Pharmacia Corporation |
Pyrazole-derivatives as p38 kinase inhibitors
|
WO2004024710A1
(en)
|
2002-09-13 |
2004-03-25 |
Glaxo Group Limited |
Urea compounds active as vanilloid receptor antagonists for the treatment of pain
|
GB0229618D0
(en)
|
2002-12-19 |
2003-01-22 |
Cancer Rec Tech Ltd |
Pyrazole compounds
|
US20040147561A1
(en)
|
2002-12-27 |
2004-07-29 |
Wenge Zhong |
Pyrid-2-one derivatives and methods of use
|
WO2004074438A2
(en)
|
2003-02-14 |
2004-09-02 |
Smithkline Beecham Corporation |
Ccr8 antagonists
|
EP1633724B1
(en)
|
2003-03-12 |
2011-05-04 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
RU2005136368A
(ru)
|
2003-04-23 |
2006-06-10 |
Глэксо Груп Лимитед (GB) |
Производные пиперазина и их применение для лечения неврологических и психиатрических заболеваний
|
FR2854158B1
(fr)
|
2003-04-25 |
2006-11-17 |
Sanofi Synthelabo |
Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
|
DE602004008291T2
(de)
|
2003-07-18 |
2008-05-08 |
Glaxo Group Limited, Greenford |
Substituierte piperidine als histamin-h3-rezeptorliganden
|
DE602004026068D1
(de)
|
2003-07-29 |
2010-04-29 |
High Point Pharmaceuticals Llc |
Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden
|
WO2005060665A2
(en)
|
2003-12-18 |
2005-07-07 |
Incyte Corporation |
3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
|
GB0403155D0
(en)
|
2004-02-12 |
2004-03-17 |
Vernalis Res Ltd |
Chemical compounds
|
EP1720545B1
(en)
|
2004-03-03 |
2014-10-29 |
ChemoCentryx, Inc. |
Bicyclic and bridged nitrogen heterocycles
|
PE20060285A1
(es)
|
2004-03-30 |
2006-05-08 |
Aventis Pharma Inc |
Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
|
EP1761496A2
(en)
|
2004-03-31 |
2007-03-14 |
Janssen Pharmaceutica N.V. |
Non-imidazole heterocyclic compounds as histamine h3-receptor ligands
|
EP1750727A2
(en)
|
2004-04-23 |
2007-02-14 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
CA2567851A1
(en)
|
2004-05-21 |
2006-01-05 |
Merck & Co., Inc. |
Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
|
GEP20105024B
(en)
|
2004-06-02 |
2010-06-25 |
Takeda Pharmaceuticals Co |
Fused heterocyclic compound
|
FR2871157A1
(fr)
|
2004-06-04 |
2005-12-09 |
Aventis Pharma Sa |
Produits biaryl aromatiques, compositions les contenant et utilisation
|
US8071624B2
(en)
|
2004-06-24 |
2011-12-06 |
Incyte Corporation |
N-substituted piperidines and their use as pharmaceuticals
|
UA85597C2
(ru)
|
2004-06-25 |
2009-02-10 |
Янссен Фармацевтика Н.В. |
Четвертичные соли как антагонисты ccr2
|
WO2006004741A2
(en)
|
2004-06-28 |
2006-01-12 |
Incyte Corporation |
3-aminocyclopentanecarboxamides as modulators of chemokine receptors
|
EP1791827A1
(en)
|
2004-08-26 |
2007-06-06 |
Kudos Pharmaceuticals Limited |
4-heteroarylmethyl substituted phthalazinone derivatives
|
GB0420831D0
(en)
|
2004-09-17 |
2004-10-20 |
Glaxo Group Ltd |
Novel compounds
|
AR051092A1
(es)
|
2004-09-20 |
2006-12-20 |
Xenon Pharmaceuticals Inc |
Derivados heterociclicos y su uso como inhibidores de la estearoil-coa
|
GB0421525D0
(en)
|
2004-09-28 |
2004-10-27 |
Novartis Ag |
Inhibitors of protein kineses
|
WO2006038734A1
(en)
|
2004-10-08 |
2006-04-13 |
Astellas Pharma Inc. |
Pyridazinone derivatives cytokines inhibitors
|
CN101087766B
(zh)
|
2004-11-02 |
2011-09-07 |
西北大学 |
哒嗪化合物、组合物和方法
|
UY29219A1
(es)
|
2004-11-22 |
2006-04-28 |
Incyte Corp |
Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
|
DE102004061751A1
(de)
|
2004-12-22 |
2006-07-06 |
Bayer Healthcare Ag |
Cyanoguanidin-substituierte Pyrazoline
|
KR101065979B1
(ko)
|
2005-02-17 |
2011-09-19 |
아스텔라스세이야쿠 가부시키가이샤 |
피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르 유도체
|
EP2527337A1
(en)
|
2005-04-14 |
2012-11-28 |
Bristol-Myers Squibb Company |
Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
|
JP2008537953A
(ja)
|
2005-04-15 |
2008-10-02 |
エラン ファーマシューティカルズ,インコーポレイテッド |
ブラジキニンb1受容体拮抗作用に有用な新規化合物
|
TW200716594A
(en)
|
2005-04-18 |
2007-05-01 |
Neurogen Corp |
Substituted heteroaryl CB1 antagonists
|
JP2008545660A
(ja)
|
2005-05-20 |
2008-12-18 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼ阻害剤として有用なピロロピリジン化合物
|
JP5121707B2
(ja)
|
2005-07-04 |
2013-01-16 |
ハイ ポイント ファーマシューティカルズ,エルエルシー |
新規医薬
|
EP1909797A4
(en)
|
2005-08-02 |
2013-02-27 |
Neurogen Corp |
DIPIPERAZINYL KETONE AND RELATED ANALOG
|
GB0517184D0
(en)
|
2005-08-22 |
2005-09-28 |
Glaxo Group Ltd |
Compounds
|
TWI329641B
(en)
|
2005-08-31 |
2010-09-01 |
Otsuka Pharma Co Ltd |
(benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
|
TW200800999A
(en)
|
2005-09-06 |
2008-01-01 |
Astrazeneca Ab |
Novel compounds
|
CA2622494A1
(en)
|
2005-09-27 |
2007-04-05 |
Irm Llc |
Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
|
JO2769B1
(en)
|
2005-10-26 |
2014-03-15 |
جانسين فارماسوتيكا ان. في |
Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
|
US20100016289A1
(en)
|
2005-11-01 |
2010-01-21 |
Kevin Sprott |
Compounds Useful as Antagonists of CCR2
|
US8067457B2
(en)
|
2005-11-01 |
2011-11-29 |
Millennium Pharmaceuticals, Inc. |
Compounds useful as antagonists of CCR2
|
BRPI0618573A2
(pt)
|
2005-11-14 |
2011-09-06 |
Irm Llc |
compostos e composições como moduladores de lxr
|
JP2009519986A
(ja)
|
2005-12-20 |
2009-05-21 |
ノバルティス アクチエンゲゼルシャフト |
代謝型グルタミン酸受容体のモジュレーターとしてのニコチン酸誘導体
|
IL172838A
(en)
|
2005-12-27 |
2010-06-16 |
Joma Int As |
Methods for production of metal oxide nano particles with controlled properties and nano particles and preparations produced thereby
|
WO2007084868A2
(en)
|
2006-01-17 |
2007-07-26 |
Kalypsys, Inc. |
Treatment of disorders by activation of the unfolded protein response
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
US7919626B2
(en)
|
2006-02-28 |
2011-04-05 |
Helicon Therapeutics, Inc. |
Pyrazole compounds and uses thereof
|
JP2009530261A
(ja)
|
2006-03-16 |
2009-08-27 |
ファイザー・プロダクツ・インク |
ピラゾール化合物
|
JP2009533435A
(ja)
|
2006-04-11 |
2009-09-17 |
メルク エンド カムパニー インコーポレーテッド |
ジアリール置換アルカン
|
US7807671B2
(en)
|
2006-04-25 |
2010-10-05 |
Bristol-Myers Squibb Company |
Diketo-piperazine and piperidine derivatives as antiviral agents
|
WO2007127448A2
(en)
|
2006-04-28 |
2007-11-08 |
Northwestern University |
Salts of pyridazine compounds
|
ES2340093T3
(es)
|
2006-06-22 |
2010-05-28 |
Biovitrum Ab (Publ) |
Derivados pirazina y piridina como inhibidores de cinasa mnk.
|
WO2008014199A2
(en)
|
2006-07-28 |
2008-01-31 |
Boehringer Ingelheim International Gmbh |
Sulfonyl compounds which modulate the cb2 receptor
|
GB0617575D0
(en)
|
2006-09-06 |
2006-10-18 |
Syngenta Ltd |
Herbicidal compounds and compositions
|
KR20090069318A
(ko)
|
2006-09-25 |
2009-06-30 |
베링거 인겔하임 인터내셔날 게엠베하 |
Cb2 수용체를 조절하는 화합물
|
CA2669917A1
(en)
|
2006-11-17 |
2008-05-22 |
Dawn M. George |
Aminopyrrolidines as chemokine receptor antagonists
|
CN103690542B
(zh)
|
2006-12-28 |
2015-11-18 |
Abbvie公司 |
聚(adp-核糖)聚合酶抑制剂
|
EP2121633A2
(en)
|
2007-02-12 |
2009-11-25 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of ad and related conditions
|
JP4785881B2
(ja)
|
2007-02-27 |
2011-10-05 |
大塚製薬株式会社 |
医薬
|
FR2915552B1
(fr)
|
2007-04-27 |
2009-11-06 |
Technip France |
Conduite tubulaire flexible pour le transport d'hydrocarbures gazeux.
|
WO2008145681A2
(en)
|
2007-05-31 |
2008-12-04 |
Boehringer Ingelheim International Gmbh |
Ccr2 receptor antagonists and uses thereof
|
AU2008270438B2
(en)
|
2007-07-02 |
2013-10-10 |
F. Hoffmann-La Roche Ag |
Imidazole derivatives as CCR2 receptor antagonists
|
US7977358B2
(en)
|
2007-07-26 |
2011-07-12 |
Hoffmann-La Roche Inc. |
Pyrazol derivatives
|
AU2008289135B2
(en)
|
2007-08-22 |
2012-02-23 |
Irm Llc |
2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
|
RU2010116821A
(ru)
|
2007-10-01 |
2011-11-10 |
Ф.Хоффманн-Ля Аг (Ch) |
N-гетероциклические биарильные карбоксамиды в качестве антагонистов рецептора ccr
|
US20100218349A1
(en)
|
2007-10-12 |
2010-09-02 |
Whang Jong O |
Tying tool for shoelace
|
WO2009067406A1
(en)
|
2007-11-20 |
2009-05-28 |
Janssen Pharmaceutica N.V. |
Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
|
WO2009066084A1
(en)
|
2007-11-21 |
2009-05-28 |
F. Hoffmann-La Roche Ag |
2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
|
EP2062889A1
(de)
|
2007-11-22 |
2009-05-27 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verbindungen
|
JP5385297B2
(ja)
|
2007-11-22 |
2014-01-08 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規化合物
|
KR101357966B1
(ko)
|
2008-06-18 |
2014-02-03 |
에프. 호프만-라 로슈 아게 |
신규 헤테로아릴 카복스아마이드 유도체
|
NZ590887A
(en)
|
2008-08-04 |
2012-09-28 |
Chdi Foundation Inc |
Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
|
GB0815369D0
(en)
|
2008-08-22 |
2008-10-01 |
Summit Corp Plc |
Compounds for treatment of duchenne muscular dystrophy
|
KR20110049851A
(ko)
|
2008-09-02 |
2011-05-12 |
베링거 인겔하임 인터내셔날 게엠베하 |
신규한 벤즈아미드, 이의 제조방법, 및 약제로서의 이의 용도
|
NZ591111A
(en)
|
2008-09-25 |
2013-08-30 |
Boehringer Ingelheim Int |
Sulfonyl compounds which selectively modulate the cb2 receptor
|
ES2551557T3
(es)
|
2008-12-19 |
2015-11-19 |
Boehringer Ingelheim International Gmbh |
Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC
|
JP2012518603A
(ja)
|
2009-02-23 |
2012-08-16 |
メルク カナダ インコーポレイテッド |
ステアロイル−コエンザイムaデルタ−9デサチュラーゼの阻害剤としての複素環誘導体
|
ES2524829T3
(es)
|
2009-12-17 |
2014-12-12 |
Boehringer Ingelheim International Gmbh |
Nuevos antagonistas del receptor CCR2 y usos de los mismos
|
EP2513086B1
(en)
|
2009-12-17 |
2015-04-29 |
Boehringer Ingelheim International GmbH |
Novel antagonists for ccr2 and uses thereof
|
JP5746228B2
(ja)
|
2010-03-05 |
2015-07-08 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Cb2受容体を選択的に調節するテトラゾール化合物
|
JP5646736B2
(ja)
|
2010-05-12 |
2014-12-24 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規ccr2受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
|
US8877745B2
(en)
|
2010-05-12 |
2014-11-04 |
Boehringer Ingelheim International Gmbh |
CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
|
WO2011144501A1
(en)
|
2010-05-17 |
2011-11-24 |
Boehringer Ingelheim International Gmbh |
Ccr2 antagonists and uses thereof
|
WO2011147772A1
(en)
|
2010-05-25 |
2011-12-01 |
Boehringer Ingelheim International Gmbh |
Ccr2 receptor antagonists
|
US8962656B2
(en)
|
2010-06-01 |
2015-02-24 |
Boehringer Ingelheim International Gmbh |
CCR2 antagonists
|
JP5786257B2
(ja)
|
2011-06-16 |
2015-09-30 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規の選択的ccr2拮抗薬
|
EP2731941B1
(en)
|
2011-07-15 |
2019-05-08 |
Boehringer Ingelheim International GmbH |
Novel and selective ccr2 antagonists
|
AU2016287584B2
(en)
*
|
2015-07-02 |
2020-03-26 |
Centrexion Therapeutics Corporation |
(4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
|