DE60140973D1 - Kristallines und reines Modafinil und Verfahren zu seiner Herstellung - Google Patents

Kristallines und reines Modafinil und Verfahren zu seiner Herstellung

Info

Publication number
DE60140973D1
DE60140973D1 DE60140973T DE60140973T DE60140973D1 DE 60140973 D1 DE60140973 D1 DE 60140973D1 DE 60140973 T DE60140973 T DE 60140973T DE 60140973 T DE60140973 T DE 60140973T DE 60140973 D1 DE60140973 D1 DE 60140973D1
Authority
DE
Germany
Prior art keywords
crystalline
preparation
pure modafinil
modafinil
pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60140973T
Other languages
English (en)
Inventor
Claude Singer
Neomi Gershon
Arina Ceausu
Anita Lieberman
Judith Aronhime
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60140973D1 publication Critical patent/DE60140973D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
DE60140973T 2000-07-27 2001-07-27 Kristallines und reines Modafinil und Verfahren zu seiner Herstellung Expired - Lifetime DE60140973D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US22649100P 2000-08-18 2000-08-18
US22916000P 2000-08-30 2000-08-30
US23008800P 2000-09-05 2000-09-05
US25933201P 2001-01-02 2001-01-02

Publications (1)

Publication Number Publication Date
DE60140973D1 true DE60140973D1 (de) 2010-02-11

Family

ID=27539819

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60126099T Expired - Lifetime DE60126099T2 (de) 2000-07-27 2001-07-27 Kristallines und reines modafinil und verfahren zu seiner herstellung
DE60140973T Expired - Lifetime DE60140973D1 (de) 2000-07-27 2001-07-27 Kristallines und reines Modafinil und Verfahren zu seiner Herstellung
DE20122504U Expired - Lifetime DE20122504U1 (de) 2000-07-27 2001-07-27 Kristallines und reines Modafinil

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60126099T Expired - Lifetime DE60126099T2 (de) 2000-07-27 2001-07-27 Kristallines und reines modafinil und verfahren zu seiner herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE20122504U Expired - Lifetime DE20122504U1 (de) 2000-07-27 2001-07-27 Kristallines und reines Modafinil

Country Status (24)

Country Link
US (3) US6849120B2 (de)
EP (3) EP2168946A1 (de)
JP (2) JP4302977B2 (de)
KR (8) KR101019448B1 (de)
CN (2) CN101186590A (de)
AT (1) ATE453618T1 (de)
AU (1) AU2001283008A1 (de)
CA (3) CA2416792C (de)
CY (1) CY1110234T1 (de)
CZ (1) CZ2003529A3 (de)
DE (3) DE60126099T2 (de)
DK (2) DK1309547T3 (de)
ES (2) ES2277937T3 (de)
HR (2) HRP20030131B1 (de)
HU (1) HUP0400927A3 (de)
IL (2) IL154122A0 (de)
IS (1) IS6699A (de)
MX (1) MXPA03000747A (de)
NZ (1) NZ524359A (de)
PL (1) PL206371B1 (de)
PT (2) PT1787980E (de)
SK (1) SK2242003A3 (de)
WO (1) WO2002010125A1 (de)
ZA (1) ZA200300672B (de)

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ES2330321T3 (es) 2003-05-16 2009-12-09 Cephalon France Procedimiento de sintesis de modafinilo.
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
EP1670753A4 (de) * 2003-09-04 2008-01-02 Cephalon Inc Modafinil-zusammensetzungen
US7368591B2 (en) * 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (de) * 2003-09-19 2005-03-23 Cephalon France Verfahren zur enantioselektiven Synthese von einzelnen Modafinil-Enantiomeren durch asymetrische Oxidierung
AU2005212229B2 (en) * 2004-02-06 2011-06-09 Cephalon, Inc. Modafinil compositions
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US20090018202A1 (en) 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
EP2292213A1 (de) * 2004-02-06 2011-03-09 Cephalon, Inc. Armodafinil Polymorph enthaltende Zusammensetzungen
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (de) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituierte Arylmethansulfinyl-Derivate
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
CN101326159A (zh) * 2005-12-09 2008-12-17 马林克罗特公司 制备莫达非尼及其类似物的方法
EP1986994A2 (de) * 2006-02-21 2008-11-05 Teva Pharmaceutical Industries Ltd Neue kristalline formen von armodafinil und ihre herstellung
KR20090031618A (ko) * 2006-07-12 2009-03-26 엘란 코포레이션, 피엘씨 나노입자형 모다피닐 제제
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
WO2008149141A2 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
WO2009025791A2 (en) * 2007-08-16 2009-02-26 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
FR2923482B1 (fr) * 2007-11-09 2010-01-29 Servier Lab Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
WO2009045488A2 (en) * 2007-10-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
US8551887B2 (en) 2009-12-22 2013-10-08 Air Products And Chemicals, Inc. Method for chemical mechanical planarization of a copper-containing substrate
CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
PE20160945A1 (es) 2013-11-15 2016-09-26 Akebia Therapeutics Inc Formas solidas de acido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acetico, composiciones, y usos de las mismas
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102393940B1 (ko) 2020-11-12 2022-05-09 주식회사 에스코넥 토션 타입 힌지 스프링
KR102369295B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 벤딩 타입 힌지 스프링
KR102369302B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 압축 타입 힌지 스프링

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Also Published As

Publication number Publication date
HUP0400927A2 (hu) 2004-07-28
CA2634702A1 (en) 2002-02-07
CN1466570A (zh) 2004-01-07
US8048222B2 (en) 2011-11-01
JP4980309B2 (ja) 2012-07-18
KR101098749B1 (ko) 2011-12-23
AU2001283008A1 (en) 2002-02-13
EP2168946A1 (de) 2010-03-31
ES2277937T3 (es) 2007-08-01
KR20090106661A (ko) 2009-10-09
JP4302977B2 (ja) 2009-07-29
KR20060097771A (ko) 2006-09-15
JP2004509080A (ja) 2004-03-25
EP1787980B1 (de) 2009-12-30
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
US20050038124A1 (en) 2005-02-17
ATE453618T1 (de) 2010-01-15
CA2685310C (en) 2012-10-16
EP1309547A1 (de) 2003-05-14
KR20070007970A (ko) 2007-01-16
ZA200300672B (en) 2004-02-18
KR20090103962A (ko) 2009-10-01
KR20100098462A (ko) 2010-09-06
CA2685310A1 (en) 2002-02-07
PT1787980E (pt) 2010-03-18
EP1309547A4 (de) 2005-03-02
KR20070097131A (ko) 2007-10-02
SK2242003A3 (en) 2003-10-07
KR20030029636A (ko) 2003-04-14
US20050034652A1 (en) 2005-02-17
KR100729292B1 (ko) 2007-06-18
DE60126099D1 (de) 2007-03-08
US7235691B2 (en) 2007-06-26
ES2337838T3 (es) 2010-04-29
CN101186590A (zh) 2008-05-28
CZ2003529A3 (cs) 2003-09-17
US20020043207A1 (en) 2002-04-18
IL154122A0 (en) 2003-07-31
EP1309547B1 (de) 2007-01-17
EP1787980A3 (de) 2007-08-08
KR20060024028A (ko) 2006-03-15
KR101081212B1 (ko) 2011-11-07
DE60126099T2 (de) 2007-11-15
PL206371B1 (pl) 2010-07-30
PL365613A1 (en) 2005-01-10
JP2009024006A (ja) 2009-02-05
IL154122A (en) 2009-07-20
CA2416792A1 (en) 2002-02-07
MXPA03000747A (es) 2003-06-04
NZ524359A (en) 2005-06-24
EP1787980A2 (de) 2007-05-23
DK1309547T3 (da) 2007-05-21
HRP20030131A2 (en) 2005-04-30
CA2416792C (en) 2010-02-09
HRP20080373A2 (en) 2008-12-31
IS6699A (is) 2003-01-24
WO2002010125A1 (en) 2002-02-07
HRP20030131B1 (en) 2011-03-31
CN100500651C (zh) 2009-06-17
CA2634702C (en) 2011-07-19
HUP0400927A3 (en) 2007-11-28
US6849120B2 (en) 2005-02-01
DE20122504U1 (de) 2005-12-29
DK1787980T3 (da) 2010-04-26
CY1110234T1 (el) 2015-01-14
KR101019448B1 (ko) 2011-03-07

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