HRP20040504A2 - Sulfonamido substituted imidazopyridines - Google Patents

Info

Publication number

HRP20040504A2

HRP20040504A2 HRP20040504A HRP20040504A2 HR P20040504 A2 HRP20040504 A2 HR P20040504A2 HR P20040504 A HRP20040504 A HR P20040504A HR P20040504 A2 HRP20040504 A2 HR P20040504A2

Authority

HR

Croatia

Prior art keywords

imidazo

pyridin

amino

ethoxymethyl

butyl

Prior art date

2001-12-06

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• 150000005232 imidazopyridines Chemical class 0.000 title description 2
• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 117
• 229910052739 hydrogen Inorganic materials 0.000 claims description 66
• 229910052799 carbon Inorganic materials 0.000 claims description 45
• -1 -alkyl-Y-alkenyl Chemical class 0.000 claims description 29
• 125000000217 alkyl group Chemical group 0.000 claims description 27
• 102000004127 Cytokines Human genes 0.000 claims description 26
• 108090000695 Cytokines Proteins 0.000 claims description 26
• 150000003839 salts Chemical class 0.000 claims description 26
• 125000001072 heteroaryl group Chemical group 0.000 claims description 23
• 239000001257 hydrogen Substances 0.000 claims description 21
• 125000003342 alkenyl group Chemical group 0.000 claims description 20
• 241001465754 Metazoa Species 0.000 claims description 19
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
• 229910052736 halogen Inorganic materials 0.000 claims description 18
• 238000011282 treatment Methods 0.000 claims description 17
• 230000015572 biosynthetic process Effects 0.000 claims description 16
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
• 125000000623 heterocyclic group Chemical group 0.000 claims description 15
• 125000001424 substituent group Chemical group 0.000 claims description 15
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
• 201000010099 disease Diseases 0.000 claims description 13
• 230000006698 induction Effects 0.000 claims description 13
• 125000003118 aryl group Chemical group 0.000 claims description 11
• 125000002947 alkylene group Chemical group 0.000 claims description 9
• 150000002367 halogens Chemical class 0.000 claims description 9
• 230000003612 virological effect Effects 0.000 claims description 9
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 8
• 125000003545 alkoxy group Chemical group 0.000 claims description 8
• 125000003282 alkyl amino group Chemical group 0.000 claims description 8
• 125000004414 alkyl thio group Chemical group 0.000 claims description 8
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 8
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
• 125000004450 alkenylene group Chemical group 0.000 claims description 7
• HNQIVZYLYMDVSB-NJFSPNSNSA-N methanesulfonamide Chemical compound [14CH3]S(N)(=O)=O HNQIVZYLYMDVSB-NJFSPNSNSA-N 0.000 claims description 6
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
• 230000001613 neoplastic effect Effects 0.000 claims description 5
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
• AOZMNNYIOVPNHJ-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(C)(=O)=O)C(COCC)=NC2=C1N AOZMNNYIOVPNHJ-UHFFFAOYSA-N 0.000 claims description 4
• GNXMSXQEEFMDPJ-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-methylsulfonylpiperidin-4-yl)ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(C)(=O)=O)CC1 GNXMSXQEEFMDPJ-UHFFFAOYSA-N 0.000 claims description 3
• 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 claims description 3
• OLKZFAZVUSSVGH-UHFFFAOYSA-N n-[4-(4-amino-2-butyl-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCCNS(C)(=O)=O)C(CCCC)=NC2=C1N OLKZFAZVUSSVGH-UHFFFAOYSA-N 0.000 claims description 3
• DGVFVEODKSWYJK-UHFFFAOYSA-N 1-[2-[1-[4-[[4-(dimethylamino)phenyl]diazenyl]phenyl]sulfonylpiperidin-4-yl]ethyl]-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC(CC1)CCN1S(=O)(=O)C(C=C1)=CC=C1N=NC1=CC=C(N(C)C)C=C1 DGVFVEODKSWYJK-UHFFFAOYSA-N 0.000 claims description 2
• IBMXTGBEHBPGLC-UHFFFAOYSA-N 1-[4-(1,1-dioxo-1,2-thiazolidin-2-yl)butyl]-6,7-dimethyl-2-propylimidazo[4,5-c]pyridin-4-amine Chemical compound CCCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCCN1CCCS1(=O)=O IBMXTGBEHBPGLC-UHFFFAOYSA-N 0.000 claims description 2
• HESNGHFXTBCTNA-UHFFFAOYSA-N 4-[2-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]ethyl]-n,n-dimethylpiperidine-1-sulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(=O)(=O)N(C)C)CC1 HESNGHFXTBCTNA-UHFFFAOYSA-N 0.000 claims description 2
• WXPSOLDEAMAJPP-UHFFFAOYSA-N 4-amino-1-[4-(dimethylsulfamoylamino)butyl]-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridine Chemical compound N1=CC(C)=C2N(CCCCNS(=O)(=O)N(C)C)C(COCC)=NC2=C1N WXPSOLDEAMAJPP-UHFFFAOYSA-N 0.000 claims description 2
• CCZSVQPAKLUELI-UHFFFAOYSA-N 4-amino-2-butyl-1-[4-(dimethylsulfamoylamino)butyl]-6,7-dimethylimidazo[4,5-c]pyridine Chemical compound N1=C(C)C(C)=C2N(CCCCNS(=O)(=O)N(C)C)C(CCCC)=NC2=C1N CCZSVQPAKLUELI-UHFFFAOYSA-N 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• DYVTWANBKVYOQI-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(C)(=O)=O)C(C)=NC2=C1N DYVTWANBKVYOQI-UHFFFAOYSA-N 0.000 claims description 2
• OXJRPUMIQFPKIY-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]butyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCCNS(C)(=O)=O)C(COCC)=NC2=C1N OXJRPUMIQFPKIY-UHFFFAOYSA-N 0.000 claims description 2
• GVVGTARNSOAMIW-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]methanesulfonamide Chemical compound N1=C(C)C=C2N(CCCCNS(C)(=O)=O)C(COCC)=NC2=C1N GVVGTARNSOAMIW-UHFFFAOYSA-N 0.000 claims description 2
• 125000003107 substituted aryl group Chemical group 0.000 claims description 2
• 229940124530 sulfonamide Drugs 0.000 claims description 2
• XLLFMFAAILQGBO-FMIVXFBMSA-N (e)-n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-2-phenylethenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)\C=C\C1=CC=CC=C1 XLLFMFAAILQGBO-FMIVXFBMSA-N 0.000 claims 1
• AYUINKIDLBLXIR-SDNWHVSQSA-N (e)-n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-2-phenylethenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)\C=C\C1=CC=CC=C1 AYUINKIDLBLXIR-SDNWHVSQSA-N 0.000 claims 1
• ZQFVHILXTVZLDV-UHFFFAOYSA-N 1-[2-(1-butylsulfonylpiperidin-4-yl)ethyl]-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-4-amine Chemical compound C1CN(S(=O)(=O)CCCC)CCC1CCN1C2=C(C)C(C)=NC(N)=C2N=C1COCC ZQFVHILXTVZLDV-UHFFFAOYSA-N 0.000 claims 1
• BFCUTJOHOPUWGQ-UHFFFAOYSA-N 2-(ethoxymethyl)-1-[2-(1-ethylsulfonylpiperidin-4-yl)ethyl]-6,7-dimethylimidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(=O)(=O)CC)CC1 BFCUTJOHOPUWGQ-UHFFFAOYSA-N 0.000 claims 1
• VEXBNBISUFJIKZ-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-naphthalen-2-ylsulfonylpiperidin-4-yl)ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound C1=CC=CC2=CC(S(=O)(=O)N3CCC(CC3)CCN3C4=C(C)C(C)=NC(N)=C4N=C3COCC)=CC=C21 VEXBNBISUFJIKZ-UHFFFAOYSA-N 0.000 claims 1
• YQHJWQMJJQCVKL-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-propan-2-ylsulfonylpiperidin-4-yl)ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(=O)(=O)C(C)C)CC1 YQHJWQMJJQCVKL-UHFFFAOYSA-N 0.000 claims 1
• QNRLLBCZBABYEU-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-[1-(4-methylsulfonylphenyl)sulfonylpiperidin-4-yl]ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC(CC1)CCN1S(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 QNRLLBCZBABYEU-UHFFFAOYSA-N 0.000 claims 1
• QHHRGOALWBPDRC-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-[1-(4-phenylphenyl)sulfonylpiperidin-4-yl]ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC(CC1)CCN1S(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 QHHRGOALWBPDRC-UHFFFAOYSA-N 0.000 claims 1
• LTWMKBUBTVKLJS-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-[1-[4-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC(CC1)CCN1S(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 LTWMKBUBTVKLJS-UHFFFAOYSA-N 0.000 claims 1
• BEHSXHFKMDXZOR-UHFFFAOYSA-N 4-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethylsulfamoyl]benzoic acid Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(C(O)=O)C=C1 BEHSXHFKMDXZOR-UHFFFAOYSA-N 0.000 claims 1
• DIKNMAGLRNPLCD-UHFFFAOYSA-N 4-amino-1-[4-(dimethylsulfamoylamino)butyl]-6,7-dimethylimidazo[4,5-c]pyridine Chemical compound N1=C(C)C(C)=C2N(CCCCNS(=O)(=O)N(C)C)C=NC2=C1N DIKNMAGLRNPLCD-UHFFFAOYSA-N 0.000 claims 1
• YPWULWOOLXIYDQ-QNEJGDQOSA-N C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S(=O)(=O)NCCCCN2C3=C(C)C(C)=NC(N)=C3N=C2)C=C1 Chemical compound C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S(=O)(=O)NCCCCN2C3=C(C)C(C)=NC(N)=C3N=C2)C=C1 YPWULWOOLXIYDQ-QNEJGDQOSA-N 0.000 claims 1
• QDJQMYUKUKPBHY-JEIPZWNWSA-N CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C(C=C1)=CC=C1\N=N\C1=CC=C(N(C)C)C=C1 Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C(C=C1)=CC=C1\N=N\C1=CC=C(N(C)C)C=C1 QDJQMYUKUKPBHY-JEIPZWNWSA-N 0.000 claims 1
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
• PMPGNVBILGZNKR-UHFFFAOYSA-N n-[1-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]-2-methylpropan-2-yl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CC(C)(C)NS(C)(=O)=O)C(COCC)=NC2=C1N PMPGNVBILGZNKR-UHFFFAOYSA-N 0.000 claims 1
• SZRXVUJCEOXNOU-UHFFFAOYSA-N n-[1-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]-2-methylpropan-2-yl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CC(C)(C)NS(=O)(=O)C(C)C)C(COCC)=NC2=C1N SZRXVUJCEOXNOU-UHFFFAOYSA-N 0.000 claims 1
• FFNYVSPQBMNFSD-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-1-(2-nitrophenyl)methanesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)CC1=CC=CC=C1[N+]([O-])=O FFNYVSPQBMNFSD-UHFFFAOYSA-N 0.000 claims 1
• CWRZRIVFNUEMEI-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-1-(7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl)methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)CC34C(CC(CC3)C4(C)C)=O)C(C)=NC2=C1N CWRZRIVFNUEMEI-UHFFFAOYSA-N 0.000 claims 1
• WABQHXXEEYRFFS-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-1-methylimidazole-4-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CN(C)C=N1 WABQHXXEEYRFFS-UHFFFAOYSA-N 0.000 claims 1
• OSOXBFCRCUBBEY-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-2,4-difluorobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(F)C=C1F OSOXBFCRCUBBEY-UHFFFAOYSA-N 0.000 claims 1
• XRIYPXXGMFEJGD-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide Chemical compound CC1=NOC(C)=C1S(=O)(=O)NCCN1C2=C(C)C(C)=NC(N)=C2N=C1C XRIYPXXGMFEJGD-UHFFFAOYSA-N 0.000 claims 1
• RHDARXLPLTTWPE-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-3-cyanobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CC(C#N)=C1 RHDARXLPLTTWPE-UHFFFAOYSA-N 0.000 claims 1
• QHQNIVIUXKXEFI-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-3-fluorobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CC(F)=C1 QHQNIVIUXKXEFI-UHFFFAOYSA-N 0.000 claims 1
• SELJXCVUXVCRJB-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-(trifluoromethoxy)benzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 SELJXCVUXVCRJB-UHFFFAOYSA-N 0.000 claims 1
• CUNIXUWTBPBNCJ-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-(trifluoromethyl)benzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 CUNIXUWTBPBNCJ-UHFFFAOYSA-N 0.000 claims 1
• WQTJKIUMGBOIHW-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-cyanobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(C#N)C=C1 WQTJKIUMGBOIHW-UHFFFAOYSA-N 0.000 claims 1
• RBFMOELWXHMFGN-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-methoxybenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NCCN1C2=C(C)C(C)=NC(N)=C2N=C1C RBFMOELWXHMFGN-UHFFFAOYSA-N 0.000 claims 1
• AMQISNMTOTWEGB-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-methylsulfonylbenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 AMQISNMTOTWEGB-UHFFFAOYSA-N 0.000 claims 1
• UWYXZBFTFOCGCT-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-phenylbenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 UWYXZBFTFOCGCT-UHFFFAOYSA-N 0.000 claims 1
• XNVXGXRWEXOWLG-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-5-chlorothiophene-2-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(Cl)S1 XNVXGXRWEXOWLG-UHFFFAOYSA-N 0.000 claims 1
• IHBYNMLOSYHLJJ-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]benzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CC=C1 IHBYNMLOSYHLJJ-UHFFFAOYSA-N 0.000 claims 1
• IQRIJRLKAATYNY-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)CCCC)C(C)=NC2=C1N IQRIJRLKAATYNY-UHFFFAOYSA-N 0.000 claims 1
• PJSNKWBCIWHBCH-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]ethanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)CC)C(C)=NC2=C1N PJSNKWBCIWHBCH-UHFFFAOYSA-N 0.000 claims 1
• HRGCOYSKRWDVEN-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=CC2=C1 HRGCOYSKRWDVEN-UHFFFAOYSA-N 0.000 claims 1
• YPILHWLBRDFQPN-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=C21 YPILHWLBRDFQPN-UHFFFAOYSA-N 0.000 claims 1
• PFWMIXCFNONSOZ-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)C(C)C)C(C)=NC2=C1N PFWMIXCFNONSOZ-UHFFFAOYSA-N 0.000 claims 1
• ZZAQZZVHOYMVDF-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]thiophene-2-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CS1 ZZAQZZVHOYMVDF-UHFFFAOYSA-N 0.000 claims 1
• YYYYWJSFGFIADJ-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-1-(7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl)methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CC34C(CC(CC3)C4(C)C)=O)C(C)=NC2=C1N YYYYWJSFGFIADJ-UHFFFAOYSA-N 0.000 claims 1
• NTHGPCKAQKTLFS-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-3-cyanobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(C#N)=C1 NTHGPCKAQKTLFS-UHFFFAOYSA-N 0.000 claims 1
• GUVQSOIOPJRLFW-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-3-fluorobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(F)=C1 GUVQSOIOPJRLFW-UHFFFAOYSA-N 0.000 claims 1
• LFCGFXWHVOOCOS-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-4-(trifluoromethoxy)benzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 LFCGFXWHVOOCOS-UHFFFAOYSA-N 0.000 claims 1
• TVKYJLLAHVDEBY-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-4-phenylbenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 TVKYJLLAHVDEBY-UHFFFAOYSA-N 0.000 claims 1
• VFIUUEZDQAZHOH-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CCCC)C(C)=NC2=C1N VFIUUEZDQAZHOH-UHFFFAOYSA-N 0.000 claims 1
• VKPBLRKAERQXDD-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]ethanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CC)C(C)=NC2=C1N VKPBLRKAERQXDD-UHFFFAOYSA-N 0.000 claims 1
• ZDOVJTNMWDBXGR-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=CC2=C1 ZDOVJTNMWDBXGR-UHFFFAOYSA-N 0.000 claims 1
• IMTHIUDVPIQGQW-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NCCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=C21 IMTHIUDVPIQGQW-UHFFFAOYSA-N 0.000 claims 1
• SLAQMZWVGJCNMY-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)C(C)C)C(C)=NC2=C1N SLAQMZWVGJCNMY-UHFFFAOYSA-N 0.000 claims 1
• HUNYTONQFMVVQS-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]thiophene-2-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CS1 HUNYTONQFMVVQS-UHFFFAOYSA-N 0.000 claims 1
• ZWRQTDAJYKXNQQ-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-2,4-difluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(F)C=C1F ZWRQTDAJYKXNQQ-UHFFFAOYSA-N 0.000 claims 1
• YHQUGQRPEUNTAM-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-3-cyanobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(C#N)=C1 YHQUGQRPEUNTAM-UHFFFAOYSA-N 0.000 claims 1
• QTDWPMAYCVQJIY-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-3-fluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(F)=C1 QTDWPMAYCVQJIY-UHFFFAOYSA-N 0.000 claims 1
• RCUYAZFEXUCGIY-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-(trifluoromethyl)benzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 RCUYAZFEXUCGIY-UHFFFAOYSA-N 0.000 claims 1
• RAEFMLIDYZOPRW-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-cyanobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(C#N)C=C1 RAEFMLIDYZOPRW-UHFFFAOYSA-N 0.000 claims 1
• VGSSAWOLIAZAJC-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-methoxybenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(OC)C=C1 VGSSAWOLIAZAJC-UHFFFAOYSA-N 0.000 claims 1
• MYBNAGKDKLUDAL-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-methylsulfonylbenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 MYBNAGKDKLUDAL-UHFFFAOYSA-N 0.000 claims 1
• QSTQQGMYOSAJBU-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-phenylbenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 QSTQQGMYOSAJBU-UHFFFAOYSA-N 0.000 claims 1
• NGSMWLVYTPXGSG-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]benzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC=C1 NGSMWLVYTPXGSG-UHFFFAOYSA-N 0.000 claims 1
• PPLLORMLEVBKNC-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CCCC)C(COCC)=NC2=C1N PPLLORMLEVBKNC-UHFFFAOYSA-N 0.000 claims 1
• KBIXFOACTVFDLS-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCCN3C4=C(C)C(C)=NC(N)=C4N=C3COCC)=CC=CC2=C1 KBIXFOACTVFDLS-UHFFFAOYSA-N 0.000 claims 1
• BUIXECQDDBJEMI-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NCCCN3C4=C(C)C(C)=NC(N)=C4N=C3COCC)=CC=C21 BUIXECQDDBJEMI-UHFFFAOYSA-N 0.000 claims 1
• OPQBBPPTDHMXBE-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)C(C)C)C(COCC)=NC2=C1N OPQBBPPTDHMXBE-UHFFFAOYSA-N 0.000 claims 1
• OAUJJHZZTTWAPU-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]thiophene-2-sulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CS1 OAUJJHZZTTWAPU-UHFFFAOYSA-N 0.000 claims 1
• CQVOJUJGWKTFNV-UHFFFAOYSA-N n-[4-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)butyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCCNS(C)(=O)=O)C(C)=NC2=C1N CQVOJUJGWKTFNV-UHFFFAOYSA-N 0.000 claims 1
• KAKVXKNFAGWHQV-UHFFFAOYSA-N n-[4-(4-amino-2-butyl-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-4-fluorobenzenesulfonamide Chemical compound CCCCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCCNS(=O)(=O)C1=CC=C(F)C=C1 KAKVXKNFAGWHQV-UHFFFAOYSA-N 0.000 claims 1
• BUIBORQARMBRLT-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-3-cyanobenzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=CC(C#N)=C1 BUIBORQARMBRLT-UHFFFAOYSA-N 0.000 claims 1
• VJHWRICYZYJJEU-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-3-fluorobenzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=CC(F)=C1 VJHWRICYZYJJEU-UHFFFAOYSA-N 0.000 claims 1
• ZLHNDVKDCSCJRI-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-4-(trifluoromethoxy)benzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 ZLHNDVKDCSCJRI-UHFFFAOYSA-N 0.000 claims 1
• DXAAAHUQPCLIOG-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-4-(trifluoromethyl)benzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 DXAAAHUQPCLIOG-UHFFFAOYSA-N 0.000 claims 1
• KOMGMKFFMHEFRP-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-4-methoxybenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NCCCCN1C2=C(C)C(C)=NC(N)=C2N=C1 KOMGMKFFMHEFRP-UHFFFAOYSA-N 0.000 claims 1
• AVLNVXZBWXJIRW-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-4-methylsulfonylbenzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 AVLNVXZBWXJIRW-UHFFFAOYSA-N 0.000 claims 1
• JYCLAMWXUHYEGY-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]-4-phenylbenzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 JYCLAMWXUHYEGY-UHFFFAOYSA-N 0.000 claims 1
• XCEGLGRJBBTOSW-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]benzenesulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=CC=C1 XCEGLGRJBBTOSW-UHFFFAOYSA-N 0.000 claims 1
• DVJKEBVYTUOIQN-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCCNS(=O)(=O)CCCC)C=NC2=C1N DVJKEBVYTUOIQN-UHFFFAOYSA-N 0.000 claims 1
• JUSQYISIHNLEAD-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]ethanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCCNS(=O)(=O)CC)C=NC2=C1N JUSQYISIHNLEAD-UHFFFAOYSA-N 0.000 claims 1
• GVPUQMOXJGGAEB-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCCCN3C=NC4=C(N)N=C(C(=C43)C)C)=CC=CC2=C1 GVPUQMOXJGGAEB-UHFFFAOYSA-N 0.000 claims 1
• VCZLRMHQUMVFJB-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCCNS(=O)(=O)C(C)C)C=NC2=C1N VCZLRMHQUMVFJB-UHFFFAOYSA-N 0.000 claims 1
• AEROFGQWFDCQRN-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]quinoline-8-sulfonamide Chemical compound C1=CN=C2C(S(=O)(=O)NCCCCN3C=NC4=C(N)N=C(C(=C43)C)C)=CC=CC2=C1 AEROFGQWFDCQRN-UHFFFAOYSA-N 0.000 claims 1
• BWHCFRFOPPHTFD-UHFFFAOYSA-N n-[4-(4-amino-6,7-dimethylimidazo[4,5-c]pyridin-1-yl)butyl]thiophene-2-sulfonamide Chemical compound C12=C(C)C(C)=NC(N)=C2N=CN1CCCCNS(=O)(=O)C1=CC=CS1 BWHCFRFOPPHTFD-UHFFFAOYSA-N 0.000 claims 1
• VMAHXYXUYYNHLY-MZNJEOGPSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-1-[(1r,4s)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C[C@]1(C2(C)C)CC[C@]2([H])CC1=O VMAHXYXUYYNHLY-MZNJEOGPSA-N 0.000 claims 1
• XJVZDRJWRKIIOS-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-1-phenylmethanesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)CC1=CC=CC=C1 XJVZDRJWRKIIOS-UHFFFAOYSA-N 0.000 claims 1
• KULAGXDQLFLPTN-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-2,4-difluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=C(F)C=C1F KULAGXDQLFLPTN-UHFFFAOYSA-N 0.000 claims 1
• YXNKVIZUVTYJOH-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-3-fluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=CC(F)=C1 YXNKVIZUVTYJOH-UHFFFAOYSA-N 0.000 claims 1
• MNLGSRLDWMGIHJ-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-4-(trifluoromethyl)benzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 MNLGSRLDWMGIHJ-UHFFFAOYSA-N 0.000 claims 1
• WOLNIMYNYBZIHG-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-4-cyanobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=C(C#N)C=C1 WOLNIMYNYBZIHG-UHFFFAOYSA-N 0.000 claims 1
• FTYRCEVOMADTNT-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-4-methoxybenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=C(OC)C=C1 FTYRCEVOMADTNT-UHFFFAOYSA-N 0.000 claims 1
• XVSPCXFVTPUQGP-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]-4-methylsulfonylbenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 XVSPCXFVTPUQGP-UHFFFAOYSA-N 0.000 claims 1
• RELZKMMVTUPYKI-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]butane-1-sulfonamide Chemical compound N1=C(C)C=C2N(CCCCNS(=O)(=O)CCCC)C(COCC)=NC2=C1N RELZKMMVTUPYKI-UHFFFAOYSA-N 0.000 claims 1
• KNCFZIDHBPIZOC-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCCCN3C4=CC(C)=NC(N)=C4N=C3COCC)=CC=CC2=C1 KNCFZIDHBPIZOC-UHFFFAOYSA-N 0.000 claims 1
• GAPGIENTCSAKKY-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]propane-2-sulfonamide Chemical compound N1=C(C)C=C2N(CCCCNS(=O)(=O)C(C)C)C(COCC)=NC2=C1N GAPGIENTCSAKKY-UHFFFAOYSA-N 0.000 claims 1
• QJFDZJJWGKGFRE-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]quinoline-8-sulfonamide Chemical compound C1=CN=C2C(S(=O)(=O)NCCCCN3C4=CC(C)=NC(N)=C4N=C3COCC)=CC=CC2=C1 QJFDZJJWGKGFRE-UHFFFAOYSA-N 0.000 claims 1
• RIKRVBHPFFNBFK-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-6-methylimidazo[4,5-c]pyridin-1-yl]butyl]thiophene-2-sulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C=C2N1CCCCNS(=O)(=O)C1=CC=CS1 RIKRVBHPFFNBFK-UHFFFAOYSA-N 0.000 claims 1
• DFULOZCIDXCHFG-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridin-1-yl]butyl]-1-methylimidazole-4-sulfonamide Chemical compound CCOCC1=NC2=C(N)N=CC(C)=C2N1CCCCNS(=O)(=O)C1=CN(C)C=N1 DFULOZCIDXCHFG-UHFFFAOYSA-N 0.000 claims 1
• RJJYXCGGAFJACZ-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridin-1-yl]butyl]-2,4-difluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=CC(C)=C2N1CCCCNS(=O)(=O)C1=CC=C(F)C=C1F RJJYXCGGAFJACZ-UHFFFAOYSA-N 0.000 claims 1
• KEALYSCRFCVXOA-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridin-1-yl]butyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide Chemical compound CCOCC1=NC2=C(N)N=CC(C)=C2N1CCCCNS(=O)(=O)C=1C(C)=NOC=1C KEALYSCRFCVXOA-UHFFFAOYSA-N 0.000 claims 1
• JRURUGXPRSUKMO-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridin-1-yl]butyl]-3-cyanobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=CC(C)=C2N1CCCCNS(=O)(=O)C1=CC=CC(C#N)=C1 JRURUGXPRSUKMO-UHFFFAOYSA-N 0.000 claims 1
• FRYFHVSURUNGBE-UHFFFAOYSA-N n-[4-[4-amino-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridin-1-yl]butyl]-3-fluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=CC(C)=C2N1CCCCNS(=O)(=O)C1=CC=CC(F)=C1 FRYFHVSURUNGBE-UHFFFAOYSA-N 0.000 claims 1
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