AR071452A1 - Inhibidores de hsp90 - Google Patents

Inhibidores de hsp90

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Publication number
AR071452A1
AR071452A1 ARP090100342A ARP090100342A AR071452A1 AR 071452 A1 AR071452 A1 AR 071452A1 AR P090100342 A ARP090100342 A AR P090100342A AR P090100342 A ARP090100342 A AR P090100342A AR 071452 A1 AR071452 A1 AR 071452A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
heterobicycloaryl
bicycloaryl
heteroaryl
Prior art date
Application number
ARP090100342A
Other languages
English (en)
Inventor
Wolfgang Reinhard Lu Notz
Young K Chen
Jeffrey A Stafford
Erick W Co
Prasuna Guntupalli
Huong-Thu Ton-Nu
John D Lawson
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR071452A1 publication Critical patent/AR071452A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Composiciones farmacéuticas, kits y artículos de fabricacion que comprenden dichos compuestos; métodos e intermediarios utiles para producir los compuestos; y métodos de uso de dichos compuestos. Reivindicacion 1: Un compuesto de la formula seleccionada del grupo que consiste en formulas (1), (2), (3) o (4), o uno de sus tautomeros, estereoisomeros o sales aceptables desde el punto de vista farmacéutico, en los cuales X es O, NR8 o CR9R9'; R1 se selecciona del grupo que consiste en hidrogeno, carbonilo, hidroxicarbonilo, oxicarbonilo, aminocarbonilo, sulfonilo, sulfinilo, alquilo C1-10, haloalquilo C1-10, heteroalquilo C1-10, hidroxialquilo C1-10, alcoxialquilo C1-10, aminoalquilo C1-10, iminoalquilo C1-10, carbonilalquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, carbonilaminoalquilo C1-10, tiocarbonilalquilo C1-10, hidroxilcarbonilalquilo C1-10, aminocarbonilalquilo C1-10, aminosulfonilalquilo C1-10, sulfonilaminoalquilo C1-10, alquilsulfonilamino C1-6-alquilo C1-10, cicloalquil C3-12-alquilo C1-5, hetero cicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno no sustituido o sustituido; R2 se selecciona del grupo que consiste en hidrogeno, halo, ciano, tio, hidroxi, carboniloxi, alcoxi C1-10, ariloxi C4-12, heteroariloxi C1-10, carbonilo, oxicarbonilo, aminocarbonilo, amino, alquilamino C1-10, sulfonilamino, aminosulfonilo, sulfonilo, sulfinilo, alquilo C1-10, hetero alquilo C1-10, haloalquilo C1-10, hidroxialquilo C1-10, carbonilalquilo C1-10, tiocarbonilalquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, iminoalquilo C1-10, cicloalquil C3-12-alquilo C1-5, hetero cicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12 cada uno sustituido o no sustituido; R3 se selecciona del grupo que consiste en hidrogeno, halo, nitro, ciano, tio, oxi, hidroxi, carboniloxi, alcoxi C1-10, ariloxi C4-12, heteroariloxi C1-10, carbonilo, oxicarbonilo, aminocarbonilo, amino, alquilamino C1-10, sulfonilamino, aminosulfonilo, sulfonilo, sulfinilo, alquilo C1-10, alquenilo C1-10, haloalquilo C1-10, hidroxialquilo C1-10, carbonilalquilo C1-10, tiocarbonilalquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, heteroalquilo C1-10, iminoalquilo C1-10, cicloalquil C3-12-alquilo C1-5, hetero cicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-15, heteroC1-14cicloalquilo, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-15, heteroC1-14arilo, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno no sustituido o sustituido; R4 se selecciona del grupo que consiste en hidrogeno, carbonilo, oxicarbonilo, amino, alquilamino C1-10, sulfonilamino, aminosulfonilo, sulfonilo, sulfinilo, alquilo C1-10, haloalquilo C1-10, hidroxialquilo C1-10, carbonilalquilo C1-10, tiocarbonilalquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, azaalquilo C1-10, iminoalquilo C1-10, cicloalquil C3-12-alquilo C1-5, heterocicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12- alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12 , bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido; R5 y R5' se seleccionan cada uno en forma independiente del grupo que consiste en hidrogeno, ciano, carbonilo, oxicarbonilo, aminocarbonilo, sulfonilo, sulfinilo, alquilo C1-10, haloalquilo C1-10, hidroxialquilo C1-10, carbonilalquilo C1-10, tiocarbonilalquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, heteroalquilo C1-10, iminoalquilo C1-10, cicloalquil C3-12-alquilo C1-5, hetero cicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido; R6 y R6' se seleccionan cada uno en forma independiente del grupo que consiste en hidrogeno, halogeno, ciano, alquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, heteroalquilo C1-10, cicloalquil C3-12-alquilo C1-5, hetero cicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido, siempre que R6' esté ausente cuando A es CR5R5'; R7 se selecciona del grupo que consiste en hidrogeno, ciano, sulfonilo, sulfinilo, alquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, azaalquilo C1-10, oxaalquilo C1-10, cicloalquil C3-12-alquilo C1-5, heterocicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12- alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12 , bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido; R8 se selecciona del grupo que consiste en hidrogeno, alquilo C1-10, hidroxialquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, cicloalquil C3-12-alquilo C1-5, hetero cicloalquil C3- 12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido; y R9 y R9' se seleccionan cada uno en forma independiente del grupo que consiste en hidrogeno, sulfonilamino, aminosulfonilo, sulfonilo, sulfinilo, alquilo C1-10, hidroxialquilo C1-10, sulfonilalquilo C1-10, sulfinilalquilo C1-10, heteroalquilo C1-10, cicloalquil C3-12, alquilo C1-5, hetero cicloalquil C3-12-alquilo C1-10, arilalquilo C1-10, heteroaril C1-10-alquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, heteroalquilo C1-10, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada un sustituido o no sustituido; siempre que para la Formula 2, cuando X es O, R1 es alquilo C1-6 sustituido con por lo menos dos grupos hidroxilo.
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