AR056338A1 - Derivados hexahidroquinolina, composiciones farmaceuticas y su uso en el tratamiento de desordenes de fertilidad - Google Patents
Derivados hexahidroquinolina, composiciones farmaceuticas y su uso en el tratamiento de desordenes de fertilidadInfo
- Publication number
- AR056338A1 AR056338A1 ARP060101780A ARP060101780A AR056338A1 AR 056338 A1 AR056338 A1 AR 056338A1 AR P060101780 A ARP060101780 A AR P060101780A AR P060101780 A ARP060101780 A AR P060101780A AR 056338 A1 AR056338 A1 AR 056338A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- amino
- 4alkyl
- alkylcarbonyl
- Prior art date
Links
- 208000021267 infertility disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- JCWLOGAMQQPDKR-UHFFFAOYSA-N 1,2,3,4,4a,5-hexahydroquinoline Chemical class C1=CCC2CCCNC2=C1 JCWLOGAMQQPDKR-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- -1 hydroxy, amino Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- GTFDKLAZHJQLIA-UHFFFAOYSA-N 4-phenyl-4,6,7,8-tetrahydro-1h-quinolin-5-one Chemical class O=C1CCCC(NC=C2)=C1C2C1=CC=CC=C1 GTFDKLAZHJQLIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 102000008175 FSH Receptors Human genes 0.000 abstract 1
- 108010060374 FSH Receptors Proteins 0.000 abstract 1
- 206010033266 Ovarian Hyperstimulation Syndrome Diseases 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 125000005090 alkenylcarbonyl group Chemical group 0.000 abstract 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de esta presente son activadores potentes del receptor FSH y se pueden utilizar para tratar desordenes de fertilidad en, por ejemplo, hiperestimulacion ovárica controlada y procedimientos IVF. Composiciones farmacéuticas que los contienen. Reivindicacion 1: Un derivado 4-fenil-5-oxo-1.4.5.6.7.8-hexahidroquinolina de acuerdo con la formula (1), caracterizado porque: R1 es alquil C1-6, alquenil C2-6 o alquinil C2-6; R2 es halogeno, alcoxi C1-4, alcoxi C1-4 fluorado, alquil C1-4, o alquil C1-4 fluorado; o R2 pueden ser H cuando R3 es R9.R10-aminosulfonil; R3 es OH, NO2, CN, alcoxi C1-4 fluorado, alcoxiC1-4-alcoxiC2-4, hidroxi-alcoxiC2-4, alcoxicarbonil C1-4, alqueniloxicarbonil C3-4, alcoxicarboniloxi C1-4, alqueniloxicarboniloxi C3-4, R7.R8-amino, R9.R10-amino, R9.R10-aminocarbonil, R9.R10-aminosulfonil o fenil-alcoxiC1-4, donde el anillo fenil se sustituye opcionalmente con uno o más sustituyentes seleccionados de hidroxi, amino, halogeno, nitro, trifluorometil, ciano, alquil C1-4, alquenil C2-4, alquinil C2-4, alcoxi C1-4, (di)-alquilaminoC1-4; R4 es R11-fenil o R1-heteroarilC2-5, donde el grupo fenil o heteroaril se sustituye opcionalmente con uno o más sustituyentes seleccionados de hidroxi, amino, halogeno, nitro, trifluorometil, ciano, alquil C1-4, alquiltio C1-4, alcoxi C1-4, alquenil C2-4, alquinil C2-4; R7 es H, alquil C1-4; R8 es alquilsulfonil C1-4, alquilcarbonil C1-4, alquenilcarbonil C2-4, cicloalquilcarbonil C3-6, alcoxicarbonil C1-4, alqueniloxicarbonil C3-4, alcoxiC1-4-alquilcarbonilC1-4, alqueniloxiC3-4-alquilcarbonilC1-4-fenilcarbonil, heteroarilcarbonil C2-5, fenil-alquilcarbonilC1-4, heteroarilC2-5-alquilcarbonilC1-4, donde el anillo fenil o el anillo heteroaromático se sustituye opcionalmente con uno o más sustituyentes seleccionados de hidroxi, amino, halogeno, nitro, trifluorometil, ciano, alquil C1-4, alquenil C2-4, alquinil C2-4, alcoxi C1-4, (di)-alquilaminoC1-4; R9 y R10 se seleccionan independientemente de H, alquil C1-6, cicloalquil C3-6, cicloalquilC3-6-alquilC1-4 y alcoxiC1-4-alquilC2-4; o R9 y R10 se pueden se pueden unir en un anillo heterocicloalquenil C4-6 o un anillo heterocicloalquil C2-6, sustituido opcionalmente con uno o más alquil C1-4 sustituyentes; R11 es H, alcoxicarbonil C1-6, R12.R13-amino, alquilcarbonil C1-6, alquilsulfonil C1-6, R14-oxi, R14.R15-amino, R14.R15-aminocarbonil, R14.R15-aminosulfonil; R12 es H, alquil C1-4; R13 es alquilsulfonil C1-4, alquilcarbonil C1-4, cicloalquilcarbonil C3-6, alcoxicarbonil C1-4, alqueniloxicarbonil C3-4, (di)-alquilaminoC1-4-alquilcarbonilC1-4, heterocicloalquilC2-6-alquilcarbonilC1-4, heterocicloalquenilC4-6-alquilcarbonilC1-4 o alcoxiC1-4-alquilcarbonilC1- 4; R14 y R15 se seleccionan independientemente de H, alquil C1-6, alquenil C3-6, alquinil C3-6, cicloalquil C3-6, cicloalquilC3-6-alquilC1-4, hidroxi-alquilC2-4, amino-alquilC2-4, alcoxiC1-4-alquilC2-4, (di)-alquilaminoC1-4-alquilC2-4, heterocicloalquilC2-6-alquilC2-4, heterocicloalquenilC4-6-alquilC2-4, fenil-alquilC1-4 y heteroarilC2-5-alquilCl-4; X es O o R16-N; Y es CH2, C(O) o SO2; Z es CN o NO2; R16 es H, alquil C1-4, alquilcarbonil C1-4; o una sal farmacéuticamente aceptable de ellos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103738 | 2005-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056338A1 true AR056338A1 (es) | 2007-10-03 |
Family
ID=34939695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101780A AR056338A1 (es) | 2005-05-04 | 2006-05-03 | Derivados hexahidroquinolina, composiciones farmaceuticas y su uso en el tratamiento de desordenes de fertilidad |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8034945B2 (es) |
| EP (1) | EP1879580B1 (es) |
| JP (1) | JP5129738B2 (es) |
| KR (1) | KR20080010427A (es) |
| CN (1) | CN101212972B (es) |
| AR (1) | AR056338A1 (es) |
| AT (1) | ATE424823T1 (es) |
| AU (1) | AU2006243190B2 (es) |
| BR (1) | BRPI0611118A2 (es) |
| CA (1) | CA2606682C (es) |
| CY (1) | CY1109076T1 (es) |
| DE (1) | DE602006005640D1 (es) |
| DK (1) | DK1879580T3 (es) |
| ES (1) | ES2322295T3 (es) |
| HR (1) | HRP20090189T1 (es) |
| IL (1) | IL186676A (es) |
| MX (1) | MX2007013742A (es) |
| NO (1) | NO20075567L (es) |
| NZ (1) | NZ562685A (es) |
| PE (1) | PE20061440A1 (es) |
| PL (1) | PL1879580T3 (es) |
| PT (1) | PT1879580E (es) |
| RS (1) | RS50968B (es) |
| RU (1) | RU2403243C2 (es) |
| SI (1) | SI1879580T1 (es) |
| UA (1) | UA92008C2 (es) |
| WO (1) | WO2006117370A1 (es) |
| ZA (1) | ZA200709094B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0520259A2 (pt) * | 2005-05-04 | 2009-09-15 | Organon Nv | composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| CN103068813B (zh) | 2010-06-15 | 2016-02-24 | 拜耳知识产权有限责任公司 | 邻氨基苯甲酸二酰胺衍生物 |
| RU2648352C1 (ru) * | 2017-07-18 | 2018-03-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения первичного бесплодия, обусловленного тромбофилиями при проведении экстракорпорального оплодотворения |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| DE4430639A1 (de) | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| CN1200114A (zh) * | 1995-10-19 | 1998-11-25 | 武田药品工业株式会社 | 作为gnrh拮抗剂的喹啉衍生物 |
| US6593335B1 (en) * | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| DE69921147T2 (de) | 1998-08-07 | 2005-02-24 | Applied Research Systems Ars Holding N.V. | Fsh mimetika zur behandlung von infertilität |
| JP2004505051A (ja) | 2000-07-27 | 2004-02-19 | スミスクライン ビーチャム コーポレーション | 卵胞刺激ホルモン活性のアゴニスト |
| SK286759B6 (sk) | 2001-07-02 | 2009-05-07 | N.V. Organon | Tetrahydrochinolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| BRPI0520259A2 (pt) | 2005-05-04 | 2009-09-15 | Organon Nv | composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto |
| UA92007C2 (ru) | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| UA92009C2 (ru) | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
-
2006
- 2006-02-05 UA UAA200711803A patent/UA92008C2/ru unknown
- 2006-05-02 BR BRPI0611118-1A patent/BRPI0611118A2/pt not_active IP Right Cessation
- 2006-05-02 AU AU2006243190A patent/AU2006243190B2/en not_active Ceased
- 2006-05-02 EP EP06754952A patent/EP1879580B1/en active Active
- 2006-05-02 WO PCT/EP2006/061976 patent/WO2006117370A1/en active Application Filing
- 2006-05-02 US US11/912,746 patent/US8034945B2/en active Active
- 2006-05-02 JP JP2008509436A patent/JP5129738B2/ja not_active Expired - Fee Related
- 2006-05-02 RS RSP-2009/0251A patent/RS50968B/sr unknown
- 2006-05-02 MX MX2007013742A patent/MX2007013742A/es active IP Right Grant
- 2006-05-02 PL PL06754952T patent/PL1879580T3/pl unknown
- 2006-05-02 PT PT06754952T patent/PT1879580E/pt unknown
- 2006-05-02 AT AT06754952T patent/ATE424823T1/de active
- 2006-05-02 CN CN2006800237472A patent/CN101212972B/zh not_active Expired - Fee Related
- 2006-05-02 SI SI200630269T patent/SI1879580T1/sl unknown
- 2006-05-02 RU RU2007144988/04A patent/RU2403243C2/ru not_active IP Right Cessation
- 2006-05-02 CA CA2606682A patent/CA2606682C/en not_active Expired - Fee Related
- 2006-05-02 NZ NZ562685A patent/NZ562685A/en not_active IP Right Cessation
- 2006-05-02 DK DK06754952T patent/DK1879580T3/da active
- 2006-05-02 DE DE602006005640T patent/DE602006005640D1/de active Active
- 2006-05-02 KR KR1020077026920A patent/KR20080010427A/ko not_active Application Discontinuation
- 2006-05-02 ES ES06754952T patent/ES2322295T3/es active Active
- 2006-05-03 PE PE2006000468A patent/PE20061440A1/es not_active Application Discontinuation
- 2006-05-03 AR ARP060101780A patent/AR056338A1/es not_active Application Discontinuation
-
2007
- 2007-10-16 IL IL186676A patent/IL186676A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709094A patent/ZA200709094B/xx unknown
- 2007-11-05 NO NO20075567A patent/NO20075567L/no not_active Application Discontinuation
-
2009
- 2009-03-31 HR HR20090189T patent/HRP20090189T1/xx unknown
- 2009-05-19 CY CY20091100532T patent/CY1109076T1/el unknown
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