HRP20051021A2 - Nicotinamide derivatives useful as pde4 inhibitors - Google Patents

Nicotinamide derivatives useful as pde4 inhibitors Download PDF

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Publication number
HRP20051021A2
HRP20051021A2 HR20051021A HRP20051021A HRP20051021A2 HR P20051021 A2 HRP20051021 A2 HR P20051021A2 HR 20051021 A HR20051021 A HR 20051021A HR P20051021 A HRP20051021 A HR P20051021A HR P20051021 A2 HRP20051021 A2 HR P20051021A2
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HR
Croatia
Prior art keywords
asthma
compound
mmol
disease
preparation
Prior art date
Application number
HR20051021A
Other languages
English (en)
Croatian (hr)
Inventor
Gordon Barber Christopher
Edward Bunnage Mark
Wilson Harvey John
Paul Mathias John
Original Assignee
Pfizer Inc.
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Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20051021A2 publication Critical patent/HRP20051021A2/hr

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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HR20051021A 2003-07-25 2005-12-22 Nicotinamide derivatives useful as pde4 inhibitors HRP20051021A2 (en)

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CA2594785A1 (en) * 2005-01-21 2006-07-27 Pfizer Limited Crystalline forms cis-5-fluoro-n-[4-(2-hydroxy-4-methylbenzamido) cyclohexyl]-2-(tetrahydrothiopyran-a-yloxy) nicotinamide
EP1683795A1 (en) * 2005-01-21 2006-07-26 Pfizer Limited Crystalline forms of cis-5-fluoro-N-¬4-(2-hydroxy-4-methylbenzamido)cyclohexyl|-2-(tetrahydrothiopyran-4-yloxy)nicotinamide
JP2008536888A (ja) * 2005-04-19 2008-09-11 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺高血圧症の治療のためのロフルミラスト
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7926591B2 (en) * 2006-02-10 2011-04-19 Halliburton Energy Services, Inc. Aqueous-based emulsified consolidating agents suitable for use in drill-in applications
WO2007101161A2 (en) * 2006-02-24 2007-09-07 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
PL2280696T3 (pl) * 2008-03-18 2015-03-31 Arena Pharm Inc Modulatory receptora prostacykliny (PGI2) użyteczne do leczenia zaburzeń z nim związanych
CN103880757B (zh) * 2014-04-15 2016-02-24 上海毕得医药科技有限公司 一种5-羟基嘧啶-2-羧酸的合成方法
ES2965069T3 (es) 2017-03-01 2024-04-11 Arena Pharm Inc Composiciones que comprenden agonistas del receptor de PGI2 y procesos para la preparación de las mismas
JP2023508978A (ja) * 2019-12-23 2023-03-06 サンフォード バーナム プレビス メディカル ディスカバリー インスティテュート エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ１（ｅｎｐｐ１）モジュレーター及びその使用
WO2021155081A1 (en) * 2020-01-31 2021-08-05 The Lubrizol Corporation Processes for producing alkyl salicylic acids and overbased detergents derived therefrom
CN111302945B (zh) * 2020-02-21 2023-06-13 上海再启生物技术有限公司 3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
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IL314717A (en) 2022-02-15 2024-10-01 United Therapeutics Corp Crystalline prostacyclin (IP) receptor agonist and uses thereof

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ID22781A (id) * 1997-04-04 1999-12-09 Pfizer Prod Inc Turunan-turunan nikotinamida
US20020111495A1 (en) * 1997-04-04 2002-08-15 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
US6740655B2 (en) * 2000-01-31 2004-05-25 Pfizer Inc Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes
MXPA02007419A (es) * 2000-01-31 2002-12-09 Pfizer Prod Inc Derivados de nicotinamida benzocondensada-heterociclilo utiles como inhibidores selectivos de las isozimas pde4.
EP1355884A1 (en) * 2001-01-31 2003-10-29 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
EE200300362A (et) * 2001-01-31 2003-12-15 Pfizer Products Inc. PDE4 isosüümide inhibiitoritena kasutatavad tiasolüül-, oksasolüül-, pürrolüül- ja imidasolüülhappeamiidi derivaadid

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ATE362930T1 (de) 2007-06-15
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