HRP20030108B1 - Stable salts of o-acetylsalicyclic with basic amino acids - Google Patents

Stable salts of o-acetylsalicyclic with basic amino acids

Info

Publication number
HRP20030108B1
HRP20030108B1 HR20030108A HRP20030108A HRP20030108B1 HR P20030108 B1 HRP20030108 B1 HR P20030108B1 HR 20030108 A HR20030108 A HR 20030108A HR P20030108 A HRP20030108 A HR P20030108A HR P20030108 B1 HRP20030108 B1 HR P20030108B1
Authority
HR
Croatia
Prior art keywords
basic amino
acetylsalicyclic
amino acids
stable salts
particle size
Prior art date
Application number
HR20030108A
Other languages
English (en)
Croatian (hr)
Inventor
Franckowiak Gerhard
Appolt Hubert
Leifker Gregor
Wirges Hans-Peter
Ledwoch Wolfram
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of HRP20030108A2 publication Critical patent/HRP20030108A2/hr
Publication of HRP20030108B1 publication Critical patent/HRP20030108B1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
HR20030108A 2000-07-18 2003-02-17 Stable salts of o-acetylsalicyclic with basic amino acids HRP20030108B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10034802A DE10034802A1 (de) 2000-07-18 2000-07-18 Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren
PCT/EP2001/007669 WO2002005782A2 (de) 2000-07-18 2001-07-05 Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren

Publications (2)

Publication Number Publication Date
HRP20030108A2 HRP20030108A2 (en) 2005-02-28
HRP20030108B1 true HRP20030108B1 (en) 2006-12-31

Family

ID=7649258

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030108A HRP20030108B1 (en) 2000-07-18 2003-02-17 Stable salts of o-acetylsalicyclic with basic amino acids

Country Status (34)

Country Link
US (2) US6773724B2 (zh)
EP (1) EP1365737B1 (zh)
JP (2) JP2004507463A (zh)
KR (1) KR100773658B1 (zh)
CN (1) CN1205176C (zh)
AR (1) AR030305A1 (zh)
AT (1) ATE293589T1 (zh)
AU (2) AU2001278471B2 (zh)
BR (1) BR0112538A (zh)
CA (1) CA2416288C (zh)
CR (1) CR6888A (zh)
CZ (1) CZ300337B6 (zh)
DE (2) DE10034802A1 (zh)
DK (1) DK1365737T3 (zh)
EC (1) ECSP034437A (zh)
ES (1) ES2241849T3 (zh)
GT (1) GT200100134A (zh)
HK (1) HK1061811A1 (zh)
HR (1) HRP20030108B1 (zh)
HU (1) HUP0302053A3 (zh)
IL (2) IL153873A0 (zh)
MX (1) MXPA03000510A (zh)
MY (1) MY134521A (zh)
NO (1) NO20030222L (zh)
PE (1) PE20020267A1 (zh)
PL (1) PL204593B1 (zh)
PT (1) PT1365737E (zh)
RS (1) RS50329B (zh)
SK (1) SK286162B6 (zh)
SV (1) SV2002000557A (zh)
TW (1) TWI299729B (zh)
UY (1) UY26841A1 (zh)
WO (1) WO2002005782A2 (zh)
ZA (1) ZA200300469B (zh)

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US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
US8142810B2 (en) 2002-05-30 2012-03-27 The Procter & Gamble Company Dietary method for modulating glucose metabolism and associated conditions and increasing longevity
DE60329167D1 (de) * 2003-05-16 2009-10-22 Cephalon France Verfahren zur Herstellung von Modafinil
EP1778652A2 (en) * 2004-08-20 2007-05-02 EntreMed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
US20060166901A1 (en) * 2005-01-03 2006-07-27 Yu Ruey J Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids
DE102005025283A1 (de) * 2005-06-02 2006-12-07 Bayer Healthcare Ag Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin
DE102005049293A1 (de) * 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
CA2656858C (en) 2006-07-09 2016-01-19 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of acetylsalicylic acid
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
KR20220107078A (ko) 2007-06-04 2022-08-01 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도
DE102008004386A1 (de) * 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen
CN101314029B (zh) * 2008-06-18 2010-12-08 四川省农业科学院实验场 乙酰水杨酸肽及其制备方法
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
CN107320732B (zh) 2008-12-04 2021-09-07 于崇曦 高穿透性组合物及其应用
CA2766048A1 (en) * 2009-06-25 2010-12-29 Tetra, Sia Novel acetylsalicylic acid salts
CN101633624B (zh) * 2009-08-04 2013-05-01 蚌埠丰原医药科技发展有限公司 改进的赖氨匹林的制备方法
FR2950625B1 (fr) * 2009-09-30 2016-12-02 Holis Tech Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue
FR2965261B1 (fr) * 2009-09-30 2012-10-26 Holis Technologies Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede
FR2973370B1 (fr) * 2011-03-29 2013-05-03 Holis Technologies Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique
CN102503845A (zh) * 2011-09-28 2012-06-20 广州普星药业有限公司 一种dl-赖氨酸阿司匹林盐的制备方法及其应用
KR102232625B1 (ko) 2012-01-18 2021-03-25 테크필즈 파마 코., 엘티디. 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물
CN102976962B (zh) * 2012-11-20 2015-02-04 南京工业大学 L-鸟氨酸阿司匹林复盐及其制备方法和应用
FR3021654B1 (fr) * 2014-05-28 2016-06-24 Unither Pharmaceuticals Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique
AU2017383071B2 (en) * 2016-12-23 2021-04-29 Aspiair Gmbh Improved synthesis of lysine acetylsalicylate · glycine particles
CN110996965A (zh) * 2017-05-30 2020-04-10 罗山制药股份有限公司 稳定、无菌和结晶的邻乙酰水杨酸(阿司匹林)的小瓶内沉积物
JPWO2019026992A1 (ja) * 2017-08-03 2020-06-18 参天製薬株式会社 クロルヘキシジンを含有する医薬組成物
CN113105326A (zh) * 2021-03-24 2021-07-13 海南卓华制药有限公司 赖氨匹林的制备方法及应用
CN114478287A (zh) * 2021-12-31 2022-05-13 蚌埠丰原医药科技发展有限公司 一种赖氨匹林晶型及制备方法和应用
CA3239851A1 (en) 2022-01-05 2023-07-13 Karlheinz Nocker Improved synthesis of lysine acetylsalicylate · glycine particles

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FR2115060A1 (en) * 1970-11-26 1972-07-07 Metabio Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
ES388158A1 (es) * 1971-02-11 1974-03-16 Liade Sa Lab Procedimiento de obtencion de sales solubles del acido ace-til salicilico.
JPS4856815A (zh) * 1971-11-13 1973-08-09
JPS55127345A (en) * 1979-03-23 1980-10-02 Kyowa Hakko Kogyo Co Ltd Preparation of acetylsalicylic acid salt
JPS5610110A (en) * 1979-07-06 1981-02-02 Green Cross Corp:The Acetyl salicylate salt preparation for injection
JPS56113741A (en) * 1980-02-13 1981-09-07 Mitsui Toatsu Chem Inc Preparation of crystal of acetylsalicylic acid salt
JPS5721345A (en) * 1980-07-15 1982-02-04 Mitsui Toatsu Chem Inc Purification of acetylsalicylate salt
CS247688B1 (cs) * 1984-12-22 1987-01-15 Evzen Kasafirek Způsob výroby soli lysinu s kyselinou acetylsalicylovou
JPS632929A (ja) * 1986-06-20 1988-01-07 Kao Corp アセチルサリチル酸製剤
EP0499142A3 (en) * 1991-02-09 1993-05-05 Hoechst Aktiengesellschaft Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non steroidal anti-flammatory drugs
DE4332093C2 (de) * 1993-09-22 1995-07-13 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
HUP0302053A2 (hu) 2003-09-29
HK1061811A1 (en) 2004-10-08
CZ2003164A3 (cs) 2003-04-16
UY26841A1 (es) 2002-02-28
AU7847101A (en) 2002-01-30
EP1365737A2 (de) 2003-12-03
DK1365737T3 (da) 2005-07-11
SV2002000557A (es) 2002-10-24
RS50329B (sr) 2009-09-08
US7449198B2 (en) 2008-11-11
PL365648A1 (en) 2005-01-10
CA2416288A1 (en) 2003-01-15
PE20020267A1 (es) 2002-06-08
ES2241849T3 (es) 2005-11-01
KR20030019586A (ko) 2003-03-06
GT200100134A (es) 2002-03-22
MXPA03000510A (es) 2004-04-20
PT1365737E (pt) 2005-08-31
CZ300337B6 (cs) 2009-04-22
SK672003A3 (en) 2003-06-03
ZA200300469B (en) 2004-06-21
CR6888A (es) 2004-10-28
HUP0302053A3 (en) 2010-03-29
IL153873A0 (en) 2003-07-31
ATE293589T1 (de) 2005-05-15
US20020091108A1 (en) 2002-07-11
TWI299729B (en) 2008-08-11
SK286162B6 (sk) 2008-04-07
KR100773658B1 (ko) 2007-11-05
WO2002005782A3 (de) 2003-10-02
PL204593B1 (pl) 2010-01-29
HRP20030108A2 (en) 2005-02-28
CN1205176C (zh) 2005-06-08
DE50105985D1 (de) 2005-05-25
IL153873A (en) 2009-05-04
EP1365737B1 (de) 2005-04-20
YU2003A (sh) 2006-08-17
MY134521A (en) 2007-12-31
AU2001278471B2 (en) 2004-07-22
BR0112538A (pt) 2003-09-09
JP2012131824A (ja) 2012-07-12
AR030305A1 (es) 2003-08-20
ECSP034437A (es) 2003-03-31
CA2416288C (en) 2009-12-22
NO20030222D0 (no) 2003-01-16
US20050009791A1 (en) 2005-01-13
JP2004507463A (ja) 2004-03-11
DE10034802A1 (de) 2002-01-31
US6773724B2 (en) 2004-08-10
WO2002005782A2 (de) 2002-01-24
NO20030222L (no) 2003-01-16
CN1468209A (zh) 2004-01-14

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