MA27931A1 - Derives de nicotinamide utiles comme inhibiteurs de pde4 - Google Patents

Derives de nicotinamide utiles comme inhibiteurs de pde4

Info

Publication number
MA27931A1
MA27931A1 MA28752A MA28752A MA27931A1 MA 27931 A1 MA27931 A1 MA 27931A1 MA 28752 A MA28752 A MA 28752A MA 28752 A MA28752 A MA 28752A MA 27931 A1 MA27931 A1 MA 27931A1
Authority
MA
Morocco
Prior art keywords
pde4 inhibitors
derivatives useful
nicotinamide derivatives
nicotinamide
preparation
Prior art date
Application number
MA28752A
Other languages
English (en)
Inventor
Christopher Gordon Barber
Mark Edward Bunnage
John Wilson Harvey
John Paul Mathias
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA27931A1 publication Critical patent/MA27931A1/fr

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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Abstract

Dérivés de nicotinamide utiles comme inhibiteurs de PDE4 La présente invention concerne des dérivés de nicotinamide de formule générale (I), dans laquelle R1, Z et R2 répondent aux définitions figurant dans le présent mémoire, et des procédés pour la préparation de, les intermédiaires utilisés dans la préparation de, des compositions contenant, et les utilisations de, ces dérivés.
MA28752A 2003-07-25 2006-01-25 Derives de nicotinamide utiles comme inhibiteurs de pde4 MA27931A1 (fr)

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MA (2) MA27931A1 (fr)
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TW (2) TW200524916A (fr)
UY (2) UY28434A1 (fr)
WO (2) WO2005009994A1 (fr)
ZA (2) ZA200510421B (fr)

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PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
EP1683795A1 (fr) * 2005-01-21 2006-07-26 Pfizer Limited Formes crystallines de cis-5-fluoro-N-¬4-(2-hydroxy-4-methylbenzamido)cyclohexyl|-2-(tetrahydrothiopyran-4-yloxy)nicotinamide
WO2006077497A1 (fr) * 2005-01-21 2006-07-27 Pfizer Limited Formes cristallines cis-5-fluoro-n-[4-(2-hydroxy-4-methylbenzamido) cyclohexyl]-2-(tetrahydrothiopyran-a-yloxy) nicotinamide
PL2366393T3 (pl) * 2005-04-19 2014-01-31 Takeda Gmbh Roflumilast do leczenia nadciśnienia płucnego
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7926591B2 (en) * 2006-02-10 2011-04-19 Halliburton Energy Services, Inc. Aqueous-based emulsified consolidating agents suitable for use in drill-in applications
WO2007101161A2 (fr) * 2006-02-24 2007-09-07 Ironwood Pharmaceuticals, Inc. Méthodes et compositions servant au traitement de troubles gastro-intestinaux
KR20210088008A (ko) * 2008-03-18 2021-07-13 아레나 파마슈티칼스, 인크. 프로스타시클린 （ｐｇｉ２） 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제
CN103880757B (zh) * 2014-04-15 2016-02-24 上海毕得医药科技有限公司 一种5-羟基嘧啶-2-羧酸的合成方法
JP7023559B2 (ja) 2017-03-01 2022-02-22 アレーナ ファーマシューティカルズ，インク． Ｐｇｉ２－受容体アゴニストを含む組成物、およびその調製のためのプロセス
US20230121698A1 (en) * 2019-12-23 2023-04-20 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) modulators and uses thereof
WO2021155081A1 (fr) * 2020-01-31 2021-08-05 The Lubrizol Corporation Procédés de production d'acides alkylsalicyliques et détergents surbasiques dérivés de ceux-ci
CN111302945B (zh) * 2020-02-21 2023-06-13 上海再启生物技术有限公司 3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
DE102020107795A1 (de) 2020-03-20 2021-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Elektronen emittierende Keramik

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TR199902432T2 (xx) * 1997-04-04 2000-01-21 Prizer Products Inc. Nikotinamid t�revleri.
US20020111495A1 (en) * 1997-04-04 2002-08-15 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
JP3917863B2 (ja) * 2000-01-31 2007-05-23 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの選択的阻害薬として有用なニコチンアミドベンゾ縮合複素環誘導体
US6740655B2 (en) * 2000-01-31 2004-05-25 Pfizer Inc Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes
CA2436535A1 (fr) * 2001-01-31 2002-08-08 Prizer Products Inc. Derives de biaryl nicotinamide utiles comme inhibiteurs d'isozymes de pde4
HUP0401305A2 (hu) * 2001-01-31 2004-10-28 Pfizer Products Inc. Tiazolil-, oxazolil-, pirrolil- és imidazolil-savamid-származékok, mint PDE4 izozimek inhibitorai és az ezeket tartalmazó gyógyszerkészítmények

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NL1026717C2 (nl) 2005-11-01
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BRPI0412910A (pt) 2006-09-26
TW200521127A (en) 2005-07-01
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CY1106343T1 (el) 2011-10-12
AR045091A1 (es) 2005-10-12
EA200600018A1 (ru) 2006-08-25
IS8242A (is) 2006-01-19
GT200400142A (es) 2005-03-03
TW200524916A (en) 2005-08-01
WO2005009994A1 (fr) 2005-02-03
HRP20051021A2 (en) 2006-05-31
JP2006528657A (ja) 2006-12-21
PA8607701A1 (es) 2005-02-04
US20060178408A1 (en) 2006-08-10
KR20060034300A (ko) 2006-04-21
DE602004004794T2 (de) 2007-12-06
CA2532249A1 (fr) 2005-02-03
CN1829712A (zh) 2006-09-06
US20050043326A1 (en) 2005-02-24
US20090035313A1 (en) 2009-02-05
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PA8607801A1 (es) 2005-02-04
EP1651640B1 (fr) 2007-02-14
JP2006528625A (ja) 2006-12-21
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AP2006003483A0 (en) 2006-02-28
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