HRP20030079B8 - Novel c-crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same - Google Patents
Novel c-crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing sameInfo
- Publication number
- HRP20030079B8 HRP20030079B8 HR20030079A HRP20030079A HRP20030079B8 HR P20030079 B8 HRP20030079 B8 HR P20030079B8 HR 20030079 A HR20030079 A HR 20030079A HR P20030079 A HRP20030079 A HR P20030079A HR P20030079 B8 HRP20030079 B8 HR P20030079B8
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- crystalline form
- novel
- butylamine salt
- pharmaceutical compositions
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical class CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 abstract 2
- 229960002582 perindopril Drugs 0.000 abstract 2
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0008792A FR2811319B1 (fr) | 2000-07-06 | 2000-07-06 | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| PCT/FR2001/002168 WO2001087836A1 (fr) | 2000-07-06 | 2001-07-06 | Nouvelle forme cristalline $g(b) du sel de tert-butylamine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HRP20030079A2 HRP20030079A2 (en) | 2003-04-30 |
| HRP20030079B1 HRP20030079B1 (en) | 2007-12-31 |
| HRP20030079B8 true HRP20030079B8 (en) | 2008-09-30 |
Family
ID=8852171
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030079A HRP20030079B8 (en) | 2000-07-06 | 2003-02-06 | Novel c-crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same |
| HR20060361A HRP20060361A8 (en) | 2000-07-06 | 2006-10-20 | Novel c-crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20060361A HRP20060361A8 (en) | 2000-07-06 | 2006-10-20 | Novel c-crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US20040029813A1 (xx) |
| EP (2) | EP1294689B1 (xx) |
| JP (2) | JP3592297B2 (xx) |
| KR (1) | KR100513571B1 (xx) |
| CN (1) | CN1328260C (xx) |
| AP (1) | AP1407A (xx) |
| AR (1) | AR029571A1 (xx) |
| AT (1) | ATE324367T1 (xx) |
| AU (2) | AU2001276419B2 (xx) |
| BG (1) | BG66131B1 (xx) |
| BR (1) | BR0112244A (xx) |
| CA (1) | CA2415442C (xx) |
| CZ (1) | CZ301765B6 (xx) |
| DE (1) | DE60119107T2 (xx) |
| DK (1) | DK1294689T3 (xx) |
| EA (1) | EA004874B1 (xx) |
| EE (1) | EE05285B1 (xx) |
| ES (1) | ES2262666T3 (xx) |
| FR (1) | FR2811319B1 (xx) |
| GE (1) | GEP20043360B (xx) |
| HK (1) | HK1058200A1 (xx) |
| HR (2) | HRP20030079B8 (xx) |
| HU (1) | HU227673B1 (xx) |
| ME (1) | ME00440B (xx) |
| MX (1) | MXPA02012921A (xx) |
| NO (1) | NO323446B1 (xx) |
| NZ (1) | NZ523234A (xx) |
| OA (1) | OA12305A (xx) |
| PL (1) | PL348493A1 (xx) |
| PT (1) | PT1294689E (xx) |
| RS (1) | RS51717B (xx) |
| SI (1) | SI1294689T1 (xx) |
| SK (1) | SK286918B6 (xx) |
| UA (1) | UA57189C2 (xx) |
| WO (1) | WO2001087836A1 (xx) |
| ZA (1) | ZA200300024B (xx) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| GB2395195A (en) | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
| JP2007507418A (ja) * | 2003-06-24 | 2007-03-29 | レ・ラボラトワール・セルヴィエ | ペリンドプリルエルブミンの新しい結晶型 |
| ATE452124T1 (de) | 2003-10-21 | 2010-01-15 | Servier Lab | Verfahren zur herstellung kristallinem perindopril erbumin |
| SI21703A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
| EA011712B1 (ru) * | 2004-03-29 | 2009-04-28 | Ле Лаборатуар Сервье | Способ производства твёрдой фармацевтической композиции |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
| SG125976A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
| SG125975A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
| JP2006290825A (ja) * | 2005-04-13 | 2006-10-26 | Shiono Chemical Co Ltd | アルファ型ペリンドプリルエルブミンの製造法 |
| WO2007017894A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE |
| MX2008002066A (es) * | 2005-08-12 | 2008-04-16 | Sandoz Ag | Neuva forma cristalina de perindopril-erbumina. |
| US20100016614A1 (en) * | 2005-08-12 | 2010-01-21 | Lek Pharmaceuticals D.D | Process for the preparation of perindopril erbumine |
| EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
| WO2007092758A2 (en) * | 2006-02-03 | 2007-08-16 | Dr. Reddy's Laboratories Ltd. | Crystalline forms of perindopril erbumine |
| FR2897865B1 (fr) * | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2897866B1 (fr) | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| WO2008050185A2 (en) * | 2006-10-26 | 2008-05-02 | Glenmark Pharmaceuticals Limited | Novel polymorphs of perindopril erbumine |
| WO2008120241A2 (en) * | 2007-03-29 | 2008-10-09 | Ipca Laboratories Limited | Novel alcohol solvates of perindopril erbumine |
| SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
| WO2009157018A2 (en) * | 2008-06-24 | 2009-12-30 | Matrix Laboratories Ltd | Novel polymorphic forms of perindopril (l)-arginine and process for the preparation thereof |
| SI23149A (sl) | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
| PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
| CN106432042A (zh) * | 2015-08-13 | 2017-02-22 | 南京华威医药科技开发有限公司 | 尼达尼布乙磺酸水合物的药物新晶型 |
| EP3842035A1 (en) | 2019-12-23 | 2021-06-30 | KRKA, d.d., Novo mesto | Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| FR2771010B1 (fr) * | 1997-11-19 | 2003-08-15 | Adir | Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires |
| FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811318B1 (fr) | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
-
2000
- 2000-07-06 FR FR0008792A patent/FR2811319B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-07 UA UA2003021021A patent/UA57189C2/uk unknown
- 2001-07-05 HU HU0102813A patent/HU227673B1/hu not_active IP Right Cessation
- 2001-07-06 EA EA200300103A patent/EA004874B1/ru not_active IP Right Cessation
- 2001-07-06 MX MXPA02012921A patent/MXPA02012921A/es active IP Right Grant
- 2001-07-06 CZ CZ20030356A patent/CZ301765B6/cs not_active IP Right Cessation
- 2001-07-06 AP APAP/P/2002/002710A patent/AP1407A/en active
- 2001-07-06 WO PCT/FR2001/002168 patent/WO2001087836A1/fr active Application Filing
- 2001-07-06 OA OA1200200398A patent/OA12305A/en unknown
- 2001-07-06 ES ES01954059T patent/ES2262666T3/es not_active Expired - Lifetime
- 2001-07-06 ME MEP-2008-669A patent/ME00440B/me unknown
- 2001-07-06 GE GE5076A patent/GEP20043360B/en unknown
- 2001-07-06 AR ARP010103225A patent/AR029571A1/es unknown
- 2001-07-06 KR KR10-2003-7000116A patent/KR100513571B1/ko not_active IP Right Cessation
- 2001-07-06 RS YU100502A patent/RS51717B/sr unknown
- 2001-07-06 AU AU2001276419A patent/AU2001276419B2/en not_active Ceased
- 2001-07-06 JP JP2001584233A patent/JP3592297B2/ja not_active Expired - Fee Related
- 2001-07-06 NZ NZ523234A patent/NZ523234A/en not_active IP Right Cessation
- 2001-07-06 SI SI200130535T patent/SI1294689T1/sl unknown
- 2001-07-06 CN CNB018123554A patent/CN1328260C/zh not_active Expired - Fee Related
- 2001-07-06 DK DK01954059T patent/DK1294689T3/da active
- 2001-07-06 EE EEP200300002A patent/EE05285B1/xx not_active IP Right Cessation
- 2001-07-06 DE DE60119107T patent/DE60119107T2/de not_active Expired - Lifetime
- 2001-07-06 SK SK148-2003A patent/SK286918B6/sk not_active IP Right Cessation
- 2001-07-06 CA CA002415442A patent/CA2415442C/fr not_active Expired - Fee Related
- 2001-07-06 US US10/312,902 patent/US20040029813A1/en not_active Abandoned
- 2001-07-06 AU AU7641901A patent/AU7641901A/xx active Pending
- 2001-07-06 EP EP01954059A patent/EP1294689B1/fr not_active Expired - Lifetime
- 2001-07-06 EP EP06075789A patent/EP1676839A3/fr not_active Withdrawn
- 2001-07-06 BR BR0112244-4A patent/BR0112244A/pt not_active Application Discontinuation
- 2001-07-06 PL PL01348493A patent/PL348493A1/xx not_active Application Discontinuation
- 2001-07-06 AT AT01954059T patent/ATE324367T1/de active
- 2001-07-06 PT PT01954059T patent/PT1294689E/pt unknown
-
2003
- 2003-01-02 ZA ZA200300024A patent/ZA200300024B/en unknown
- 2003-01-06 NO NO20030050A patent/NO323446B1/no not_active IP Right Cessation
- 2003-02-05 BG BG107533A patent/BG66131B1/bg unknown
- 2003-02-06 HR HR20030079A patent/HRP20030079B8/xx not_active IP Right Cessation
-
2004
- 2004-02-12 HK HK04100953A patent/HK1058200A1/xx not_active IP Right Cessation
- 2004-07-13 JP JP2004206159A patent/JP2005002121A/ja active Pending
-
2005
- 2005-02-04 US US11/052,489 patent/US7259181B2/en not_active Expired - Fee Related
-
2006
- 2006-10-20 HR HR20060361A patent/HRP20060361A8/xx not_active Application Discontinuation
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