AR045091A1 - Derivados de nicotinamida utiles como inhibidores de pde4 - Google Patents

Derivados de nicotinamida utiles como inhibidores de pde4

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Publication number
AR045091A1
AR045091A1 ARP040102622A ARP040102622A AR045091A1 AR 045091 A1 AR045091 A1 AR 045091A1 AR P040102622 A ARP040102622 A AR P040102622A AR P040102622 A ARP040102622 A AR P040102622A AR 045091 A1 AR045091 A1 AR 045091A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
halo
alkoxy
pde4 inhibitors
Prior art date
Application number
ARP040102622A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR045091A1 publication Critical patent/AR045091A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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Abstract

La presente se refiere a derivados de nicotinamida útiles como inhibidores de PDE4, procedimientos para su preparación, compuestos intermedios, composiciones farmacéuticas que los contienen y usos. Reivindicación 1: Un compuesto de fórmula (1) en la que R1 se selecciona entre H, halo, y alquilo C1-4; Z es un grupo de enlace seleccionado entre CO y SO2; R2 se selecciona entre fenilo, bencilo, naftilo, heteroarilo y cicloalquilo C3-8, cada uno de los cuales está sustituido con 1 sustituyente seleccionado entre alcoxi C1-6, (cicloalquil(C-8))-alcoxi (C1-6), hidroxi-alcoxi C2-6, (cicloalquil (C3-8))oxi y fenilo sustituido con alcoxi C1-6 (estando dicho fenilo opcionalmente sustituido adicionalmente con OH y/o halo), y cada uno de los cuales está opcionalmente sustituido adicionalmente con 1 o 2 sustituyentes seleccionados cada uno independientemente entre halo, CN, CONR3R4, alquilo C1-6, halo-alquilo C1-6, OH, hidroxi-alquilo C1-6, (cicloalquil (C3-8))-alquilo (C1-6), cicloalquilo C3-8 y NR3R4; y cada uno de R3 y R4 se selecciona independientemente entre H, alquilo C1-4 y SO2-alquilo C1-4; y sales y solvatos farmacéuticamente aceptables de los mismos.
ARP040102622A 2003-07-25 2004-07-23 Derivados de nicotinamida utiles como inhibidores de pde4 AR045091A1 (es)

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WO2006077497A1 (en) * 2005-01-21 2006-07-27 Pfizer Limited Crystalline forms cis-5-fluoro-n-[4-(2-hydroxy-4-methylbenzamido) cyclohexyl]-2-(tetrahydrothiopyran-a-yloxy) nicotinamide
US8648100B2 (en) * 2005-04-19 2014-02-11 Takeda Gmbh Roflumilast for the treatment of pulmonary hypertension
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
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CN103880757B (zh) * 2014-04-15 2016-02-24 上海毕得医药科技有限公司 一种5-羟基嘧啶-2-羧酸的合成方法
KR102432505B1 (ko) 2017-03-01 2022-08-12 아레나 파마슈티칼스, 인크. Pgi2-수용체 효능제를 포함하는 조성물 및 그의 제조 방법
AU2020412779A1 (en) * 2019-12-23 2022-06-23 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) modulators and uses thereof
US20230088684A1 (en) * 2020-01-31 2023-03-23 The Lubrizol Corporation Processes for Producing Alkyl Salicylic Acids and Overbased Detergents Derived Therefrom
CN111302945B (zh) * 2020-02-21 2023-06-13 上海再启生物技术有限公司 3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
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