HRP20030131B1 - Crystalline and pure modafinil, and process of preparing the same - Google Patents

Crystalline and pure modafinil, and process of preparing the same

Info

Publication number
HRP20030131B1
HRP20030131B1 HR20030131A HRP20030131A HRP20030131B1 HR P20030131 B1 HRP20030131 B1 HR P20030131B1 HR 20030131 A HR20030131 A HR 20030131A HR P20030131 A HRP20030131 A HR P20030131A HR P20030131 B1 HRP20030131 B1 HR P20030131B1
Authority
HR
Croatia
Prior art keywords
crystalline
preparing
same
modafinil
mixture
Prior art date
Application number
HR20030131A
Other languages
English (en)
Croatian (hr)
Inventor
Aronhime Judith
Gershon Neomi
Singer Claude
Ceausu Arina
Liberman Anita
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of HRP20030131A2 publication Critical patent/HRP20030131A2/hr
Publication of HRP20030131B1 publication Critical patent/HRP20030131B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Metallurgy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Laminated Bodies (AREA)
  • Glass Compositions (AREA)
HR20030131A 2000-07-27 2003-02-21 Crystalline and pure modafinil, and process of preparing the same HRP20030131B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US22649100P 2000-08-18 2000-08-18
US22916000P 2000-08-30 2000-08-30
US23008800P 2000-09-05 2000-09-05
US25933201P 2001-01-02 2001-01-02
PCT/US2001/023689 WO2002010125A1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Publications (2)

Publication Number Publication Date
HRP20030131A2 HRP20030131A2 (en) 2005-04-30
HRP20030131B1 true HRP20030131B1 (en) 2011-03-31

Family

ID=27539819

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20030131A HRP20030131B1 (en) 2000-07-27 2003-02-21 Crystalline and pure modafinil, and process of preparing the same
HR20080373A HRP20080373A2 (en) 2000-07-27 2008-07-28 Crystalline and pure modafinil, and process of preparing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
HR20080373A HRP20080373A2 (en) 2000-07-27 2008-07-28 Crystalline and pure modafinil, and process of preparing the same

Country Status (24)

Country Link
US (3) US6849120B2 (ko)
EP (3) EP1309547B1 (ko)
JP (2) JP4302977B2 (ko)
KR (8) KR100729292B1 (ko)
CN (2) CN101186590A (ko)
AT (1) ATE453618T1 (ko)
AU (1) AU2001283008A1 (ko)
CA (3) CA2685310C (ko)
CY (1) CY1110234T1 (ko)
CZ (1) CZ2003529A3 (ko)
DE (3) DE20122504U1 (ko)
DK (2) DK1309547T3 (ko)
ES (2) ES2277937T3 (ko)
HR (2) HRP20030131B1 (ko)
HU (1) HUP0400927A3 (ko)
IL (2) IL154122A0 (ko)
IS (1) IS6699A (ko)
MX (1) MXPA03000747A (ko)
NZ (1) NZ524359A (ko)
PL (1) PL206371B1 (ko)
PT (2) PT1309547E (ko)
SK (1) SK2242003A3 (ko)
WO (1) WO2002010125A1 (ko)
ZA (1) ZA200300672B (ko)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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EP1309547B1 (en) * 2000-07-27 2007-01-17 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
WO2002030414A1 (en) * 2000-10-11 2002-04-18 Cephalon, Inc. Compositions comprising modafinil compounds
PL215226B1 (pl) 2000-10-11 2013-11-29 Cephalon Kompozycja farmaceutyczna zawierajaca zwiazek modafinilu, sposób jej wytwarzania oraz jej zastosowanie
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
EP1515703A1 (en) 2002-06-21 2005-03-23 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
TW200413296A (en) * 2002-08-09 2004-08-01 Cephalon France Modafinil polymorphic forms
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
JP2006518754A (ja) * 2003-02-24 2006-08-17 マリンクロッド・インコーポレイテッド ベンズヒドリルチオアセトアミドの改良製法
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
ES2330321T3 (es) * 2003-05-16 2009-12-09 Cephalon France Procedimiento de sintesis de modafinilo.
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
JP4842819B2 (ja) * 2003-09-04 2011-12-21 セフアロン・インコーポレーテツド モダフィニル組成物
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP2292213A1 (en) * 2004-02-06 2011-03-09 Cephalon, Inc. Compositions comprising a polymorphic form of armodafinil
US20090018202A1 (en) 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
EP1718607A4 (en) * 2004-02-06 2008-05-28 Cephalon Inc COMPOSITIONS BASED ON MODAFINIL
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US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007070238A2 (en) * 2005-12-09 2007-06-21 Mallinckrodt Inc. Processes for the preparation of modafinil and analogs thereof
JP2009508880A (ja) * 2006-02-21 2009-03-05 テバ ファーマシューティカル インダストリーズ リミティド アルモダフィニルの新規な結晶形とその調製方法
EP2043623A4 (en) * 2006-07-12 2013-03-20 Elan Pharma Int Ltd NANOPARTICLE FORMULATIONS OF MODAFINIL
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
EP2155664A2 (en) * 2007-06-04 2010-02-24 Generics Ýuk¨Limited Novel process
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
FR2923482B1 (fr) * 2007-11-09 2010-01-29 Servier Lab Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
US20090105346A1 (en) * 2007-10-02 2009-04-23 Alexandr Jegorov Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
US8551887B2 (en) 2009-12-22 2013-10-08 Air Products And Chemicals, Inc. Method for chemical mechanical planarization of a copper-containing substrate
CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102393940B1 (ko) 2020-11-12 2022-05-09 주식회사 에스코넥 토션 타입 힌지 스프링
KR102369302B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 압축 타입 힌지 스프링
KR102369295B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 벤딩 타입 힌지 스프링

Citations (2)

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Publication number Priority date Publication date Assignee Title
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US5719168A (en) * 1993-06-30 1998-02-17 Laboratoire L. Lafon Acetamide derivatives and their use as feeding behaviour modifiers

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US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
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JP2006518754A (ja) 2003-02-24 2006-08-17 マリンクロッド・インコーポレイテッド ベンズヒドリルチオアセトアミドの改良製法
CA2420180A1 (en) 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
US20040229941A1 (en) 2003-05-13 2004-11-18 Cephalon, Inc. Analeptic and antidepressant combinations
AR045423A1 (es) 2003-05-13 2005-10-26 Cephalon Inc Combinaciones de analiticos y antidepresivos
AR045314A1 (es) 2003-05-13 2005-10-26 Cephalon Inc Composiciones farmaceuticas de analepticos y antidepresivos
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US4177290A (en) * 1977-03-31 1979-12-04 Laboratoire L. Lafon Acetamide derivatives
US5719168A (en) * 1993-06-30 1998-02-17 Laboratoire L. Lafon Acetamide derivatives and their use as feeding behaviour modifiers

Also Published As

Publication number Publication date
JP4980309B2 (ja) 2012-07-18
KR20060024028A (ko) 2006-03-15
JP4302977B2 (ja) 2009-07-29
ES2277937T3 (es) 2007-08-01
EP1787980B1 (en) 2009-12-30
CA2685310C (en) 2012-10-16
DE60126099D1 (de) 2007-03-08
ATE453618T1 (de) 2010-01-15
IS6699A (is) 2003-01-24
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
HRP20080373A2 (en) 2008-12-31
KR20070007970A (ko) 2007-01-16
ES2337838T3 (es) 2010-04-29
KR20090106661A (ko) 2009-10-09
US20050034652A1 (en) 2005-02-17
PL206371B1 (pl) 2010-07-30
US7235691B2 (en) 2007-06-26
MXPA03000747A (es) 2003-06-04
KR101098749B1 (ko) 2011-12-23
KR20070097131A (ko) 2007-10-02
IL154122A (en) 2009-07-20
CA2634702A1 (en) 2002-02-07
CN100500651C (zh) 2009-06-17
KR20100098462A (ko) 2010-09-06
SK2242003A3 (en) 2003-10-07
KR101081212B1 (ko) 2011-11-07
HUP0400927A2 (hu) 2004-07-28
HRP20030131A2 (en) 2005-04-30
CA2685310A1 (en) 2002-02-07
KR100729292B1 (ko) 2007-06-18
US20020043207A1 (en) 2002-04-18
AU2001283008A1 (en) 2002-02-13
NZ524359A (en) 2005-06-24
CN1466570A (zh) 2004-01-07
EP1787980A2 (en) 2007-05-23
EP1309547A1 (en) 2003-05-14
KR20060097771A (ko) 2006-09-15
CY1110234T1 (el) 2015-01-14
JP2009024006A (ja) 2009-02-05
JP2004509080A (ja) 2004-03-25
DK1787980T3 (da) 2010-04-26
KR20030029636A (ko) 2003-04-14
EP2168946A1 (en) 2010-03-31
ZA200300672B (en) 2004-02-18
CZ2003529A3 (cs) 2003-09-17
CA2634702C (en) 2011-07-19
DE20122504U1 (de) 2005-12-29
EP1309547B1 (en) 2007-01-17
US6849120B2 (en) 2005-02-01
DE60140973D1 (de) 2010-02-11
PL365613A1 (en) 2005-01-10
EP1309547A4 (en) 2005-03-02
CA2416792A1 (en) 2002-02-07
DK1309547T3 (da) 2007-05-21
IL154122A0 (en) 2003-07-31
WO2002010125A1 (en) 2002-02-07
PT1787980E (pt) 2010-03-18
US8048222B2 (en) 2011-11-01
US20050038124A1 (en) 2005-02-17
KR101019448B1 (ko) 2011-03-07
KR20090103962A (ko) 2009-10-01
CN101186590A (zh) 2008-05-28
HUP0400927A3 (en) 2007-11-28
EP1787980A3 (en) 2007-08-08
CA2416792C (en) 2010-02-09
DE60126099T2 (de) 2007-11-15

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