DE60013326D1 - Verbindungen und verfahren zur behandlung von schmerz - Google Patents

Verbindungen und verfahren zur behandlung von schmerz

Info

Publication number
DE60013326D1
DE60013326D1 DE60013326T DE60013326T DE60013326D1 DE 60013326 D1 DE60013326 D1 DE 60013326D1 DE 60013326 T DE60013326 T DE 60013326T DE 60013326 T DE60013326 T DE 60013326T DE 60013326 D1 DE60013326 D1 DE 60013326D1
Authority
DE
Germany
Prior art keywords
connections
treating pain
structural diagram
pain
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60013326T
Other languages
English (en)
Other versions
DE60013326T2 (de
Inventor
Dean Gordon Brown
Wenhua Xiao
Rebecca Ann Urbanek
Megan Murphy
Michael Bare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60013326D1 publication Critical patent/DE60013326D1/de
Publication of DE60013326T2 publication Critical patent/DE60013326T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
DE60013326T 1999-12-23 2000-12-19 Verbindungen und verfahren zur behandlung von schmerz Expired - Fee Related DE60013326T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17190699P 1999-12-23 1999-12-23
US171906P 1999-12-23
US23688000P 2000-09-29 2000-09-29
US236880P 2000-09-29
PCT/SE2000/002606 WO2001047923A1 (en) 1999-12-23 2000-12-19 Compounds and methods for the treatment of pain

Publications (2)

Publication Number Publication Date
DE60013326D1 true DE60013326D1 (de) 2004-09-30
DE60013326T2 DE60013326T2 (de) 2005-09-08

Family

ID=26867560

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60013326T Expired - Fee Related DE60013326T2 (de) 1999-12-23 2000-12-19 Verbindungen und verfahren zur behandlung von schmerz

Country Status (6)

Country Link
EP (1) EP1244663B1 (de)
JP (1) JP2003519145A (de)
AT (1) ATE274513T1 (de)
AU (1) AU2566101A (de)
DE (1) DE60013326T2 (de)
WO (1) WO2001047923A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026738A1 (en) * 2000-09-29 2002-04-04 Astrazeneca Ab 1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-b]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN
EP1325004A1 (de) 2000-09-29 2003-07-09 AstraZeneca AB 1,2,5,10-tetrahydropyridazino[4,5-b]chinolin-1,10-dione und ihre verwendung zur behandlung von schmerzen
US20050070544A1 (en) * 2000-09-29 2005-03-31 Astrazeneca Ab 1,2,5,10-tetrahydropyridazino{4,5-b}quinoline-1,10-diones and their use for the treatment of pain
WO2003051841A2 (en) * 2001-12-14 2003-06-26 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
WO2004111006A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Para-subtituted phenyl carbamates as inhibitors of hormone sensitive lipase
SE0403172D0 (sv) * 2004-12-23 2004-12-23 Astrazeneca Ab Manufacturing process
AU2007231012B2 (en) * 2006-03-24 2013-07-04 The Feinstein Institute For Medical Research Phenolic hydrazone macrophage migration inhibitory factor inhibitors
US9999944B2 (en) 2012-08-28 2018-06-19 Hobart Brothers Company Systems and methods for welding electrodes
EP3055101A2 (de) 2013-10-09 2016-08-17 Hobart Brothers Company Systeme und verfahren für korrosionsbeständige schweisselektroden

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111266A (en) * 1993-10-22 2002-03-10 Zeneca Ltd 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) * 1994-11-12 1995-01-04 Zeneca Ltd Pyridazino quinoline compounds
GB9507318D0 (en) * 1995-04-07 1995-05-31 Zeneca Ltd Alpha substituted pyridazino quinoline compounds

Also Published As

Publication number Publication date
EP1244663A1 (de) 2002-10-02
WO2001047923A1 (en) 2001-07-05
EP1244663B1 (de) 2004-08-25
ATE274513T1 (de) 2004-09-15
AU2566101A (en) 2001-07-09
DE60013326T2 (de) 2005-09-08
JP2003519145A (ja) 2003-06-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee